Microbiome in Gastric Cancer: New Opportunities and Challenges

Microbiome in Gastric Cancer: New Opportunities and Challenges | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 13 March 2025 V1 Latest version Share on Microbiome in Gastric Cancer: New Opportunities and Challenges Authors : Meihang Du 0009-0007-7806-760X , Ziyuan Liu , Dandan Geng , Wei Kang , Shi Jiao , Liwei An [email protected] , and Zhaocai Zhou Authors Info & Affiliations https://doi.org/10.22541/au.174188954.43024572/v1 200 views 136 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The tumor-associated microbiota represents a novel cancer hallmark, yet the interplay between diverse microorganisms, such as bacteria, viruses and fungi, and tumorigenesis remains elusive. Gastric cancer (GC) has long been considered a type of microbiome-associated tumor because of the epidemiological identification of Helicobacter pylori and Epstein–Barr virus as key carcinogenic microorganisms. Nevertheless, the detailed molecular and cellular mechanisms by which these microbial infections eventually drive GC are still debated. Furthermore, recent advancements in technology have enabled the identification of an increasing number of novel microorganisms implicated in the pathogenesis of cancer development, especially from the perspectives of fungal ecology and intracellular bacteria, as well as the microbiota ecosystem. Here, we summarize the recent progress in the study of GC-related pathogens, emphasizing the emerging roles of fungal ecology and bacterial‒fungal interactions (BFIs) in gastric tumorigenesis and highlighting new opportunities for developing microbiome-engineered therapeutic strategies for GC. Supplementary Material File (microbiome in gastric cancer.docx) Download 1.48 MB Information & Authors Information Version history V1 Version 1 13 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords gastric cancer (gc) microbiome microbiota-engineered biotherapy Authors Affiliations Meihang Du 0009-0007-7806-760X Shanghai Tenth People's Hospital Department of Stomatology View all articles by this author Ziyuan Liu Shanghai Tenth People's Hospital Department of Stomatology View all articles by this author Dandan Geng Anhui University of Science and Technology Medical School View all articles by this author Wei Kang The Chinese University of Hong Kong State Key Laboratory of Translational Oncology View all articles by this author Shi Jiao Fudan University View all articles by this author Liwei An [email protected] Shanghai Tenth People's Hospital Department of Stomatology View all articles by this author Zhaocai Zhou Fudan University View all articles by this author Metrics & Citations Metrics Article Usage 200 views 136 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Meihang Du, Ziyuan Liu, Dandan Geng, et al. Microbiome in Gastric Cancer: New Opportunities and Challenges. Authorea . 13 March 2025. DOI: https://doi.org/10.22541/au.174188954.43024572/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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