New perspective: Bench to bedside evidence of the role of CD8+ T cells in Alzheimer’s disease：a systemic review

New perspective: Bench to bedside evidence of the role of CD8+ T cells in Alzheimer’s disease：a systemic review | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 18 March 2025 V1 Latest version Share on New perspective: Bench to bedside evidence of the role of CD8+ T cells in Alzheimer’s disease：a systemic review Authors : Yong Peng 0000-0001-8390-7668 [email protected] , Shun-yu Yao , Huan Yang , Xiuli Zhang , Sugimoto Kazuo , Jia Liu , Miao-qiao Du , Lan-xin Lin , Xu-hui Kang , and Dai-yi Jiang Authors Info & Affiliations https://doi.org/10.22541/au.174230848.83463910/v1 197 views 136 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Amyloid beta plaques and tau tangles are the primary hallmarks of Alzheimer’s disease (AD). Recently, marked advances have been made in terms of passive anti-Aβ immunotherapy for AD, which have been supported by evidence from AD animal models and clinical trials. While innate immunity significantly contributes to the pathology of AD, it does not fully clarify the immune mechanisms linked to its pathogenesis. Consequently, focus should be directed toward adaptive immunity, encompassing both humoral immunity, primarily governed by B cells, and cellular immunity, predominantly influenced by T cells. T cells, in particular, may also be important in AD pathogenesis, as indicated by many lines of evidence from clinical and animal studies. Furthermore, T cells that infiltrate the central nervous system (CNS) have demonstrated both protective and detrimental effects on neural tissue in AD. Because autoreactive CD8+ T cells were expected to be cytotoxic to CNS cells, they have received less attention. Nevertheless, a significant amount of evidence now suggests that CD8+ Treg cells play a role in multiple diseases. However, the function of anti-Aβ-specific CD8+ T cells in AD has remained ambiguous. Many subsets of CD8+ T cells exist, which have been well-studied in terms of autoimmunity. We suggest that these CD8+ T cell subsets identified in AD studies could constitute a promising area for future AD research. Supplementary Material File (ad and cd8 t cells-20250318.docx) Download 47.00 KB Information & Authors Information Version history V1 Version 1 18 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords neuroimmunology t cells Authors Affiliations Yong Peng 0000-0001-8390-7668 [email protected] Affiliated Hospital of Hunan Traditional Chinese Medical College View all articles by this author Shun-yu Yao Affiliated Hospital of Hunan Traditional Chinese Medical College View all articles by this author Huan Yang Xiangya Hospital Central South University View all articles by this author Xiuli Zhang Hunan University of Chinese Medicine View all articles by this author Sugimoto Kazuo Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital View all articles by this author Jia Liu Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital View all articles by this author Miao-qiao Du Affiliated Hospital of Hunan Traditional Chinese Medical College View all articles by this author Lan-xin Lin Affiliated Hospital of Hunan Traditional Chinese Medical College View all articles by this author Xu-hui Kang Affiliated Hospital of Hunan Traditional Chinese Medical College View all articles by this author Dai-yi Jiang Affiliated Hospital of Hunan Traditional Chinese Medical College View all articles by this author Metrics & Citations Metrics Article Usage 197 views 136 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Yong Peng, Shun-yu Yao, Huan Yang, et al. New perspective: Bench to bedside evidence of the role of CD8+ T cells in Alzheimer’s disease：a systemic review. Authorea . 18 March 2025. DOI: https://doi.org/10.22541/au.174230848.83463910/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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