Oral Contraceptive Treatment for Endometriosis Following Conservative Surgery:a Meta-analysis

Objective: To evaluate the clinical effects of oral contraceptive for the treatment of endometriosis(EMs) after conservative surgery. Methods:We searched Pubmed,the Cochrane library,CBM, CNKI and Wan-Fang databases for the randomized controlled trials(RCTs) about oral contraceptive for the treatment of EMs after conservative surgery between 2000 and 2013. According to the evaluation standards of Cochrane Handbook 5.0.1,the RevMan 5.0 software for Meta analysis was used in this Meta-analysis. Results: 9 studies involving 869 patients met the inclusion criteria,including 3 foreign articles and 6 Chinese articles. The results of Meta-analysis showed as follows: ① The remission rate of oral contraceptive group increased(OR= 3.13,95%CI:1.66-6.00,P=0.000 5); ② The oral contraceptive group of EMs′s postoperative recurrence rate obviously decreased(OR=0.25,95%CI:0.17-0.36,P0.000 01);③ The pregnancy rate of the oral contraceptive group and comparative groups existed insignificant difference(OR=1.55,95%CI:0.79-3.04,P=0.21). Conclusions: The oral contraceptive can improve the remission rate and reduce the recurrence rate. This Meta-analysis results still need to be verified by large samples and multicenter studies.