Evidence on the Stability of Nanoparticles of Comirnarty® in Syringes

Abstract Moving towards a real mass vaccination in the context of COVID-19, healthcare professionals are required to face some criticisms limiting the storage and transport of Comirnaty® as diluted dose in 1mL-syringe. Here, the physical stability of lipid nanoparticles in “real-world” conditions was evaluated, comparing the effects of different syringe materials, temperature and mechanical stress on number and particle size distribution. the positive results of such proof-of-concept can support the preparation and transport of doses to hospitals or vaccination settings.