Systematic review of humeral shaft fracture (OTA/AO 12) complicated with iatrogenic radial nerve injury: Can nerve fibers span a 3cm nerve defect?

Systematic review of humeral shaft fracture (OTA/AO 12) complicated with iatrogenic radial nerve injury: Can nerve fibers span a 3cm nerve defect? | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Systematic review of humeral shaft fracture (OTA/AO 12) complicated with iatrogenic radial nerve injury: Can nerve fibers span a 3cm nerve defect? Zeyu Zhang, Zhongpei Lin, Qinglin Qiu, Xincai Xiao, Shouwen Su, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3972889/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 25 Jul, 2024 Read the published version in European Journal of Medical Research → Version 1 posted 10 You are reading this latest preprint version Abstract Objectives: Compare and analyze the relationship between the implant (bone plate VS. intramedullary nail), surgical approach and iatrogenic radial nerve injury. Report a case which indicates the possible distance between two nerve stumps which radial never might crawl through. Methods: Reviewed the literatures on humeral fracture (OTA/AO 11/12/13 A/B/C 9 ) combined with radial nerve injury was retrieved in PubMed. Screening scope includes: 1) Chinese or English literature, 2) adult humeral fracture, 3) preoperative radial nerve continuity, 4) non-pathological fracture, 5) non-periprosthetic fracture, 6) must involve humeral shaft (OTA/AO 12). Exclusion criteria: 1) No full text in Chinese or English; 2) Unable to judge surgical approach. Rejection criteria: 1) Misinclusion; 2) Unable to judge whether the humeral shaft was involved (OTA/AO 12). Results: 1. The rate of iatrogenic radial nerve injury with bone plate and intramedullary nail was 6.82% (313/4589) and 2.58% (23/893) respectively (p < 0.05). 2.In cases with open reduction and internal fixation with a plate with a definite surgical approach (excluding MIPO), the rate of radial nerve injury was 7.44% (259/3483). The corresponding rates were 3.7% (3/82) for deltopectoral approach, 5.65% (111/1963) for anterolateral approach, 13.54% (26/192) for lateral approach and 9.55% (119/1246) for posterior approach. There were statistical differences between anterolateral and lateral approaches and anterolateral and posterior approaches. 3.The injury rates of radial nerve were 7.26% (301/4145) for plate internal fixation, 2.58% (23/893) for intramedullary nail and 2.70% (12/444) for MIPO. There were statistical differences between plate fixation and intramedullary nail, plate fixation and MIPO (p 0.05). 4. The radial nerve injury rates were 0.00% (0/33) for Anteromedial MIPO, 2.67% (10/374) for Anterolateral MIPO and 5.40% (2/37) for Posterior MIPO. (p > 0.05) 5. The radial nerve injury rates were 2.87% (21/732) for anterograde intramedullary nail and 1.2% (2/161) for retrograde intramedullary nail. (p > 0.05) 6. In nonunion surgery, the rate of iatrogenic radial nerve injury was 15.0% (9/60) for anterolateral approach, 16.7% (2/12) for lateral approach and 18.2% (6/33) for posterior approach. (p > 0.05) Conclusion: During humeral shaft fracture operation, the incidence of iatrogenic radial nerve injury was 6.82% in bone plate and 2.58% in intramedullary nails, respectively. Compared with lateral and posterior approaches, the anterolateral surgical approach had a lower incidence of radial nerve injury. The rate of iatrogenic radial nerve injury in MIPO was lower than that in open reduction and internal fixation. There was no difference in the incidence of iatrogenic radial nerve injury between anterograde and retrograde intramedullary nailing. In the human body, regenerated radial nerve fibers can span a 4cm nerve defect area. Level of Evidence: Level IV Iatrogenic radial nerve injury Humerus Nerve regeneration Neurotmesis Figures Figure 1 Figure 2 Instruction Humeral shaft fractures account for about 1–5% of all fractures 1–4 and 20% of humeral fractures 5 . A considerable part of humeral shaft fractures needs surgical treatment, and iatrogenic nerve injury may occur during operation. A single-center retrospective study by Entezari et al. found that the incidence of humeral shaft fracture combined with iatrogenic nerve injury was 4.6% (7/154), and all involved radial nerve 6 . The incidence of humeral shaft fracture complicated with radial nerve injury varies among different literatures. The retrospective study by Claessen et al. of 6 hospitals found that the incidence of humeral shaft fracture complicated with iatrogenic radial nerve injury was about 7% (18/259) 7 . It is reported that the incidence of iatrogenic radial nerve injury is different with different implants and different surgical approaches. Amer et al. reviewed 3 literatures and reported that the incidence of nerve injury was 10.8% (12/111) for open reduction and internal fixation with plate and 0% (0/104) for intramedullary nail 8 . A retrospective study by Claessen et al. on 6 hospitals found that the corresponding probabilities of nerve injury were 4% (7/165) for anterolateral approach, 22% (2/9) for lateral approach and 11% (9/85) for posterior approach 7 . This paper intends to search the literature on humeral shaft fracture complicated with radial nerve injury from 2000 to October 2023 in the PubMed database and compare and analyze the relationship between the implant (bone plate VS . intramedullary nail), surgical approach and iatrogenic radial nerve injury, to assist clinicians in selecting implants and surgical approach. Methods 1. Document retrieval: The literatures on humeral fracture (OTA/AO 11/12/13 A/B/C 9 ) combined with radial nerve injury was retrieved in PubMed with "(humeral fracture) AND (iatrogenic radial nerve injury)" as the search term. Screening scope includes: 1) Chinese or English literature, 2) adult humeral fracture, 3) preoperative radial nerve continuity, 4) non-pathological fracture, 5) non-periprosthetic fracture, 6) must involve humeral shaft (OTA/AO 12). Exclusion criteria: 1) No full text in Chinese or English; 2) Unable to judge surgical approach. Rejection criteria: 1) Misinclusion; 2) Unable to judge whether the humeral shaft was involved (OTA/AO 12). A total of 142 literatures were retrieved and finally, 53 effective literatures were included by manual screening. The data on implant types and surgical approaches were extracted from the literature. Data used for comparison and analysis included: 1. implant types (bone plate and intramedullary nail); 2. deltopectoral approach, anterolateral approach, lateral approach and posterior approach of bone plate, among which triceps-splitting approach and triceps-reflecting approach were statistically analyzed respectively 10,11 ; 3. Anteromedial 12,13 , anterolateral approach and posterior approach of minimally invasive plate osteosynthesis(MIPO); 4. Anterograde and retrograde intramedullary nail. The data were analyzed by SPSS 27.0, and the qualitative data were tested by chi-square test, and p < 0.05 referred statistically significant difference. 2. Introduction of typical cases. Results 1. Comparison of iatrogenic radial nerve injury with different implants (bone plate and intramedullary nail) A total of 53 articles were included, including 46 articles about bone plates and 15 articles about intramedullary nail. The total number of cases was 6205, including 4589 cases of the bone plate, 893 cases of intramedullary nail and 723 cases of uncertain internal fixation. The rate of iatrogenic radial nerve injury combined with humeral shaft fracture was 6.16% (382/6205). The rate of iatrogenic radial nerve injury with bone plate and intramedullary nail was 6.82% (313/4589) and 2.58% (23/893) respectively ( p < 0.05) (Table 1 ). Table 1 Comparison of iatrogenic radial nerve injury caused by bone plate VS intramedullary nail Injury Non-injury Chi-square value P value Bone plate 313 (6.8%) 4276 (93.2%) 23.414 < 0.001 Intramedullary nail 23 (2.6%) 870 (97.4%) 2. Comparison of iatrogenic radial nerve injury by different surgical approaches (excluding MIPO) Twenty-four articles about open reduction and internal fixation with plate via definit approaches were included, including 2 on deltopectoral approach, 14 on anterolateral approach, 5 on lateral approach and 14 on posterior approach. The total number of cases was 3483, including 82 cases of deltopectoral approach, 1963 cases of anterolateral approach, 192 cases of lateral approach and 1246 cases of posterior approach. In cases with open reduction and internal fixation with a plate with a definite surgical approach (excluding MIPO), the incidence of radial nerve injury was 7.44% (259/3483). The corresponding incidences were 3.7% (3/82) for deltopectoral approach, 5.65% (111/1963) for anterolateral approach, 13.54% (26/192) for lateral approach and 9.55% (119/1246) for posterior approach (Table 2 and Fig. 1). Table 2 Comparison of iatrogenic radial nerve injuries of(deltopectoral, anterolateral, lateral and posterior approaches (excluding MIPO) Injury Non-injury Chi-square value P value Deltopectoral 3 (3.7%) 79 (96.3%) 29.243 < 0.001 Anterolateral 111 (5.7%) 1852 (94.3%) Lateral 26 (13.5%) 166 (86.5%) Posterior 119 (9.6%) 1127 (90.4%) There were 13 literatures without a definite approach of plate operation, and the incidence of radial nerve injury was 6.34% (42/662), which was not included in the statistics. 3. Comparison of iatrogenic radial nerve injury caused by plate internal fixation, intramedullary nail and MIPO Fifty-two articles were included, where plates were involved in 37 articles, intramedullary nails were involved in 15 articles, and MIPO was involved in 16 articles. The total number of cases was 5482, including 4145 cases of plate fixation, 893 cases of intramedullary nail and 444 cases of MIPO. The injury rates of radial nerve were 7.26% (301/4145), 2.58% (23/893) and 2.70% (12/444), respectively. There were statistical differences between plate fixation and intramedullary nail, plate fixation and MIPO (p 0.05) (Table 3 ). Table 3 Comparison of iatrogenic radial nerve injury caused by open reduction and plate fixation, intramedullary nail and MIPO Injury Non-injury Chi-square value P value Plate fixation 301 (7.3%) 3844 (92.7%) 37.902 < 0.001 Intramedullary nail 23 (2.6%) 870 (97.4%) MIPO 12 (2.7%) 432 (97.3%) 4. Comparison of iatrogenic radial nerve injury caused by MIPO through different surgical approaches Sixteen articles were included, including 2 articles of anteromedial MIPO, 13 articles of anterolateral MIPO, and 1 article of posterior MIPO. The total number of cases was 444, including 33 cases of anteromedial MIPO, 374 cases of anterolateral MIPO and 37 cases of posterior MIPO. The radial nerve injury rates were 0.00% (0/33), 2.67% (10/374) and 5.40% (2/37). There was no significant difference among them ( p > 0.05) (Table 4 ). Table 4 Comparison of anteromedial, anterolateral and posterior MIPO iatrogenic radial nerve injuries Injury Non-injury Fisher value P value Anteromedial MIPO 0 (0.0%) 33 (100%) 1.654 0.432 Anterolateral MIPO 10 (2.7%) 364 (97.8%) Posterior MIPO 2 (5.4%) 35 (94.6%) A retrospective study by Huang et al. proposed an anterolateral double-incision approach. The proximal incision was made at the median anterior humerus, the biceps brachii was pulled medially, and the lateral third of brachialis was split to expose the fracture position. The distal incision was made between brachioradialis and triceps 14 . In this paper, we included it in the anterolateral MIPO approach. 5. Comparison of iatrogenic radial nerve injury caused by intramedullary nail Fifteen articles were included here, including 12 articles on anterograde intramedullary nail and 4 articles on retrograde intramedullary nail. The total number of cases was 893, including 732 cases of anterograde intramedullary nail and 161 cases of retrograde intramedullary nail. The proportion of radial nerve injury was 2.87% (21/732) and 1.2% (2/161) respectively, and there was no significant difference between them ( p > 0.05) (Table 5 ). Table 5 Comparison of iatrogenic radial nerve injury caused by anterograde and retrograde intramedullary nail Injury Non-injury Fisher value P value Anterograde 21 (2.9%) 711 (97.1%) 1.392 0.406 Retrograde 2 (1.2%) 159 (98.8%) 6. Comparison of iatrogenic radial nerve injury in nonunion surgery There were 3 articles about nonunion, including 1 article on intramedullary nail and 3 articles on bone plates. Among them, 1 article was about anterolateral/deltopectoral approach. There were 129 cases, including 24 cases of intramedullary nail and 105 cases of bone plate, where 60 cases were anterolateral approach, 12 cases were lateral approach, and 33 cases were posterior approach. All intramedullary nails were retrograde and there were no iatrogenic nerve injuries. The rate of iatrogenic radial nerve injury was 15.0% (9/60) in cases of anterolateral approach, 16.7% (2/12) in cases of lateral approach and 18.2% (6/33) in cases of posterior approach. There was no significant difference among them ( p > 0.05) (Table 6 ). Table 6 Comparison of anteromedial, lateral and posterior iatrogenic radial nerve injuries Injury Non-injury Chi-square value P value Anterolateral 9 (15.0%) 51 (85.0%) 0.336 0.927 Lateral 2 (16.7%) 10 (83.3%) Posterior 6 (18.2%) 27 (81.8%) A set of data in Oliver et al.'s study was not included in the statistics because it could not distinguish the anterolateral approach or deltopectoral approach 15 . Case report A 14-year-old male patient, who underwent open reduction and plate internal fixation in local hospital due to humeral shaft fracture, could not extend his finger and wrist after operation. Though partial wrist extension function (muscle strength grade II+) was recovered seven months after operation, he still could not extend his finger. Thus, he was admitted to our hospital and electromyography showed radial nerve injury, and ultrasound examination suggested nerve injury and a high possibility of neurotmesis. A radial nerve defect of 4cm was found during our operation, and no normal nerve fiber connection was found between the stumps. Autologous sural nerve graft was taken to repair the radial nerve defect. Postoperative 6-month telephone follow-up showed the patient recovered the extension function of fingers and wrists (Fig. 2). Discussion The overall age distribution of patients with humeral shaft fracture was a bimodal pattern, with a small peak at 21–30 years old and a large peak at 71–80 years old 16 . The main groups were young people suffering from high-energy trauma and old people suffering from low-energy trauma [ 4 ]. Entezari et al. found in the correlation research that distal-third humeral shaft fractures ( p < 0.001, OR 6.3), high-energy trauma ( p = 0. 049, OR 1.7), open fracture ( p = 0. 048, OR 2.1) and concomitant vascular injury ( p < 0.001, OR 26.9) were independent predictive factors, which were easy to lead to primary nerve injury [ 6 ]. Peripheral nerve injury is one of the common complications of humeral shaft fracture in the early stage. A prospective study by James et al. on more than 5,700 patients with multiple injuries suggested that radial nerve injury was the most common peripheral nerve injury, and 9.5% of humeral fractures were complicated with radial nerve injury 17 . Niver reviewed literatures and found that the rate of humeral shaft fractures associated with radial nerve injury was about 2–17% 10,18–20 . Shao et al found in their retrospective study that the rate of humeral shaft fracture complicated with radial nerve injury was 11.8% (532/4517), and the middle and distal humeral shaft fractures were more likely to damage radial nerve 21 . However, Ljungquist et al. mentioned that the rate of radial nerve injury caused by humeral shaft fracture was 22% 22 , and Streufert et al. summarized the case data of two centers and found that the incidence of radial nerve injury was 18.4% (48/261) 23 . Entezari et al. reported that the incidence of humeral shaft fracture complicated with nerve injury was about 25.5% (96/376), among which radial nerve injury accounted for about 94%, and the iatrogenic nerve injury incidence of humeral shaft fracture was 4.6% (7/154), all of which involved radial nerve 6 . In our study, the total rate of iatrogenic radial nerve injury caused by humeral shaft fracture was 6.16% (382/6205), and there was no significant statistical difference with the former ( p > 0.05). 1. Comparison of iatrogenic radial nerve injury with different implants (bone plate and intramedullary nail) The iatrogenic injury rates of the radial nerve caused by different treatment methods are different. For example, it has been reported that the iatrogenic injury rate of radial nerve of bone plate was 6.5%-12.0%, and that of intramedullary nails was 2.7-5.0% 4,24,25 . This is similar to our statistical results, bone plate of 6.82% (313/4589), intramedullary nail of 2.58% (23/893). Amer et al. included three pieces of literatures in their meta-analysis study, and the results showed that for humeral shaft fracture (OTA/AO 12), plate (10.8%, 12/111) was more likely to cause iatrogenic radial nerve injury than intramedullary nail (0%, 0/104) ( p = 0.0004 < 0.05) 8 . However, Streufert et al. reported that the two-center study from 2008 to 2016 suggested that the iatrogenic radial nerve injury rate of the plate was 15.6% (10/64) in the middle humeral shaft and 15% (16/107) in the distal humeral shaft 23 , which may be related to the diagnosis and treatment level of medical centers. Ouyang et al. conducted a meta-analysis on 10 randomized controlled trials (RCT) and 439 cases and found that compared with intramedullary nail, bone plate avoided the risk of postoperative acromion impingement and limited shoulder joint movement, but there was no significant difference in iatrogenic radial nerve injury ( p = 0.28 > 0.05) 26 . Kurup et al. Reviewed five low-quality (unstratified) randomized trials, involving 260 participants, and reached the same conclusion as Ouyang et al. 27 . We included 3 articles about nonunion, involving 1 article about intramedullary nails and 3 articles about bone plates. Martínez et al. studied the treatment of middle and upper 2/3 of humeral shaft nonunion and found that the rate of iatrogenic radial nerve injury in non-reamed intramedullary nail and bone graft group was lower than that in open reduction and plate internal fixation group (0%, 0/24 VS . 11.54%, 3/26) 28 . However, Singh et al. studied humeral shaft nonunion and found that there was no difference between intramedullary nail and plate internal fixation by posterior approach in nonunion healing time, joint function and iatrogenic radial nerve injury rate (0%, 0/20 VS . 10%, 2/20) 29 . Koh et al. studied 379 cases of humeral shaft nonunion in 18 trauma centers, and found that there was no difference among anterolateral, lateral and posterior approaches (triceps-reflecting and triceps-splitting) approach, and fracture location (middle humerus) was the only related factor of radial nerve injury ( p = 0. 02) 30 . Olarte et al. found that radial nerve transposition was an effective auxiliary means for internal fixation of humeral shaft fracture, which was suitable for high-risk nonunion patients 31 . A retrospective study of 19 patients by Chamseddine et al. found that medial transposition of the radial nerve was a safe and reliable method for patients who needed to take out internal fixation and nonunion 32 . Zalavras et al. provided a protocol for the treatment of nonunion of humeral shaft fracture and reported that 41 cases of nonunion were healed within 17 years without iatrogenic radial nerve injury; the protocol was also applicable to patients with long-term nonunion caused by complications 33 . 2. Comparison of iatrogenic radial nerve injury by different surgical approaches (excluding MIPO) Surgical approaches for humeral fractures included deltopectoral approach 34 , anteromedial approach 12,13 , anterolateral approach, lateral approach and posterior approach. The posterior approach included triceps-reflecting approach (Bryan-Morrey) 35 , modified triceps-reflecting approach (Gerwin/Hotchkiss/Weiland) 36 , triceps-reflecting anconeus pedicle approach (TRAP) 37 , triceps-on approach/paratricipital approach (Alonso-Llames), triceps-splitting approach, the chevron olecranon V osteotomy, and tongue-shaped flap approach, etc. Surgical approaches for humeral shaft fractures mainly included anterolateral, lateral and posterior approaches, and occasionally deltopectoral approach 34 . Anteromedial approach was only seen in two pieces of literatures for MIPO treatment of humeral shaft fractures 12,13 . A retrospective study of 6 hospitals by Claessen et al. found that the rate of iatrogenic radial nerve injury caused by humeral shaft fracture was 7% (18/259); the surgical approach was related to iatrogenic radial nerve injury (p 1); the incidence of iatrogenic radial nerve injury was 4% (7/165) in the anterolateral approach, 22% (2/9) in the lateral approach, and 11% (9/85) in the posterior approach 7 . In our results, The rate of iatrogenic radial nerve injury in humeral shaft fracture was 6.16% (382/6205), which was similar to the results of Claessen (anterolateral: 5.65%, 111/1963; Posterior: 9.55%, 119/1246; p > 0.05); while the rate of radial nerve injury in lateral approach was 13.54% (26/192), which was lower than that of Claessen (22%, 2/9), but there was no statistical difference (p > 0.05). Different from the former, in our study, there were statistical differences between anterolateral approach and lateral approach, and between anterolateral approach and posterior approach in the rate of iatrogenic radial nerve injury ( p > 0.05). Multiple regression analysis by Shoji et al. showed that iatrogenic radial nerve injury had nothing to do with surgical approach and timing, but it was related to distal humeral fracture (AO/OTA 12A/B/C) and secondary or multiple operations due to a previous fracture, which was an independent risk factor 38 . Streufert et al. analyzed the case data of two centers and found that there was no difference in iatrogenic radial nerve injury rate among the three approaches: which were anterior/anterolateral approach (6/84), triceps lifting approach (14/78) and triceps-splitting approach (6/51) ( p = 0.11) 23 . A meta-analysis conducted by Shon et al. on 1303 cases in 9 studies showed that the rate of iatrogenic radial nerve injury through posterior approach was significantly higher than that through anterolateral approach (13.88%, 69/497 VS . 5.16%, 35/687) (OR 2.72; 95% CI, 1.70–4.35; p 0.05), but there was a significant difference between posterior approach and anterolateral approach (7.4%, 119/1246 VS . 5.65%, 111/1963 p < 0.01). The main reason may be that the former had a small sample size and needed further specific study. 3. Comparison between open reduction and internal fixation (plate and intramedullary nail) and MIPO in iatrogenic radial nerve injury A review by Tetsworth et al. suggested that MIPO had a lower rate of iatrogenic radial nerve injury 40 . A meta-analysis of two randomized controlled trials and three non-randomized controlled trials by Yu et al. found that the rate of iatrogenic radial nerve injury in patients with MIPO was lower than that of traditional open reduction and internal fixation ( p = 0. 006) 41 . A meta-analysis by Hu et al. included 391 patients and 8 studies, involving 4 randomized controlled trials (RCTs), 2 prospective cohort trials and 2 retrospective cohort trials 42 . It was also found that the iatrogenic radial nerve injury rate in the MIPO group was lower than that in open reduction and internal fixation, and the adjacent joint function score of MIPO was higher than that of intramedullary nail (IMN) ( p < 0.05). Zhao et al. obtained the same results in a network meta-analysis of 16 randomized controlled trials (OR, 11.09; 95% CI, 1.80-124.20) 43 . However, they also found that the incidence of acromion impingement in the intramedullary nail group was higher than that in the open reduction and plate internal fixation group (OR, 0.13; 95% CI, 0.03–0.37) and MIPO group (OR, 0.08; 95% CI, 0.00-0.69). There were no differences between Intramedullary nails, open reduction and plate internal fixation, and MIPO in delayed union, nonunion and infection of humeral fractures 43 . Our results showed that the rate of iatrogenic radial nerve injury in MIPO was lower than that in open reduction and internal fixation (2.70%, 12/444 vs 7.26%, 301/4145) (p < 0.05), which was consistent with the mentioned literatures. 4. Comparison of iatrogenic radial nerve injury caused by MIPO through different surgical approaches At present, the main surgical approaches for the treatment of humeral shaft fractures by MIPO are anterolateral or posterior. However, Yang et al. found that medial MIPO was a safe surgical method for extra-articular fractures of the middle and distal humerus (0%, 0/12) 12 . A single-center retrospective study by Liu et al. found that the radial nerve injury rate of anteromedial MIPO was low (0%, 0/21). The median nerve, ulnar nerve and brachial artery were protected by brachial muscle through the subbrachial tunnel without injury 13 . The results of this study showed that there was no significant difference among anterolateral MIPO, anteromedial MIPO and posterior MIPO in the rate of iatrogenic radial nerve injury ( p > 0.05). 5. Comparison of iatrogenic radial nerve injury caused by an intramedullary nail through different approaches There are two methods of intramedullary nailing for humeral shaft fracture: anterograde nail and retrograde nail. In this review, we found that there was no statistical difference in the incidence of iatrogenic radial nerve injury between anterograde and retrograde nailing ( p > 0.05). Li et al. also found in their retrospective study that there was no significant difference in iatrogenic radial nerve injury rate between anterograde and retrograde intramedullary nailing 44 . 6. The crawling regeneration distance of nerve fibers in radial nerve defect Iatrogenic radial nerve injury includes continuation and discontinuation. In the latter, nerve defects often occur during secondary exploration, accompanied by permanent loss of sensory and motor function. However, in this study, a 14-year-old male child was observed, with a 4cm distance between the two nerve stumps, without an obvious continuous nerve bundle between the two nerve stumps, which suggested that the proximal nerve fibers crawled into the distal nerve stump through scar tissue and recovered part of the wrist extensor muscle strength. This case indicated that the regeneration ability of radial nerve was very strong, especially in children and adolescents. If the possibility of iatrogenic radial nerve injury is found, it should be actively explored and repaired. 7. Selection and optimization of implants Wang et al. found that pre-contouring plates on 3D-printed fracture models can better help young doctors complete operations 45 . For transverse fractures, 6-hole or 7-hole plates are generally used. However, clinically, most fractures are short oblique or long oblique fractures, even comminuted fractures. Therefore, 8–10 hole plates are often used in clinics. Taking a 10-hole plate as an example, the anatomical study of Chirattikalwong et al. on 56 humerus found that when a 4.5 mm 10-hole compression plate was used for fixation of the middle humeral shaft fracture through an anterolateral approach, the radial nerve would be damaged by the second to sixth holes, and the fourth hole and the fifth hole had the highest rate of injuries 46 . The anatomical study of Chuaychosakoon et al. on 18 upper limbs also held that when the middle humeral shaft fracture was fixed with a 4.5mm 10 holes compression plate through an anterolateral approach, the radial nerve and/or deep brachial artery would be damaged by the second to fifth holes, while the fourth and fifth holes were most likely to damage them, with the injury ratios of 100% and 66.7% respectively. The relative ratio of the distance between the fourth hole and the lateral epicondyle of the humerus to the length of the humerus was 0.56. The author suggested that a single-layer cortical screw should be used at the fourth hole 47 . An anatomical study by Noger et al. found that when distal interlocking fixation was performed with non-reamed intramedullary nails through an anterograde approach, the medial and lateral locking nails in the middle easily damaged the radial nerve, median nerve, ulnar nerve and brachial artery. The author believed that using the two anteroposterior screws was safe. If you want to improve the locking stability, it is recommended to complete the internal and external locking of the middle screw holes under direct vision 48 . A retrospective study by Helm et al. found that anterograde intramedullary nail combined with cerclage can reduce the incidence of nonunion (2.6%, 2/78) without increasing the incidence of iatrogenic radial nerve injury (4.59%, 5/109) 49 . 8. Conclusion During humeral shaft fracture operation, the incidence of iatrogenic radial nerve injury was 6.82% in bone plate and 2.58% in intramedullary nails, respectively. Compared with lateral and posterior approaches, the anterolateral surgical approach had a lower incidence of radial nerve injury. The rate of iatrogenic radial nerve injury in MIPO was lower than that in open reduction and internal fixation. There was no difference in the incidence of iatrogenic radial nerve injury between anterograde and retrograde intramedullary nailing. In the human body, regenerated radial nerve fibers can span a 4cm nerve defect area. Declarations Ethical Approval Not applicable Funding Not applicable Availability of data and materials All datasets used can be accessed on Pubmed Competing Interest declaration ： The authors declare that they have no conflict of interests. References Cole PA, Wijdicks CA. The Operative Treatment of Diaphyseal Humeral Shaft Fractures. 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Medial minimally invasive percutaneous plate osteosynthesis for humeral shaft fractures: a case series and novel technique description. Arch Orthop Trauma Surg. 2023;143(11):6657-6664. Huang Q, Lu Y, Wang ZM, Sun L, Ma T, Wang Q, et al. Anterolateral approach with two incisions versus posterior median approach in the treatment of middle- and distal-third humeral shaft fractures. J Orthop Surg Res. 2021;16(1):197. Oliver WM, Molyneux SG, White TO, Clement ND, Duckworth AD, Keating JF. Open Reduction and Internal Fixation for Humeral Shaft Nonunion: Bone Grafting Is Not Routinely Required and Avoids Donor Site Morbidity. J Orthop Trauma. 2021;35(8):414-423. Adams J. Fractures of the shaft of the humerus: an epidemiological study of 401 fractures. Yearbook of Hand and Upper Limb Surgery. 2008;2008:9-10. Noble J, Munro CA, Prasad VS, Midha R. Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. J Trauma. 1998;45(1):116-122. 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Hand Surg Rehabil. 2019;38(1):2-13. Bumbasirevic M, Palibrk T, Lesic A, Atkinson HD. Radial nerve palsy. EFORT Open Rev. 2016;1(8):286-294. Ouyang H, Xiong J, Xiang P, Cui Z, Chen L, Yu B. Plate versus intramedullary nail fixation in the treatment of humeral shaft fractures: an updated meta-analysis. Journal of Shoulder and Elbow Surgery. 2013;22(3):387-395. Kurup H, Hossain M, Andrew JG. Dynamic compression plating versus locked intramedullary nailing for humeral shaft fractures in adults. Cochrane Database of Systematic Reviews. Published online June 15, 2011. Martínez AA, Cuenca J, Herrera A. Treatment of humeral shaft nonunions: nailing versus plating. Arch Orthop Trauma Surg. 2004;124(2):92-95. Singh AK, Arun GR, Narsaria N, Srivastava A. Treatment of non-union of humerus diaphyseal fractures: a prospective study comparing interlocking nail and locking compression plate. Arch Orthop Trauma Surg. 2014;134(7):947-953. Koh J, Tornetta P, Walker B, Jones C, Sharmaa T, Sems S, et al. What is the Real Rate of Radial Nerve Injury After Humeral Nonunion Surgery? J Orthop Trauma. 2020;34(8):441-446. Olarte CM, Darowish M, Ziran BH. Radial nerve transposition with humeral fracture fixation: preliminary results. Clin Orthop Relat Res. 2003;(413):170-174. Chamseddine AH, Abdallah A, Zein H, Taha A. Transfracture medial transposition of the radial nerve associated with plate fixation of the humerus. Int Orthop. 2017;41(7):1463-1470. Zalavras CG, Yasmeh S, Bougioukli S. Surgical management of humeral shaft nonunions. Success of a consistent protocol over 17 years. Injury. 2021;52(12):3580-3587. Nicolaci G, Maes V, Lollino N, Putzeys G. How to treat proximal and middle one-third humeral shaft fractures: the role of helical plates. Musculoskelet Surg. 2023;107(2):231-238. Bryan RS, Morrey BF. Extensive posterior exposure of the elbow. A triceps-sparing approach. Clin Orthop Relat Res. 1982;(166):188-192. Gerwin M, Hotchkiss RN, Weiland AJ. Alternative operative exposures of the posterior aspect of the humeral diaphysis with reference to the radial nerve. J Bone Joint Surg Am. 1996;78(11):1690-1695. O’Driscoll SW. The triceps-reflecting anconeus pedicle (TRAP) approach for distal humeral fractures and nonunions. Orthop Clin North Am. 2000;31(1):91-101. Shoji K, Heng M, Harris MB, Appleton PT, Vrahas MS, Weaver MJ. Time From Injury to Surgical Fixation of Diaphyseal Humerus Fractures Is Not Associated With an Increased Risk of Iatrogenic Radial Nerve Palsy. J Orthop Trauma. 2017;31(9):491-496. Shon HC, Yang JY, Lee Y, Cho JW, Oh JK, Lim EJ. Iatrogenic radial nerve palsy in the surgical treatment of humerus shaft fracture -anterolateral versus posterior approach: A systematic review and meta-analysis. J Orthop Sci. 2023;28(1):244-250. Tetsworth K, Hohmann E, Glatt V. Minimally Invasive Plate Osteosynthesis of Humeral Shaft Fractures: Current State of the Art. Journal of the American Academy of Orthopaedic Surgeons. 2018;26(18):652-661. Yu B feng, Liu L le, Yang G jing, Zhang L, Lin X peng. Comparison of minimally invasive plate osteosynthesis and conventional plate osteosynthesis for humeral shaft fracture: A meta-analysis. Medicine. 2016;95(39):e4955. Hu X, Xu S, Lu H, Chen B, Zhou X, He X, et al. Minimally invasive plate osteosynthesis vs conventional fixation techniques for surgically treated humeral shaft fractures: a meta-analysis. J Orthop Surg Res. 2016;11(1):59. Zhao JG, Wang J, Meng XH, Zeng XT, Kan SL. Surgical interventions to treat humerus shaft fractures: A network meta-analysis of randomized controlled trials. PLoS ONE. 2017;12(3):e0173634. Li W yi, Zhang B song, Zhang L, Zheng S hui, Wang S mao. [Comparative study of antegrade and retrograde intramedullary nailing for the treatment of humeral shaft fractures]. Zhongguo Gu Shang. 2009;22(3):199-201. Wang Q, Hu J, Guan J, Chen Y, Wang L. Proximal third humeral shaft fractures fixed with long helical PHILOS plates in elderly patients: benefit of pre-contouring plates on a 3D-printed model-a retrospective study. J Orthop Surg Res. 2018;13(1):203. Chirattikalwong S, Suwannaphisit S, Wuttimanop W, Chuaychoosakoon C. Risk of Radial Nerve Injury in Anterolateral Humeral Shaft Plating. J Am Acad Orthop Surg. 2022;30(18):903-909. Chuaychoosakoon C, Chirattikalwong S, Wuttimanop W, Boonriong T, Parinyakhup W, Suwannaphisit S. The risk of iatrogenic radial nerve and/or profunda brachii artery injury in anterolateral humeral plating using a 4.5 mm narrow DCP: A cadaveric study. PLoS ONE. 2021;16(11):e0260448. Noger M, Berli MC, Fasel JHD, Hoffmeyer PJ. The risk of injury to neurovascular structures from distal locking screws of the Unreamed Humeral Nail (UHN): A cadaveric study. Injury. 2007;38(8):954-957. von der Helm F, Fenwick A, Reuter J, Adolf-Lisitano L, Mayr E, Förch S. New ways of treatment of fractures of the humeral shaft: does the combination of intramedullary nail osteosynthesis and cerclage improve the healing process? Eur J Trauma Emerg Surg. 2022;48(4):3081-3087. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 25 Jul, 2024 Read the published version in European Journal of Medical Research → Version 1 posted Editorial decision: Revision requested 30 May, 2024 Reviews received at journal 16 May, 2024 Reviewers agreed at journal 09 May, 2024 Reviewers agreed at journal 29 Apr, 2024 Reviews received at journal 21 Apr, 2024 Reviewers agreed at journal 17 Apr, 2024 Reviewers invited by journal 17 Apr, 2024 Editor assigned by journal 08 Mar, 2024 Submission checks completed at journal 06 Mar, 2024 First submitted to journal 20 Feb, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3972889","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":276730977,"identity":"92148260-2658-480e-bbd0-66079ac8661b","order_by":0,"name":"Zeyu Zhang","email":"","orcid":"","institution":"Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Zeyu","middleName":"","lastName":"Zhang","suffix":""},{"id":276730978,"identity":"f1daacb4-d9c9-48c3-81a5-59e0f6718e86","order_by":1,"name":"Zhongpei Lin","email":"","orcid":"","institution":"Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Zhongpei","middleName":"","lastName":"Lin","suffix":""},{"id":276730979,"identity":"4f62460e-ecac-4c03-ae72-c82b75d2b3d9","order_by":2,"name":"Qinglin Qiu","email":"","orcid":"","institution":"Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Qinglin","middleName":"","lastName":"Qiu","suffix":""},{"id":276730980,"identity":"fe315f10-6598-4d3b-be94-bbe7c3471869","order_by":3,"name":"Xincai Xiao","email":"","orcid":"","institution":"Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Xincai","middleName":"","lastName":"Xiao","suffix":""},{"id":276730981,"identity":"0b3df1ff-564f-46f9-8e16-d33300ec7787","order_by":4,"name":"Shouwen Su","email":"","orcid":"","institution":"Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Shouwen","middleName":"","lastName":"Su","suffix":""},{"id":276730982,"identity":"a67915a0-3da4-4444-8647-fe97b8bf1381","order_by":5,"name":"Xiaoyue Wen","email":"","orcid":"","institution":"Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"prefix":"","firstName":"Xiaoyue","middleName":"","lastName":"Wen","suffix":""},{"id":276730983,"identity":"7e2bc68e-847c-4b6d-80b3-64c2b48be5ec","order_by":6,"name":"Bo He","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAtklEQVRIiWNgGAWjYBACAwYeBhCSY2BnbCBNizEDM6laEhuYiXWYOXvvwQdvKuzS+5uZ26R5dzDI84sdwK/FsudcsuGcM8m5Mw4zArWcYTCcOTuBgMNu5JhJ87YdyG0Aa2ljSDC4TUjL/TdgLenyxGu5wQPWkmBAvJYzeWC/GG48zNhsObdNggi/HD8LDjF5uePtD2+8bbOR55cmoAUZsEgwMEgQrxwEmD+Qpn4UjIJRMApGCgAAMAo/uOtgnKoAAAAASUVORK5CYII=","orcid":"","institution":"Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":true,"prefix":"","firstName":"Bo","middleName":"","lastName":"He","suffix":""}],"badges":[],"createdAt":"2024-02-20 13:32:55","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3972889/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3972889/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s40001-024-01981-7","type":"published","date":"2024-07-25T16:15:55+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":52295828,"identity":"e32f63b8-cc0d-4ec4-b57a-c57a1dc23a54","added_by":"auto","created_at":"2024-03-08 17:56:45","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":91913,"visible":true,"origin":"","legend":"\u003cp\u003eComparison of iatrogenic radial nerve injury by differrent surgical approaches (excluding MIPO) Note: \"*\" indicates statistical differences between anterolateral and lateral approaches and anterolateral and posterior approaches.\u003c/p\u003e","description":"","filename":"Fig1forEJMR.png","url":"https://assets-eu.researchsquare.com/files/rs-3972889/v1/52ef3c2875cab30103821f80.png"},{"id":52295829,"identity":"48aa1ed4-54e7-4ce7-b732-8e5a9bd0e793","added_by":"auto","created_at":"2024-03-08 17:56:45","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":1636491,"visible":true,"origin":"","legend":"\u003cp\u003eTypical case: A) Postoperative functional image of right upper limb. B) Radial nerve stumps were exposed, and the yellow plastic sling indicates the distal stump of radial nerve. C) The arrow indicates the proximal stump of radial nerve. D) Nerve epineurium and bundles were trimmed to facilitate suturing. After removing neuromata, normal neural papillae were showed, and nerve defect was 4.3cm. E) Post-transplantation of 5.0cm auto-nerve (sural nerve).\u003c/p\u003e","description":"","filename":"Fig2forEJMR.jpg","url":"https://assets-eu.researchsquare.com/files/rs-3972889/v1/7e448c40bcff9d7e710b57f6.jpg"},{"id":61596228,"identity":"c2c052b9-7dfb-448f-83fd-455ccb1078ab","added_by":"auto","created_at":"2024-08-01 17:25:51","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2167631,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3972889/v1/8dce65a5-57e9-4212-b03c-585bae84da51.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Systematic review of humeral shaft fracture (OTA/AO 12) complicated with iatrogenic radial nerve injury: Can nerve fibers span a 3cm nerve defect?","fulltext":[{"header":"Instruction","content":" \u003cp\u003eHumeral shaft fractures account for about 1–5% of all fractures\u003csup\u003e1–4\u003c/sup\u003e and 20% of humeral fractures \u003csup\u003e5\u003c/sup\u003e. A considerable part of humeral shaft fractures needs surgical treatment, and iatrogenic nerve injury may occur during operation. A single-center retrospective study by Entezari et al. found that the incidence of humeral shaft fracture combined with iatrogenic nerve injury was 4.6% (7/154), and all involved radial nerve \u003csup\u003e6\u003c/sup\u003e. The incidence of humeral shaft fracture complicated with radial nerve injury varies among different literatures. The retrospective study by Claessen et al. of 6 hospitals found that the incidence of humeral shaft fracture complicated with iatrogenic radial nerve injury was about 7% (18/259) \u003csup\u003e7\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eIt is reported that the incidence of iatrogenic radial nerve injury is different with different implants and different surgical approaches. Amer et al. reviewed 3 literatures and reported that the incidence of nerve injury was 10.8% (12/111) for open reduction and internal fixation with plate and 0% (0/104) for intramedullary nail \u003csup\u003e8\u003c/sup\u003e. A retrospective study by Claessen et al. on 6 hospitals found that the corresponding probabilities of nerve injury were 4% (7/165) for anterolateral approach, 22% (2/9) for lateral approach and 11% (9/85) for posterior approach \u003csup\u003e7\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eThis paper intends to search the literature on humeral shaft fracture complicated with radial nerve injury from 2000 to October 2023 in the PubMed database and compare and analyze the relationship between the implant (bone plate \u003cem\u003eVS\u003c/em\u003e. intramedullary nail), surgical approach and iatrogenic radial nerve injury, to assist clinicians in selecting implants and surgical approach.\u003c/p\u003e "},{"header":"Methods","content":"\u003cp\u003e1. Document retrieval:\u003c/p\u003e\u003cp\u003eThe literatures on humeral fracture (OTA/AO 11/12/13 A/B/C \u003csup\u003e9\u003c/sup\u003e) combined with radial nerve injury was retrieved in PubMed with \"(humeral fracture) AND (iatrogenic radial nerve injury)\" as the search term. Screening scope includes: 1) Chinese or English literature, 2) adult humeral fracture, 3) preoperative radial nerve continuity, 4) non-pathological fracture, 5) non-periprosthetic fracture, 6) must involve humeral shaft (OTA/AO 12). Exclusion criteria: 1) No full text in Chinese or English; 2) Unable to judge surgical approach. Rejection criteria: 1) Misinclusion; 2) Unable to judge whether the humeral shaft was involved (OTA/AO 12). A total of 142 literatures were retrieved and finally, 53 effective literatures were included by manual screening.\u003c/p\u003e\u003cp\u003eThe data on implant types and surgical approaches were extracted from the literature. Data used for comparison and analysis included: 1. implant types (bone plate and intramedullary nail); 2. deltopectoral approach, anterolateral approach, lateral approach and posterior approach of bone plate, among which triceps-splitting approach and triceps-reflecting approach were statistically analyzed respectively \u003csup\u003e10,11\u003c/sup\u003e; 3. Anteromedial \u003csup\u003e12,13\u003c/sup\u003e, anterolateral approach and posterior approach of minimally invasive plate osteosynthesis(MIPO); 4. Anterograde and retrograde intramedullary nail. The data were analyzed by SPSS 27.0, and the qualitative data were tested by chi-square test, and \u003cem\u003ep\u003c/em\u003e \u0026lt; 0.05 referred statistically significant difference.\u003c/p\u003e\u003cp\u003e2. Introduction of typical cases.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e1. Comparison of iatrogenic radial nerve injury with different implants (bone plate and intramedullary nail)\u003c/p\u003e \u003cp\u003eA total of 53 articles were included, including 46 articles about bone plates and 15 articles about intramedullary nail. The total number of cases was 6205, including 4589 cases of the bone plate, 893 cases of intramedullary nail and 723 cases of uncertain internal fixation.\u003c/p\u003e \u003cp\u003eThe rate of iatrogenic radial nerve injury combined with humeral shaft fracture was 6.16% (382/6205). The rate of iatrogenic radial nerve injury with bone plate and intramedullary nail was 6.82% (313/4589) and 2.58% (23/893) respectively (\u003cem\u003ep\u003c/em\u003e \u0026lt; 0.05) (Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e\u003cdiv class=\"gridtable\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003ctable float=\"Yes\" id=\"Tab1\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eComparison of iatrogenic radial nerve injury caused by bone plate VS intramedullary nail\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003c/colgroup\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eInjury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eNon-injury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eChi-square value\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eP value\u003c/p\u003e \u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eBone plate\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e313 (6.8%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e4276 (93.2%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e \u003cp\u003e23.414\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt; 0.001\u003c/p\u003e \u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eIntramedullary nail\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e23 (2.6%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e870 (97.4%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/table\u003e\u003c/div\u003e \u003cp\u003e\u003c/p\u003e \u003cp\u003e2. Comparison of iatrogenic radial nerve injury by different surgical approaches (excluding MIPO)\u003c/p\u003e \u003cp\u003eTwenty-four articles about open reduction and internal fixation with plate via definit approaches were included, including 2 on deltopectoral approach, 14 on anterolateral approach, 5 on lateral approach and 14 on posterior approach. The total number of cases was 3483, including 82 cases of deltopectoral approach, 1963 cases of anterolateral approach, 192 cases of lateral approach and 1246 cases of posterior approach.\u003c/p\u003e \u003cp\u003eIn cases with open reduction and internal fixation with a plate with a definite surgical approach (excluding MIPO), the incidence of radial nerve injury was 7.44% (259/3483). The corresponding incidences were 3.7% (3/82) for deltopectoral approach, 5.65% (111/1963) for anterolateral approach, 13.54% (26/192) for lateral approach and 9.55% (119/1246) for posterior approach (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e and Fig.\u0026nbsp;1).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e\u003cdiv class=\"gridtable\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003ctable float=\"Yes\" id=\"Tab2\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eComparison of iatrogenic radial nerve injuries of(deltopectoral, anterolateral, lateral and posterior approaches (excluding MIPO)\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003c/colgroup\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eInjury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eNon-injury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eChi-square value\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eP value\u003c/p\u003e \u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eDeltopectoral\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e3 (3.7%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e79 (96.3%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e \u003cp\u003e29.243\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt; 0.001\u003c/p\u003e \u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eAnterolateral\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e111 (5.7%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e1852 (94.3%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eLateral\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e26 (13.5%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e166 (86.5%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePosterior\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e119 (9.6%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e1127 (90.4%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/table\u003e\u003c/div\u003e \u003cp\u003e\u003c/p\u003e \u003cp\u003eThere were 13 literatures without a definite approach of plate operation, and the incidence of radial nerve injury was 6.34% (42/662), which was not included in the statistics.\u003c/p\u003e \u003cp\u003e3. Comparison of iatrogenic radial nerve injury caused by plate internal fixation, intramedullary nail and MIPO\u003c/p\u003e \u003cp\u003eFifty-two articles were included, where plates were involved in 37 articles, intramedullary nails were involved in 15 articles, and MIPO was involved in 16 articles. The total number of cases was 5482, including 4145 cases of plate fixation, 893 cases of intramedullary nail and 444 cases of MIPO. The injury rates of radial nerve were 7.26% (301/4145), 2.58% (23/893) and 2.70% (12/444), respectively. There were statistical differences between plate fixation and intramedullary nail, plate fixation and MIPO (p \u0026lt; 0.05), but no difference between an intramedullary nail and MIPO (\u003cem\u003ep\u003c/em\u003e \u0026gt; 0.05) (Table\u0026nbsp;\u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e\u003cdiv class=\"gridtable\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003ctable float=\"Yes\" id=\"Tab3\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eComparison of iatrogenic radial nerve injury caused by open reduction and plate fixation, intramedullary nail and MIPO\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003c/colgroup\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eInjury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eNon-injury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eChi-square value\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eP value\u003c/p\u003e \u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePlate fixation\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e301 (7.3%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e3844 (92.7%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e \u003cp\u003e37.902\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt; 0.001\u003c/p\u003e \u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eIntramedullary nail\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e23 (2.6%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e870 (97.4%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eMIPO\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e12 (2.7%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e432 (97.3%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/table\u003e\u003c/div\u003e \u003cp\u003e\u003c/p\u003e \u003cp\u003e4. Comparison of iatrogenic radial nerve injury caused by MIPO through different surgical approaches\u003c/p\u003e \u003cp\u003eSixteen articles were included, including 2 articles of anteromedial MIPO, 13 articles of anterolateral MIPO, and 1 article of posterior MIPO. The total number of cases was 444, including 33 cases of anteromedial MIPO, 374 cases of anterolateral MIPO and 37 cases of posterior MIPO. The radial nerve injury rates were 0.00% (0/33), 2.67% (10/374) and 5.40% (2/37). There was no significant difference among them (\u003cem\u003ep\u003c/em\u003e \u0026gt; 0.05) (Table\u0026nbsp;\u003cspan refid=\"Tab4\" class=\"InternalRef\"\u003e4\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e\u003cdiv class=\"gridtable\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003ctable float=\"Yes\" id=\"Tab4\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 4\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eComparison of anteromedial, anterolateral and posterior MIPO iatrogenic radial nerve injuries\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003c/colgroup\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eInjury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eNon-injury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eFisher value\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cem\u003eP value\u003c/em\u003e\u003c/p\u003e \u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eAnteromedial MIPO\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e0 (0.0%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e33 (100%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e \u003cp\u003e1.654\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e0.432\u003c/p\u003e \u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eAnterolateral MIPO\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e10 (2.7%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e364 (97.8%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePosterior MIPO\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e2 (5.4%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e35 (94.6%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/table\u003e\u003c/div\u003e \u003cp\u003e\u003c/p\u003e \u003cp\u003eA retrospective study by Huang et al. proposed an anterolateral double-incision approach. The proximal incision was made at the median anterior humerus, the biceps brachii was pulled medially, and the lateral third of brachialis was split to expose the fracture position. The distal incision was made between brachioradialis and triceps \u003csup\u003e14\u003c/sup\u003e. In this paper, we included it in the anterolateral MIPO approach.\u003c/p\u003e \u003cp\u003e5. Comparison of iatrogenic radial nerve injury caused by intramedullary nail\u003c/p\u003e \u003cp\u003eFifteen articles were included here, including 12 articles on anterograde intramedullary nail and 4 articles on retrograde intramedullary nail. The total number of cases was 893, including 732 cases of anterograde intramedullary nail and 161 cases of retrograde intramedullary nail. The proportion of radial nerve injury was 2.87% (21/732) and 1.2% (2/161) respectively, and there was no significant difference between them (\u003cem\u003ep\u003c/em\u003e \u0026gt; 0.05) (Table\u0026nbsp;\u003cspan refid=\"Tab5\" class=\"InternalRef\"\u003e5\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e\u003cdiv class=\"gridtable\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003ctable float=\"Yes\" id=\"Tab5\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 5\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eComparison of iatrogenic radial nerve injury caused by anterograde and retrograde intramedullary nail\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003c/colgroup\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eInjury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eNon-injury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eFisher value\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cem\u003eP value\u003c/em\u003e\u003c/p\u003e \u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eAnterograde\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e21 (2.9%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e711 (97.1%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e \u003cp\u003e1.392\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e0.406\u003c/p\u003e \u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eRetrograde\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e2 (1.2%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e159 (98.8%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/table\u003e\u003c/div\u003e \u003cp\u003e\u003c/p\u003e \u003cp\u003e6. Comparison of iatrogenic radial nerve injury in nonunion surgery\u003c/p\u003e \u003cp\u003eThere were 3 articles about nonunion, including 1 article on intramedullary nail and 3 articles on bone plates. Among them, 1 article was about anterolateral/deltopectoral approach. There were 129 cases, including 24 cases of intramedullary nail and 105 cases of bone plate, where 60 cases were anterolateral approach, 12 cases were lateral approach, and 33 cases were posterior approach. All intramedullary nails were retrograde and there were no iatrogenic nerve injuries. The rate of iatrogenic radial nerve injury was 15.0% (9/60) in cases of anterolateral approach, 16.7% (2/12) in cases of lateral approach and 18.2% (6/33) in cases of posterior approach. There was no significant difference among them (\u003cem\u003ep\u003c/em\u003e \u0026gt; 0.05) (Table\u0026nbsp;\u003cspan refid=\"Tab6\" class=\"InternalRef\"\u003e6\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e\u003cdiv class=\"gridtable\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003ctable float=\"Yes\" id=\"Tab6\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 6\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eComparison of anteromedial, lateral and posterior iatrogenic radial nerve injuries\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003c/colgroup\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eInjury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eNon-injury\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eChi-square value\u003c/p\u003e \u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cem\u003eP\u003c/em\u003e value\u003c/p\u003e \u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eAnterolateral\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e9 (15.0%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e51 (85.0%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e \u003cp\u003e0.336\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e0.927\u003c/p\u003e \u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eLateral\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e2 (16.7%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e10 (83.3%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePosterior\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e6 (18.2%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e27 (81.8%)\u003c/p\u003e \u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/table\u003e\u003c/div\u003e \u003cp\u003e\u003c/p\u003e \u003cp\u003eA set of data in Oliver et al.'s study was not included in the statistics because it could not distinguish the anterolateral approach or deltopectoral approach \u003csup\u003e15\u003c/sup\u003e.\u003c/p\u003e "},{"header":"Case report","content":"\u003cp\u003eA 14-year-old male patient, who underwent open reduction and plate internal fixation in local hospital due to humeral shaft fracture, could not extend his finger and wrist after operation. Though partial wrist extension function (muscle strength grade II+) was recovered seven months after operation, he still could not extend his finger. Thus, he was admitted to our hospital and electromyography showed radial nerve injury, and ultrasound examination suggested nerve injury and a high possibility of neurotmesis. A radial nerve defect of 4cm was found during our operation, and no normal nerve fiber connection was found between the stumps. Autologous sural nerve graft was taken to repair the radial nerve defect. Postoperative 6-month telephone follow-up showed the patient recovered the extension function of fingers and wrists (Fig.\u0026nbsp;2).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe overall age distribution of patients with humeral shaft fracture was a bimodal pattern, with a small peak at 21\u0026ndash;30 years old and a large peak at 71\u0026ndash;80 years old \u003csup\u003e16\u003c/sup\u003e. The main groups were young people suffering from high-energy trauma and old people suffering from low-energy trauma [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. Entezari et al. found in the correlation research that distal-third humeral shaft fractures (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.001, OR 6.3), high-energy trauma (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0. 049, OR 1.7), open fracture (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0. 048, OR 2.1) and concomitant vascular injury (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.001, OR 26.9) were independent predictive factors, which were easy to lead to primary nerve injury [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e].\u003c/p\u003e \u003cp\u003ePeripheral nerve injury is one of the common complications of humeral shaft fracture in the early stage. A prospective study by James et al. on more than 5,700 patients with multiple injuries suggested that radial nerve injury was the most common peripheral nerve injury, and 9.5% of humeral fractures were complicated with radial nerve injury\u003csup\u003e17\u003c/sup\u003e. Niver reviewed literatures and found that the rate of humeral shaft fractures associated with radial nerve injury was about 2\u0026ndash;17% \u003csup\u003e10,18\u0026ndash;20\u003c/sup\u003e. Shao et al found in their retrospective study that the rate of humeral shaft fracture complicated with radial nerve injury was 11.8% (532/4517), and the middle and distal humeral shaft fractures were more likely to damage radial nerve \u003csup\u003e21\u003c/sup\u003e. However, Ljungquist et al. mentioned that the rate of radial nerve injury caused by humeral shaft fracture was 22% \u003csup\u003e22\u003c/sup\u003e, and Streufert et al. summarized the case data of two centers and found that the incidence of radial nerve injury was 18.4% (48/261) \u003csup\u003e23\u003c/sup\u003e. Entezari et al. reported that the incidence of humeral shaft fracture complicated with nerve injury was about 25.5% (96/376), among which radial nerve injury accounted for about 94%, and the iatrogenic nerve injury incidence of humeral shaft fracture was 4.6% (7/154), all of which involved radial nerve\u003csup\u003e6\u003c/sup\u003e. In our study, the total rate of iatrogenic radial nerve injury caused by humeral shaft fracture was 6.16% (382/6205), and there was no significant statistical difference with the former (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.05).\u003c/p\u003e \u003cp\u003e1. Comparison of iatrogenic radial nerve injury with different implants (bone plate and intramedullary nail)\u003c/p\u003e \u003cp\u003eThe iatrogenic injury rates of the radial nerve caused by different treatment methods are different. For example, it has been reported that the iatrogenic injury rate of radial nerve of bone plate was 6.5%-12.0%, and that of intramedullary nails was 2.7-5.0% \u003csup\u003e4,24,25\u003c/sup\u003e. This is similar to our statistical results, bone plate of 6.82% (313/4589), intramedullary nail of 2.58% (23/893). Amer et al. included three pieces of literatures in their meta-analysis study, and the results showed that for humeral shaft fracture (OTA/AO 12), plate (10.8%, 12/111) was more likely to cause iatrogenic radial nerve injury than intramedullary nail (0%, 0/104) (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.0004\u0026thinsp;\u0026lt;\u0026thinsp;0.05) \u003csup\u003e8\u003c/sup\u003e. However, Streufert et al. reported that the two-center study from 2008 to 2016 suggested that the iatrogenic radial nerve injury rate of the plate was 15.6% (10/64) in the middle humeral shaft and 15% (16/107) in the distal humeral shaft \u003csup\u003e23\u003c/sup\u003e, which may be related to the diagnosis and treatment level of medical centers.\u003c/p\u003e \u003cp\u003eOuyang et al. conducted a meta-analysis on 10 randomized controlled trials (RCT) and 439 cases and found that compared with intramedullary nail, bone plate avoided the risk of postoperative acromion impingement and limited shoulder joint movement, but there was no significant difference in iatrogenic radial nerve injury (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.28\u0026thinsp;\u0026gt;\u0026thinsp;0.05) \u003csup\u003e26\u003c/sup\u003e. Kurup et al. Reviewed five low-quality (unstratified) randomized trials, involving 260 participants, and reached the same conclusion as Ouyang et al. \u003csup\u003e27\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eWe included 3 articles about nonunion, involving 1 article about intramedullary nails and 3 articles about bone plates. Mart\u0026iacute;nez et al. studied the treatment of middle and upper 2/3 of humeral shaft nonunion and found that the rate of iatrogenic radial nerve injury in non-reamed intramedullary nail and bone graft group was lower than that in open reduction and plate internal fixation group (0%, 0/24 \u003cem\u003eVS\u003c/em\u003e. 11.54%, 3/26) \u003csup\u003e28\u003c/sup\u003e. However, Singh et al. studied humeral shaft nonunion and found that there was no difference between intramedullary nail and plate internal fixation by posterior approach in nonunion healing time, joint function and iatrogenic radial nerve injury rate (0%, 0/20 \u003cem\u003eVS\u003c/em\u003e. 10%, 2/20) \u003csup\u003e29\u003c/sup\u003e. Koh et al. studied 379 cases of humeral shaft nonunion in 18 trauma centers, and found that there was no difference among anterolateral, lateral and posterior approaches (triceps-reflecting and triceps-splitting) approach, and fracture location (middle humerus) was the only related factor of radial nerve injury (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0. 02) \u003csup\u003e30\u003c/sup\u003e. Olarte et al. found that radial nerve transposition was an effective auxiliary means for internal fixation of humeral shaft fracture, which was suitable for high-risk nonunion patients \u003csup\u003e31\u003c/sup\u003e. A retrospective study of 19 patients by Chamseddine et al. found that medial transposition of the radial nerve was a safe and reliable method for patients who needed to take out internal fixation and nonunion \u003csup\u003e32\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eZalavras et al. provided a protocol for the treatment of nonunion of humeral shaft fracture and reported that 41 cases of nonunion were healed within 17 years without iatrogenic radial nerve injury; the protocol was also applicable to patients with long-term nonunion caused by complications \u003csup\u003e33\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003e2. Comparison of iatrogenic radial nerve injury by different surgical approaches (excluding MIPO)\u003c/p\u003e \u003cp\u003eSurgical approaches for humeral fractures included deltopectoral approach \u003csup\u003e34\u003c/sup\u003e, anteromedial approach \u003csup\u003e12,13\u003c/sup\u003e, anterolateral approach, lateral approach and posterior approach. The posterior approach included triceps-reflecting approach (Bryan-Morrey) \u003csup\u003e35\u003c/sup\u003e, modified triceps-reflecting approach (Gerwin/Hotchkiss/Weiland)\u003csup\u003e36\u003c/sup\u003e, triceps-reflecting anconeus pedicle approach (TRAP)\u003csup\u003e37\u003c/sup\u003e, triceps-on approach/paratricipital approach (Alonso-Llames), triceps-splitting approach, the chevron olecranon V osteotomy, and tongue-shaped flap approach, etc.\u003c/p\u003e \u003cp\u003eSurgical approaches for humeral shaft fractures mainly included anterolateral, lateral and posterior approaches, and occasionally deltopectoral approach \u003csup\u003e34\u003c/sup\u003e. Anteromedial approach was only seen in two pieces of literatures for MIPO treatment of humeral shaft fractures \u003csup\u003e12,13\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eA retrospective study of 6 hospitals by Claessen et al. found that the rate of iatrogenic radial nerve injury caused by humeral shaft fracture was 7% (18/259); the surgical approach was related to iatrogenic radial nerve injury (p\u0026thinsp;\u0026lt;\u0026thinsp;0.034), which was the only related factor (OR\u0026thinsp;=\u0026thinsp;6.4\u0026thinsp;\u0026gt;\u0026thinsp;1); the incidence of iatrogenic radial nerve injury was 4% (7/165) in the anterolateral approach, 22% (2/9) in the lateral approach, and 11% (9/85) in the posterior approach \u003csup\u003e7\u003c/sup\u003e. In our results, The rate of iatrogenic radial nerve injury in humeral shaft fracture was 6.16% (382/6205), which was similar to the results of Claessen (anterolateral: 5.65%, 111/1963; Posterior: 9.55%, 119/1246; \u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.05); while the rate of radial nerve injury in lateral approach was 13.54% (26/192), which was lower than that of Claessen (22%, 2/9), but there was no statistical difference (p\u0026thinsp;\u0026gt;\u0026thinsp;0.05). Different from the former, in our study, there were statistical differences between anterolateral approach and lateral approach, and between anterolateral approach and posterior approach in the rate of iatrogenic radial nerve injury (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.05).\u003c/p\u003e \u003cp\u003eMultiple regression analysis by Shoji et al. showed that iatrogenic radial nerve injury had nothing to do with surgical approach and timing, but it was related to distal humeral fracture (AO/OTA 12A/B/C) and secondary or multiple operations due to a previous fracture, which was an independent risk factor \u003csup\u003e38\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eStreufert et al. analyzed the case data of two centers and found that there was no difference in iatrogenic radial nerve injury rate among the three approaches: which were anterior/anterolateral approach (6/84), triceps lifting approach (14/78) and triceps-splitting approach (6/51) (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.11) \u003csup\u003e23\u003c/sup\u003e. A meta-analysis conducted by Shon et al. on 1303 cases in 9 studies showed that the rate of iatrogenic radial nerve injury through posterior approach was significantly higher than that through anterolateral approach (13.88%, 69/497 \u003cem\u003eVS\u003c/em\u003e. 5.16%, 35/687) (OR 2.72; 95% CI, 1.70\u0026ndash;4.35; \u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.0001) \u003csup\u003e39\u003c/sup\u003e. There was no significant difference between triceps-reflecting (3.9%, 2/51) and triceps-splitting (7.96%, 25/314) (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.05), but there was a significant difference between posterior approach and anterolateral approach (7.4%, 119/1246 \u003cem\u003eVS\u003c/em\u003e. 5.65%, 111/1963 \u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.01). The main reason may be that the former had a small sample size and needed further specific study.\u003c/p\u003e \u003cp\u003e3. Comparison between open reduction and internal fixation (plate and intramedullary nail) and MIPO in iatrogenic radial nerve injury\u003c/p\u003e \u003cp\u003eA review by Tetsworth et al. suggested that MIPO had a lower rate of iatrogenic radial nerve injury \u003csup\u003e40\u003c/sup\u003e. A meta-analysis of two randomized controlled trials and three non-randomized controlled trials by Yu et al. found that the rate of iatrogenic radial nerve injury in patients with MIPO was lower than that of traditional open reduction and internal fixation (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0. 006) \u003csup\u003e41\u003c/sup\u003e. A meta-analysis by Hu et al. included 391 patients and 8 studies, involving 4 randomized controlled trials (RCTs), 2 prospective cohort trials and 2 retrospective cohort trials \u003csup\u003e42\u003c/sup\u003e. It was also found that the iatrogenic radial nerve injury rate in the MIPO group was lower than that in open reduction and internal fixation, and the adjacent joint function score of MIPO was higher than that of intramedullary nail (IMN) (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.05). Zhao et al. obtained the same results in a network meta-analysis of 16 randomized controlled trials (OR, 11.09; 95% CI, 1.80-124.20) \u003csup\u003e43\u003c/sup\u003e. However, they also found that the incidence of acromion impingement in the intramedullary nail group was higher than that in the open reduction and plate internal fixation group (OR, 0.13; 95% CI, 0.03\u0026ndash;0.37) and MIPO group (OR, 0.08; 95% CI, 0.00-0.69). There were no differences between Intramedullary nails, open reduction and plate internal fixation, and MIPO in delayed union, nonunion and infection of humeral fractures \u003csup\u003e43\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eOur results showed that the rate of iatrogenic radial nerve injury in MIPO was lower than that in open reduction and internal fixation (2.70%, 12/444 vs 7.26%, 301/4145) (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05), which was consistent with the mentioned literatures.\u003c/p\u003e \u003cp\u003e4. Comparison of iatrogenic radial nerve injury caused by MIPO through different surgical approaches\u003c/p\u003e \u003cp\u003eAt present, the main surgical approaches for the treatment of humeral shaft fractures by MIPO are anterolateral or posterior. However, Yang et al. found that medial MIPO was a safe surgical method for extra-articular fractures of the middle and distal humerus (0%, 0/12) \u003csup\u003e12\u003c/sup\u003e. A single-center retrospective study by Liu et al. found that the radial nerve injury rate of anteromedial MIPO was low (0%, 0/21). The median nerve, ulnar nerve and brachial artery were protected by brachial muscle through the subbrachial tunnel without injury \u003csup\u003e13\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eThe results of this study showed that there was no significant difference among anterolateral MIPO, anteromedial MIPO and posterior MIPO in the rate of iatrogenic radial nerve injury (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.05).\u003c/p\u003e \u003cp\u003e5. Comparison of iatrogenic radial nerve injury caused by an intramedullary nail through different approaches\u003c/p\u003e \u003cp\u003eThere are two methods of intramedullary nailing for humeral shaft fracture: anterograde nail and retrograde nail. In this review, we found that there was no statistical difference in the incidence of iatrogenic radial nerve injury between anterograde and retrograde nailing (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.05). Li et al. also found in their retrospective study that there was no significant difference in iatrogenic radial nerve injury rate between anterograde and retrograde intramedullary nailing \u003csup\u003e44\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003e6. The crawling regeneration distance of nerve fibers in radial nerve defect\u003c/p\u003e \u003cp\u003eIatrogenic radial nerve injury includes continuation and discontinuation. In the latter, nerve defects often occur during secondary exploration, accompanied by permanent loss of sensory and motor function. However, in this study, a 14-year-old male child was observed, with a 4cm distance between the two nerve stumps, without an obvious continuous nerve bundle between the two nerve stumps, which suggested that the proximal nerve fibers crawled into the distal nerve stump through scar tissue and recovered part of the wrist extensor muscle strength. This case indicated that the regeneration ability of radial nerve was very strong, especially in children and adolescents. If the possibility of iatrogenic radial nerve injury is found, it should be actively explored and repaired.\u003c/p\u003e \u003cp\u003e7. Selection and optimization of implants\u003c/p\u003e \u003cp\u003eWang et al. found that pre-contouring plates on 3D-printed fracture models can better help young doctors complete operations \u003csup\u003e45\u003c/sup\u003e. For transverse fractures, 6-hole or 7-hole plates are generally used. However, clinically, most fractures are short oblique or long oblique fractures, even comminuted fractures. Therefore, 8\u0026ndash;10 hole plates are often used in clinics. Taking a 10-hole plate as an example, the anatomical study of Chirattikalwong et al. on 56 humerus found that when a 4.5 mm 10-hole compression plate was used for fixation of the middle humeral shaft fracture through an anterolateral approach, the radial nerve would be damaged by the second to sixth holes, and the fourth hole and the fifth hole had the highest rate of injuries \u003csup\u003e46\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eThe anatomical study of Chuaychosakoon et al. on 18 upper limbs also held that when the middle humeral shaft fracture was fixed with a 4.5mm 10 holes compression plate through an anterolateral approach, the radial nerve and/or deep brachial artery would be damaged by the second to fifth holes, while the fourth and fifth holes were most likely to damage them, with the injury ratios of 100% and 66.7% respectively. The relative ratio of the distance between the fourth hole and the lateral epicondyle of the humerus to the length of the humerus was 0.56. The author suggested that a single-layer cortical screw should be used at the fourth hole \u003csup\u003e47\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eAn anatomical study by Noger et al. found that when distal interlocking fixation was performed with non-reamed intramedullary nails through an anterograde approach, the medial and lateral locking nails in the middle easily damaged the radial nerve, median nerve, ulnar nerve and brachial artery. The author believed that using the two anteroposterior screws was safe. If you want to improve the locking stability, it is recommended to complete the internal and external locking of the middle screw holes under direct vision \u003csup\u003e48\u003c/sup\u003e. A retrospective study by Helm et al. found that anterograde intramedullary nail combined with cerclage can reduce the incidence of nonunion (2.6%, 2/78) without increasing the incidence of iatrogenic radial nerve injury (4.59%, 5/109) \u003csup\u003e49\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003e8. Conclusion\u003c/p\u003e \u003cp\u003eDuring humeral shaft fracture operation, the incidence of iatrogenic radial nerve injury was 6.82% in bone plate and 2.58% in intramedullary nails, respectively. Compared with lateral and posterior approaches, the anterolateral surgical approach had a lower incidence of radial nerve injury. The rate of iatrogenic radial nerve injury in MIPO was lower than that in open reduction and internal fixation. There was no difference in the incidence of iatrogenic radial nerve injury between anterograde and retrograde intramedullary nailing. In the human body, regenerated radial nerve fibers can span a 4cm nerve defect area.\u003c/p\u003e "},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthical Approval\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll datasets used can be accessed on Pubmed\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting Interest declaration\u003c/strong\u003e\u003cstrong\u003e：\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no conflict of interests.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eCole PA, Wijdicks CA. 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J Orthop Surg Res. 2018;13(1):203.\u003c/li\u003e\n\u003cli\u003eChirattikalwong S, Suwannaphisit S, Wuttimanop W, Chuaychoosakoon C. Risk of Radial Nerve Injury in Anterolateral Humeral Shaft Plating. J Am Acad Orthop Surg. 2022;30(18):903-909.\u003c/li\u003e\n\u003cli\u003eChuaychoosakoon C, Chirattikalwong S, Wuttimanop W, Boonriong T, Parinyakhup W, Suwannaphisit S. The risk of iatrogenic radial nerve and/or profunda brachii artery injury in anterolateral humeral plating using a 4.5 mm narrow DCP: A cadaveric study. PLoS ONE. 2021;16(11):e0260448.\u003c/li\u003e\n\u003cli\u003eNoger M, Berli MC, Fasel JHD, Hoffmeyer PJ. The risk of injury to neurovascular structures from distal locking screws of the Unreamed Humeral Nail (UHN): A cadaveric study. Injury. 2007;38(8):954-957.\u003c/li\u003e\n\u003cli\u003evon der Helm F, Fenwick A, Reuter J, Adolf-Lisitano L, Mayr E, F\u0026ouml;rch S. New ways of treatment of fractures of the humeral shaft: does the combination of intramedullary nail osteosynthesis and cerclage improve the healing process? Eur J Trauma Emerg Surg. 2022;48(4):3081-3087.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"european-journal-of-medical-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ejmr","sideBox":"Learn more about [European Journal of Medical Research](http://eurjmedres.biomedcentral.com)","snPcode":"40001","submissionUrl":"https://submission.nature.com/new-submission/40001/3","title":"European Journal of Medical Research","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Iatrogenic radial nerve injury, Humerus, Nerve regeneration, Neurotmesis","lastPublishedDoi":"10.21203/rs.3.rs-3972889/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3972889/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eObjectives:\u003c/strong\u003e Compare and analyze the relationship between the implant (bone plate VS. intramedullary nail), surgical approach and iatrogenic radial nerve injury. Report a case which indicates the possible distance between two nerve stumps which radial never might crawl through.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e Reviewed the literatures on humeral fracture (OTA/AO 11/12/13 A/B/C\u003csup\u003e9\u003c/sup\u003e) combined with radial nerve injury was retrieved in PubMed. Screening scope includes: 1) Chinese or English literature, 2) adult humeral fracture, 3) preoperative radial nerve continuity, 4) non-pathological fracture, 5) non-periprosthetic fracture, 6) must involve humeral shaft (OTA/AO 12). Exclusion criteria: 1) No full text in Chinese or English; 2) Unable to judge surgical approach. Rejection criteria: 1) Misinclusion; 2) Unable to judge whether the humeral shaft was involved (OTA/AO 12).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e 1. The rate of iatrogenic radial nerve injury with bone plate and intramedullary nail was 6.82% (313/4589) and 2.58% (23/893) respectively (p \u0026lt; 0.05). 2.In cases with open reduction and internal fixation with a plate with a definite surgical approach (excluding MIPO), the rate of radial nerve injury was 7.44% (259/3483). The corresponding rates were 3.7% (3/82) for deltopectoral approach, 5.65% (111/1963) for anterolateral approach, 13.54% (26/192) for lateral approach and 9.55% (119/1246) for posterior approach. There were statistical differences between anterolateral and lateral approaches and anterolateral and posterior approaches. 3.The injury rates of radial nerve were 7.26% (301/4145) for plate internal fixation, 2.58% (23/893) for intramedullary nail and 2.70% (12/444) for MIPO. There were statistical differences between plate fixation and intramedullary nail, plate fixation and MIPO (p \u0026lt; 0.05), but no difference between an intramedullary nail and MIPO (p \u0026gt; 0.05). 4. The radial nerve injury rates were 0.00% (0/33) for Anteromedial MIPO, 2.67% (10/374) for Anterolateral MIPO and 5.40% (2/37) for Posterior MIPO. (p \u0026gt; 0.05) 5. The radial nerve injury rates were 2.87% (21/732) for anterograde intramedullary nail and 1.2% (2/161) for retrograde intramedullary nail. (p \u0026gt; 0.05) 6. In nonunion surgery, the rate of iatrogenic radial nerve injury was 15.0% (9/60) for anterolateral approach, 16.7% (2/12) for lateral approach and 18.2% (6/33) for posterior approach. (p \u0026gt; 0.05)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e During humeral shaft fracture operation, the incidence of iatrogenic radial nerve injury was 6.82% in bone plate and 2.58% in intramedullary nails, respectively. Compared with lateral and posterior approaches, the anterolateral surgical approach had a lower incidence of radial nerve injury. The rate of iatrogenic radial nerve injury in MIPO was lower than that in open reduction and internal fixation. There was no difference in the incidence of iatrogenic radial nerve injury between anterograde and retrograde intramedullary nailing. In the human body, regenerated radial nerve fibers can span a 4cm nerve defect area.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eLevel of Evidence:\u003c/strong\u003e Level IV\u003c/p\u003e","manuscriptTitle":"Systematic review of humeral shaft fracture (OTA/AO 12) complicated with iatrogenic radial nerve injury: Can nerve fibers span a 3cm nerve defect?","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-03-08 17:56:41","doi":"10.21203/rs.3.rs-3972889/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-05-30T08:10:57+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-05-16T13:38:17+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"101573177381414166267838624333837596289","date":"2024-05-09T07:34:04+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"176808761510436903952719932357524571864","date":"2024-04-29T11:42:49+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-04-21T17:17:37+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"60dff49e-59f6-406a-ad8b-b09a08cc4d53","date":"2024-04-18T01:36:44+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2024-04-17T21:26:02+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-03-08T09:25:30+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-03-06T09:45:33+00:00","index":"","fulltext":""},{"type":"submitted","content":"European Journal of Medical Research","date":"2024-02-20T13:27:24+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"european-journal-of-medical-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ejmr","sideBox":"Learn more about [European Journal of Medical Research](http://eurjmedres.biomedcentral.com)","snPcode":"40001","submissionUrl":"https://submission.nature.com/new-submission/40001/3","title":"European Journal of Medical Research","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c929259b-df3a-4ed9-92af-d506e15b46d6","owner":[],"postedDate":"March 8th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2024-08-01T17:06:51+00:00","versionOfRecord":{"articleIdentity":"rs-3972889","link":"https://doi.org/10.1186/s40001-024-01981-7","journal":{"identity":"european-journal-of-medical-research","isVorOnly":false,"title":"European Journal of Medical Research"},"publishedOn":"2024-07-25 16:15:55","publishedOnDateReadable":"July 25th, 2024"},"versionCreatedAt":"2024-03-08 17:56:41","video":"","vorDoi":"10.1186/s40001-024-01981-7","vorDoiUrl":"https://doi.org/10.1186/s40001-024-01981-7","workflowStages":[]},"version":"v1","identity":"rs-3972889","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3972889","identity":"rs-3972889","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}