Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis urogenital infections in patients with infertility. Results from a large cross-sectional study.

Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis urogenital infections in patients with infertility. 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Results from a large cross-sectional study. Daniela Andrea Paira, Guillermo Molina, Andrea Daniela Tissera, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-209613/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 8 You are reading this latest preprint version Abstract Female and male infertility have been associated to Chlamydia trachomatis , Ureaplasma urealyticum and Mycoplasma hominis urogenital infections. However, evidence from large studies assessing their prevalence and putative associations in patients with infertility is still needed. The study design was a cross-sectional study including 1554 female and 3610 male patients with infertility in Cordoba, Argentina. In women, the prevalence of C. trachomatis , U. urealyticum and M. hominis urogenital infection was 4.3%, 31.1% and 12.1% whereas in men it was 5.8%, 19.2% and 5.3%, respectively. C. trachomatis infection was significantly more prevalent in men whereas U. urealyticum and M. hominis infections were more prevalent in women. Besides, C. trachomatis and U. urealyticum infections were significantly higher patients younger than 25 years. Moreover, U. urealyticum and M. hominis infections were associated to each other in either infertile women or men. Our data revealed that C. trachomatis , U. urealyticum and M. hominis are prevalent uropathogens in infertile patients. Of clinical importance, C. trachomatis and U. urealyticum infections were more prevalent in young patients whereas U. urealyticum and M. hominis are reciprocal risk factors of their co-infection. These results highlight the importance of including the screening of urogenital infections in the diagnostic workup of infertility. Urology & Nephrology Infectious Diseases General Microbiology Sexual & Reproductive Medicine Chlamydia trachomatis Ureaplasma urealyticum Mycoplasma hominis infertility infection prevalence Figures Figure 1 Introduction Urogenital infections are known causes of infertility 1 . Currently, infertility affects 15–20% of reproductive-aged couples worldwide and women and men equally contribute to infertility cases 1 , 2 . Sexually transmitted infections can impair fertility by different mechanisms: by directly damaging organs and gametes and/or, indirectly, by the induced inflammation and associated tissue damage, scarring and obstruction 1 , 3 . Moreover, infection-induced genital inflammation may alter the normal immunomodulation process that naturally occurs in the female genital tract after mating to facilitate fertilization, embryo implantation and promote embryo growth for a successful pregnancy 4 . Besides being the most frequent sexually transmitted bacterial infection worldwide, Chlamydia trachomatis is a common infection associated to infertility 5 . In women, C. trachomatis is a known cause of different urogenital pathologies such as acute urethritis, cervicitis and salpingitis that may lead to severe reproductive complications including pelvic inflammatory disease, chronic pelvic pain, ectopic pregnancy, miscarriage and tubal infertility 6 , 7 . In men, C. trachomatis is considered the most common agent of non-gonococcal urethritis and may cause epididymitis-orchitis, prostatitis, sperm tract obstructions and alterations in sperm quality 8 , 9 . On the other hand, Mycoplasma hominis and Ureaplasma urealyticum have also been recognized as sexually transmitted infections that could impair human fertility 1 . Although they are both known to colonize the female and male reproductive tracts as commensals, cumulative growing evidence has shown they are emerging sexually transmitted opportunistic pathogens able to cause asymptomatic chronic disorders affecting female and male fertility 10 – 15 . In men, U. urealyticum and M. hominis are causes of non-gonococcal urethritis contaminating semen during ejaculation. Moreover, U. urealyticum has been proposed to cause prostatitis, epididymitis and infertility 1 . In addition, reported data have shown that both U. urealyticum and M. hominis could impair sperm quality 11 , 16 , 17 . In women, U. urealyticum and M. hominis may cause different pathologies including acute urethritis, bacterial vaginosis, pelvic inflammatory disease and tubal infertility 14 , 18 , 19 . Moreover, the asymptomatic colonization by mycoplasmas or ureaplasmas could induce pro-inflammatory immune responses in the endometrium that may impair pregnancy outcomes 2 , 9 , 14 , 20 . The detection rates of C. trachomatis , U. urealyticum and M. hominis in the urogenital tract form infertile women and men has shown striking variations across regions and countries and in different groups when individuals were classified according to age, ethnicity and socioeconomic status 5,21−23 . In that regard, a growing number of studies have been reported during the last decade. However, compelling available data from large cross-sectional studies is scarce 21 – 23 . Moreover, reported data about the association of these infections in either infertile women or men is limited 21 – 23 . Since these infections may play a significant role in the etiology of infertility, we herein conducted a large observational investigation into urogenital C. trachomatis , U. urealyticum and M. hominis infections in infertile women and men seeking care for infertility. Moreover, we analyzed the associations among infections and with demographic parameters such as patient sex and age. Results Prevalence of C. trachomatis, U. urealyticum and M. hominis urogenital infection A total of 5164 of infertile patients (1554 women and 3610 men) were enrolled in the study. The overall prevalence of urogenital C. trachomatis , U. urealyticum and M. hominis detection in the total population was 5.3%, 22.8% and 7.4%, respectively (Table 1). Interestingly, U. urealyticum infection showed a remarkably higher overall prevalence than the others uropathogens analyzed. The prevalence of C. trachomatis infection was significantly higher in men than in women (5.8% versus 4.3%, p=0.034 ; Tables 1 and 2). Conversely, we found a significantly higher prevalence of both U. urealyticum and M. hominis infection in women (31.1 and 12.1, respectively) than in men (19.2 and 5.3%, respectively) ( p <0.001 and p <0.001; Tables 1 and 2). Table 1. Prevalence of urogenital infections in infertile patients Total Women Men (n = 5164) (n = 1554) (n = 3610) Chlamydia trachomatis, n (%) 275 (5.3%) 67 (4.3%) 208 (5.8%) Ureaplasma urealyticum, n (%) 1176 (22.8%) 484 (31.1%) 692 (19.2%) Mycoplasma hominis, n (%) 380 (7.4%) 88 (12.1%) 192 (5.3%) Table 2. Prevalence of infections in infertile patients according to sex and age Patients C. trachomatis infection U. urealyticum infection M. hominis infection Variables n n (prevalence) Odds ratio 95% CI p n (prevalence) Odds ratio 95% CI p n (prevalence) Odds ratio 95% CI p Sex Women 1554 67 (4.3%) 1.00 (ref.) 484 (31.1%) 1.00 (ref.) 188 (12.1%) 1.00 (ref.) Men 3610 208 (5.8%) 1.36 1.02-1.80 0.034 * 692 (19.2%) 0.52 0.46-0.60 <0.001 * 192 (5.3%) 0.41 0.33-0.50 40 355 17 (4.8%) 1.00 (ref.) 107 (30.1%) 1.00 (ref.) 43 (12.1%) 1.00 (ref.) 40 - 25 1130 47 (4.2%) 0.94 0.50-1.78 0.847 341 (30.2%) 0.88 0.66-1.17 0.372 135 (11.9%) 0.80 0.55-1.19 0.275 40 1356 88 (6.5%) 1.00 (ref.) 233 (17.2%) 1.00 (ref.) 72 (5.3%) 1.00 (ref.) 40 - 25 2161 106 (4.9%) 0.71 0.52-0.95 0.021* 433 (20.0%) 1.26 1.04-1.51 0.016* 116 (5.4%) 1.03 0.75-1.41 0.863 < 25 93 14 (15.1%) 2.51 1.40-4.48 0.002* 26 (28.0%) 1.66 1.04-2.66 0.034* 4 (4.3%) 0.72 0.26-2.02 0.532 Univariate analysis. 95%CI: 95% confident interval. A * p <0.05 was considered statistically significant. Associations among C. trachomatis, U. urealyticum and M. hominis urogenital infections When assessing the co-infection between C. trachomatis and U. urealyticum , no significant association was found in either infertile women (OR: 1.62, 95% CI: 0.99-2.69, p ˃0.05) or men (OR: 1.07, 95% CI: 0.76-1.52, p ˃0.05) (Figure 1a, d). In fact, a similar prevalence of U. urealyticum was found in C. trachomatis infected (41.8%, 28/67) and C. trachomatis non-infected (30.7%, 456/1487) women (Figure 1a, Table 3). In addition, a comparable prevalence of U. urealyticum were found in C. trachomatis infected (20.2%, 42/208) and C. trachomatis non-infected (19.1%, 650/3402) men (Figure 1d, Table 3). Table 3. C. trachomatis, U. urealyticum and M. hominis co-infections in infertile patients C. trachomatis M. hominis Women Men Women Men Positive Negative Positive Negative Positive Negative Positive Negative (n=67) (n=1487) (n=208) (n=3402) (n=188) (n=1366) (n=192) (n=3418) U. urealyticum Positive n (%) 28 (41.8%) 456 (30.7%) 42 (20.2%) 650 (19.1%) 171 (90.9%) * 313 (22.9%) 178 (92.7%) * 514 (15.0%) Negative n (%) 39 (58.2%) 1031 (69.3%) 166 (79.8%) 2752 (80.9%) 17 (9.1%) 1053 (77.1%) 14 (7.3%) 2904 (85.0%) M. hominis Positive n (%) 12 (17.9%) 176 (11.8%) 14 (6.7%) 178 (5.2%) - - - - Negative n (%) 55 (82.1%) 1311 (88.2%) 194 (93.3%) 3224 (94.8%) - - - - Univariate analysis. 95%CI: 95% confident interval. A * p <0.05 was considered statistically significant. Likewise, there was no significant association between C. trachomatis and M. hominis infections in either women (OR: 1.63, 95% CI: 0.83-3.07, p ˃0.05) or men (OR: 1.31, 95% CI: 0.75-32.24, p ˃0.05) (Figure 1b, e). From the 67 women infected with C. trachomatis , 12 were positive for M. hominis (17.9%), whereas 176 out of the 1487 C. trachomatis -negative women were positive for M. hominis (11.8%) (Figure 1b, Table 3). Also, a comparable prevalence of M. hominis was found in either C. trachomatis infected (6.7%, 14/208) or C. trachomatis non-infected (5.2%, 178/3402) men (Figure 1e, Table 3). Interestingly, a significant association between M. hominis and U. urealyticum infection was found in women (OR: 33.84, 95% CI: 20.25-56.86, p <0.0001) as well as in men (OR: 71.83, 95% CI: 41.89-187.10, p <0.0001) (Figure 1c, Table 3). As detailed in Table 3, from the 188 women positive for M. hominis , 171 (91.0%) were positive for U. urealyticum . Similarly, a significantly increased prevalence of U. urealyticum (92.7%) was found in M. hominis positive men (Figure 1f). In fact, from the 192 men positive for M. hominis detection, 178 (92.7%) were positive for U. urealyticum (Table 3). Multivariate regression analysis further confirmed these tight associations, indicating that U. urealyticum and M. hominis act as mutual risk factors of infection either in women or men (Supplementary Table S1). Noteworthy, only 2.0% of infected women (11 out of 539) and 1.5% of infected men (13 out of 871) were co-infected with the three uropathogens analyzed (Supplementary Figure S1). Demographic parameters associated to C. trachomatis, U. urealyticum and M. hominis infection Remarkably, C. trachomatis , U. urealyticum and M. hominis infections were significantly associated with patient sex and age (Table 2). In fact, univariate regression analysis revealed that C. trachomatis infection was more likely to be detected in infertile men than in women with an odds ratio of 1.36 (95% CI: 1.02-1.80, p =0.034) (Table 2). Moreover, a significant association was particularly found between C. trachomatis infection and men younger than 25 years (OR: 2.51, 95% CI: 1.40-4.48, p=0.002, Table 2) indicating that men, and especially those younger than 25 years, are at higher risk of infection than women (Table 2). Multivariate analysis further confirmed these associations (Supplementary Table S1). On the contrary, U. urealyticum and M. hominis infections were associated to females, since men were less likely at risk of U. urealyticum and M. hominis infection than women with odds ratios of 0.52 (95% IC: 0.46-0.60, p<0.001, Table 2) and 0.41 (95% CI: 0.33-0.50, p <0.001, Table 2), respectively. In addition, when analyzing the association of infection with patient sex and age, it was found that U. urealyticum was more prevalent in patients younger than 25 years, either in women or men (OR: 2.27, 95% CI: 1.33-3.89, p =0.003, and OR: 1.66, 95% CI: 1.04-2.66, p =0.034, respectively; Table 2). Multivariate analysis further confirmed these data (Supplementary Table S1). These results indicate that C. trachomatis , U. urealyticum and M. hominis urogenital infections are associated with patient sex and age. In fact, individuals younger than 25 years at the highest risk of C. trachomatis and U. urealyticum infection. Moreover, our data show that men are at higher risk of C. trachomatis infection and, conversely, women are at higher risk of U. urealyticum and M. hominis infection. Discussion Chlamydia trachomatis , U. urealyticum and M. hominis are amongst the most frequent sexually transmitted bacterial infections. Moreover, they have been associated to infertility in either females or males 1 – 3 , 10 , 22 . Therefore, compelling data about the prevalence of urogenital C. trachomatis , U. urealyticum and M. hominis infection and their possible associations in infertile patients is of utmost importance. It has been shown that the prevalence of urogenital C. trachomatis infection in infertile men and women varies considerable across nations and regions and according to the subject population under study 24 , 25 . Besides, although a growing number of studies about the prevalence of urogenital U. urealyticum and M. hominis infections in infertile patients have been reported during the last decade, compelling available data from large cross-sectional studies of is still scarce 21 – 23 . Thus, we herein conducted a large observational investigation into urogenital C. trachomatis , U. urealyticum and M. hominis infections in women and men with infertility. Our data revealed a high overall prevalence of C. trachomatis , U. urealyticum and M. hominis infection in infertile patients. When analyzing data according to patient sex, the prevalence of C. trachomatis , U. urealyticum and M. hominis infection was 4.3%, 31.1% and 12.1% in infertile women, and 5.8%, 19.2% and 5.3% in infertile men, respectively. Univariate and multivariate regression analyses revealed that C. trachomatis infection was significantly more prevalent in infertile men whereas U. urealyticum and M. hominis infections were significantly more prevalent in infertile women. The higher prevalence of C. trachomatis urogenital infection we found in men with respect to women could be due to the fact that urogenital infections in men are much more frequently asymptomatic than in women 8 . Besides, our results are in line with recently reported data showing that the prevalence of U. urealyticum and M. hominis urogenital infections is higher in infertile women than in infertile men 17 . Furthermore, our results also showed that C. trachomatis and U. urealyticum infections were significantly more prevalent in young patients, particularly in those younger than 25, indicating that age as a risk factor and in agreement with previously reported data 26 , 27 . In fact, it is known that sexually transmitted infections are directly related to sexual experience, having young people more frequent sexual intercourses, less consistency of condom use and one or multiple sexual partners 26 , 27 . On the other hand, when assessing co-infections, only 2.0% of women and 1.5% of men were co-infected with the three uropathogens analyzed. Our results support previously reported data. In a large observational study, Chen et al. found a prevalence of C. trachomatis infection of 3.5% in a population of 666 women seeking care for assisted reproduction in China, being significantly highest in patients younger than 25 years 28 . Moreover, Piscopo et al. reported a prevalence of C. trachomatis infection of 3.7% in women with tubal infertility in Brazil 29 . Besides and similar to our data, a prevalence of C. trachomatis infection of 4.3% in infertile men from Jordan has been reported 30 . Moreover, our results are in line with reported data by Sleha et al. , who found a prevalence of U. urealyticum and M. hominis urogenital infection of 39.6% and 8.1%, respectively, in Czech women undergoing an initial infertility evaluation 31 . In addition, Gdoura et al. found a prevalence of U. urealyticum and M. hominis of 15.4% and 9.6% in male partners from infertile couples from Tunisia 32 . Similar data were also reported in infertile men from China 33 . However, significantly different prevalence rates of urogenital C. trachomatis , U. urealyticum or M. hominis infection in infertile women or men have been reported in other studies. In comparison with our data, a much lower prevalence of U. urealyticum infection was described in infertile men from Italy 34 . Similarly, Boeri et al. recently reported lower prevalences of C. trachomatis and M. hominis infection in Italian men with primary infertility 35 . Moreover, in a study conducted in infertile men from Spain, Veiga et al. found lower rates of C. trachomatis , U. urealyticum and M. hominis infection than ours (0.9%, 15.1% and 0.9%, respectively) 6 . In addition, considerably lower prevalence rates of C. trachomatis , U. urealyticum and M. hominis infection were reported in infertile women from the USA and Iran 36 , 37 . Several factors could underlie these differences such as disparities in population under study (geographical location, age, ethnicity, religion, socio-economic status, access to medical care, etc.) or study design (prospective versus retrospective, patient population size, methods used for diagnosis, etc.). However, our results are in line with cumulative reported data and supported by the large patient population analyzed, including 5164 infertile individuals (1554 women and 3610 men). Besides, our data revealed that C. trachomatis infection was not associated to either U. urealyticum or M. hominis in infertile women as well as in men. Conversely, and supporting recently reported data 38 – 40 , U. urealyticum or M. hominis were significantly associated to each other in either infertile women or men, indicating that U. urealyticum or M. hominis urogenital infection increased the risk of M. hominis or U. urealyticum co-infection. This tight infection association could be due to shared infection routes and/or pathophysiologic mechanisms 1 , 10 . To our knowledge, this is the first cross-sectional study to investigate the prevalence and association of C. trachomatis , U. urealyticum and M. hominis in infertile women and men from Argentina. Being one of the few cross-sectional study performed in Latin American countries 21 , 23 and the large number of patients analyzed are the main strengths of our study. However, our study has some limitations such as it did not include control groups of fertile women and men, in whom the prevalence of the infections under analysis could have been different from their infertile counterparts. Moreover, we did not have the information of the partner couple of every infertile women or men enrolled, which could have provided important information about infection concordance. In conclusion, our results indicate that urogenital C. trachomatis , U. urealyticum and M. hominis infections are prevalent in infertile patients. C. trachomatis infection was significantly more prevalent in infertile men whereas U. urealyticum and M. hominis infections were more prevalent in infertile women. Of clinical importance, C. trachomatis and U. urealyticum infections were more prevalent in young patients, especially in those younger than 25 years. Moreover, U. urealyticum and M. hominis showed to be reciprocal risk factors of their co-infection in either infertile women or men. Overall, these results point out the importance to include the microbiological screening of urogenital infections in the diagnostic workup of infertility. Moreover, they highlight the need to reinforce preventive strategies at the primary healthcare level. Increasing awareness among people and health care practitioners are efficient approaches for the prevention of infection transmission. Future research is needed to unveil the true impacts of these uropathogens and the underlying pathophysiological mechanisms, which would allow the identification of proper and efficient treatments to more effectively reduce the burden of infertility. Methods Study design, patients and samples This prospective, cross-sectional study was performed on a total cohort of 5164 patients (1554 females and 3610 males) seeking care for infertility at a joint Academic, Urology and Reproduction Health Center from Cordoba, Argentina, between January 2015 and November 2019. Inclusion criteria were female or male aged 18-60 years, not taking antibiotics when sampling or during the last 3 weeks, and with a recent diagnosis of infertility based on a thorough self-reported sexual and medical history 41 . Vaginal-swab and semen samples were collected from female and male patients, respectively. Vaginal swabs were collected by a dedicated operator who inserted Dacron swabs into the vagina up to the vault and rotated the swab in the vaginal vault. The specimens were immediately transferred to a tube containing cervical cell preservation solution and processed for analysis. Semen samples were collected by masturbation after 2-7 days of sexual abstinence and processed within 1 h of collection. Ethical approval The study was carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) standards and the Argentinian legislation for protection of personal data (Law 25326). The experimental protocol was approved by the Institutional Ethics Committee from the Hospital Nacional de Clinicas, Universidad Nacional de Cordoba (RePIS #3512). All patients provided a signed written informed consent form agreeing to share their own anonymous information prior to enrollment. DNA extraction and C. trachomatis detection Total DNA was extracted from vaginal or semen samples and C. trachomatis infection detected by polymerase chain reaction (PCR) using the Chlamydia trachomatis 330/740 IC PCR kit (Sacace Biotechnologies Srl, Como, Italy) and within 4 h of sample collection. M. hominis and U. urealyticum detection M. hominis or U. urealyticum infections were assessed by culture using the commercially available colorimetric kit Mycofast RevolutioN (ELITech Group, Puteaux, France). Briefly, 100 μl of vaginal swab seeded transport medium or semen were added to the M. hominis and U. urealyticum wells, sealed and incubated at 37°C ± 1°C for 24 h. After incubation, orange or red color changes indicated the presence of M. hominis and/or U. urealyticum , respectively. Statistics Demographic characteristics (age, sex) and co-infections were compared between infected and non-infected patients using the chi-square test and the odds ratios (OR) and 95% confidence intervals (CI) were calculated. Univariate and multivariate logistic regression analyses for all variables were performed to determine associations or risk factors for infections. The SPSS statistical software package (version 17.0; SPSS Inc., Chicago, USA) and GraphPad Prism 8.0.1 were used for analyses. A p<0.05 was considered statistically significant. Declarations Ethical approval The study was carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) standards and the Argentinian legislation for protection of personal data (Law 25326). The experimental protocol was approved by the Institutional Ethics Committee from the Hospital Nacional de Clinicas, Universidad Nacional de Cordoba (RePIS #3512). All patients provided a signed written informed consent form agreeing to share their own anonymous information prior to enrollment. Authors’ contributions R.D.M., G.M., and R.M. participated in the conception and design of the study. G.M., D.A.P., A.D.T., C.O. and R.I.M. participated in the acquisition, analysis and interpretation of data. R.D.M. wrote the manuscript text and D.A.P. prepared the figure and tables. All authors critically reviewed the manuscript and approved the final version before submission. 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Am J Obstet Gynecol. 216 , 1–9 https://doi.org/10.1016/j.ajog.2016.08.008 (2017). Redgrove, K. A. & McLaughlin, E. A. The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword. Front Immunol. 5 , 534 https://doi.org/10.3389/fimmu.2014.00534 (2014). Tang, W. et al. Pregnancy and fertility-related adverse outcomes associated with Chlamydia trachomatis infection: a global systematic review and meta-analysis. Sex Transm Infect. 96 , 322–329 https://doi.org/10.1136/sextrans-2019-053999 (2020). Aung, E. T. et al. International travel as risk factor for Chlamydia trachomatis infections among young heterosexuals attending a sexual health clinic in Melbourne, Australia, 2007 to 2017. Euro Surveill. 24 , https://doi.org/10.2807/1560-7917.ES.2019.24.44.1900219 (2019). CDC. Sexually Transmitted Disease Surveillance 2018.. (2019). Chen, H. et al. Chlamydia trachomatis and Human Papillomavirus Infection in Women From Southern Hunan Province in China: A Large Observational Study. Front Microbiol. 11 , 827 https://doi.org/10.3389/fmicb.2020.00827 (2020). Piscopo, R. C. et al. Increased prevalence of endocervical Mycoplasma and Ureaplasma colonization in infertile women with tubal factor. JBRA Assist Reprod. 24 , 152–157 https://doi.org/10.5935/1518-0557.20190078 (2020). Abusarah, E. A., Awwad, Z. M., Charvalos, E. & Shehabi, A. A. Molecular detection of potential sexually transmitted pathogens in semen and urine specimens of infertile and fertile males. Diagn Microbiol Infect Dis. 77 , 283–286 https://doi.org/10.1016/j.diagmicrobio.2013.05.018 (2013). Sleha, R. et al. Prevalence of Mycoplasma hominis and Ureaplasma urealyticum in women undergoing an initial infertility evaluation. Epidemiol Mikrobiol Imunol 65 ,232–237. Gdoura, R. et al. Assessment of Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, and Mycoplasma genitalium in semen and first void urine specimens of asymptomatic male partners of infertile couples. J Androl. 29 , 198–206 https://doi.org/10.2164/jandrol.107.003566 (2008). Song, T., Liu, Z., Zhang, Y., Han, Y. & Huang, J. Detection of Ureaplasma spp. serovars in genital tract of infertile males. J Clin Lab Anal. 33 , e22865 https://doi.org/10.1002/jcla.22865 (2019). Moretti, E. et al. The presence of bacteria species in semen and sperm quality. J Assist Reprod Genet. 26 , 47–56 https://doi.org/10.1007/s10815-008-9283-5 (2009). Boeri, L. et al. Semen infections in men with primary infertility in the real-life setting. Fertil Steril. 113 , 1174–1182 https://doi.org/10.1016/j.fertnstert.2020.01.034 (2020). Moridi, K. et al. Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019). BMC Public Health. 20 , 1020 https://doi.org/10.1186/s12889-020-08962-5 (2020). Imudia, A. N., Detti, L., Puscheck, E. E., Yelian, F. D. & Diamond, M. P. The prevalence of ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis and neisseria gonorrhoeae infections, and the rubella status of patients undergoing an initial infertility evaluation. J Assist Reprod Genet. 25 , 43–46 https://doi.org/10.1007/s10815-007-9192-z (2008). Lee, J. Y. & Yang, J. S. Prevalence and Antimicrobial Susceptibility of Mycoplasma hominis and Ureaplasma Species in Nonpregnant Female Patients in South Korea Indicate an Increasing Trend of Pristinamycin-Resistant Isolates. Antimicrob Agents Chemother. 64 , https://doi.org/10.1128/AAC.01065-20 (2020). Lee, M. Y., Kim, M. H., Lee, W. I., Kang, S. Y. & Jeon, Y. L. Prevalence and Antibiotic Susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in Pregnant Women. Yonsei Med J. 57 , 1271–1275 https://doi.org/10.3349/ymj.2016.57.5.1271 (2016). Buzo, B. F. et al. Association between Mycoplasma and Ureaplasma airway positivity, ammonia levels, and outcomes post-lung transplantation: A prospective surveillance study. Am J Transplant. https://doi.org/10.1111/ajt.16394 (2020). Zegers-Hochschild, F. et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril 92 , 1520–1524, doi: 10.1016/j.fertnstert.2009.09.009 (2009). Additional Declarations No competing interests reported. Supplementary Files Supplementaryinformation.pdf Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Major revision 28 Apr, 2021 Reviews received at journal 17 Mar, 2021 Reviewers agreed at journal 04 Mar, 2021 Reviewers invited by journal 04 Mar, 2021 Editor assigned by journal 23 Feb, 2021 Editor invited by journal 09 Feb, 2021 Submission checks completed at journal 09 Feb, 2021 First submitted to journal 05 Feb, 2021 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-209613","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":11079721,"identity":"975e34fb-7d42-4b55-921f-12ce930fd2d4","order_by":0,"name":"Daniela Andrea Paira","email":"","orcid":"","institution":"CIBICI-CONICET. Facultad de Ciencias Químicas. Universidad Nacional de Córdoba. Argentina.","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Daniela","middleName":"Andrea","lastName":"Paira","suffix":""},{"id":11079722,"identity":"c95eff22-ed77-46c1-82b8-b312ef63d46e","order_by":1,"name":"Guillermo Molina","email":"","orcid":"","institution":"Servicio de Urología y Andrología. Hospital Privado Universitario de Córdoba. Córdoba. Argentina.","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Guillermo","middleName":"","lastName":"Molina","suffix":""},{"id":11079723,"identity":"df869f6a-bc9e-4604-a955-a6a51b6b322d","order_by":2,"name":"Andrea Daniela Tissera","email":"","orcid":"","institution":"Laboratorio de Andrología y Reproducción (LAR). Córdoba. Argentina.","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Andrea","middleName":"Daniela","lastName":"Tissera","suffix":""},{"id":11079724,"identity":"1cbd77c6-190e-40e8-ae1c-c07802cb0da9","order_by":3,"name":"Carolina Olivera","email":"","orcid":"","institution":"CIBICI-CONICET. Facultad de Ciencias Químicas. Universidad Nacional de Córdoba. Argentina.","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Carolina","middleName":"","lastName":"Olivera","suffix":""},{"id":11079725,"identity":"ba2054a8-316e-4373-9739-a48357d9eb3f","order_by":4,"name":"Rosa Isabel Molina","email":"","orcid":"","institution":"Laboratorio de Andrología y Reproducción (LAR). Córdoba. Argentina.","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Rosa","middleName":"Isabel","lastName":"Molina","suffix":""},{"id":11079726,"identity":"383b5dfb-dcf9-4eb4-8df1-714f737aba23","order_by":5,"name":"Ruben Dario Motrich","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAxklEQVRIiWNgGAWjYNACA4YEfgiLmSj1jA0gLZINpGlhYEgwOECsFvNph48/riiwyzO+kXvwA0OFdWID+9kHeLXI3E5LbDxjkFxsdiMvWYLhTHpiA0+6AV4tEtI5ho0NBgcSt93IMWNgbDuc2MCQht9hcC2bZ4C0/ANq4X9GpJYNEiAtDUAtEgRtSUuc2WCQnDjjzBtjiYRj6cZtEgRtST7wseGPXWJ/e47hhw811rL9/ARsQQUJQMxGioZRMApGwSgYBdgBAO1uQvQUOEGzAAAAAElFTkSuQmCC","orcid":"","institution":"CIBICI-CONICET. Facultad de Ciencias Químicas. Universidad Nacional de Córdoba. Argentina.","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Ruben","middleName":"Dario","lastName":"Motrich","suffix":""}],"badges":[],"createdAt":"2021-02-05 14:14:11","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-209613/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-209613/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":6154747,"identity":"97f35dd6-775b-4e4e-b857-3f7cee2536c9","added_by":"auto","created_at":"2021-02-19 22:34:28","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":41989,"visible":true,"origin":"","legend":"C. trachomatis (Ct), U. urealyticum (Uu) and M. hominis (Mh) co-infections/colonizations in infertile patients. Frequency of positive Uu infection/colonization in Ct-infected (Ct+) or Ct-non infected (Ct-) women (a) or men (d). Frequency of positive Mh infection/colonization in Ct-infected (Ct+) or Ct-non infected (Ct-) women (b) or men (e). Frequency of positive Uu infection/colonization in Mh-infected/colonized (Mh+) or Mh-non infected/colonized (Mh-) women (c) or men (f). Data are shown as frequency. Chi square test were assessed and odds ratio with 95% confident interval (OR, 95% CI) calculated. A *p\u003c0.05 was considered statistically significant.","description":"","filename":"OnlineFigure1.png","url":"https://assets-eu.researchsquare.com/files/rs-209613/v1/5bb90771dd1feb79d357dd23.png"},{"id":13667517,"identity":"215a3ee9-c266-41e2-bf9b-9569404eb721","added_by":"auto","created_at":"2021-09-17 10:53:32","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":435420,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-209613/v1/6df9603a-ede5-4950-beb4-228ceec14dd6.pdf"},{"id":6154481,"identity":"0ae13e0e-77ce-4d24-b9bb-6c4781b981da","added_by":"auto","created_at":"2021-02-19 22:31:29","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":108007,"visible":true,"origin":"","legend":"","description":"","filename":"Supplementaryinformation.pdf","url":"https://assets-eu.researchsquare.com/files/rs-209613/v1/9b5b6e9daa7db107c42ec1c5.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis urogenital infections in patients with infertility. Results from a large cross-sectional study.","fulltext":[{"header":"Introduction","content":" \u003cp\u003eUrogenital infections are known causes of infertility \u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u003c/sup\u003e. Currently, infertility affects 15\u0026ndash;20% of reproductive-aged couples worldwide and women and men equally contribute to infertility cases \u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e,\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e\u003c/sup\u003e. Sexually transmitted infections can impair fertility by different mechanisms: by directly damaging organs and gametes and/or, indirectly, by the induced inflammation and associated tissue damage, scarring and obstruction \u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e,\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u003c/sup\u003e. Moreover, infection-induced genital inflammation may alter the normal immunomodulation process that naturally occurs in the female genital tract after mating to facilitate fertilization, embryo implantation and promote embryo growth for a successful pregnancy \u003csup\u003e\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e\u003c/sup\u003e. Besides being the most frequent sexually transmitted bacterial infection worldwide, \u003cem\u003eChlamydia trachomatis\u003c/em\u003e is a common infection associated to infertility \u003csup\u003e\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e\u003c/sup\u003e. In women, \u003cem\u003eC. trachomatis\u003c/em\u003e is a known cause of different urogenital pathologies such as acute urethritis, cervicitis and salpingitis that may lead to severe reproductive complications including pelvic inflammatory disease, chronic pelvic pain, ectopic pregnancy, miscarriage and tubal infertility \u003csup\u003e\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e,\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e\u003c/sup\u003e. In men, \u003cem\u003eC. trachomatis\u003c/em\u003e is considered the most common agent of non-gonococcal urethritis and may cause epididymitis-orchitis, prostatitis, sperm tract obstructions and alterations in sperm quality \u003csup\u003e\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e,\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e\u003c/sup\u003e. On the other hand, \u003cem\u003eMycoplasma hominis\u003c/em\u003e and \u003cem\u003eUreaplasma urealyticum\u003c/em\u003e have also been recognized as sexually transmitted infections that could impair human fertility \u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u003c/sup\u003e. Although they are both known to colonize the female and male reproductive tracts as commensals, cumulative growing evidence has shown they are emerging sexually transmitted opportunistic pathogens able to cause asymptomatic chronic disorders affecting female and male fertility \u003csup\u003e\u003cspan additionalcitationids=\"CR11 CR12 CR13 CR14\" citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u003c/sup\u003e. In men, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e are causes of non-gonococcal urethritis contaminating semen during ejaculation. Moreover, U. urealyticum has been proposed to cause prostatitis, epididymitis and infertility \u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u003c/sup\u003e. In addition, reported data have shown that both \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e could impair sperm quality \u003csup\u003e\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e,\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e,\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e\u003c/sup\u003e. In women, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e may cause different pathologies including acute urethritis, bacterial vaginosis, pelvic inflammatory disease and tubal infertility \u003csup\u003e\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e,\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e,\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u003c/sup\u003e. Moreover, the asymptomatic colonization by mycoplasmas or ureaplasmas could induce pro-inflammatory immune responses in the endometrium that may impair pregnancy outcomes \u003csup\u003e\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e,\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e,\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e,\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eThe detection rates of \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e in the urogenital tract form infertile women and men has shown striking variations across regions and countries and in different groups when individuals were classified according to age, ethnicity and socioeconomic status \u003csup\u003e5,21\u0026minus;23\u003c/sup\u003e. In that regard, a growing number of studies have been reported during the last decade. However, compelling available data from large cross-sectional studies is scarce \u003csup\u003e\u003cspan additionalcitationids=\"CR22\" citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e\u003c/sup\u003e. Moreover, reported data about the association of these infections in either infertile women or men is limited \u003csup\u003e\u003cspan additionalcitationids=\"CR22\" citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e\u003c/sup\u003e. Since these infections may play a significant role in the etiology of infertility, we herein conducted a large observational investigation into urogenital \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections in infertile women and men seeking care for infertility. Moreover, we analyzed the associations among infections and with demographic parameters such as patient sex and age.\u003c/p\u003e "},{"header":"Results","content":"\u003cp\u003e\u003cem\u003ePrevalence of C. trachomatis, U. urealyticum and M. hominis urogenital infection\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eA total of 5164 of infertile patients (1554 women and 3610 men) were enrolled in the study. The overall prevalence of urogenital \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u0026nbsp;\u003c/em\u003eand\u003cem\u003e\u0026nbsp;M. hominis\u0026nbsp;\u003c/em\u003edetection in the total population was 5.3%, 22.8% and 7.4%, respectively (Table 1). Interestingly, \u003cem\u003eU. urealyticum\u003c/em\u003e infection showed a remarkably higher overall prevalence than the others uropathogens analyzed. The prevalence of \u003cem\u003eC. trachomatis\u003c/em\u003e infection was significantly higher in men than in women (5.8% versus 4.3%, \u003cem\u003ep=0.034\u003c/em\u003e; Tables 1 and 2). Conversely, we found a significantly higher prevalence of both \u003cem\u003eU. urealyticum\u0026nbsp;\u003c/em\u003eand\u003cem\u003e\u0026nbsp;M. hominis\u003c/em\u003e infection in women (31.1 and 12.1, respectively) than in men (19.2 and 5.3%, respectively) (\u003cem\u003ep\u003c/em\u003e\u0026lt;0.001 and \u003cem\u003ep\u003c/em\u003e\u0026lt;0.001; Tables 1 and 2).\u0026nbsp;\u003c/p\u003e\n\u003ctable style=\"border: none;width:449.0pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 440pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003eTable 1.\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003ePrevalence of urogenital infections in infertile patients\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 187.65pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 15pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.3pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 15pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 69.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 15pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 106pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 15pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 179pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 1.25in;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003eTotal\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 85.5pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003eWomen\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 94.5pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003eMen\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 179pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 15pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 1.25in;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 15pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e(n\u003cem\u003e=\u003c/em\u003e\u003c/span\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e5164)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 85.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 15pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e(n\u003cem\u003e=\u003c/em\u003e\u003c/span\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e1554)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 94.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 15pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e(n\u003cem\u003e=\u003c/em\u003e\u003c/span\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e3610)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 179pt;padding: 0in 3.5pt;height: 4pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 1.25in;padding: 0in 3.5pt;height: 4pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 85.5pt;padding: 0in 3.5pt;height: 4pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 94.5pt;padding: 0in 3.5pt;height: 4pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 179pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cem\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003eChlamydia trachomatis, n\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 1.25in;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e275 (5.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 85.5pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e67 (4.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 94.5pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 208 (5.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 179pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cem\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003eUreaplasma urealyticum, n\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 1.25in;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e1176 (22.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 85.5pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e484 (31.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 94.5pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; 692 (19.2%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 179pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cem\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003eMycoplasma hominis, n\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e(%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 1.25in;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e380 (7.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 85.5pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 88 (12.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 94.5pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 192 (5.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 179pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 5.05pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 1.25in;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 5.05pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 85.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 5.05pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 94.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 5.05pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable style=\"width: 7.6e+2pt;border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"47\" style=\"width: 755.25pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Arial\",sans-serif;color:black;'\u003eTable 2.\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;color:black;'\u003ePrevalence of infections in infertile patients according to sex and age\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22.4pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 62.2pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 26.95pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 35.05pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 16.35pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 9.25pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 66.65pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 40.75pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width: 46.5pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 9.25pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 35.05pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 40.6pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 9.25pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45.25pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 52.05pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width: 37.1pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 9.25pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 39.55pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 36.95pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 9.25pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45.25pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 52.05pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 8.3pt;padding: 0in 3.5pt;height: 14pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22.4pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 17.8pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 44.4pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-left:-17.0pt;text-indent:17.0pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003ePatients\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 8.95pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-left:-17.0pt;text-indent:17.0pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"13\" style=\"width: 209.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-left:4.9pt;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;C. trachomatis\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;infection\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.25pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"14\" style=\"width: 219.3pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003eU. urealyticum\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;infection\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.25pt;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"12\" style=\"width: 211.1pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003eM. hominis\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;infection\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" style=\"width: 48pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003eVariables\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.6pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-right:1.75pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; n\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 9.65pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-right:1.75pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 60.4pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003en (prevalence)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 52.1pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003eOdds ratio\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 40.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-left:.9pt;text-align:center;text-indent:-.9pt;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e95% CI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; p\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cem\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width: 75.65pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;text-indent:7.25pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;n (prevalence)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 45.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003eOdds ratio\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 52.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e95% CI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 37.1pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; p\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width: 78.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-left:-.8pt;text-align:center;text-indent:9.0pt;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; n (prevalence)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 45.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003eOdds ratio\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 52.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e95% CI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 37.1pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 3.5pt;height: 14.5pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; p\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003ctable style=\"width: 7.6e+2pt;border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:44.7pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003eSex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:44.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:35.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:39.2pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:66.65pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:40.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:46.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:35.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:40.6pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:45.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:52.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:39.55pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:36.95pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:45.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:52.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.2pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:8.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:40.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003eWomen\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:27.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e1554\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:67.45pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e67 (4.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width:94.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 1.00 (ref.)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:37.55pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:75.8pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;484 (31.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:97.6pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 1.00 (ref.)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:78.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; 188 (12.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:95.35pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 1.00 (ref.)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:8.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:40.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003eMen\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:27.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e3610\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:67.45pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e208 (5.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:19.45pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:43.8pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp;1.36\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:50.95pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e1.02-1.80\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:35.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e0.034 *\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width:75.8pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;692 (19.2%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:45.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 0.52\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:52.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp;0.46-0.60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026lt;0.001 *\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width:78.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e192 (5.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:45.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 0.41\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:52.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e0.33-0.50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026lt;0.001 *\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003ctable style=\"width: 7.6e+2pt;border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:22.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:44.35pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:35.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:38.95pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:66.65pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:46.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:35.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:40.6pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:45.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:52.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:39.55pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:36.95pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:45.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:52.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width:44.8pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003eAge (y.o.)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:51.15pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:59.65pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"7\" style=\"width:140.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:38.7pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:34.95pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:40.6pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:45.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:52.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:39.55pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:36.95pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:45.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:47.6pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width:44.8pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003eWomen\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:51.15pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:59.65pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"7\" style=\"width:140.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:38.7pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:34.95pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:40.6pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:45.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:52.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:39.55pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:36.95pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:45.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:47.6pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:8.7pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:40.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026gt; 40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:27.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e355\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:67.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e17 (4.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:132.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 1.00 (ref.)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:76.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; 107 (30.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"8\" style=\"width:134.7pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;1.00 (ref.)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:78.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; 43 (12.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"8\" style=\"width:95.35pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 1.00 (ref.)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003ctable style=\"width: 7.6e+2pt;border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:8.65pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:39.85pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e40 - 25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:27.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e1130\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:67.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e47 (4.2%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:45.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp; 0.94\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:49.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e0.50-1.78\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:49.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e0.847\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:76.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e341 (30.2%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:45.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 0.88\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:52.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 0.66-1.17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 0.372\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"7\" style=\"width:78.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e135 (11.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:45.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;0.80\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:52.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e0.55-1.19\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:33.4pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e0.275\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:8.65pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:39.85pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026lt; 25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:27.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e69\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:67.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e3 (4.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:45.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp; 0.96\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:49.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e0.26-3.50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:49.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e0.949\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:76.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;36 (52.2%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:45.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 2.27\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:52.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 1.33-3.89\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e0.003*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"7\" style=\"width:78.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; 10 (14.5%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:45.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;1.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:52.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e0.49-2.22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:33.4pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e0.910\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:22.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:22.2pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:44.25pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:38.95pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:66.65pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:40.75pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"7\" style=\"width:46.5pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.3pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:40.6pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:45.3pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width:52.05pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:39.55pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:36.95pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:45.3pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:52.05pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.75pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" style=\"width:44.2pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003eMen\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:44.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:38.95pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:66.65pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:40.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"7\" style=\"width:46.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:40.6pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:45.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width:52.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:39.55pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:36.95pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:45.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:52.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.75pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:8.65pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:39.85pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026gt; 40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:27.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e1356\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:67.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e88 (6.5%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"8\" style=\"width:132.3pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 1.00 (ref.)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:76.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; 233 (17.2%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"9\" style=\"width:97.6pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;1.00 (ref.)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"7\" style=\"width:78.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;72 (5.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"9\" style=\"width:95.35pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 1.00 (ref.)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:37.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003ctable style=\"width: 7.6e+2pt;border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:8.65pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:39.85pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e40 - 25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:27.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e2161\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:67.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e106 (4.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:45.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp; 0.71\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:54.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp; 0.52-0.95\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:37.55pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e0.021*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:76.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 433 (20.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:45.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;1.26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:52.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;1.04-1.51\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:50.55pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e0.016*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:76.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;116 (5.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:41.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e1.03\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:52.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e0.75-1.41\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:33.4pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e0.863\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:8.65pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:39.85pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026lt; 25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:27.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e93\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:67.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e14 (15.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:45.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;2.51\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:54.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp; 1.40-4.48\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:37.55pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e0.002*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:76.05pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; 26 (28.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:45.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e1.66\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:52.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;1.04-2.66\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:50.55pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e0.034*\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.25pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:76.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;4 (4.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.0pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:41.5pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e0.72\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:52.1pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e0.26-2.02\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:33.4pt;padding:0in 3.5pt 0in 3.5pt;height:14.0pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e0.532\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:23.5pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:36.45pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family: \"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:46.15pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:right;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:54.45pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:76.85pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:37.2pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:48.65pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:79.65pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:9.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:47.65pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:54.8pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:39.05pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:80.7pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:47.9pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:25.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.25pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 3.5pt 0in 3.5pt;height:3.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003eUnivariate analysis. 95%CI:\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e95% confident interval. A *\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003ewas considered statistically significant.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eAssociations among C. trachomatis, U. urealyticum and M. hominis urogenital infections\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eWhen assessing the co-infection between \u003cem\u003eC. trachomatis\u0026nbsp;\u003c/em\u003eand \u003cem\u003eU. urealyticum\u003c/em\u003e, no significant association was found in either infertile women (OR: 1.62, 95% CI: 0.99-2.69, \u003cem\u003ep\u003c/em\u003e˃0.05) or men (OR: 1.07, 95% CI: 0.76-1.52, \u003cem\u003ep\u003c/em\u003e˃0.05) (Figure 1a, d). In fact, a similar prevalence of \u003cem\u003eU. urealyticum\u003c/em\u003e was found in \u003cem\u003eC. trachomatis\u003c/em\u003e infected (41.8%, 28/67) and \u003cem\u003eC. trachomatis\u003c/em\u003e non-infected (30.7%, 456/1487) women (Figure 1a, Table 3). In addition, a comparable prevalence of \u003cem\u003eU. urealyticum\u003c/em\u003e were found in \u003cem\u003eC. trachomatis\u003c/em\u003e infected (20.2%, 42/208) and \u003cem\u003eC. trachomatis\u003c/em\u003e non-infected (19.1%, 650/3402) men (Figure 1d, Table 3).\u003c/p\u003e\n\u003ctable style=\"width: 7.0e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width:412.3pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-left:-5.4pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Arial\",sans-serif;color:black;'\u003eTable 3.\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Arial\",sans-serif;color:black;'\u003eC. trachomatis, U. urealyticum and M. hominis co-infections in infertile patients\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width: 290.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:1.2in;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.25in;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width: 289.9pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.25in;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width: 290.1pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Arial\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:1.2in;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.25in;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width:289.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-top:3.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;text-align:center;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Arial\",sans-serif;color:black;'\u003eC. trachomatis\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.25in;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-top:3.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width:290.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-top:3.0pt;margin-right:0in;margin-bottom:3.0pt;margin-left:0in;text-align:center;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Arial\",sans-serif;color:black;'\u003eM. hominis\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:1.2in;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.25in;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:138.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;color:black;'\u003eWomen\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:138.2pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003eMen\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.25in;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:138.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;color:black;'\u003eWomen\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:138.2pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003eMen\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:1.2in;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.25in;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.25in;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:1.2in;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.25in;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;color:black;'\u003e(n=67)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e(n=1487)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e(n=208)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e(n=3402)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.25in;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;color:black;'\u003e(n=188)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;color:black;'\u003e(n=1366)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times 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style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003eNegative n (%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.25in;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;color:black;'\u003e55 (82.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;color:black;'\u003e1311 (88.2%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.5pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e194 (93.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e3224 (94.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.25in;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.7pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;margin-bottom:3.0pt;text-align:center;'\u003e\u003cspan style='font-size:12px;font-family:\"Arial\",sans-serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:7px;font-family:\"Arial\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003eUnivariate analysis. 95%CI:\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003e95% confident interval. A *\u003cem\u003ep\u003c/em\u003e\u0026lt;0.05\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:11px;font-family:\"Arial\",sans-serif;'\u003ewas considered statistically significant.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003eLikewise, there was no significant association between \u003cem\u003eC. trachomatis\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections in either women (OR: 1.63, 95% CI: 0.83-3.07, \u003cem\u003ep\u003c/em\u003e˃0.05) or men (OR: 1.31, 95% CI: 0.75-32.24, \u003cem\u003ep\u003c/em\u003e˃0.05) (Figure 1b, e). From the 67 women infected with \u003cem\u003eC. trachomatis\u003c/em\u003e, 12 were positive for \u003cem\u003eM. hominis\u003c/em\u003e (17.9%), whereas 176 out of the 1487 \u003cem\u003eC. trachomatis\u003c/em\u003e-negative women were positive for \u003cem\u003eM. hominis\u003c/em\u003e (11.8%) (Figure 1b, Table 3). Also, a comparable prevalence of \u003cem\u003eM. hominis\u003c/em\u003e was found in either \u003cem\u003eC. trachomatis\u003c/em\u003e infected (6.7%, 14/208) or \u003cem\u003eC. trachomatis\u003c/em\u003e non-infected (5.2%, 178/3402) men (Figure 1e, Table 3).\u003c/p\u003e\n\u003cp\u003eInterestingly, a significant association between \u003cem\u003eM. hominis\u003c/em\u003e and \u003cem\u003eU. urealyticum\u003c/em\u003e infection was found in women (OR: 33.84, 95% CI: 20.25-56.86, \u003cem\u003ep\u003c/em\u003e\u0026lt;0.0001) as well as in men (OR: 71.83, 95% CI: 41.89-187.10, \u003cem\u003ep\u003c/em\u003e\u0026lt;0.0001) (Figure 1c, Table 3). As detailed in Table 3, from the 188 women positive for \u003cem\u003eM. hominis\u003c/em\u003e, 171 (91.0%) were positive for \u003cem\u003eU. urealyticum\u003c/em\u003e. Similarly, a significantly increased prevalence of \u003cem\u003eU. urealyticum\u003c/em\u003e (92.7%) was found in \u003cem\u003eM. hominis\u003c/em\u003e positive men (Figure 1f). In fact, from the 192 men positive for \u003cem\u003eM. hominis\u003c/em\u003e detection, 178 (92.7%) were positive for \u003cem\u003eU. urealyticum\u003c/em\u003e (Table 3). Multivariate regression analysis further confirmed these tight associations, indicating that \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e act as mutual risk factors of infection either in women or men (Supplementary Table S1). \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eNoteworthy, only 2.0% of infected women (11 out of 539) and 1.5% of infected men (13 out of 871) were co-infected with the three uropathogens analyzed (Supplementary Figure S1).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eDemographic parameters associated to C. trachomatis, U. urealyticum and M. hominis infection\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eRemarkably, \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections were significantly associated with patient sex and age (Table 2). In fact, univariate regression analysis revealed that \u003cem\u003eC. trachomatis\u003c/em\u003e infection was more likely to be detected in infertile men than in women with an odds ratio of 1.36 (95% CI: 1.02-1.80, \u003cem\u003ep\u003c/em\u003e=0.034) (Table 2). Moreover, a significant association was particularly found between \u003cem\u003eC. trachomatis\u003c/em\u003e infection and men younger than 25 years (OR: 2.51, 95% CI: 1.40-4.48, p=0.002, Table 2) indicating that men, and especially those younger than 25 years, are at higher risk of infection than women (Table 2). Multivariate analysis further confirmed these associations (Supplementary Table S1).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eOn the contrary, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections were associated to females, since men were less likely at risk of \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infection than women with odds ratios of 0.52 (95% IC: 0.46-0.60, p\u0026lt;0.001, Table 2) and 0.41 (95% CI: 0.33-0.50, \u003cem\u003ep\u003c/em\u003e\u0026lt;0.001, Table 2), respectively. In addition, when analyzing the association of infection with patient sex and age, it was found that \u003cem\u003eU. urealyticum\u003c/em\u003e was more prevalent in patients younger than 25 years, either in women or men (OR: 2.27, 95% CI: 1.33-3.89, \u003cem\u003ep\u003c/em\u003e=0.003, and OR: 1.66, 95% CI: 1.04-2.66, \u003cem\u003ep\u003c/em\u003e=0.034, respectively; Table 2). Multivariate analysis further confirmed these data (Supplementary Table S1).\u003c/p\u003e\n\u003cp\u003eThese results indicate that \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e urogenital infections are associated with patient sex and age. In fact, individuals younger than 25 years at the highest risk of \u003cem\u003eC. trachomatis\u003c/em\u003e and \u003cem\u003eU. urealyticum\u003c/em\u003e infection. Moreover, our data show that men are at higher risk of \u003cem\u003eC. trachomatis\u003c/em\u003e infection and, conversely, women are at higher risk of \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infection.\u0026nbsp;\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003e\u003cem\u003eChlamydia trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e are amongst the most frequent sexually transmitted bacterial infections. Moreover, they have been associated to infertility in either females or males \u003csup\u003e\u003cspan additionalcitationids=\"CR2\" citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e,\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e\u003c/sup\u003e. Therefore, compelling data about the prevalence of urogenital \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infection and their possible associations in infertile patients is of utmost importance. It has been shown that the prevalence of urogenital \u003cem\u003eC. trachomatis\u003c/em\u003e infection in infertile men and women varies considerable across nations and regions and according to the subject population under study \u003csup\u003e\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e,\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e\u003c/sup\u003e. Besides, although a growing number of studies about the prevalence of urogenital \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections in infertile patients have been reported during the last decade, compelling available data from large cross-sectional studies of is still scarce \u003csup\u003e\u003cspan additionalcitationids=\"CR22\" citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e\u003c/sup\u003e. Thus, we herein conducted a large observational investigation into urogenital \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections in women and men with infertility. Our data revealed a high overall prevalence of \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infection in infertile patients. When analyzing data according to patient sex, the prevalence of \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infection was 4.3%, 31.1% and 12.1% in infertile women, and 5.8%, 19.2% and 5.3% in infertile men, respectively. Univariate and multivariate regression analyses revealed that \u003cem\u003eC. trachomatis\u003c/em\u003e infection was significantly more prevalent in infertile men whereas \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections were significantly more prevalent in infertile women. The higher prevalence of \u003cem\u003eC. trachomatis\u003c/em\u003e urogenital infection we found in men with respect to women could be due to the fact that urogenital infections in men are much more frequently asymptomatic than in women \u003csup\u003e\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e\u003c/sup\u003e. Besides, our results are in line with recently reported data showing that the prevalence of \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e urogenital infections is higher in infertile women than in infertile men \u003csup\u003e\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e\u003c/sup\u003e. Furthermore, our results also showed that \u003cem\u003eC. trachomatis\u003c/em\u003e and \u003cem\u003eU. urealyticum\u003c/em\u003e infections were significantly more prevalent in young patients, particularly in those younger than 25, indicating that age as a risk factor and in agreement with previously reported data \u003csup\u003e\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e,\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e\u003c/sup\u003e. In fact, it is known that sexually transmitted infections are directly related to sexual experience, having young people more frequent sexual intercourses, less consistency of condom use and one or multiple sexual partners \u003csup\u003e\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e,\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e\u003c/sup\u003e. On the other hand, when assessing co-infections, only 2.0% of women and 1.5% of men were co-infected with the three uropathogens analyzed.\u003c/p\u003e\u003cp\u003eOur results support previously reported data. In a large observational study, Chen \u003cem\u003eet al.\u003c/em\u003e found a prevalence of \u003cem\u003eC. trachomatis\u003c/em\u003e infection of 3.5% in a population of 666 women seeking care for assisted reproduction in China, being significantly highest in patients younger than 25 years \u003csup\u003e\u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e\u003c/sup\u003e. Moreover, Piscopo \u003cem\u003eet al.\u003c/em\u003e reported a prevalence of \u003cem\u003eC. trachomatis\u003c/em\u003e infection of 3.7% in women with tubal infertility in Brazil \u003csup\u003e\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e\u003c/sup\u003e. Besides and similar to our data, a prevalence of \u003cem\u003eC. trachomatis\u003c/em\u003e infection of 4.3% in infertile men from Jordan has been reported \u003csup\u003e\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e\u003c/sup\u003e. Moreover, our results are in line with reported data by Sleha \u003cem\u003eet al.\u003c/em\u003e, who found a prevalence of \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e urogenital infection of 39.6% and 8.1%, respectively, in Czech women undergoing an initial infertility evaluation \u003csup\u003e\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e\u003c/sup\u003e. In addition, Gdoura \u003cem\u003eet al.\u003c/em\u003e found a prevalence of \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e of 15.4% and 9.6% in male partners from infertile couples from Tunisia \u003csup\u003e\u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e\u003c/sup\u003e. Similar data were also reported in infertile men from China \u003csup\u003e\u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e\u003cp\u003eHowever, significantly different prevalence rates of urogenital \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e or \u003cem\u003eM. hominis\u003c/em\u003e infection in infertile women or men have been reported in other studies. In comparison with our data, a much lower prevalence of \u003cem\u003eU. urealyticum\u003c/em\u003e infection was described in infertile men from Italy \u003csup\u003e\u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e\u003c/sup\u003e. Similarly, Boeri \u003cem\u003eet al.\u003c/em\u003e recently reported lower prevalences of \u003cem\u003eC. trachomatis\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infection in Italian men with primary infertility \u003csup\u003e\u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e\u003c/sup\u003e. Moreover, in a study conducted in infertile men from Spain, Veiga \u003cem\u003eet al.\u003c/em\u003e found lower rates of \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infection than ours (0.9%, 15.1% and 0.9%, respectively) \u003csup\u003e\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e\u003c/sup\u003e. In addition, considerably lower prevalence rates of \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infection were reported in infertile women from the USA and Iran \u003csup\u003e\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e36\u003c/span\u003e,\u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e37\u003c/span\u003e\u003c/sup\u003e. Several factors could underlie these differences such as disparities in population under study (geographical location, age, ethnicity, religion, socio-economic status, access to medical care, etc.) or study design (prospective versus retrospective, patient population size, methods used for diagnosis, etc.). However, our results are in line with cumulative reported data and supported by the large patient population analyzed, including 5164 infertile individuals (1554 women and 3610 men).\u003c/p\u003e\u003cp\u003eBesides, our data revealed that \u003cem\u003eC. trachomatis\u003c/em\u003e infection was not associated to either \u003cem\u003eU. urealyticum\u003c/em\u003e or \u003cem\u003eM. hominis\u003c/em\u003e in infertile women as well as in men. Conversely, and supporting recently reported data \u003csup\u003e\u003cspan additionalcitationids=\"CR39\" citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e\u003c/sup\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e or \u003cem\u003eM. hominis\u003c/em\u003e were significantly associated to each other in either infertile women or men, indicating that \u003cem\u003eU. urealyticum\u003c/em\u003e or \u003cem\u003eM. hominis\u003c/em\u003e urogenital infection increased the risk of \u003cem\u003eM. hominis\u003c/em\u003e or \u003cem\u003eU. urealyticum\u003c/em\u003e co-infection. This tight infection association could be due to shared infection routes and/or pathophysiologic mechanisms \u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e,\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e\u003cp\u003eTo our knowledge, this is the first cross-sectional study to investigate the prevalence and association of \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e in infertile women and men from Argentina. Being one of the few cross-sectional study performed in Latin American countries \u003csup\u003e\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e,\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e\u003c/sup\u003e and the large number of patients analyzed are the main strengths of our study. However, our study has some limitations such as it did not include control groups of fertile women and men, in whom the prevalence of the infections under analysis could have been different from their infertile counterparts. Moreover, we did not have the information of the partner couple of every infertile women or men enrolled, which could have provided important information about infection concordance.\u003c/p\u003e\u003cp\u003eIn conclusion, our results indicate that urogenital \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections are prevalent in infertile patients. \u003cem\u003eC. trachomatis\u003c/em\u003e infection was significantly more prevalent in infertile men whereas \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections were more prevalent in infertile women. Of clinical importance, \u003cem\u003eC. trachomatis\u003c/em\u003e and \u003cem\u003eU. urealyticum\u003c/em\u003e infections were more prevalent in young patients, especially in those younger than 25 years. Moreover, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e showed to be reciprocal risk factors of their co-infection in either infertile women or men. Overall, these results point out the importance to include the microbiological screening of urogenital infections in the diagnostic workup of infertility. Moreover, they highlight the need to reinforce preventive strategies at the primary healthcare level. Increasing awareness among people and health care practitioners are efficient approaches for the prevention of infection transmission. Future research is needed to unveil the true impacts of these uropathogens and the underlying pathophysiological mechanisms, which would allow the identification of proper and efficient treatments to more effectively reduce the burden of infertility.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cem\u003eStudy design, patients and samples\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThis prospective, cross-sectional study was performed on a total cohort of 5164 patients (1554 females and 3610 males) seeking care for infertility at a joint Academic, Urology and Reproduction Health Center from Cordoba, Argentina, between January 2015 and November 2019. Inclusion criteria were female or male aged 18-60 years, not taking antibiotics when sampling or during the last 3 weeks, and with a recent diagnosis of infertility based on a thorough self-reported sexual and medical history \u003ca href=\"#_ENREF_41\" title=\"Zegers-Hochschild, 2009 #208\"\u003e\u003csup\u003e41\u003c/sup\u003e\u003c/a\u003e. Vaginal-swab and semen samples were collected from female and male patients, respectively. Vaginal swabs were collected by a dedicated operator who inserted Dacron swabs into the vagina up to the vault and rotated the swab in the vaginal vault. The specimens were immediately transferred to a tube containing cervical cell preservation solution and processed for analysis. Semen samples were collected by masturbation after 2-7 days of sexual abstinence and processed within 1 h of collection.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eEthical approval\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe study was carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) standards and the Argentinian legislation for protection of personal data (Law 25326). The experimental protocol was approved by the Institutional Ethics Committee from the Hospital Nacional de Clinicas, Universidad Nacional de Cordoba (RePIS #3512). All patients provided a signed written informed consent form agreeing to share their own anonymous information prior to enrollment.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eDNA extraction and C. trachomatis detection\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eTotal DNA was extracted from vaginal or semen samples and \u003cem\u003eC. trachomatis\u003c/em\u003e infection detected by polymerase chain reaction (PCR) using the \u003cem\u003eChlamydia trachomatis\u003c/em\u003e 330/740 IC PCR kit (Sacace Biotechnologies Srl, Como, Italy) and within 4 h of sample collection.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eM. hominis\u003c/em\u003e and \u003cem\u003eU. urealyticum\u003c/em\u003e detection\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eM. hominis\u003c/em\u003e or \u003cem\u003eU. urealyticum\u003c/em\u003e infections were assessed by culture using the commercially available colorimetric kit Mycofast RevolutioN (ELITech Group, Puteaux, France). Briefly, 100 \u0026mu;l of vaginal swab seeded transport medium or semen were added to the \u003cem\u003eM. hominis\u003c/em\u003e and \u003cem\u003eU. urealyticum\u003c/em\u003e wells, sealed and incubated at 37\u0026deg;C\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u0026deg;C for 24 h. After incubation, orange or red color changes indicated the presence of \u003cem\u003eM. hominis\u003c/em\u003e and/or \u003cem\u003eU. urealyticum\u003c/em\u003e, respectively.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eStatistics\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eDemographic characteristics (age, sex) and co-infections were compared between infected and non-infected patients using the chi-square test and the odds ratios (OR) and 95% confidence intervals (CI) were calculated. Univariate and multivariate logistic regression analyses for all variables were performed to determine associations or risk factors for infections. The SPSS statistical software package (version 17.0; SPSS Inc., Chicago, USA) and GraphPad Prism 8.0.1 were used for analyses. A \u003cem\u003ep\u0026lt;0.05\u003c/em\u003e was considered statistically significant.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003ch2\u003eEthical approval\u003c/h2\u003e\u003cp\u003e The study was carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) standards and the Argentinian legislation for protection of personal data (Law 25326). The experimental protocol was approved by the Institutional Ethics Committee from the Hospital Nacional de Clinicas, Universidad Nacional de Cordoba (RePIS #3512). All patients provided a signed written informed consent form agreeing to share their own anonymous information prior to enrollment.\u003c/p\u003e\u003c/p\u003e \u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; contributions\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eR.D.M., G.M., and R.M. participated in the conception and design of the study. G.M., D.A.P., A.D.T., C.O. and R.I.M. participated in the acquisition, analysis and interpretation of data. R.D.M. wrote the manuscript text and D.A.P. prepared the figure and tables. All authors critically reviewed the manuscript and approved the final version before submission.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdditional Information\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eCompeting interests\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no competing interests.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eGimenes, F. \u003cem\u003eet al.\u003c/em\u003e Male infertility: a public health issue caused by sexually transmitted pathogens. \u003cem\u003eNat Rev Urol.\u003c/em\u003e \u003cb\u003e11\u003c/b\u003e, 672\u0026ndash;687 \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://doi.org/10.1038/nrurol.2014.285\u003c/span\u003e\u003c/span\u003e (2014).\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eVander Borght, M. \u0026amp; Wyns, C. 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F. \u003cem\u003eet al.\u003c/em\u003e Association between Mycoplasma and Ureaplasma airway positivity, ammonia levels, and outcomes post-lung transplantation: A prospective surveillance study. \u003cem\u003eAm J Transplant.\u003c/em\u003e \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://doi.org/10.1111/ajt.16394\u003c/span\u003e\u003c/span\u003e (2020).\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eZegers-Hochschild, F. \u003cem\u003eet al.\u003c/em\u003e International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. \u003cem\u003eFertil Steril\u003c/em\u003e \u003cb\u003e92\u003c/b\u003e, 1520\u0026ndash;1524, doi:\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.fertnstert.2009.09.009\u003c/span\u003e\u003c/span\u003e (2009).\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, infertility, infection, prevalence","lastPublishedDoi":"10.21203/rs.3.rs-209613/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-209613/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eFemale and male infertility have been associated to \u003cem\u003eChlamydia trachomatis\u003c/em\u003e, \u003cem\u003eUreaplasma urealyticum\u003c/em\u003e and \u003cem\u003eMycoplasma hominis\u003c/em\u003e urogenital infections. However, evidence from large studies assessing their prevalence and putative associations in patients with infertility is still needed. The study design was a cross-sectional study including 1554 female and 3610 male patients with infertility in Cordoba, Argentina. In women, the prevalence of \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e urogenital infection was 4.3%, 31.1% and 12.1% whereas in men it was 5.8%, 19.2% and 5.3%, respectively. \u003cem\u003eC. trachomatis\u003c/em\u003e infection was significantly more prevalent in men whereas \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections were more prevalent in women. Besides, \u003cem\u003eC. trachomatis\u003c/em\u003e and \u003cem\u003eU. urealyticum\u003c/em\u003e infections were significantly higher patients younger than 25 years. Moreover, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e infections were associated to each other in either infertile women or men. Our data revealed that \u003cem\u003eC. trachomatis\u003c/em\u003e, \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e are prevalent uropathogens in infertile patients. Of clinical importance, \u003cem\u003eC. trachomatis\u003c/em\u003e and \u003cem\u003eU. urealyticum\u003c/em\u003e infections were more prevalent in young patients whereas \u003cem\u003eU. urealyticum\u003c/em\u003e and \u003cem\u003eM. hominis\u003c/em\u003e are reciprocal risk factors of their co-infection. These results highlight the importance of including the screening of urogenital infections in the diagnostic workup of infertility.\u003c/p\u003e","manuscriptTitle":"Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis urogenital infections in patients with infertility. Results from a large cross-sectional study.","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-02-19 22:31:26","doi":"10.21203/rs.3.rs-209613/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2021-04-28T05:01:39+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2021-03-17T13:47:37+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"54ff91d5-bb54-48a6-81bf-28fc8e3ed2f8","date":"2021-03-04T15:10:21+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2021-03-04T15:06:15+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2021-02-23T13:55:13+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2021-02-09T09:28:13+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2021-02-09T09:11:10+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2021-02-05T14:07:37+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"b53acce2-d65e-4a17-a245-559d6d08665e","owner":[],"postedDate":"February 19th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":2514246,"name":"Urology \u0026 Nephrology"},{"id":2514247,"name":"Infectious Diseases"},{"id":2514248,"name":"General Microbiology"},{"id":2514249,"name":"Sexual \u0026 Reproductive Medicine"}],"tags":[],"updatedAt":"2021-06-22T04:59:10+00:00","versionOfRecord":[],"versionCreatedAt":"2021-02-19 22:31:26","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-209613","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-209613","identity":"rs-209613","version":["v1"]},"buildId":"GqpaHPwrfC8PjnIFayRh5","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}