Simvastatin versus triptorelin in prevention of pain recurrences after surgery for endometriosis

Kargar M, Mona Kargar, Hadjibabaie M, Molouk Hadjibabaie, Gholami K, Kheirollah Gholami
Medical science monitor : international medical journal of experimental and clinical research · 2013 · vol. 19 , pp. 858 · doi:10.12659/MSM.889682 · PMID:24129167 · PMC3808233
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This letter to the editor compares simvastatin and triptorelin for preventing pain recurrences after surgery for endometriosis.

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This letter to the editor references a concurrent study comparing simvastatin and triptorelin for preventing pain recurrences after surgical treatment of endometriosis. The authors highlight that while triptorelin is a standard medical therapy, simvastatin offers an alternative mechanism via HMG-CoA reductase inhibition. The text serves as a commentary on the clinical relevance of these pharmacological interventions in managing postoperative symptoms associated with the disease. This paper is centrally about endometriosis — specifically discussing pharmacological strategies for pain management following surgical intervention.

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Abstract

ABSTRACT:

Keywords

Endometriosis - surgery, Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use, Laparoscopy - adverse effects, Pain, Postoperative - prevention & control, Simvastatin - therapeutic use

References

1. Almassinokiani F, Mehdizadeh A, Sariri E, Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis: Med Sci Monit, 2013; 19; 534-39, pmid: 23828228 2. : Highlights of prescribing information, FDA label for triptorelin (Trelstar) available online at: viewed on 13.08.2013http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020715s030,021288s027,022437s007lbl.pdf 3. American Diabetes Association, Standards of Medical Care in Diabetes: Diabetes Care, 2013; S11-66, pmid: 23264422 In Press Clinical Research Prevalence and Associated Risk Factors of Osteoporosis in Community-Dwelling Older Adults in China: A Cross...Med Sci Monit In Press; DOI: 10.12659/MSM.953854 Clinical Research Classical and Speech Therapy Olfactory Training in the Treatment of COVID-19–Related Olfactory DisordersMed Sci Monit In Press; DOI: 10.12659/MSM.952546 Clinical Research Trends and Characteristics of Pediatric Acute Poisoning in Ordos, China: A Decade-Long Retrospective AnalysisMed Sci Monit In Press; DOI: 10.12659/MSM.952868 Review article Psychosocial Interventions for Alcohol Use Disorder: A Review of Efficacy, Mechanisms, and Clinical Implica...Med Sci Monit In Press; DOI: 10.12659/MSM.952777 Most Viewed Current Articles 17 Jan 2024 : Review article 14,182,187 Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799 Med Sci Monit 2024; 30:e942799 13 Nov 2021 : Clinical Research 3,775,704 Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788 Med Sci Monit 2021; 27:e932788 14 Dec 2022 : Clinical Research 2,475,739 Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990 Med Sci Monit 2022; 28:e937990 16 May 2023 : Clinical Research 710,167 Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387 Med Sci Monit 2023; 29:e940387

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Hydroxymethylglutaryl-CoA Reductase Inhibitors Laparoscopy Postoperative Pain Postoperative Pain Simvastatin Endometriosis Endometriosis Female Female Humans Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hydroxymethylglutaryl-CoA Reductase Inhibitors Laparoscopy Laparoscopy Postoperative Pain Postoperative Pain Simvastatin Simvastatin

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europepmc
last seen: 2026-10-25T09:32:14.900964+00:00
pubmed
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