Neural field model simulation of changes in cortical slow-wave sleep events by sensory stimulation in plasticity-evolving NREM sleep

Neural field model simulation of changes in cortical slow-wave sleep events by sensory stimulation in plasticity-evolving NREM sleep | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Neural field model simulation of changes in cortical slow-wave sleep events by sensory stimulation in plasticity-evolving NREM sleep Felipe A. Torres, Patricio Orio, María-José Escobar This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1922749/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Brain activity during sleep transits between discretely described stages according to different brain dynamics. In particular, the slow-wave sleep stage (N2 and N3) presents events of interest for the memory consolidation process, such as slow oscillations and sleep spindles. Evidence exists that adequate timing between a slow oscillation and a sleep spindles, together with the increase in number and power, correlates with the performance in memory consolidation tasks. Nevertheless, how the results depend on the ongoing sleep stage is unclear, considering that stimulation is typically applied only at the N3 stage. Then, the effects of stimuli application in sleep macro-architecture during the same night are not well understood. Using a mean-field model of the thalamocortical activity, including dynamics of sleep cycle, we test the effects of stimuli application on the occurrence of slow-wave events. We evaluated three stimulation conditions in different time windows transiting from the N2 to N3 sleep stage. In our findings, closed-loop stimulation elicits higher quantity of slow oscillations and sleep spindles for near N3 brain dynamic. Further, closed-loop stimulation increases the co-occurrence of slow oscillations and sleep spindles. Interestingly, stimuli application does not significantly impact the trajectory of sleep dynamics, concordant with the null effect in sleep macro-architecture reported from experimental results. Finally, we noted that the lack of refractory periods in intra-thalamic dynamics results in a high occurrence of sleep spindles with stimuli application, which is not observed in the experimental results. Neural field theory slow-wave sleep stimulation events co-occurrence Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1922749","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":126809672,"identity":"6118f456-ec67-4692-a252-cfa632d8e283","order_by":0,"name":"Felipe A. 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