RDW: A New Predictive Indicator in Pancreatic Cystic Neoplasms.

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Hüseyin Fahri Martlı, Muhammed Fatih Acehan, Sadettin Er, Ahmet Şimşek, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3260255/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Background The incidence of pancreatic cystic neoplasms (PCN) is increasing over time. However, identifying between benign and malignant cysts remains difficult. The final diagnosis is always made by postoperative pathology, even with recommendations for cytology and endosonography.This study aimed to investigate the malignancy probability of PCNs using simple clinical and biochemical parameters. Method A retrospective analysis was conducted on 70 patients who underwent surgery for pancreatic cystic neoplasms. Based on postoperative pathology, patients were divided into two groups: Group A, which included those with benign or low-grade dysplasia and Group B which included those with dysplasia malignancy or high-grade dysplasia. A comparison was made between pathology results and clinical and laboratory data. Results Out of the 70 patients, 42 (60%) were in Group A,and 28 (40%) were in Group B. Univariate analysis revealed that age, diabetes mellitus, red cell distribution width (RDW), and albumin were examined as potential predictors of malignancy in pancreatic cystic neoplasms. In the multivariate analysis, age and RDW were established as independent variables. The AUC values of age, RDW, and the combination of age and RDW for malignancy or high-grade dysplasia were 0.798 (95% CI: 0.695-0.900), 0.801 (95% CI: 0.692-0.911), and 0.858 (95% CI: 0.771-0.944), respectively. Conclusion The differentiation between benign and malignant PCN can only be achieved through advanced and specialized investigations. Postoperative pathology is still the most precise means of diagnosis. Age and RDW can be used as additional criteria to select patients for endosonography and cytological evaluation, and to precisely identify patients who might need surgical intervention. Pancreatic Cysts RDW Pancreatic Cancer Figures Figure 1 Introduction Pancreatic cystic neoplasms (PCNs) are becoming more common due to developments in the radiographic techniques. These tumors, occurring in around 15%of the general population, pose a considerable diagnostic challenge because of the difficulty in differentiating between benign, premalignant, and malignant types.(1,2) The indeterminate nature of intraductal papillary mucinous neoplasms (IPMNs), a prevalent subtype of PCNs, is exemplified in their management, analogous to the paradox of Schrodinger's cat. This comparison highlights the inherent uncertainty in identifying the neoplasm's characteristics without using surgical intervention (3). The importance of developing preoperative diagnostic strategies is underscored by the range of surgical interventions, which regrettably extends from potentially premature procedures for low-grade dysplasia to delayed interventions for invasive carcinoma.(4). Even with routine serum biomarkers and cross-sectional radiographic tests like computed tomography (CT) and magnetic resonance imaging (MRI) available, these methods are not very good at correctly identifying patients who require early surgical intervention. Recommendations now categorize cysts not just by their likelihood to become cancerous but also by identifying "worrisome features," which help determine the necessity for endoscopic ultrasonography (EUS) or EUS combined with fine-needle aspiration biopsy (FNA) for additional assessment (5-7). The specialized character of EUS-FNA, restricted availability, and inconsistent diagnostic accuracy pose significant barriers to its general application (8,9). Recent findings indicate that certain clinical and laboratory factors such as elevated CA19-9 levels, neutrophil-lymphocyte ratio (NLR), jaundice, newly diagnosed diabetes mellitus, and cyst-related pancreatitis may indicate a higher likelihood of malignancy in pancreatic cystic neoplasms (PCNs) (7,10). The aim of this study was to help with the early and accurate classification of PCN by assessing biochemical markers and demographic variables that are regularly used preoperatively. Materials and Methods Patients and Methods A retrospective analysis was conducted on 94 patients who underwent surgery for PCN at Ankara Bilkent City Hospital between 2019 and 2023. Cysts in all anatomical regions of the pancreas (head, body, tail) were included. According to the postoperative pathology results, patients with benign or low-grade dysplasia were classified as Group A, while patients with malignancy or high-grade dysplasia were classified as Group B. Ethical approval for this study was obtained from the Ankara Bilkent City Hospital Ethics Committee under the approval number E-1-23-3616. Patients with a history of hematological, autoimmune and rheumatological diseases, recent blood transfusions, those under the age of 18, and those with any malignancy diagnosis were excluded. Among the screened patient group, 24 patients who underwent diagnostic EUS±FNA and didn’t suggest surgery were excluded. The remaining 70 patients were analyzed for the relationship between their postoperative pathology results and preoperative demographic data and laboratory findings. Statistical analysis For statistical analyses, IBM SPSS 26.0 for Windows (IBM Corp., Armonk, NY, USA) was utilized. To assess the normality of the data distribution, the Shapiro-Wilk test was utilized. For categorical variables, the Mann-Whitney U test or the Student's t-test was utilized, while the Pearson chi-square or Fisher's exact test was applied to continuous variables. The univariate logistic regression analysis incorporated parameters that were significantly associated with malignancy or high-grade dysplasia, as detected at a p < 0.1 level. In order to ascertain independent predictors, parameters that were associated with malignancy or high-grade dysplasia at a significance level of p < 0.1 in the univariate analysis were incorporated into the forward stepwise multivariate logistic regression analysis. In calculating odds ratios (ORs) for the predictors, confidence intervals (CIs) of 95% were utilized. The statistical analysis involved determining the area under the curve (AUC) values of independent predictors and the combination of independent predictors through the utilization of receiver operating characteristic (ROC) curve analysis with 95% confidence intervals. The ROC curve was employed to ascertain the suitable cut-off values for the independent predictors in accordance with Youden's method. A risk analysis was conducted after calculating sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) at the optimal cut-off values of the predictors. In all analyses, a P value less than 0.05 was deemed to be statistically significant. Results Table 1 shows the comparative baseline characteristics of the patients. Table 2 shows the results of univariate and multivariate logistic regression analyzes for malignant or high-grade dysplasia. Age (OR: 1.067; 95% CI: 1.014-1.122, p= 0.012) and RDW (OR: 1.784; 95% CI: 1.172-2.715, p= 0.007) were identified as independent predictors in the multivariate analysis. Appropriate cut-off values for age and RDW were 55 years and 16.1%, respectively.The sensitivity and specificity at this age cut-off were 96.4% and 54.8%, respectively, with a negative predictive value of 95.8%. The sensitivity and specificity at this threshold for RDW were 53.6% and 97.6%, respectively, with a positive predictive value of 93.8. Age≥ 55 years and RDW≥ 16.1% increased the risk of malignant or high-grade dysplasia approximately 33-fold (OR: 32.7; 95% CI: 4.1-263.3) and 47-fold (OR: 47.3; 95% CI: 5.7-393.4), respectively (Table 3). According to the analysis of the ROC curve illustrated in Figure 1, the AUC values of age, RDW, and the combination of age and RDW for malignancy or high-grade dysplasia were 0.798 (95% CI: 0.695-0.900), 0.801 (95% CI: 0.692-0.911), and 0.858 (95% CI: 0.771-0.944), respectively. Discussion Determining the necessity of surgery for patients with PCN remains a significant challenge. A range of diagnostic approaches, including routine serum biochemical assays, cross-sectional imaging, molecular testing, endoscopic ultrasound with or without fine-needle aspiration (EUS±FNA), contrast-enhanced EUS, and sophisticated cytological evaluations, are advocated to address this issue (9,11). Parameters such as elevated CA19-9 levels, jaundice, new-onset diabetes mellitus (DM), and the NLR have been shown to be associated with malignancy in pancreatic cysts based on simple clinical and laboratory data (5–7,10). This research is the first to show the statistically significant predictive utility of red cell distribution width (RDW) in forecasting malignancy in PCNs, making a unique addition to the current literature. According to the research, neoplastic development and malignant conversion occur in the context of inflammation (12,13). Although the exact reason for the significant association of RDW with diagnosis and prognosis is not fully understood, it has been suggested that it may be related to erythropoietin inhibition and the shortened lifespan of red blood cells due to oxidative stress, which are important markers of inflammation (12). Furthermore, there are various research associated to RDW in terms of cancer diagnosis and prognosis (12,14-16). However, in this study, an RDW value above 16.1 was found to positively predict the malignant potential of pancreatic cysts with a sensitivity of 93.8%. As shown in this study and other studies, parameters indicating inflammation are important markers in the diagnosis and progression of malignancy (17–19). Indeed, C-reactive protein (CRP) levels are known to be higher in pancreatic cancers linked with inflammatory processes (20). In different studies, the NLR has been investigated for its role in the differentiation of benign and malignant IPMNs, with sensitivity ranging from 56% to 73.1% and specificity ranging from 58% to 87% (10,21,22). In this study, however, parameters such as NLR, platelet-to-lymphocyte ratio (PLR), and CRP were not found to be significant. However, RDW was found to be superior to other inflammatory markers in terms of positive predictive value, both in the literature and in this study. The risk of pancreatic adenocarcinoma (PCA) increasing with age (2,13). In the elderly, the frequency of PCN can reach up to 37% (1). The association between advanced age and malignancy is attributed to factors such as increased oxidative stress, exposure to malignancy-related factors such as smoking, DM, and alcohol consumption over a prolonged period, as well as age-related DNA hypermethylation and methylation defects (11,23). Therefore, it is expected that our study would show a higher malignancy risk in elderly patients. However, it is noteworthy that this study is the first to demonstrate a 95.8% negative predictive value for malignant PCNs in the population under the age of 55.The substantial NPV suggests that this method is highly dependable in excluding malignancy, particularly in patients younger than 55 years of age. Current guidelines mostly rely on imaging data to make recommendations(5-7). When it comes to discriminating between benign and malignant differentiation, computed tomography (CT) and magnetic resonance imaging (MRI) are highly successful at properly identifying and ruling out these disorders. While CT is known for its varying accuracy in detection and exclusion, MRI is acknowledged for its relative reliability in both areas(24). Brugge's study found that endoscopic ultrasound (EUS) had a modest level of accuracy in a forward-looking analysis(8). Furthermore, when EUS is paired with fine-needle aspiration (EUS+FNA), it improves the ability to reliably diagnose and exclude conditions within a specified confidence interval(9). This information highlights the subtle capabilities and limitations of various diagnostic methods in accurately identifying pancreatic diseases. Endoscopic ultrasound examination (EUS) enables a comprehensive evaluation of specific anatomical attributes of pancreatic cysts, including the diameter of the principal pancreatic duct and the presence of mural nodules, both of which may serve as indicators of malignancy. Notably, the cyst must meet a specific size requirement in order for these characteristics to be evaluated precisely. (3,9) In a study by Sun, parameters such as a main pancreatic duct diameter greater than 10mm, large mural nodules, and high CA19-9 levels were found to be associated with advanced PCN (18). Notwithstanding these observations, the accuracy rate of diagnosis achieved through the combination of EUS and fine-needle aspiration (EUS±FNA) is estimated to be around 25.5%. This figure underscores the constraints and unpredictability of this diagnostic methodology, which is notably susceptible to the proficiency of the operator. By integrating uncomplicated, non-invasive biomarkers like age and red cell distribution width (RDW) in conjunction with conventional imaging modalities such as CT/MRI and the more invasive EUS±FNA, the precision of cyst identification could potentially be improved. Furthermore, as the prevalence of PCN detection rises, the task of identifying appropriate candidates for sophisticated diagnostic techniques such as EUS±FNA becomes progressively more formidable. According to the findings of this research, age and RDW may play a crucial role in determining which patients would benefit from additional diagnostic testing. (1). The main limitations of this study are its retrospective design, single-center nature, and the limited number of included patients. Another limitation is that pancreatic tumours in the head, body, and tail have different biological backgrounds, despite the fact that cysts from all parts of the pancreas were included in this study. Conclusion It has been demonstrated that patients with red cell distribution width (RDW) values over the threshold are more likely to have malignant pancreatic cystic neoplasms (PCN). Conversely, a population below the established cutoff age shows a greater chance of benign PCN presentations. We suggest the use of RDW as a new, inexpensive, simple, and easily applicable parameter in the differentiation of PCN and in selecting patients for endosonography. Declarations Conflict Of Interest The authors declare that they have no conflict of interest. Funding The authors received no financial support for the research and authorship of this article. References 1. Farrell JJ. Prevalence, Diagnosis and Management of Pancreatic Cystic Neoplasms: Current Status and Future Directions. Gut Liver [Internet]. 2015 Sep 1 [cited 2023 Jun 23];9(5):571–89. Available from: https://pubmed.ncbi.nlm.nih.gov/26343068/ 2. Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology [Internet]. 2020 Jan 1 [cited 2023 Jun 23];76(2):182–8. Available from: https://pubmed.ncbi.nlm.nih.gov/31433515/ 3. Cattelani A, Perri G, Marchegiani G, Salvia R, Crinò SF. Risk Models for Pancreatic Cyst Diagnosis. Gastrointest Endosc Clin N Am [Internet]. 2023 Jul 1 [cited 2023 Jun 23];33(3). Available from: https://pubmed.ncbi.nlm.nih.gov/37245940/ 4. 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Comparative baseline characteristics of the patients Parameters Overall n = 70 Group A n = 42 Group B n = 28 P value Age, years 59.59 ± 16.61 52.74 ± 16.85 69.86 ± 9.58 <0.001 Gender 0.058 Female 42 (60.0%) 29 (69.0%) 13 (46.4%) Male 28 (40.0%) 13 (31.0%) 15 (53.6%) Cigarette smoking 7 (10.0%) 2 (4.8%) 5 (17.9%) 0.107 Presence of chronic pancreatitis 18 (25.7%) 9 (21.4%) 9 (32.1%) 0.315 Major comorbidity Coronary artery disease 11 (15.7%) 5 (11.9%) 6 (21.4%) 0.328 Hypertension 24 (34.3%) 14 (33.3%) 10 (35.7%) 0.837 Diabetes mellitus 25 (35.7%) 9 (21.4%) 16 (57.1%) 0.002 Other 9 (12.9%) 3 (7.1%) 6 (21.4%) 0.142 Localization of tumor Head 39 (55.7%) 19 (45.2%) 20 (71.4%) 0.031 Body 21 (30.0%) 16 (38.1%) 5 (17.9%) 0.070 Tail 9 (12.9%) 6 (14.3%) 3 (10.7%) - Extensive 1 (1.4%) 1 (2.4%) 0 - Length of tumor (in long-axis), cm 3.5 (2.5-5.5) 4 (2-6) 3 (2.5-5) 0.838 Pathological diagnosis - Benign lesion 12 (17.1%) 12 (28.6%) 0 Serous neoplasms 9 (12.9%) 9 (21.4%) 0 Mucinous cystic neoplasm 11 (15.7%) 9 (21.4%) 2 (7.1%) IPMN 16 (22.9%) 10 (23.8%) 6 (21.4%) Adenocarcinoma 20 (28.5%) 0 20 (71.4%) Other* 2 (2.8%) 2 (4.8%) 0 Laboratory findings Red cell distribution width, % 14.2 (13.5-16) 13.7 (13.3-14.6) 16.2 (14.1-17.3) <0.001 Neutrophil-lymphocyte ratio 2.47 (1.95-3.78) 2.33 (1.90-3.53) 2.56 (2.14-4.60) 0.096 Lymphocyte-monocyte ratio 4.01 (2.73-6.50) 4.23 (2.81-6.61) 3.46 (2.50-4.55) 0.112 Platelet-lymphocyte ratio 145 (107-194) 126 (106-157) 178 (118-238) 0.008 Mean platelet volume, fL 8.5 (7.8-9.2) 8.3 (7.9-8.9) 8.7 (7.7-9.3) 0.272 Albumin, g/L 43 (40-46) 45 (41-46) 41 (34-45) 0.008 CA 19-9, U/mL 13.6 (5.2-95) 9.3 (3.2-37.5) 21.7 (12-211.7) 0.009 *Includes pseudocyst (1) and neuroendocrine tumor (1). IPMN; intraductal papillary mucinous neoplasm. Table 2. Univariate and multivariate regression analyzes to predict malignancy or high-grade dysplasia Parameters Univariate analysis Multivariate analysis OR (95% CI) P value OR (95% CI) P value Age 1.095 (1.042-1.150) <0.001 1.067 (1.014-1.122) 0.012 Male gender 2.574 (0.957-6.925) 0.061 Diabetes mellitus 4.889 (1.710-13.977) 0.003 Red cell distribution width 2.240 (1.485-3.380) <0.001 1.784 (1.172-2.715) 0.007 Neutrophil-lymphocyte ratio 1.145 (0.927-1.414) 0.208 Platelet-lymphocyte ratio 1.005 (0.999-1.012) 0.092 Albumin 0.914 (0.844-0.989) 0.026 CA 19-9 1.003 (0.999-1.007) 0.152 Abbreviations: OR; odds ratio, CI; confidence interval. Table 3. Predictive values of independent predictors for malignancy or high-grade dysplasia at appropriate cut-off values Parameters Cut-off value Number (%) of patients* Sensitivity (%) Specificity (%) PPV (%) NPV (%) OR (95% CI) Age, years ≥ 55 46 (65.7) 96.4 54.8 58.7 95.8 32.7 (4.1-263.3) Red cell distribution width, % ≥ 16.1 16 (22.9) 53.6 97.6 93.8 75.9 47.3 (5.7-393.4) *Number (%) of patients above the given cut-off values. Abbreviations: PPV; Positive predictive value, NPV; Negative predictive value, OR; Odds ratio, CI; confidence interval. Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3260255","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":227382835,"identity":"1528ef80-dc64-451d-9fc4-785409b9ca49","order_by":0,"name":"Hüseyin Fahri Martlı","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA8ElEQVRIie3PoQrCQBzH8f8xmOVk9Uw+gUGEiTDxQSwbwizqE4j8V2ayTxB8CzFODpYUq7Ci3TCbFvHu1CJsq4b7pj9jH34cgE73h1WQArjqNDC+oTxIEBcRGn+JSXC3RGCCYDmBDzGqigAUk8ohyc6wqbfXQcC7W2fWmHOxMnX6uYROBpELaXOVEOTjvc/svSdI4o8xh/Rg1BJvSUlkShJyZseCyDuPUOuqSE+RjiTHSwlh7xVPESLJqWyFvVcGkenhbhH6tc1JrLgFb6HWqEXukHYjg/PsETqWfRxeztnUySUq8vz94hb9rtPpdLrSXo5yYUZDhF1zAAAAAElFTkSuQmCC","orcid":"","institution":"Ankara City Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Hüseyin","middleName":"Fahri","lastName":"Martlı","suffix":""},{"id":227382836,"identity":"fd989218-3ed3-4962-9853-70a58cf549fd","order_by":1,"name":"Muhammed Fatih Acehan","email":"","orcid":"","institution":"Ankara City Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Muhammed","middleName":"Fatih","lastName":"Acehan","suffix":""},{"id":227382837,"identity":"be0ae8dc-1056-4024-874a-e5b6d82a989a","order_by":2,"name":"Sadettin Er","email":"","orcid":"","institution":"Ankara City Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Sadettin","middleName":"","lastName":"Er","suffix":""},{"id":227382838,"identity":"17e7f075-ee36-4d51-a95d-5884a7d9772d","order_by":3,"name":"Ahmet Şimşek","email":"","orcid":"","institution":"Ankara City Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ahmet","middleName":"","lastName":"Şimşek","suffix":""},{"id":227382839,"identity":"0251e7e0-e007-4f09-95af-e4da45e36fd2","order_by":4,"name":"Eda Şahingöz","email":"","orcid":"","institution":"Ankara City Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Eda","middleName":"","lastName":"Şahingöz","suffix":""},{"id":227382840,"identity":"40d0b525-5ba7-4ffb-9469-452acad60e43","order_by":5,"name":"Aziz Ahmet Sürel","email":"","orcid":"","institution":"Ankara City Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Aziz","middleName":"Ahmet","lastName":"Sürel","suffix":""}],"badges":[],"createdAt":"2023-08-13 14:29:12","currentVersionCode":2,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false,"coiExplicitlySet":false},"doi":"10.21203/rs.3.rs-3260255/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-3260255/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":53268768,"identity":"54cfb885-c018-4b99-9409-42cba1bbee61","added_by":"auto","created_at":"2024-03-22 16:03:40","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":34490,"visible":true,"origin":"","legend":"\u003cp\u003eROC curve showing predictive performances of age, RDW, and the combination of age and RDW for malignancy or high-grade dysplasia.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eAUC; area under the curve, CI; confidence interval, RDW; red cell distribution width, ROC; receiver operating characteristic.\u003c/em\u003e\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-3260255/v2/6f4615f6251c4e2a82b6a5a4.png"},{"id":53269415,"identity":"7d3a1212-07f2-4ea7-9ea4-41277284cbe4","added_by":"auto","created_at":"2024-03-22 16:11:41","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":304587,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3260255/v2/0679be91-05bc-4eaa-9f5e-2f5da616e416.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003e\u003cstrong\u003eRDW: A New Predictive Indicator in Pancreatic Cystic Neoplasms.\u003c/strong\u003e\u003c/p\u003e","fulltext":[{"header":"Introduction","content":"\u003cp\u003ePancreatic cystic neoplasms (PCNs) are becoming more common due to developments in the radiographic techniques. These tumors, occurring in around 15%of the general population, pose a considerable diagnostic challenge because of the difficulty in differentiating between benign, premalignant, and malignant types.(1,2) The indeterminate nature of intraductal papillary mucinous neoplasms (IPMNs), a prevalent subtype of PCNs, is exemplified in their management, analogous to the paradox of Schrodinger\u0026apos;s cat. This comparison highlights the inherent uncertainty in identifying the neoplasm\u0026apos;s characteristics without using surgical intervention (3). The importance of developing preoperative diagnostic strategies is underscored by the range of surgical interventions, which regrettably extends from potentially premature procedures for low-grade dysplasia to delayed interventions for invasive carcinoma.(4). Even with routine serum biomarkers and cross-sectional radiographic tests like computed tomography (CT) and magnetic resonance imaging (MRI) available, these methods are not very good at correctly identifying patients who require early surgical intervention. Recommendations now categorize cysts not just by their likelihood to become cancerous but also by identifying \u0026quot;worrisome features,\u0026quot; which help determine the necessity for endoscopic ultrasonography (EUS) or EUS combined with fine-needle aspiration biopsy (FNA) for additional assessment (5-7). The specialized character of EUS-FNA, restricted availability, and inconsistent diagnostic accuracy pose significant barriers to its general application (8,9). Recent findings indicate that certain clinical and laboratory factors such as elevated CA19-9 levels, neutrophil-lymphocyte ratio (NLR), jaundice, newly diagnosed diabetes mellitus, and cyst-related pancreatitis may indicate a higher likelihood of malignancy in pancreatic cystic neoplasms (PCNs) (7,10).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe aim of this study was to help with the early and accurate classification of PCN by assessing biochemical markers and demographic variables that are regularly used preoperatively.\u003c/p\u003e"},{"header":"Materials and Methods","content":"\u003cp\u003e\u003cstrong\u003ePatients and Methods\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA retrospective analysis was conducted on 94 patients who underwent surgery for PCN at Ankara Bilkent City Hospital between 2019 and 2023.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eCysts in all anatomical regions of the pancreas (head, body, tail) were included. According to the postoperative pathology results, patients with benign or low-grade dysplasia were classified as Group A, while patients with malignancy or high-grade dysplasia were classified as Group B.\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eEthical approval for this study was obtained from the Ankara Bilkent City Hospital Ethics Committee under the approval number E-1-23-3616. Patients with a history of hematological, autoimmune and rheumatological diseases, recent blood transfusions, those under the age of 18, and those with any malignancy diagnosis were excluded.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;Among the screened patient group, 24 patients who underwent diagnostic EUS\u0026plusmn;FNA and didn\u0026rsquo;t suggest surgery were excluded. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe remaining 70 patients were analyzed for the relationship between their postoperative pathology results and preoperative demographic data and laboratory findings.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFor statistical analyses, IBM SPSS 26.0 for Windows (IBM Corp., Armonk, NY, USA) was utilized. To assess the normality of the data distribution, the Shapiro-Wilk test was utilized. For categorical variables, the Mann-Whitney U test or the Student\u0026apos;s t-test was utilized, while the Pearson chi-square or Fisher\u0026apos;s exact test was applied to continuous variables. The univariate logistic regression analysis incorporated parameters that were significantly associated with malignancy or high-grade dysplasia, as detected at a p \u0026lt; 0.1 level. In order to ascertain independent predictors, parameters that were associated with malignancy or high-grade dysplasia at a significance level of p \u0026lt; 0.1 in the univariate analysis were incorporated into the forward stepwise multivariate logistic regression analysis. In calculating odds ratios (ORs) for the predictors, confidence intervals (CIs) of 95% were utilized. The statistical analysis involved determining the area under the curve (AUC) values of independent predictors and the combination of independent predictors through the utilization of receiver operating characteristic (ROC) curve analysis with 95% confidence intervals. The ROC curve was employed to ascertain the suitable cut-off values for the independent predictors in accordance with Youden\u0026apos;s method. A risk analysis was conducted after calculating sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) at the optimal cut-off values of the predictors. In all analyses, a P value less than 0.05 was deemed to be statistically significant.\u0026nbsp;\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eTable 1 shows the comparative baseline characteristics of the patients. Table 2 shows the results of univariate and multivariate logistic regression analyzes for malignant or high-grade dysplasia.\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eAge (OR: 1.067; 95% CI: 1.014-1.122, p= 0.012) and RDW (OR: 1.784; 95% CI: 1.172-2.715, p= 0.007) were identified as independent predictors in the multivariate analysis. Appropriate cut-off values for age and RDW were 55 years and 16.1%, respectively.The sensitivity and specificity at this age cut-off were 96.4% and 54.8%, respectively, with a negative predictive value of 95.8%. The sensitivity and specificity at this threshold for RDW were 53.6% and 97.6%, respectively, with a positive predictive value of 93.8. \u0026nbsp;Age\u0026ge; 55 years and RDW\u0026ge; 16.1% increased the risk of malignant or high-grade dysplasia approximately 33-fold (OR: 32.7; 95% CI: 4.1-263.3) and 47-fold (OR: 47.3; 95% CI: 5.7-393.4), respectively (Table 3). According to the analysis of the ROC curve illustrated in Figure 1, the AUC values of age, RDW, and the combination of age and RDW for malignancy or high-grade dysplasia were 0.798 (95% CI: 0.695-0.900), 0.801 (95% CI: 0.692-0.911), and 0.858 (95% CI: 0.771-0.944), respectively.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eDetermining the necessity of surgery for patients with PCN remains a significant challenge.\u0026nbsp;A range of diagnostic approaches, including routine serum biochemical assays, cross-sectional imaging, molecular testing, endoscopic ultrasound with or without fine-needle aspiration (EUS\u0026plusmn;FNA), contrast-enhanced EUS, and sophisticated cytological evaluations, are advocated to address this issue\u0026nbsp;(9,11). Parameters such as elevated CA19-9 levels, jaundice, new-onset diabetes mellitus (DM), and the NLR have been shown to be associated with malignancy in pancreatic cysts based on simple clinical and laboratory data (5\u0026ndash;7,10). This research is the first to show the statistically significant predictive utility of red cell distribution width (RDW) in forecasting malignancy in PCNs, making a unique addition to the current literature.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eAccording to the research, neoplastic development and malignant conversion occur in the context of inflammation (12,13). Although the exact reason for the significant association of RDW with diagnosis and prognosis is not fully understood, it has been suggested that it may be related to erythropoietin inhibition and the shortened lifespan of red blood cells due to oxidative stress, which are important markers of inflammation (12).\u0026nbsp;Furthermore, there are various research associated to RDW in terms of cancer diagnosis and prognosis (12,14-16). However, in this study, an RDW value above 16.1 was found to positively predict the malignant potential of pancreatic cysts with a sensitivity of 93.8%. As shown in this study and other studies, parameters indicating inflammation are important markers in the diagnosis and progression of malignancy (17\u0026ndash;19). Indeed, C-reactive protein (CRP) levels are known to be higher in pancreatic cancers linked with inflammatory processes (20). In different studies, the NLR has been investigated for its role in the differentiation of benign and malignant IPMNs, with sensitivity ranging from 56% to 73.1% and specificity ranging from 58% to 87% (10,21,22). In this study, however, parameters such as NLR, platelet-to-lymphocyte ratio (PLR), and CRP were not found to be significant. However, RDW was found to be superior to other inflammatory markers in terms of positive predictive value, both in the literature and in this study.\u003c/p\u003e\n\u003cp\u003eThe risk of pancreatic adenocarcinoma (PCA) increasing with age (2,13). In the elderly, the frequency of PCN can reach up to 37% (1). The association between advanced age and malignancy is attributed to factors such as increased oxidative stress, exposure to malignancy-related factors such as smoking, DM, and alcohol consumption over a prolonged period, as well as age-related DNA hypermethylation and methylation defects (11,23). Therefore, it is expected that our study would show a higher malignancy risk in elderly patients. However, it is noteworthy that this study is the first to demonstrate a 95.8% negative predictive value for malignant PCNs in the population under the age of 55.The substantial NPV suggests that this method is highly dependable in excluding malignancy, particularly in patients younger than 55 years of age.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eCurrent guidelines mostly rely on imaging data to make recommendations(5-7). When it comes to discriminating between benign and malignant differentiation, computed tomography (CT) and magnetic resonance imaging (MRI) are highly successful at properly identifying and ruling out these disorders. While CT is known for its varying accuracy in detection and exclusion, MRI is acknowledged for its relative reliability in both areas(24). Brugge\u0026apos;s study found that endoscopic ultrasound (EUS) had a modest level of accuracy in a forward-looking analysis(8). Furthermore, when EUS is paired with fine-needle aspiration (EUS+FNA), it improves the ability to reliably diagnose and exclude conditions within a specified confidence interval(9). This information highlights the subtle capabilities and limitations of various diagnostic methods in accurately identifying pancreatic diseases.\u0026nbsp;Endoscopic ultrasound examination (EUS) enables a comprehensive evaluation of specific anatomical attributes of pancreatic cysts, including the diameter of the principal pancreatic duct and the presence of mural nodules, both of which may serve as indicators of malignancy. Notably, the cyst must meet a specific size requirement in order for these characteristics to be evaluated precisely.\u0026nbsp;(3,9) In a study by Sun, parameters such as a main pancreatic duct diameter greater than 10mm, large mural nodules, and high CA19-9 levels were found to be associated with advanced PCN (18).\u0026nbsp;Notwithstanding these observations, the accuracy rate of diagnosis achieved through the combination of EUS and fine-needle aspiration (EUS\u0026plusmn;FNA) is estimated to be around 25.5%. This figure underscores the constraints and unpredictability of this diagnostic methodology, which is notably susceptible to the proficiency of the operator. By integrating uncomplicated, non-invasive biomarkers like age and red cell distribution width (RDW) in conjunction with conventional imaging modalities such as CT/MRI and the more invasive EUS\u0026plusmn;FNA, the precision of cyst identification could potentially be improved. Furthermore, as the prevalence of PCN detection rises, the task of identifying appropriate candidates for sophisticated diagnostic techniques such as EUS\u0026plusmn;FNA becomes progressively more formidable. According to the findings of this research, age and RDW may play a crucial role in determining which patients would benefit from additional diagnostic testing.\u0026nbsp;(1).\u003c/p\u003e\n\u003cp\u003eThe main limitations of this study are its retrospective design, single-center nature, and the limited number of included patients. Another limitation is that pancreatic tumours in the head, body, and tail have different biological backgrounds, despite the fact that cysts from all parts of the pancreas were included in this study.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIt has been demonstrated that patients with red cell distribution width (RDW) values over the threshold are more likely to have malignant pancreatic cystic neoplasms (PCN). Conversely, a population below the established cutoff age shows a greater chance of benign PCN presentations. We suggest the use of RDW as a new, inexpensive, simple, and easily applicable parameter in the differentiation of PCN and in selecting patients for endosonography.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eConflict Of Interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors received no financial support for the research and authorship of this article.\u003c/p\u003e"},{"header":"References","content":"\u003cp\u003e1.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Farrell JJ. Prevalence, Diagnosis and Management of Pancreatic Cystic Neoplasms: Current Status and Future Directions. 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Available from:\u0026nbsp;\u003ca href=\"https://link.springer.com/article/10.1007/s10620-020-06481-2\"\u003ehttps://link.springer.com/article/10.1007/s10620-020-06481-2\u003c/a\u003e\u003c/p\u003e\n\u003cp\u003e19.\u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Lu F, Pan S, Qi Y, Li X, Wang J. The Clinical Application Value of RDW, CA153, and MPV in Breast Cancer. Clin Lab [Internet]. 2021 [cited 2023 Jun 26];67(2):277\u0026ndash;83. Available from:\u0026nbsp;\u003ca href=\"https://pubmed.ncbi.nlm.nih.gov/33616344/\"\u003ehttps://pubmed.ncbi.nlm.nih.gov/33616344/\u003c/a\u003e\u003c/p\u003e\n\u003cp\u003e20 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; Liu, T., Zhang, Q., Song, C., Siyin, S. T., Chen, S., Zhang, Q., Song, M., Cao, L., \u0026amp; Shi, H. (2022). C-reactive protein trajectories and the risk of all cancer types: A prospective cohort study. International journal of cancer, 151(2), 297\u0026ndash;307. https://doi.org/10.1002/ijc.34012\u003c/p\u003e\n\u003cp\u003e21.\u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Arima K, Okabe H, Hashimoto D, Chikamoto A, Kuroki H, Taki K, et al. The Neutrophil-to-Lymphocyte Ratio Predicts Malignant Potential in Intraductal Papillary Mucinous Neoplasms. Journal of Gastrointestinal Surgery [Internet]. 2015 Dec 1 [cited 2023 Jun 26];19(12):2171\u0026ndash;7. Available from: https://link.springer.com/article/10.1007/s11605-015-2973-2\u003c/p\u003e\n\u003cp\u003e22.\u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Sugimachi K, Mano Y, Matsumoto Y, Nakanoko T, Uehara H, Nakashima Y, et al. Neutrophil-to-lymphocyte Ratio as a Predictor of Malignancy of Intraductal Papillary Mucinous Neoplasms. Anticancer Res [Internet]. 2021 Mar 1 [cited 2023 Jun 26];41(3):1663\u0026ndash;9. Available from: https://ar.iiarjournals.org/content/41/3/1663\u003c/p\u003e\n\u003cp\u003e23.\u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Chen L, Ganz PA, Sehl ME. DNA Methylation, Aging, and Cancer Risk: A Mini-Review. Frontiers in bioinformatics [Internet]. 2022 Jun 2 [cited 2023 Jun 27];2. Available from:\u0026nbsp;\u003ca href=\"https://pubmed.ncbi.nlm.nih.gov/36304336/\"\u003ehttps://pubmed.ncbi.nlm.nih.gov/36304336/\u003c/a\u003e\u003c/p\u003e\n\u003cp\u003e24.\u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Jones MJ, Buchanan AS, Neal CP, Dennison AR, Metcalfe MS, Garcea G. Imaging of indeterminate pancreatic cystic lesions: a systematic review. Pancreatology. 2013;13(4):436\u0026ndash;42.\u003c/p\u003e\n\u003cp\u003e25. \u0026nbsp; \u0026nbsp; \u0026nbsp; Khashab MA, Kim K, Lennon AM, Shin EJ, Tignor AS, Amateau SK, et al. Should we do EUS/FNA on patients with pancreatic cysts? The incremental diagnostic yield of EUS over CT/MRI for prediction of cystic neoplasms. Pancreas [Internet]. 2013 May [cited 2023 Jun 27];42(4):717\u0026ndash;21. Available from:\u0026nbsp;\u003ca href=\"https://pubmed.ncbi.nlm.nih.gov/23558241\"\u003ehttps://pubmed.ncbi.nlm.nih.gov/23558241\u003c/a\u003e\u003c/p\u003e"},{"header":"Tables","content":"\u003cdiv align=\"center\" style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;'\u003e\n \u003ctable style=\"width:430.65pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width: 430.65pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 115%;font-family:\"Times New Roman\",serif;'\u003eTable 1.\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eComparative baseline characteristics of the patients\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 115%;font-family:\"Times New Roman\",serif;'\u003eParameters\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOverall\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003en = 70\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eGroup A\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003en = 42\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eGroup B\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003en = 28\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003evalue\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:7.1pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eAge, years\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e59.59 \u0026plusmn; 16.61\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e52.74 \u0026plusmn; 16.85\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e69.86 \u0026plusmn; 9.58\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:7.1pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eGender\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e0.058\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:7.1pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eFemale\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e42 (60.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e29 (69.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e13 (46.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:7.1pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eMale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e28 (40.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e13 (31.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e15 (53.6%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:7.1pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eCigarette smoking\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e7 (10.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e2 (4.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e5 (17.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.107\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:7.1pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePresence of chronic pancreatitis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e18 (25.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e9 (21.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e9 (32.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.315\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:7.1pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eMajor comorbidity\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:7.1pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eCoronary artery disease\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e11 (15.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e5 (11.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e6 (21.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.328\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:21.3pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eHypertension\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e24 (34.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e14 (33.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e10 (35.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.837\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:21.3pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eDiabetes mellitus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e25 (35.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e9 (21.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e16 (57.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.002\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:21.3pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOther\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e9 (12.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e3 (7.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e6 (21.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.142\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eLocalization of tumor\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:14.2pt;line-height: 115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003eHead\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e39 (55.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e19 (45.2%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e20 (71.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.031\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:14.2pt;line-height: 115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003eBody\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e21 (30.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e16 (38.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e5 (17.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.070\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:14.2pt;line-height: 115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003eTail\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e9 (12.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e6 (14.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e3 (10.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:14.2pt;line-height: 115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003eExtensive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e1 (1.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e1 (2.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eLength of tumor (in long-axis), cm\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e3.5 (2.5-5.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e4 (2-6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e3 (2.5-5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.838\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePathological diagnosis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e12 (17.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e12 (28.6%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:14.2pt;line-height: 115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eSerous neoplasms\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e9 (12.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e9 (21.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:14.2pt;line-height: 115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eMucinous cystic neoplasm\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e11 (15.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e9 (21.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e2 (7.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:14.2pt;line-height: 115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eIPMN\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e16 (22.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e10 (23.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e6 (21.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:14.2pt;line-height: 115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eAdenocarcinoma\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e20 (28.5%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e20 (71.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:14.2pt;line-height: 115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOther*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e2 (2.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:7.1pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eLaboratory findings\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:21.3pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eRed cell distribution width, %\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e14.2 (13.5-16)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e13.7 (13.3-14.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e16.2 (14.1-17.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:21.3pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNeutrophil-lymphocyte ratio\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e2.47 (1.95-3.78)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e2.33 (1.90-3.53)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e2.56 (2.14-4.60)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.096\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:21.3pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eLymphocyte-monocyte ratio\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e4.01 (2.73-6.50)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e4.23 (2.81-6.61)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e3.46 (2.50-4.55)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.112\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:21.3pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePlatelet-lymphocyte ratio\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e145 (107-194)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e126 (106-157)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e178 (118-238)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.008\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:21.3pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eMean platelet volume, fL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e8.5 (7.8-9.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e8.3 (7.9-8.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e8.7 (7.7-9.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.272\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:21.3pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eAlbumin,\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eg/L\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e43 (40-46)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e45 (41-46)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e41 (34-45)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.008\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 150.5pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:21.3pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-indent:-7.1pt;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eCA 19-9, U/mL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81.7pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e13.6 (5.2-95)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e9.3 (3.2-37.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e21.7 (12-211.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003e0.009\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width: 430.65pt;border: medium;padding: 0in 5.4pt 0in 5.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e*Includes pseudocyst (1) and neuroendocrine tumor (1).\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eIPMN;\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003cem\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eintraductal papillary mucinous neoplasm.\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;'\u003e\u003cspan style=\"color:black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width:427.0pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"width: 427pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eTable 2.\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;Univariate and multivariate regression analyzes to predict\u0026nbsp;\u003c/span\u003e\u003cspan style=\"color:windowtext;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003emalignancy or high-grade dysplasia\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 138.05pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eParameters\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 140.1pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eUnivariate analysis\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.35pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 134.5pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eMultivariate analysis\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.7pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eOR (95% CI)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border-width: 1.5pt medium;border-style: solid none;border-color: rgb(0, 0, 10) currentcolor;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.35pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eOR (95% CI)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border-width: 1.5pt medium;border-style: solid none;border-color: rgb(0, 0, 10) currentcolor;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;value\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 138.05pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eAge\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.7pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e1.095 (1.042-1.150)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.35pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e1.067 (1.014-1.122)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e0.012\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 138.05pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eMale gender\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.7pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e2.574 (0.957-6.925)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e0.061\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.35pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 138.05pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eDiabetes mellitus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.7pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e4.889 (1.710-13.977)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e0.003\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.35pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 138.05pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eRed cell distribution width\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.7pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e2.240 (1.485-3.380)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.35pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e1.784 (1.172-2.715)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e0.007\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 138.05pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eNeutrophil-lymphocyte ratio\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.7pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e1.145 (0.927-1.414)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e0.208\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.35pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 138.05pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003ePlatelet-lymphocyte ratio\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.7pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e1.005 (0.999-1.012)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e0.092\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.35pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 138.05pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eAlbumin\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.7pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e0.914 (0.844-0.989)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e0.026\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.35pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 138.05pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eCA 19-9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.7pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e1.003 (0.999-1.007)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family: \"Times New Roman\",serif;color:windowtext;'\u003e0.152\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.35pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.4pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt 0in 5.65pt;height: 10pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:center;line-height:115%;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"width: 427pt;border: medium;padding: 0in 5.4pt 0in 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;line-height:115%;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;color:windowtext;'\u003eAbbreviations: OR; odds ratio, CI; confidence interval.\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;'\u003e\u003cspan style=\"color:windowtext;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width:507.7pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 7.05in;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 12.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eTable 3.\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePredictive values of independent predictors for\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003emalignancy or high-grade dysplasia at appropriate cut-off values\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 125pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 19.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eParameters\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 19.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eCut-off value\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.4pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 19.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNumber (%) of patients*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.25pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 19.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eSensitivity\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(%)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 19.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eSpecificity\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(%)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.25pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 19.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003ePPV\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(%)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 19.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eNPV\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(%)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.95pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 19.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eOR\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e(95% CI)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 125pt;border: medium;padding: 0in 5.4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eAge, years\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border: medium;padding: 0in 5.4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026ge; 55\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.4pt;border: medium;padding: 0in 5.4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e46 (65.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.25pt;border: medium;padding: 0in 5.4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e96.4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15pt;border: medium;padding: 0in 5.4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e54.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.25pt;border: medium;padding: 0in 5.4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e58.7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border: medium;padding: 0in 5.4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e95.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.95pt;border: medium;padding: 0in 5.4pt;height: 9.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e32.7 (4.1-263.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 125pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 3.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family: \"Times New Roman\",serif;'\u003eRed cell distribution width, %\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 3.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e\u0026ge; 16.1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.4pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 3.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e16 (22.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.25pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 3.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e53.6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.15pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 3.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e97.6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.25pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 3.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e93.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 3.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e75.9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.95pt;border-width: medium medium 1.5pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(0, 0, 10);border-image: none;padding: 0in 5.4pt;height: 3.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e47.3 (5.7-393.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 7.05in;border: medium;padding: 0in 5.4pt;height: 5.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e*Number (%) of patients above the given cut-off values.\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;color:#00000A;text-align:justify;line-height: 115%;'\u003e\u003cem\u003e\u003cspan style='font-size:16px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eAbbreviations: PPV; Positive predictive value, NPV; Negative predictive value, OR; Odds ratio, CI; confidence interval.\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Pancreatic Cysts, RDW, Pancreatic Cancer","lastPublishedDoi":"10.21203/rs.3.rs-3260255/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3260255/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe incidence of pancreatic cystic neoplasms (PCN) is increasing over time. However, identifying between benign and malignant cysts remains difficult. The final diagnosis is always made by postoperative pathology, even with recommendations for cytology and endosonography.This study aimed to investigate the malignancy probability of PCNs using simple clinical and biochemical parameters.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA retrospective analysis was conducted on 70 patients who underwent surgery for pancreatic cystic neoplasms. Based on postoperative pathology, patients were divided into two groups: Group A, which included those with benign or low-grade dysplasia and Group B which included those with dysplasia malignancy or high-grade dysplasia. A comparison was made between pathology results and clinical and laboratory data.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eOut of the 70 patients, 42 (60%) were in Group A,and 28 (40%) were in Group B. Univariate analysis revealed that age, diabetes mellitus, red cell distribution width (RDW), and albumin were examined as potential predictors of malignancy in pancreatic cystic neoplasms. In the multivariate analysis, age and RDW were established as independent variables. The AUC values of age, RDW, and the combination of age and RDW for malignancy or high-grade dysplasia were 0.798 (95% CI: 0.695-0.900), 0.801 (95% CI: 0.692-0.911), and 0.858 (95% CI: 0.771-0.944), respectively.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe differentiation between benign and malignant PCN can only be achieved through advanced and specialized investigations. Postoperative pathology is still the most precise means of diagnosis. Age and RDW can be used as additional criteria to select patients for endosonography and cytological evaluation, and to precisely identify patients who might need surgical intervention.\u003c/p\u003e","manuscriptTitle":"RDW: A New Predictive Indicator in Pancreatic Cystic Neoplasms.","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2024-03-22 16:03:35","doi":"10.21203/rs.3.rs-3260255/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2023-08-18 15:29:22","doi":"10.21203/rs.3.rs-3260255/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"0a722fa7-4730-403f-a254-c7dd8dcf68d3","owner":[],"postedDate":"March 22nd, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2023-10-19T09:44:35+00:00","versionOfRecord":[],"versionCreatedAt":"2024-03-22 16:03:35","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-3260255","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3260255","identity":"rs-3260255","version":["v2"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}