The Effect of Haemoglobin and Blood Transfusion on Preterm Infant Gut Perfusion and Injury

The Effect of Haemoglobin and Blood Transfusion on Preterm Infant Gut Perfusion and Injury | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Article The Effect of Haemoglobin and Blood Transfusion on Preterm Infant Gut Perfusion and Injury Claire Howarth, Christian Mifsud, Jayanta Banerjee Banerjee, Simon Eaton, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3781686/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract There is significant uncertainty regarding the role of anaemia or blood transfusion in the development of necrotising enterocolitis in preterm infants. We conducted a prospective observational study of 48 preterm infants born at <30 weeks gestation in whom, gut perfusion and injury were assessed weekly by: 60 minutes Near Infrared Spectroscopy (NIRS) measurements (sTOI/sFTOE); stool calprotectin; urine intestinal and liver FABP; and TFF-3 until either 36 weeks post conceptional age or discharge. Exclusion criteria included Fetal Growth Restriction (FGR), and abnormal antenatal Dopplers. Haemoglobin levels were measured in parallel with NIRS measurements. NIRS and the urine and stool biomarkers of gut injury were evaluated up to 72 hours before/after transfusion and pre/post measurements compared. Our results demonstrated no significant association of Haemoglobin with either sTOI/sFTOE or any gut biomarker level. There was no significant difference in pre and post RBCT NIRS measurements or gut biomarker levels. We showed no association of anaemia or transfusion with gut injury in preterm infants. Further studies with standardised methods of examining the relationship between anaemia, transfusion, and gut injury are needed in FGR infants. Health sciences/Biomarkers Health sciences/Gastroenterology/Gastrointestinal diseases Full Text Additional Declarations There is NO Competing Interest. Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3781686","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":266536774,"identity":"03e906dd-dcc8-463a-91d9-1a22b79a9842","order_by":0,"name":"Claire Howarth","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA+ElEQVRIiWNgGAWjYDACdgaGA0AqAcxhbLBhMCCohRlZy8GGNKiWBPxaEEoONhwmrIW/mfnh4YoKhjx+ieRnnz/uOJ9nzn+A7cHHH7i1SBxmMzh45gxDseSMNOMZB8/cLrackcBuOAOPLQbMDAYHG9sYEjfcTjBmONh2O3HDDQY2aR68Wtg/HGz8B9KS/hmo5VzihvMH2KT/4NXCA7SlAaQlB2TLgcQNBxLYpPF5X+IwT8HBhmMSiTPnvylmONuWDHRYYptkTxpuLfzt7Zs/NtTYJPbzHN/MUNlmB3TY4WMSP2xwa4FZhsxhbCCofhSMglEwCkYBfgAAEBxYqJmgFMcAAAAASUVORK5CYII=","orcid":"","institution":"Homerton Healthcare NHS Foundation Trust","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Claire","middleName":"","lastName":"Howarth","suffix":""},{"id":266536775,"identity":"75b3c916-5f3e-4aed-884e-7dfeb9117638","order_by":1,"name":"Christian Mifsud","email":"","orcid":"","institution":"University College London Great Ormond Street Institute of Child Health; 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stool calprotectin; urine intestinal and liver FABP; and TFF-3 until either 36 weeks post conceptional age or discharge. \r\n\r\nExclusion criteria included Fetal Growth Restriction (FGR), and abnormal antenatal Dopplers. Haemoglobin levels were measured in parallel with NIRS measurements. NIRS and the urine and stool biomarkers of gut injury were evaluated up to 72 hours before/after transfusion and pre/post measurements compared. \r\n\r\nOur results demonstrated no significant association of Haemoglobin with either sTOI/sFTOE or any gut biomarker level. There was no significant difference in pre and post RBCT NIRS measurements or gut biomarker levels. \r\n\r\nWe showed no association of anaemia or transfusion with gut injury in preterm infants. Further studies with standardised methods of examining the relationship between anaemia, transfusion, and gut injury are needed in FGR infants.","manuscriptTitle":"The Effect of Haemoglobin and Blood Transfusion on Preterm Infant Gut Perfusion and Injury","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-02-01 10:09:55","doi":"10.21203/rs.3.rs-3781686/v1","editorialEvents":[],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"communications-medicine","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"commsmed","sideBox":"Learn more about [Communications Medicine](http://www.nature.com/commsmed)","snPcode":"43856","submissionUrl":"https://mts-commsmed.nature.com/cgi-bin/main.plex","title":"Communications Medicine","twitterHandle":"@commsmedicine","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Communications Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"0a4dadd0-4bc7-4f6c-89b9-ae653c816783","owner":[],"postedDate":"February 1st, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":28092873,"name":"Health sciences/Biomarkers"},{"id":28092874,"name":"Health sciences/Gastroenterology/Gastrointestinal diseases"}],"tags":[],"updatedAt":"2024-02-01T10:09:55+00:00","versionOfRecord":[],"versionCreatedAt":"2024-02-01 10:09:55","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3781686","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3781686","identity":"rs-3781686","version":["v1"]},"buildId":"veTbxFhMMB0_faC6-Wkog","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}