Chlorogenic Acid in Metabolic Diseases: From Bench to Bedside

Chlorogenic Acid in Metabolic Diseases: From Bench to Bedside | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL British Journal of Clinical Pharmacology This is a preprint and has not been peer reviewed. Data may be preliminary. 15 May 2026 V1 Latest version Share on Chlorogenic Acid in Metabolic Diseases: From Bench to Bedside Authors : Yalin Lin [email protected] , Zhiqiang Ke 0009-0009-3454-9329 [email protected] , and Fei Cai [email protected] Authors Info & Affiliations https://doi.org/10.22541/authorea.15003367/v1 Under Review British Journal of Clinical Pharmacology Peer review timeline 21 views 20 downloads Contents Abstract Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Metabolic diseases encompass a range of chronic pathological conditions characterized by disruptions in glucose, lipid, and protein metabolism. This category primarily includes obesity, diabetes mellitus, non-alcoholic fatty liver disease, and metabolic syndrome, whose rising global prevalence poses a substantial public health burden. Chlorogenic acid, a naturally occurring phenolic compound widely found in coffee, tea, and medicinal plants, has recently drawn considerable research interest due to its multifaceted pharmacological properties, including the regulation of glucose and lipid metabolism, attenuation of oxidative stress, and suppression of inflammatory responses. This review systematically summarizes the roles and underlying mechanisms of chlorogenic acid in the management of various metabolic diseases. Existing evidence indicates that chlorogenic acid exerts beneficial effects in ameliorating obesity, diabetes, non-alcoholic fatty liver disease, metabolic syndrome, and hypertension. The proposed mechanisms are primarily attributed to its antioxidant and anti-inflammatory activities, modulation of gut microbiota composition, and protective effects on target organs. Information & Authors Information Version history V1 Version 1 15 May 2026 Peer review timeline Under Review British Journal of Clinical Pharmacology 14 May 2026 Submitted 15 May 2026 Submission Checks Completed Collection British Journal of Clinical Pharmacology Authors Affiliations Yalin Lin [email protected] View all articles by this author Zhiqiang Ke 0009-0009-3454-9329 [email protected] View all articles by this author Fei Cai [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 21 views 20 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Yalin Lin, Zhiqiang Ke, Fei Cai. Chlorogenic Acid in Metabolic Diseases: From Bench to Bedside. Authorea . 15 May 2026. DOI: https://doi.org/10.22541/authorea.15003367/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. 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