Effectiveness of nirsevimab against respiratory syncytial virus-related hospitalisation in Madeira, Portugal: 2023-24 season

Effectiveness of nirsevimab against respiratory syncytial virus-related hospitalisation in Madeira, Portugal: 2023-24 season | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 25 January 2025 V1 Latest version Share on Effectiveness of nirsevimab against respiratory syncytial virus-related hospitalisation in Madeira, Portugal: 2023-24 season Authors : Andreia Filipa Cavaco Afonso 0009-0004-5095-6569 [email protected] , Fátima José Côrte Pestana , Mariana Conceição Faria Rodrigues , Alexandra Sofia Gomes Andrade , José Alves , Teresa Celeste Gomes Jacinto , Edite Rodrigues da Costa , Bruna Raquel Figueira Ornelas de Gouveia , Bernardo Nuno Fernandes Camacho , and Ana Cristina Pestana Figueira Freitas Authors Info & Affiliations https://doi.org/10.22541/au.173780129.99727424/v1 705 views 352 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection (LRTI) hospitalisations in infants. Madeira was the first Portuguese region to recommend immunoprophylaxis with nirsevimab, an anti-RSV monoclonal antibody, for all infants in their first RSV season. The immunisation campaign, from November 2023 to March 2024, targeted infants born during the campaign (seasonal group), and those born between April and October, 2023 (catch-up group). This study aimed to assess nirsevimab effectiveness in preventing RSV-related LRTI hospitalisations. Methods: A population-based longitudinal observational study was conducted. Follow-up lasted until 150 days post-immunisation, campaign end (non-recipients), hospitalisation, or death, whichever occurred first. Nirsevimab effectiveness was estimated using an adjusted Cox proportional hazards model. The number needed to immunise (NNI) was calculated from absolute risk reduction. Averted cases were estimated from historical data, excluding the COVID-19 pandemic period. Results: The overall immunisation rate was 97.4% (1710/1756): similar in the seasonal (97.7%, 728/745) and catch-up (97.1%, 982/1011) groups. RSV-related LRTI hospitalisations occurred in 0.4% (6/1710) of nirsevimab recipients versus 4.3% (2/46) of non-recipients, with an estimated effectiveness of 94.6% (95% CI 72.6-98.9). NNI was 25. Supplemental oxygen therapy duration decreased significantly compared to previous seasons ( P =.039). Number of averted cases was 45 (IQR 15-83), with a 79.6% reduction in hospitalisations (IQR 62.6-90.9). Conclusion: Nirsevimab was effective in reducing RSV-related LRTI hospitalisations in a real-world setting, offering useful evidence for future RSV immunisation strategies. Supplementary Material File (figure 1.pptx) Download 38.23 KB File (figure 2.pptx) Download 127.59 KB File (main text file.docx) Download 32.84 KB File (tables 1-4.pptx) Download 58.92 KB Information & Authors Information Version history V1 Version 1 25 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords hospitalisation immunoprophylaxis lower respiratory tract infection monoclonal antibody nirsevimab respiratory syncytial virus Authors Affiliations Andreia Filipa Cavaco Afonso 0009-0004-5095-6569 [email protected] Hospital Dr Nelio Mendonca View all articles by this author Fátima José Côrte Pestana Hospital Dr Nelio Mendonca View all articles by this author Mariana Conceição Faria Rodrigues Hospital Dr Nelio Mendonca View all articles by this author Alexandra Sofia Gomes Andrade Hospital Dr Nelio Mendonca View all articles by this author José Alves Hospital Dr Nelio Mendonca View all articles by this author Teresa Celeste Gomes Jacinto Hospital Dr Nelio Mendonca View all articles by this author Edite Rodrigues da Costa Hospital Dr Nelio Mendonca View all articles by this author Bruna Raquel Figueira Ornelas de Gouveia Regional Health Directorate, Government of Autonomous Region of Madeira, Funchal, Portugal Interactive Technologies Institute (ITI-LARYSyS), Funchal, Portugal Saint Joseph of Cluny Higher School of Nursing (ESESJCluny), Funchal, Portugal View all articles by this author Bernardo Nuno Fernandes Camacho Hospital Dr Nelio Mendonca View all articles by this author Ana Cristina Pestana Figueira Freitas Hospital Dr Nelio Mendonca View all articles by this author Metrics & Citations Metrics Article Usage 705 views 352 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Andreia Filipa Cavaco Afonso, Fátima José Côrte Pestana, Mariana Conceição Faria Rodrigues, et al. Effectiveness of nirsevimab against respiratory syncytial virus-related hospitalisation in Madeira, Portugal: 2023-24 season. Authorea . 25 January 2025. DOI: https://doi.org/10.22541/au.173780129.99727424/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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