Temsirolimus and antimüllerian hormone protect fertility and the ovarian reserve against chemotherapy-induced damage in a murine model

Lara Houeis, Graziella van der Plancke, Luciana Cacciottola, Apolline Goudmaeker, Candice Kluyskens, Margherita Zipponi, Jean‐Paul Dehoux, Jacques Donnez, Marie‐Madeleine Dolmans
In: Fertility and Sterility · 2025 · vol. 125(1) , pp. 137–147 · doi:10.1016/j.fertnstert.2025.07.030 · PMID:40712967 · W4412701698
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-13 ⓘ

Temsirolimus and anti-Müllerian hormone were found to protect fertility and the ovarian reserve from chemotherapy-induced damage in a murine model.

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The paper evaluated whether temsirolimus, anti-Müllerian hormone (AMH), or their combination can protect ovarian reserve and fertility outcomes after chemotherapy in a mouse model, using reproductive endpoints and ovarian assessments of follicle/ovarian status. The main finding was that treated animals showed preservation of fertility capacity and markers of ovarian reserve compared with chemotherapy-exposed controls. The study’s limitations include that results are based on an animal model with preclinical endpoints, which may not directly translate to humans. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Temsirolimus and anti-Müllerian hormone protect fertility and the ovarian reserve against chemotherapy-induced damage in a murine model (2026) Fertility and Sterility — Vol. 125, n° 1, p. 137-147 (2025) (2026) Fertility and Sterility — Vol. 125, n° 1, p. 137-147 (2025) Open Access - Adobe PDF - 21.35 MB - Authors - Author Houeis, Lara UCLouvain - Author van der plancke, Graziella UCLouvain - Author Cacciottola, Luciana UCLouvain - Author Goudmaeker, Apolline UCLouvain - Author Kluyskens, Candice UCLouvain - Author Zipponi, Margherita UCLouvain - Author Dehoux, Jean-Paul UCLouvain - Author Donnez, Jacques UCLouvain - Author - et. al. - Affiliations - APA - Chicago - FWB Houeis, L., van der plancke, G., Cacciottola, L., Goudmaeker, A., Kluyskens, C., Zipponi, M., Dehoux, J.-P., Donnez, J., Dolmans, M.-M., & et al. (2026). Temsirolimus and anti-Müllerian hormone protect fertility and the ovarian reserve against chemotherapy-induced damage in a murine model. Fertility and Sterility, 125(1), 137-147. https://doi.org/10.1016/j.fertnstert.2025.07.030 (Original work published 2025)

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