Statistical features of the general population of patients with genital endometriosis
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by claude@2026-06, 2026-06-13
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This study statistically analyzed a population of 120 women with genital endometriosis, finding a symmetrical normal distribution with a median age of 30 and confirming the population's homogeneity and trustworthy results.
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by claude@2026-06, 2026-06-13
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The study analyzed a general population dataset of 120 patients diagnosed with stage II genital endometriosis who had marked pelvic pain, using mainly parametric statistical approaches to assess whether the overall patient measurements followed a normal distribution. Eligible participants were women aged 20–45 with a confirmed diagnosis (clinico-laboratory and functional methods), while exclusions included age outside this range, conditions or allergies affecting treatment, acute illness, and general contraindications to physiotherapy. The paper’s key aim was to identify whether normality-related statistical features were present in this patient population to support further clinical analysis, with ethical approval documented by a local committee. This paper is centrally about endometriosis — it focuses on statistical features (normal distribution characteristics) of the general population of stage II genital endometriosis patients with significant pelvic pain.
Abstract
Abstract. It is relevant to study the incidence of genital endometriosis, for which radical treatment methods have not been found yet. This study should also include a statistical analysis of the general population of patients included in the research, followed by clinical trials. Object and methods. A statistical analysis of the general population of patients was carried out with the following values: N (120), mode (Mo), median (Me), simple arithmetic mean (M) and its standard deviation (M ± δ), variation indicators (R-range): dispersion (D), standard deviation (δ); coefficient of variation (V); quartiles (Q) and their range (IQR). We also determined the tkp value (according to the Student distribution table) with a probability of values of 0.95 and texp, as well as scattering indicators — minimum (min) and maximum (max), dispersion (S2), asymmetry (As), kurtosis (Ex), and others. To test the hypothesis about the type of distribution, we used the Pearson goodness-of-fit test. Additionally, the standard sampling error for the mean (E), the marginal sampling error (ε), and the confidence interval (CI) were estimated. Using the distribution table, we found the χ2 values; the random error of the lower (tL) and upper bound (tU), and the confidence interval of the standard deviation were calculated. Results and discussion. The following indicators were calculated: average and standard deviation (M ± δ); Mo and Me had an equal value. The sample range was calculated; the sample quartiles divided the given population into four equal parts, where Q2 (25 %) was equal to 30 years, Q1 (25 %) corresponded to 27 years, Q3 — to 34 years (25 %), and IQR corresponded to 7 years. Notably, 28 people were under 27 years old and over 34. To exclude anomalous distribution, outliers were determined using the Tukey method; outliers over 55 years turned out to be rigid. The value of the indicator V=18.89 % was determined; that was less than 30 %, which indicated the homogeneity of the population and weak variation. The standard sampling error for the mean (E), marginal sampling error (ε), and confidence interval for dispersion were calculated. The value of the χ2 indicator was estimated according to the distribution table. The random error of the dispersion of the lower (tL) and upper bound (tU) was determined. The significance score of the asymmetry index was calculated using the mean square error of the asymmetry coefficient (SAs). Conclusion. As it follows from statistical analysis, this general population had all the signs of a symmetrical normal distribution, therefore, the results obtained are trustworthy.
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Известно, что проблема общей заболеваемости эндометриозом обусловлена многими факторами [1–3]. При этом ни один из факторов риска заболевания не имеет определяющего значения, не найдены до настоящего времени радикальные методы лечения, поэтому в данном настоящем исследовании мы предположили, что для дальнейшего клинического анализа необходимо выявить наличие признаков нормального распределения в генеральной совокупности изучаемых больных.
Дизайн исследования. В данной работе проводился статистический анализ генеральной совокупности (n = 120) больных с диагнозом «генитальный эндометриоз II cтадии» с выраженными тазовыми болями. До начала лечения использовались в основном данные параметрической статистики для выяснения наличия нормальности распределения генеральной совокупности больных [4–6]. Пациенты находились на лечении в г. Ханты-Мансийске ХМАО-Югра на базе ООО «Центр восстановительной медицины и реабилитологии «Нео-Клиника»».
Проведение научного исследования было одобрено локальным этическим комитетом ФГБУ ДПО «ЦГМА» (протокол от 07.02.2023 № 1/2023).
Критерии включения в исследование:
• установленный диагноз генитальный «эндометриоз II cтадии» с выраженными тазовыми болями, подтвержденный клинико-лабораторными и функциональными методами;
• репродуктивный возраст (20–45 лет);
• подписание информированного согласия пациенткой.
Критерии невключения в исследование:
• возраст женщины моложе 20 лет и старше 45 лет;
• аллергические реакции в анамнезе или индивидуальная непереносимость используемых лекарственных средств;
• острая стадия любого заболевания;
• общие противопоказания к физиотерапии.
Критерии исключения из исследования:
• нежелание пациента участвовать в настоящем исследовании;
• несоблюдение пациентом правил участия в исследовании;
• появление причин в ходе исследования, угрожающих безопасности пациента;
• общие противопоказания к физиотерапии.
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