IMPACT OF THE MICROBIOLOGY ON ENDOMETRIOSIS SYMPTOMS AND QUALITY OF LIFE

Daud Akhtar, Dr Bukhtawar Akhtar, Dr.Samiyah Tasleem
In: Journal of Medical & Health Sciences Review · 2025 · vol. 2(2) · doi:10.62019/sybe4y82 · W4411557804
article OA: bronze CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-08 · read from full text ⓘ

This cross-sectional study investigated the relationship between the microbiome and symptoms in 100 women diagnosed with endometriosis using 16S rRNA sequencing. The researchers found significant differences in microbial diversity compared to controls, with specific profiles correlating strongly to both symptom severity and impaired quality of life scores. While the authors note that further research is needed to explore therapeutic implications, they conclude that microbiome alterations may contribute to the development and severity of the condition. This paper is centrally about endometriosis — specifically examining how vaginal or pelvic microbiome composition influences pain levels and overall quality of life in affected patients.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a persistent gynecological disorder affecting millions of females worldwide, characterized by the growth of endometrial tissue outside the uterus. This condition leads to symptoms such as pelvic pain, dysmenorrhea, and infertility, significantly impacting quality of life. Recent studies have suggested a potential link among the microbiome and endometriosis symptoms, highlighting the importance of exploring this relationship further. Objective: To investigate the relationship among the microbiome and endometriosis symptoms, quality of life, and potential therapeutic implications in women. Methods:This cross-sectional study aimed to explore the relationship between the microbiome and endometriosis. In this study, 100 women (aged 25-35 years) were recruited that diagnosed with endometriosis using consecutive sampling method, from gynecology clinics in tertiary care hospitals. Endometriosis Health Profile-30 (EHP-30) was used to assess the quality of life. 16S rRNA sequencing was used to assess the analyze microbial diversity and composition. Results: Significant differences in microbial diversity and composition were observed between women with endometriosis and controls. 75% of participants reported moderate to severe pelvic pain. EHP-30 scores indicated significant impairment in quality of life, with mean scores of 65.4 ± 12.1. Specific microbial profiles correlated with symptom severity (r = 0.42, p < 0.001) and quality of life (r = -0.38, p < 0.01). Conclusion:This study highlights the potential role of the microbiome in endometriosis symptoms and quality of life. The findings suggest that alterations in the microbiome may contribute to the development and severity of endometriosis symptoms. Further research is needed to explore microbiome-targeted therapies and their potential to alleviate symptoms and improve quality of life for women with endometriosis.
Full text 2,581 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Objective

To investigate the relationship among the microbiome and endometriosis symptoms, quality of life, and potential therapeutic implications in women. Methods:This cross-sectional study aimed to explore the relationship between the microbiome and endometriosis. In this study, 100 women (aged 25-35 years) were recruited that diagnosed with endometriosis using consecutive sampling method, from gynecology clinics in tertiary care hospitals. Endometriosis Health Profile-30 (EHP-30) was used to assess the quality of life. 16S rRNA sequencing was used to assess the analyze microbial diversity and composition.

Results

Significant differences in microbial diversity and composition were observed between women with endometriosis and controls. 75% of participants reported moderate to severe pelvic pain. EHP-30 scores indicated significant impairment in quality of life, with mean scores of 65.4 ± 12.1. Specific microbial profiles correlated with symptom severity (r = 0.42, p < 0.001) and quality of life (r = -0.38, p < 0.01). Conclusion:This study highlights the potential role of the microbiome in endometriosis symptoms and quality of life. The findings suggest that alterations in the microbiome may contribute to the development and severity of endometriosis symptoms. Further research is needed to explore microbiome-targeted therapies and their potential to alleviate symptoms and improve quality of life for women with endometriosis. Downloads Downloads Published Issue Section License All articles published in the Journal of Medical & Health Sciences Review (JMHSR) remain the copyright of their respective authors. JMHSR publishes its content under the Creative Commons Attribution‑NonCommercial 4.0 International License (CC BY‑NC 4.0), which allows readers to freely share, copy, adapt, and build upon the work for non‑commercial purposes, provided proper credit is given to both the authors and the journal.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Outcome instruments

EHP-30

Condition tags

endometriosisdysmenorrheainfertility

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK