Primary squamous cell carcinoma of the ovary. Report of 37 cases

Pins MR, M R Pins, Young RH, R H Young, Daly WJ, W J Daly, Scully RE, R E Scully
The American journal of surgical pathology · 1996 · vol. 20(7) , pp. 823–33 · doi:10.1097/00000478-199607000-00005 · PMID:8669530
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This study describes 37 cases of primary ovarian squamous cell carcinoma, differentiating between those associated with dermoid cysts, endometriosis, or pure, and finds that tumor stage and grade correlate best with overall survival.

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This study analyzes 37 cases of primary ovarian squamous cell carcinoma, categorizing them into those associated with dermoid cysts, endometriosis, or pure epithelial origins. The researchers detailed the clinical and pathological features of each subgroup, noting that tumors linked to endometriosis were consistently high-grade and associated with significantly poorer survival outcomes compared to those arising from dermoid cysts. A major finding was that all five patients with endometriosis-associated carcinoma who had adequate follow-up data died from their disease within a mean of five months. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

A total of 37 cases of ovarian primary squamous cell carcinoma (SCC)-19 associated with a dermoid cyst (SCCD), seven associated with endometriosis (SCCE), and 11 pure (SCCP)-are described. The last 18 cases belong within the new World Health Organization category of SCC in the surface epithelial-stromal category. The 19 patients with SCCD were 21-75 (mean, 52) years old; three of the carcinomas were in situ and seven, six, and three tumors were stages I, II, and III, respectively. The tumors and associated dermoid cysts were 6-35 cm in greatest dimension, usually forming mural nodules with intracavitary protrusion and focal necrosis and hemorrhage; two, seven, and seven tumors were grades 1, 2, and 3, respectively. SCCD was focally associated with a columnar epithelial cyst lining in 13 cases, suggesting an origin therein. One patient with stage I, grade 1 SCCD also had squamous cell carcinoma in situ (CIS) of the cervix. The seven patients with SCCE were 29-70 (mean, 49) years old, and one, three, one, and two tumors were stages I, II, III, and IV, respectively; all of the tumors were grade 3. One was associated with squamous cell carcinoma in situ of the cervix. The 11 patients with SCCP were 27-73 (mean, 56) years old, and one, four, five, and one tumors were stages I, II, III, and IV, respectively. The tumors were 6-26 cm in greatest diameter, usually solid with focal necrosis; one and 10 tumors were grades 2 and 3, respectively. Three patients with SCCP also had cervical squamous cell carcinoma in situ. The patients with SCCE had a poorer overall survival than those with SCCD. Five of the six patients with SCCE for whom adequate follow-up information was available died of their disease (mean survival, 5 months); also, in all five cases of SCCE reported in the literature, the patients died of their disease (mean survival, 4 months). The stage of the tumor and its grade correlated best with overall survival for all three types of SCC.
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Primary Squamous Cell Carcinoma of the Ovary Report of 37 Cases - Michael R. Pins - Robert H. Young - William J. Daly - Robert E. Scully A total of 37 cases of ovarian primary squamous cell carcinoma (SCC)—19 associated with a dermoid cyst (SCCD), seven associated with endometriosis (SCCE), and 11 pure (SCCP)—are described. The last 18 cases belong within the new World Health Organization category of SCC in the surface epithelial-stromal category. The 19 patients with SCCD were 21-75 (mean, 52) years old; three of the carcinomas were in situ and seven, six, and three tumors were stages I, II, and III, respectively. The tumors and associated dermoid cysts were 6-35 cm in greatest dimension, usually forming mural nodules with intracavitary protrusion and focal necrosis and hemorrhage; two, seven, and seven tumors were grades 1, 2, and 3, respectively. SCCD was focally associated with a columnar epithelial cyst lining in 13 cases, suggesting an origin therein. One patient with stage I, grade 1 SCCD also had squamous cell carcinoma in situ (CIS) of the cervix. The seven patients with SCCE were 29-70 (mean, 49) years old, and one, three, one, and two tumors were stages I, II, III, and IV, respectively; all of the tumors were grade 3. One was associated with squamous cell carcinoma in situ of the cervix. The 11 patients with SCCP were 27-73 (mean, 56) years old, and one, four, five, and one tumors were stages I, II, III, and IV, respectively. The tumors were 6-26 cm in greatest diameter, usually solid with focal necrosis; one and 10 tumors were grades 2 and 3, respectively. Three patients with SCCP also had cervical squamous cell carcinoma in situ. The patients with SCCE had a poorer overall survival than those with SCCD. Five of the six patients with SCCE for whom adequate follow-up information was available died of their disease (mean survival, 5 months); also, in all five cases of SCCE reported in the literature, the patients died of their disease (mean survival, 4 months). The stage of the tumor and its grade correlated best with overall survival for all three types of SCC.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Squamous Cell Ovarian Neoplasms Adult Adult Aged Aged Carcinoma in Situ Carcinoma in Situ Carcinoma in Situ Carcinoma in Situ Carcinoma, Squamous Cell Carcinoma, Squamous Cell Carcinoma, Squamous Cell Dermoid Cyst Dermoid Cyst Dermoid Cyst Dermoid Cyst Endometriosis Endometriosis Endometriosis

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