Global Patterns and Trends of Infertility in Reproductive-Aged Women with Polycystic Ovary Syndrome: A longitudinal observational study

Global Patterns and Trends of Infertility in Reproductive-Aged Women with Polycystic Ovary Syndrome: A longitudinal observational study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 3 June 2025 V1 Latest version Share on Global Patterns and Trends of Infertility in Reproductive-Aged Women with Polycystic Ovary Syndrome: A longitudinal observational study Authors : Hongwei Tang , Huijie Yu , Yusen He , Yongru He , Cong Wang , Ke Li , Yongjian Liu , Tingting Zhou , and Dongfang Liu [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174897734.48788984/v1 207 views 141 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objective: To assess global and regional trends in infertility burden among reproductive-aged women with polycystic ovary syndrome (PCOS) from 1990 to 2021. Design: Longitudinal observational study. Setting: Global data from the Global Burden of Disease (GBD) 2021 database. Population: Women aged 15-49 years diagnosed with PCOS in 204 countries and territories. Methods: We extracted data on PCOS prevalence and associated infertility from the GBD 2021 dataset. Infertility was categorized into primary and secondary types. Analyses were conducted across age groups, GBD regions, and socio-demographic index (SDI) levels. Trends were quantified using estimated annual percentage change (EAPC), and associations between infertility burden and SDI were evaluated. Main outcome measures: Age- and region-specific prevalence of PCOS and the proportion of associated infertility, including subtype distribution and temporal change. Results: From 1990 to 2021, global PCOS cases increased from 34.8 to 65.8 million. Infertility among these women rose from 18.22% to 19.00%, with the highest proportion (21.9%) in the 35-39 age group. Low-SDI regions had fewer cases but higher infertility proportions. Equatorial Guinea showed the largest increase in infertility cases (+772%), while the Central African Republic had the highest proportion in 2021 (21.84%). An inverse correlation was observed between SDI and infertility proportion. Conclusions: The global burden of PCOS-related infertility has grown over the past three decades, with significant disparities by age, region, and development level. Targeted strategies are needed to improve reproductive care access and reduce inequities, particularly in low-SDI settings. Supplementary Material File (pcos_manuscript.docx) Download 127.52 KB File (table 1.docx) Download 28.18 KB Information & Authors Information Version history V1 Version 1 03 June 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords endocrinology epidemiology epidemiology: infertility reproductive science: polycystic ovary syndrome Authors Affiliations Hongwei Tang The Second Affiliated Hospital of Chongqing Medical University View all articles by this author Huijie Yu The Second Affiliated Hospital of Chongqing Medical University View all articles by this author Yusen He The Second Affiliated Hospital of Chongqing Medical University View all articles by this author Yongru He The Second Affiliated Hospital of Chongqing Medical University View all articles by this author Cong Wang The Second Affiliated Hospital of Chongqing Medical University View all articles by this author Ke Li The Second Affiliated Hospital of Chongqing Medical University View all articles by this author Yongjian Liu The Second Affiliated Hospital of Chongqing Medical University View all articles by this author Tingting Zhou The Second Affiliated Hospital of Chongqing Medical University View all articles by this author Dongfang Liu [email protected] The Second Affiliated Hospital of Chongqing Medical University View all articles by this author Metrics & Citations Metrics Article Usage 207 views 141 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Hongwei Tang, Huijie Yu, Yusen He, et al. Global Patterns and Trends of Infertility in Reproductive-Aged Women with Polycystic Ovary Syndrome: A longitudinal observational study. Authorea . 03 June 2025. DOI: https://doi.org/10.22541/au.174897734.48788984/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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