New generation of nanozyme based-tooth bleaching gel with dual effect: tooth whitening and enamel microhardness improving

Teeth discoloration is one of prevalent aesthetic concerns resulted from intrinsic/ extrinsic reasons. Bleaching process can be a valuable treatment for patients with severe discolorations, which can cause an immediate change in their teeth color. According to literature review, use of commercial products owing to their high concentration of hydrogen peroxide can lead to lessen the enamel microhardness. Regarding these issues, the purpose of this present scenario is the design of novel three-components dental bleaching systems based on cerium oxide (CeO 2 ) nanozyme with dual impact, whitening of teeth as well as enhancement of the enamel microhardness. This system composed of three sections: whitening gel (i.e. gel includes H 2 O 2 ), the activator gel (i.e. gel includes CeO 2 nanozyme) and supplemental gel (i.e. gel includes hydroxyapatite). Base on in vitro and clinical studies, the synthesized whitening system not only is able to bleach the stained teeth but also possesses the microhardness improvement ability. Interestingly, the clinical case reports in current study reveal the remarkable change of tooth color by using the prepared in-office whitening dental gel.