Effects of using mifepristone alone or combined with resolving stasis resolving and killing pain capsules for adenomyosis

Objective: To evaluate the clinical efficacy of using Mifepristone alone or combined with resolving stasis resolving and killing pain capsules for adenomyosis.Methods: Eighty adenomyosis patients were randomly divided into observation group and control group by half.The control group was given oral mifepristone at the dosage of 12.5 mg/d for 3 consecutive months.While the observation group was also given resolving stasis resolving and killing pain capsules,4 capsules per time,3 times / d based on mifepristone therapy.Three months after withdrawal of drugs,dysmenorrhea and change of serum CA125 were observed and compared.Results:After medication,ministration circle stopped in all patients,and serum CA125 level all decreased,but the difference was not significant.Three months after withdrawal of drugs,all patients got their circle again,but the serum CA 125 of the control group was significant higher than that of the observation group(t=3.64,P0.01);dysmenorrhea score of the observation group was significant lower that that of the control group 3 months after withdrawal of drugs,though no significant difference was found before the treatment.(P0.01).Conclusion: Mifepristone combining with resolving stasis resolving and killing pain capsules is effective on adenomyosis,and efficacy is superior to that using mifepristone alone.