Undescribed triterpenoids obtained from Dictamnus dasycarpus Turcz and their anti-proliferation activities

Three new triterpenoids, named dictamtriterpenol B-D ( 1-3 ), along with ten known compounds ( 4-13 ), were isolated from Dictamnus dasycarpus Turcz. The structures of all compounds were characterized by spectroscopic methods, including IR, HR-ESI-MS, 1D and 2D NMR. Furthermore, HepG2 and A549 cell lines were used to evaluate their anti-proliferation activities. And compounds 1 , 5 , and 8 (IC 50 values in the range of 1.84±0.03 to 14.98±0.39 μ M) displayed significant anti-proliferation activity against HepG2 cells. As well as compounds 1 , 4 , 9 , 10 , and 13 (IC 50 values in the range of 1.63±0.04 to 8.56±1.46 μ M) displayed significant anti-proliferation activity against A549 cells.