Treatment of patients with long-standing unexplained subfertility with in vitro fertilization

Peter F.J. Donderwinkel; Hester van der Vaart; Victorien M. Wolters; Arnold Simons; Gerard Kroon; M. J. Heineman

doi:10.1016/s0015-0282(99)00518-x

Treatment of patients with long-standing unexplained subfertility with in vitro fertilization

Peter F.J. Donderwinkel, Hester van der Vaart, Victorien M. Wolters, Arnold Simons, Gerard Kroon, M. J. Heineman

In: Fertility and Sterility · 2000 · vol. 73(2) , pp. 334–337 · doi:10.1016/s0015-0282(99)00518-x · PMID:10685539 · W2122452346

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This paper investigates the effectiveness of in vitro fertilization (IVF) for treating long-standing unexplained subfertility.

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Abstract

ObjectiveTo evaluate whether IVF is an effective treatment for long-standing unexplained subfertility.DesignRetrospective cohort study.SettingTertiary care infertility center in a university hospital.Patient(s)Two hundred two couples with unexplained subfertility of 2 years' duration or more who attended the center for their first IVF attempt.Intervention(s)Couples were placed on a waiting list for IVF. They received no treatment until IVF was started.Main outcome measure(s)Pregnancy rate (PR) while on the waiting list and PR after IVF treatment.Result(s)Complete data sets were available for 131 couples. Seventeen of 131 women became pregnant while waiting for IVF treatment (PR 0.9% per exposure cycle), whereas 45 of 119 receiving IVF treatment became pregnant (PR 17% per IVF attempt).Conclusion(s)IVF treatment has substantial added value over waiting and is an efficient treatment for long-standing unexplained subfertility.

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Cites (1)

Treatment-Independent Pregnancy among Infertile Couples 1983

Cited by (1)

Female Infertility: Other Causes 2001

References (10)

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Cited by (1)

Female Infertility: Other Causes 2001

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[1] Treatment-Independent Pregnancy among Infertile Couples 1983