FSHR and FSHB variants infertile women with endometriosis

Bianca Bianco
2021 · doi:10.17632/2yhwkbw74m · W6887839568
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study evaluated the association of FSHB and FSHR variants with hormonal profiles and IVF outcomes in infertile Brazilian women with endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper assessed whether FSHB:c.-211G>T and FSHR:c.919G>A and FSHR:c.2039G>A single nucleotide variants, individually and in combination, influence hormonal profiles and IVF reproduction outcomes in infertile Brazilian women with endometriosis. The study included 213 participants who underwent IVF, with genotyping performed using TaqMan real-time PCR and outcome comparisons made across genotypes and genetic models. The paper’s analysis focused on associations between these variants and variability in FSH/LH levels and IVF-related reproductive outcomes, as framed by prior reports. This paper is centrally about endometriosis — it evaluates FSHR/FSHB genetic variants as modifiers of hormone levels and IVF outcomes in women with endometriosis-related infertility.

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Abstract

Single nucleotide variants (SNVs) FSHB:c.-211G>T, FSHR:c.919G>A, and FSHR:c.2039G>A were reported to be associated with the variability in FSH and LH levels, and in vitro fertilization (IVF) outcomes. We aimed to evaluate the effects of FSHB:c.-211G>T, FSHR:c.919G>A, and FSHR:c.2039G>A variants, alone and combined, on the hormonal profile and reproduction outcomes of women with endometriosis. The study comprised 213 infertile Brazilian women with endometriosis who underwent IVF treatment. Genotyping was performed using TaqMan real-time PCR. Variables were compared according to the genotypes of each variant and genetic models.
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FSHR and FSHB variants infertile women with endometriosis Published: 13 September 2021| Version 1 | DOI: 10.17632/2yhwkbw74m.1 Contributor: Bianca BiancoDescription Single nucleotide variants (SNVs) FSHB:c.-211G>T, FSHR:c.919G>A, and FSHR:c.2039G>A were reported to be associated with the variability in FSH and LH levels, and in vitro fertilization (IVF) outcomes. We aimed to evaluate the effects of FSHB:c.-211G>T, FSHR:c.919G>A, and FSHR:c.2039G>A variants, alone and combined, on the hormonal profile and reproduction outcomes of women with endometriosis. The study comprised 213 infertile Brazilian women with endometriosis who underwent IVF treatment. Genotyping was performed using TaqMan real-time PCR. Variables were compared according to the genotypes of each variant and genetic models. Files Institutions - Faculdade de Medicina do ABC Categories Genetics, In Vitro Fertilization, Endometriosis

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endometriosis

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