Endometrial Stromal Sarcomas: Case Series of Rare Mesenchymal Uterine Tumour

International Journal of Medical Science and Innovative Research (IJMSIR)
2025 · doi:10.5281/zenodo.15647687 · W6930748798
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated deep summary by claude@2026-07, 2026-07-03 · read from full text ⓘ

This paper presents a case series of seven patients with endometrial stromal sarcoma (ESS), describing their clinical presentation and clinical course in a perimenopausal population with symptoms such as abnormal vaginal bleeding, abdominal pain, and rapid abdominal enlargement. The authors report that ESS is often clinically mistaken for conditions including leiomyoma, adenomyosis, or intrauterine polyps and is frequently diagnosed postoperatively based on histopathology, with tumors typically positive for estrogen and progesterone receptors (ER/PR). A key limitation is that the work is a small descriptive case series, without comparative or controlled methodology to establish broader clinical conclusions. The paper mentions adenomyosis as part of the differential diagnosis and diagnostic confusion, making it relevant to adenomyosis research despite its main focus being ESS case descriptions.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Abstract Endometrial stromal sarcoma (ESS) is a rare malignant tumor of endometrium compromising 10 % of all uterine sarcomas occurring in perimenopausal age group. Patient’s mainly present with symptoms of abnormal vaginal bleeding, abdominal pain and rapid enlargement of abdomen. They are usually mistaken as leiomyoma, adenomyosis or intrauterine polyps and majority of time they are diagnosed postoperatively on histopathology. These tumours are mostly positive for both estrogen and progesterone receptors (ER/PR). Here we describe seven cases of ESS and their clinical course.
Full text 3,629 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

Endometrial stromal sarcoma (ESS) is a rare malignant tumor of endometrium compromising 10 % of all uterine sarcomas occurring in perimenopausal age group. Patient’s mainly present with symptoms of abnormal vaginal bleeding, abdominal pain and rapid enlargement of abdomen. They are usually mistaken as leiomyoma, adenomyosis or intrauterine polyps and majority of time they are diagnosed postoperatively on histopathology. These tumours are mostly positive for both estrogen and progesterone receptors (ER/PR). Here we describe seven cases of ESS and their clinical course. Files DHIRAJ.pdf Files (1.2 MB) | Name | Size | Download all | |---|---|---| | md5:ed479708d9ee20339fe6313162b0ce2d | 1.2 MB | Preview Download | Additional details Software - Repository URL - https://ijmsir.com/issue/archive_issue/118/Issue%202%20April

References

- 1. Tavassoli FA, Devilee P. WHO Classification of Pathology and genetics of tumours of the breast and female genital organs. In: Tavassoli FA, Devilee P, editors, Lyon, France: IARC Press; 2003. p. 233-6. 2. Beer, T.W.; Buchanan, R.; Buckley, C.H. Uterine stromal sarcoma following tamoxifen treatment. J. Clin. Pathol. 1995, 48, 596. [CrossRef] 3. Toprak U, Paaolu E, Karademir MA, Gülbay M. Sonographic, CT, and MRI findings of endometrial stromal sarcoma located in the myometrium and associated with peritoneal inclusion cyst. AJR Am J Roentgenol2004;182:1531-3. 4. NCCN clinical practice guidelines in oncology. Soft tissue sarcoma. Version 2. 2020. National Comprehensive Cancer Network, Inc.;2020. 5. B.-L. L. Seagle, A. Shilpi, S. Buchanan, C. Goodman, and S. Shahabi, "Low-grade and high-grade endometrial stromal sarcoma: A National Cancer Database study," Gynecologic Oncology, vol. 146, no. 2, pp. 254–262, 201 6. Zhu XQ, Shi YF, Cheng X, Zhao CL, Wu YZ. Detail Immunohistichemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leomyoma. Gynaecol Oncol 2004;92:71-9 7. Halbwed I, Ullmann R, Kremser ML, Man YG, Moud NI, Lax S, et al. Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization. Gynecol Oncol 2005;2:582-7. 8. Agoff SN, Grieco VS, Garcia R, Gown AM Immunohistochemical distinction of endometrial stromal sarcoma and cellular leiomyoma. Appl Immunohistochem Mol Morphol2001;9:164-9. 9. Sumathi VP, McCluggage WG. CD 10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis. J Clin Pathol2002;55:391-2. 10. Spano JP, Soria JC, Kambouchner M, Piperno-Neuman S, Morin F, Morere JF, et al. Long-term survival of patients given hormonal therapy for metastatic endometrial stromal sarcoma. Med Oncol 2003;20:87-93. 11. Alkasi O, Meinhold-Heerlein I, Zaki R, Fasching P, Maass N, Jonat W, et al. Long-term disease-free survival after hormonal therapy of a patient with recurrent low grade endometrial stromal sarcoma: A case report. Arch GynecolObstet2009;279:57-60. 12. Malouf GG, Duclos J, Rey A, Duvillard P, Lazar V, Haie-Meder C, et al. Impact of adjuvant treatment modalities on the management of patients with stages I-II endometrial stromal sarcoma Ann Oncol 2010;21:2102-6. 13. Bodner K, Adler BB, Obermair A, Windbichler G, Petru E, Mayerhofer S, et al. Prognostic parameters in endometrial stromal sarcoma: A clinicopathologic study in 31 patients. Gynecol Oncol 2001;81:160S-5S.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

adenomyosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-05-11T03:21:22.254778+00:00
License: CC0 · commercial use OK