A multidimensional model of memory complaints in elderly individuals and the associated hub regions

A multidimensional model of memory complaints in elderly individuals and the associated hub regions | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article A multidimensional model of memory complaints in elderly individuals and the associated hub regions Veronique Paban, Ahmad Mheich, Laure Spieser, Mathilde Sacher This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3099399/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Memory complaints are highly prevalent among middle-aged and older adults, and they are frequently reported in individuals experiencing subjective cognitive decline (SCD). SCD has received increasing attention due to its implications for the early detection of dementia. The factors contributing to memory complaints in SCD appear to be multifaceted and require further identification. To address this, we employed structural equation modeling to investigate the relationships between various factors, such as metacognitive beliefs, personality, anxiety, depression, self-esteem, and resilience, and memory complaints. Our findings revealed that self-esteem and conscientiousness significantly influenced memory complaints. At the cerebral level, analysis of delta and theta electroencephalographic frequency bands recorded during rest was conducted to identify hub regions using a local centrality metric known as betweenness centrality. Notably, our study demonstrated that certain brain regions undergo changes in their hub roles in response to the pathology of SCD. Specifically, the inferior temporal gyrus and the left orbitofrontal area transition into hubs, while the dorsolateral prefrontal cortex and the middle temporal gyrus lose their hub function in the presence of SCD. This rewiring of the neural network may be interpreted as a compensatory response employed by the brain in response to SCD, wherein functional connectivity is maintained or restored by reallocating resources to other regions. Health sciences/Diseases Biological sciences/Neuroscience/Cognitive neuroscience Figures Figure 1 Figure 2 Figure 3 Figure 4 Full Text Additional Declarations No competing interests reported. Supplementary Files SupplInfoTotalPaban.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3099399","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":214262110,"identity":"7e59a309-83b4-47ad-8057-e4708a74e184","order_by":0,"name":"Veronique Paban","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABEUlEQVRIie3RsYrCMBjA8ZRCXL7WVSmer5Aj4NKXMQjNJPQBHHoIuUm7ttO9QqdbrxKoiw8gxKGH4AscuJzIRVvuQFrvxhvyhxAy/PIFgpDJ9G8j1Wbr9YCQFdXH/G+E/hA8/n3YhbDo+9hCyHrxvg9Dn8XIWX2Esx3P1Fz00OyVRdgpG8lmTWlCOEsjd+IlxWGa7VaaFEqTDmki/STAHhDJshyIB1hOsy2b0xPWZCgaH9Z/OVTkLQf6CWfJiSYEnS9TcCPp9nA9BcHIc4Qca/JUWuIOgcCmQDhNpBv46VI+pleyVFS0ENwprD2c/EH8vJAqPMqhu+Vljo5qELeQOv0jNtzedg9Un3hLTCaTyVT3BcmhXEebLYkmAAAAAElFTkSuQmCC","orcid":"","institution":"Aix Marseille Univ, CNRS, LNC (Laboratoire de Neurosciences Cognitives - UMR 7291)","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Veronique","middleName":"","lastName":"Paban","suffix":""},{"id":214262112,"identity":"5bb7b9ce-a3a3-4e81-b049-11e20b3ff2ee","order_by":1,"name":"Ahmad Mheich","email":"","orcid":"","institution":"CHUV-Centre Hospitalier Universitaire Vaudois, Lausanne University Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ahmad","middleName":"","lastName":"Mheich","suffix":""},{"id":214262115,"identity":"ae19d134-88bc-475b-8616-70d88c6d2f30","order_by":2,"name":"Laure Spieser","email":"","orcid":"","institution":"Aix Marseille Univ, CNRS, LNC (Laboratoire de Neurosciences Cognitives - UMR 7291)","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Laure","middleName":"","lastName":"Spieser","suffix":""},{"id":214262117,"identity":"05088bf7-4ce3-40f1-af79-b464612bb4a5","order_by":3,"name":"Mathilde Sacher","email":"","orcid":"","institution":"Univ Toulouse Jean-Jaurès, CNRS, LCLLE (Laboratoire Cognition, Ergonomie - UMR 5263)","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Mathilde","middleName":"","lastName":"Sacher","suffix":""}],"badges":[],"createdAt":"2023-06-23 08:44:23","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3099399/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3099399/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":39467443,"identity":"dd3afd09-e898-449e-9884-f868237c9f65","added_by":"auto","created_at":"2023-07-03 14:13:36","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":292644,"visible":true,"origin":"","legend":"\u003cp\u003eStructural model of the direct effects of memory complaints on neuropsychological tests, emotional distress, metacognitive beliefs, and personality factors in non-SCD (A) and SCD (B) participants.\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-3099399/v1/7f2595e00a2c566a0482c334.png"},{"id":39467445,"identity":"a3f702e9-84a8-4c39-83a9-e9b9b4404659","added_by":"auto","created_at":"2023-07-03 14:13:36","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":69401,"visible":true,"origin":"","legend":"\u003cp\u003eBoxplots showing similarity index of SCD vs non-SCD in delta and theta bands.\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-3099399/v1/cd181d7ebd725e58083bd480.png"},{"id":39467444,"identity":"5ebaf746-6a6c-43ac-a541-d3148653842c","added_by":"auto","created_at":"2023-07-03 14:13:36","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":247635,"visible":true,"origin":"","legend":"\u003cp\u003eVenn diagram analysis of hub regions of interest (ROIs) in the theta frequency band. The diagram illustrates the overlapping hubs among individuals without (non-SCD) and with SCD, as well as the hubs exclusively identified in each group.\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-3099399/v1/b7e17568ab4393c96d85432a.png"},{"id":39469877,"identity":"9cee1454-84f1-48c4-8d33-fe5c945451bd","added_by":"auto","created_at":"2023-07-03 14:21:36","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":297227,"visible":true,"origin":"","legend":"\u003cp\u003eVenn diagram analysis of hub regions of interest (ROIs) in the delta frequency band. 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