Analysis on the influencing factors of pregnancy outcome during in vitro fertilization and embryo transfer cycles in patients with endometriosis

Objective: To explore the influencing factors of pregnancy outcome during in vitro fertilization( IVF) or intracytoplasmic sperm injection( ICSI) cycles in patients with endometriosis. Methods: A total of 321 patients receiving IVF and( or) ICSI in department of reproductive medicine in Shenzhen Hospital of Beijing University from January 2011 to March 2013 were analyzed retrospectively,then the patients were divided into endometriosis group( 143 patients) and control group( 178 patients); the patients in endometriosis group and control group were further divided into pregnancy subgroup and non- pregnancy subgroup; the clinical data in different groups were summarized. Results: In endometriosis group,compared with non- pregnancy subgroup,antral follicle count in pregnancy subgroup increased,the dosage of Gn decreased,estradiol level on the day of human chorionic gonadotropin( h CG) injection,the number of retrieved oocytes,the number of embryos transferred and the number of frozen embryos increased,there were statistically significant differences( P 0. 05).In control group,there was no statistically significant difference in the indexes above- mentioned between pregnancy subgroup and non-pregnancy subgroup( P 0. 05); in endometriosis group,the values of body mass index( BMI) in pregnancy subgroup and non- pregnancy subgroup were( 20. 72 ± 2. 41) kg / m2and( 19. 86 ± 1. 96) kg / m2,respectively,there was statistically significant difference( P 0. 05).In control group,the values of BMI in pregnancy subgroup and non- pregnancy subgroup were( 21. 33 ± 2. 52) kg / m2and( 21. 39 ±2. 99) kg / m2,respectively,there was no statistically significant difference( P 0. 05). There was no statistically significant difference in antral follicle count,the dosage of Gn,estradiol level on the day of h CG injection,the number of retrieved oocytes,the number of embryos transferred,the number of frozen embryos and BMI between pregnancy subgroup in endometriosis group and pregnancy subgroup in control group( P 0. 05). The number of frozen embryos and BMI in non- pregnancy subgroup in endometriosis group were significantly lower than those in non- pregnancy subgroup in control group,but there was no statistically significant difference in the other indexes( P 0. 05).Conclusion: The patients with endometriosis who succeed in IVF and get pregnancy have good ovary response and high BMI. Ovary response is an important influencing factor of IVF outcome.