The Action of Chemokines in the Pathogenesis of Endometriosis

Endometriosis is one of the common gynecological diseases defined by the presence,growth,and invasion of endometrial tissue outside the uterine cavity.It is mainly associated with chronic pelvic pain,dysmenorrhe and infertility and its prevalence increases year by year.Although many hypotheses have been proposed,the etiology of the disease remains an enigma.Inflammation and dysimmunity are important pathologic basis of endometriosis,Attachment-aggression-angiogenesis is the basic step of occurrence and development of EMs.Recent studies have suggested that the chemokines are involved in cultivation of endometriosis in the course of chemokine,adhesion,invasion,angiogenesis and cell proliferation and apoptosis and other important links.In this article,we make the review on the roles of chemotactic factor in occurrence and development of EMs.