Reparative Effects of Schizophyllum commune Oat Bran Fermentation Broth on UVB-induced Skin Inflammation via the JAK/STAT Pathway

Abstract Human immortal keratinocyte cells (HaCaT) are induced with UVB to establish an injury model, which is used as the basis to investigate whether oat bran fermentation broth (OBF) has reparative effect on skin inflammation and damage to the skin barrier due to UVB irradiation. The results show that compared with unfermented oat bran (OB), OBF has higher structural homogeneity, and increased molecular weight size, active substances content and in vitro antioxidant activity. OBF has a scavenging effect on excess ROS and increases the intracellular levels of antioxidant enzymes. In addition, it was found that OBF has a stronger inhibitory effect on the release of inflammatory factors than OB, and increase the synthesis of AQP3 and FLG proteins, and decrease the secretion of KLK-7. OBF can inhibit the transcription level of inflammatory factors by inhibiting the JAK/STAT signaling pathway. Safety experiments show that OBF has a high safety profile.