Semaglutide inducing resolution of proliferative diabetic retinopathy: A case report

Purpose: To describe a case of regression of proliferative diabetic retinopathy (PDR) following treatment with semaglutide Methods Case report. Results The case describes a 47-year-old woman with type 2 diabetes, obesity, hypertension, and dyslipidaemia who had difficulty controlling her blood sugar levels despite oral hypoglycaemic medications. She presented with proliferative diabetic retinopathy (PDR) in her right eye and severe non-proliferative diabetic retinopathy (NPDR) in her left eye. After missing her follow-up appointment for PRP, her general practitioner initiated semaglutide therapy. Despite minimal changes in glycaemic control, the patient exhibited resolution of neovascularisation in her right eye and improved diabetic macular oedema (DMO) within six weeks of semaglutide therapy. Conclusion This case report suggests a potential independent role for semaglutide in managing PDR.