Visual Analysis of Cell Death in Bladder Cancer — A Bibliometrics-Based Comprehensive Study

2025 · doi:10.1101/2025.08.10.669556
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The paper conducted a bibliometric, visual analysis of global research on bladder cancer cell death mechanisms, using 5,392 Web of Science publications from 1991–2024 and tools including VOSviewer for co-authorship/keyword clustering and CiteSpace for citation bursts. It found that China and the US led output, with the University of Texas System and UTMD Anderson Cancer Center as top institutions, Journal of Urology as highest output venue, and Cancer Research as highest impact; it also identified Kim Wun-Jae as most productive and Jemal A as most co-cited. Keyword and citation trends showed increasing integration of cell death pathways with immunotherapy and photodynamic therapy aimed at overcoming chemoresistance. The study’s caveat is that its scope is limited to Web of Science records and the trends are derived from bibliometric metrics rather than direct experimental results. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Cell death mechanisms offer therapeutic strategies for bladder cancer, yet lack comprehensive bibliometric analysis. Map global research trends and hotspots in bladder cancer cell death mechanisms via bibliometrics. We analyzed 5,392 publications (1991–2024) from Web of Science using VOSviewer (co- authorship/keyword clustering), CiteSpace (citation bursts), and GraphPad Prism (statistics). Metrics included: (1) Temporal trends, (2) Country/institution contributions, (3) Journal impact, (4) Citation dynamics, (5) Collaboration networks, (6) Conceptual hotspots. China and the US led research output. Top institutions:University of Texas System (USA; 178 publications), UTMD Anderson Cancer Center (USA; 123), Nanjing Medical University (China; 122), Journal of Urology had the highest output (106 publications); Cancer Research (IF:12.5) the highest impact. Kim Wun-Jae was the most productive author (37 articles); Jemal A the most co-cited (446 citations). Keyword and citation analyses revealed emerging integration of cell death mechanisms with immunotherapy (IT) and photodynamic therapy (PDT) to overcome chemoresistance. This study delineates the evolution of bladder cancer cell death research and identifies IT/PDT as promising resistance-overcoming strategies grounded in targeted cell death pathways.
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Abstract Cell death mechanisms offer therapeutic strategies for bladder cancer, yet lack comprehensive bibliometric analysis. Map global research trends and hotspots in bladder cancer cell death mechanisms via bibliometrics. We analyzed 5,392 publications (1991–2024) from Web of Science using VOSviewer (co- authorship/keyword clustering), CiteSpace (citation bursts), and GraphPad Prism (statistics). Metrics included: (1) Temporal trends, (2) Country/institution contributions, (3) Journal impact, (4) Citation dynamics, (5) Collaboration networks, (6) Conceptual hotspots. China and the US led research output. Top institutions:University of Texas System (USA; 178 publications), UTMD Anderson Cancer Center (USA; 123), Nanjing Medical University (China; 122), Journal of Urology had the highest output (106 publications); Cancer Research (IF:12.5) the highest impact. Kim Wun-Jae was the most productive author (37 articles); Jemal A the most co-cited (446 citations). Keyword and citation analyses revealed emerging integration of cell death mechanisms with immunotherapy (IT) and photodynamic therapy (PDT) to overcome chemoresistance. This study delineates the evolution of bladder cancer cell death research and identifies IT/PDT as promising resistance-overcoming strategies grounded in targeted cell death pathways. Competing Interest Statement The authors have declared no competing interest.

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