Transcriptome analysis of molecular mechanism to pyrethroids resistance in Spodoptera litura

Transcriptome analysis of molecular mechanism to pyrethroids resistance in Spodoptera litura | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Transcriptome analysis of molecular mechanism to pyrethroids resistance in Spodoptera litura Dongzhi Li, Yu Mei, Jianhua Wang, Xiling Chen, Chengju Wang, Li Xu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.9783/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Spodoptera litura is a destructive agricultural pest and had evolved resistance to multiple insecticides, especially pyrethroids. At present, the resistance mechanism to pyrethroids remains unclear. Results Four field-collected populations, namely CZ, LF, NJ and JD, were identified to have high resistance to pyrethroids, and the resistant ratio ranged from 40.8 to 1764.0-fold. To explore pyrethroids resistance mechanism, the transcriptome between pyrethroid-resistant (LF and NJ) and pyrethroid-susceptible (GX) populations were compared by RNA-sequence. Results showed that multiple differential expressed genes were enriched in metabolism-related GO terms and KEGG pathways. 35 up-regulated metabolism-related genes were screened to verify by qRT-PCR. Consistent up-regulation of 13 unigenes, including 3 P450s, 4 GSTs, 1 UGTs, 4 COEs and 1ABC, were verified in the additional pyrethroids resistant populations CZ and JD. The expression level of CYP3 and GST3, which were homologous to CYP321A8 and GST1, respectively, showed good correlation with their pyrethroids resistance level among CZ, LF, NJ and JD populations. While the expression level of CYP12, CYP14, COE4 and ABC5 showed good correlation with their pyrethroids resistance level in at least three populations. UGT5 had the highest expression level among the tested UGT genes in the four pyrethroids resistant populations. Conclusion CYP3, CYP12, CYP14, GST3, COE4, UGT5 and ABC5 play important roles in pyrethroids resistance among the four field-collected populations. Our study provided a valuable resource for further study of pyrethroid resistance mechanisms in S. litura. Epigenetics & Genomics Spodoptera litura pyrethroids resistance mechanism transcriptome metabolism-related Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Background The common cutworm, Spodoptera litura (Fabricius), is a polyphagous agricultural pest worldwide and caused enormous losses to many economical crops like cotton, soybean, tobacco and vegetables. Insecticides resistance developed rapidly in the last decades due to its extensively application. To date, S. litura has evolved high resistance to multiple conventional and new insecticides, which led to both failure control of pest and the destruction of natural enemies [1-6]. Insecticides resistance is the consequence of pest evolutionary adaptation to insecticides selection, a genetic phenomenon, which is conferred by target-site-based resistance (TSR) and non-target-based resistance (NTSR) mechanisms [7]. TSR is endowed by gene mutations in target enzymes, which can be easily detected by sequencing. Multiple mutations in sodium channel conferring resistance to pyrethroid insecticides had been identified in insect species, such as L1014F, L1014S, M918V, L925I, E435K, C785R, P1999L, F1538I, A1410V, M1524I, D1549V, T929I and M918T [8-9]. NTSR is achieved by mechanisms reducing insecticide concentration reaching the target-site, including metabolism-based resistance, which enhanced detoxification rate of insecticide by cytochrome P450 monooxygenase (P450), glutathione S -transferase (GST), carboxylesterases (COE), UDP-glycosyltransferase (UGT) and ATP-binding cassette transporters (ABC) [10]. Synergism is the primary step to identify the involvement of metabolism-related enzyme by piperonyl butoxide (PBO), diethyl maleate (DEM) and S,S,S-tributylphosphorothioate (DEF), which are inhibitors of P450, GST and COE, respectively [7]. The determination of putative gene expression and detoxification enzyme activity is also employed to explore the mechanism of metabolism-based resistance. However, these methods only establishing the resistance phenotype is metabolic involved, fails to comprehensively identify the individual genes responsible for insecticide resistance. The transcriptome is the complete set of all transcripts within a cell or tissue, that reflect the mRNA expression levels of different genes in a given sample [11]. RNA-Sequence (RNA-Seq) provided opportunity for the comprehensive analysis of pest transcriptome without reference genome in greater depth than ever before [12]. Although multiple researches have investigated the resistance of S. litura to various insecticides, molecular mechanism of metabolic resistance in S. litura is still not well defined due to lack of detailed genetic and sequence information [13-14]. In addition, pyrethroid insecticides were widely applied to control S. litura and other agricultural pests, for its high efficiency and low toxicity to mammalian animals. Yet excessive usage has imposed pyrethroids resistance the most severe situation [15]. To minimize the evolution of resistance and prolong the life time of insecticide, the molecular mechanisms for pyrethroids resistance in this pest should be declared. In this study, RNA-seq was performed by Illumina HiSeq™ 2000 sequencing platform and the transcriptome of pyrethroid-resistant and pyrethroid-susceptible populations were compared to provide new insights into mechanism of metabolism-based resistance to pyrethroids in S. litura . Results Toxicity of insecticides to S. litura Eleven insecticides were chosen to test the toxicity to the larvae of GX, LF and NJ populations. High level resistance to fenvalerate, beta-cypermethrin and cyhalothrin were found, which were 809.5-, 141.3-, 1764.0-fold in LF population and 322.0-, 40.8-, 951.0-fold in NJ population, respectively, compared with that in GX population (Table 1-3). LF and NJ populations showed no resistance to phoxim, profenofos, chlorpyrifos and emamectin benzoate, with resistance ratio (RR) lower than 5.0-fold. However, low resistance had been developed to chlorantraniliprole, bromine cyantraniliprole, imidacloprid and methomyl, with RR ranged from 4.0 to 19.8-fold. The results above indicated that field-collect populations of S. litura had high level resistance to pyrethroid, which was urgent to be managed. (Table 1-3 Insert here) To determine the involvement of detoxification enzyme for pyrethroids resistance in S. litura , the synergists of P450, COE and GST, namely PBO, DEF and DEM, were used before pyrethroids treatment. Results showed that PBO increased pyrethroids toxicity distinctly in both LF and NJ populations, while DEF and DEM increased fenvalerate and cyhalothrin toxicity slightly and had no influence on beta-cypermethrin toxicity (Figure 1). (Figure 1 Insert here) Illumina sequencing and reads assembly RNA-Seq was conducted with three cDNA libraries of GX, LF and NJ populations, respectively. Clean reads ranging from 51429712 to 60901328 per cDNA library were obtained by removing reads containing adapter, ploy-N and low quality reads from raw data (Table 4). According to the sequence analysis, almost 97% raw reads had Phred-like quality score at the Q20 level (an error probability of 1%), with GC content around 47%. Clean reads were used to assemble 140003 transcripts and 82014 unigenes ranging from 201 to 29587 bp (Table 5). Pearson correlation coefficients of different RNA samples in the same population ranged from 0.868 to 0.916, which was higher than 0.525 to 0.648 between different populations (Additional file 1). (Table 4-5 Insert here) Functional annotation of unigenes Seven databases, (NCBI non-redundant protein sequences database (Nr), NCBI non-redundant nucleotide sequences data-base (Nt), Pfam (Protein family), KOG/COG (Clusters of Orthologous Groups of proteins), Swiss-port, KyotoEncyclopedia of Genes and Genomes (KEGG) and Geneontology (GO) database) were used for unigenes functional annotation. There are 47185 (57.53%) unigenes annotated in at least one databases, and 8974 (10.94%) unigenes annotated in all databases. Among the annotated unigenes, 50.24% hit in Nr database, 39.15% in GO database and 38.87% in Pfam database (Table 6). More than 90% annotated unigenes had nucleotides similarity above 60% (Additional file 2). The results of Nr database annotation indicated that S. litura has 41.3% sequence similarity to Bombyx mori , 16.2% to Danaus plexippus , 14.1% to Plutella xylostella , 1.9 % to Helicoverpa armigera and 1.6% to Papilio xuthus (Additional file 3). (Table 6 Insert here) GO assignments were used to predict gene function. Total 82014 unigenes were classified into 54 subgroups, including molecular function (MF), biological process (BP) and cellular component (CC). In BP, cellular process was the largest subgroup, followed by metabolic process and single-organism process. In CC, the largest two subgroups were cell and cell part, respectively. For MF, binding and catalytic activity formed the largest two subgroups (Figure 2). (Figure 2 Insert here) KEGG database was used for understanding high-level functions and utilities of the biological system from molecular-level information. 20164 unigenes were divided into five groups, among which 5622 unigenes (27.88%) were involved in organism systems; 5563 unigenes (27.59%) were involved in metabolism; 3023 unigenes (14.99%) were involved in environmental information processing; 3002 unigenes (14.89%) were involved in cellular processes; 2954 unigenes (14.65%) were involved in genetic information processing (Figure 3). (Figure 3 Insert here) Differential gene expression among LFvsGX and NJvsGX groups In order to explore the molecular mechanism of pyrethroid resistance, differentially expressed genes (DEGs) were selected according to q -value1. Compared with the transcriptome of GX population, there are 18043 DEGs (10063 up-regulated and 7980 down-regulated) in LF population and 20370 DEGs (11147 up-regulated and 9223 down-regulated) in NJ population, respectively. And 11739 DEGs were found involved in both LFvsGX and NJvsGX groups, including 5720 up-regulated and 5442 down-regulated genes (Additional file 4). GO and KEGG enrichment of the DEGs To further analysis the function of DEGs, GO and KEGG enrichment analysis were conducted. According to GO enrichment, the up-regulated unigenes in LFvsGX group were enriched into multiple GO terms belonging to 20 BP, 5 CC and 20 MF; while 20 BP and 20 MF in NJvsGX group. In BP, the top three largest GO terms were metabolic process, single-organism process and oxidation-reduction process in both LFvsGX and NJvsGX groups. In MF, the top three largest GO terms were catalytic activity, hydrolase activity and oxidoreductase activity in LFvsGX group, while catalytic activity, oxidoreductase activity and peptidase activity in NJvsGX group (Figure 4). (Figure 4 Insert here) Much less unigenes were significantly enriched in the down-regulated GO terms in both LFvsGX and NJvsGX groups, including chitin metabolic process and chitin binding, which indicated that different epidermal penetration rate may be involved in pyrethroid resistant S. litura populations (Figure 5). (Figure 5 Insert here) Among the top-twenty enriched KEGG pathway terms in LFvsGX and NJvsGX groups, fourteen terms were shared in both groups, including metabolism of xenobiotics by cytochrome P450 and drug metabolism-cytochrome P450 pathways (figure 6). The results of GO and KEGG enrichment suggested that metabolism was the main enriched terms of DEGs and should be a main reason of pyrethroids resistance in S. litura. (Figure 6 Insert here) Validation of the candidate DEGs Based on the high reading count and significant high expression level in RNA-Seq, 14 P450, 5 COE, 5 GST, 5 UGT and 6 ABC up-regulated unigenes were screened out and validated by qRT-PCR. Among the 35 selected DEGs, 30 unigenes (including 14 P450, 5 GST, 5 UGT, 4 COE, and 1 ABC) were both significantly up-regulated by qRT-PCR validation in LFvsGX and NJvsGX groups (Table 7). CYP12 (annotated as CYP6AE43) had the highest expression level among all the P450 unigenes, with 358.27-fold in LF and 237.95-fold in NJ population. UGT5 (annotated as UGT33T2) had the highest expression level among all the UGT unigenes, with 309.49-fold in LF and 3236.54-fold in NJ population. (Table 7 Insert here) The expression of candidate DEGs in additional two field populations CZ and JD are another two field populations with high resistance level to pyrethroid insecticides. Compared with GX population, CZ showed 84.5-fold resistance to fenvalerate, 11.5-fold resistance to beta cypermethrin and 678.5-fold resistance to cyhalothrin (Table 8), while JD showed 9123.5-fold resistance to fenvalerate, 642.0-fold resistance to beta cypermethrin and 6986.0-fold resistance to cyhalothrin (Table 9). (Table 8-9 Insert here) Based on the RR values, resistance level of JD>LF>NJ>CZ>GX could be concluded. To further validate candidate DEGs, the expression level of the up-regulated DEGs in LF and NJ populations were also determined by qRT-PCR in CZ and JD populations. Results indicated that 13 unigenes (CYP3, CYP12, CYP14, GST1, GST2, GST3, GST4, UGT5, COE1, COE2, COE4, COE5 and ABC5) were also significantly higher expressed in the two additional populations. UGT5 had the highest expression level among all the tested UGT genes in the four pyrethroids resistant populations. The expression level of CYP3 and GST3 among the four field-collected populations conformed well with their pyrethroid resistance level. While the expression level of CYP12, CYP14, COE4 and ABC5, showed good correlation with their pyrethroids resistant level in at least three field-collected populations (Table 10). (Table 10 Insert here) Disscusion Insecticides continue to be key weapon for insect control in agriculture. However, the evolution of insecticides resistance due to strong selection imposed by widespread insecticides usage threatens the weapons’ availability. Studying the molecular mechanism of insecticides resistance, especially for metabolism-based resistance, provides valuable insights into how genetic, physiological and biochemical changes in insects and opens windows for improving future pest control. In the present study, the transcriptome of GX, NJ and LF populations were sequenced by Illumina platform with high criteria of data quality (Table 4), enabling assembling of 140003 transcripts and 82014 unigenes (Table 5-6). GO and KEGG enrichment analysis of DEGs indicated that LF and NJ populations have relative high ability in oxidation-reduction activity, hydrolase activity and P450 involved metabolic process than GX population (Figure 4, 6). Recently, Cheng et al. [16] conducted the genome sequencing of S. litura , and 138 P450, 47 GST, 110 COE and 54 ABC genes were annotated, which was consistent with our transcriptome results (Table 11). In addition, the validation of genes expression level showed that RNA-Seq results were well coincident with that of qRT-PCR (Table 10). Therefore, the RNA-Seq results were reliable and this information will facilitate further researches on pyrethroids resistance and other physiological processed in S. litura . (Table 11 Insert here) Bioassay result in LF and NJ populations of S. litura showed high level resistance to fenvalerate, beta cypermethrin and cyhalothrin (Table 1-3). However, resistance to beta cypermethrin was much lower than that to fenvalerate and cyhalothrin in both LF and NJ populations, which might result from different sets of detoxification enzymes to each insecticide. No cross-resistance between organophosphates and pyrethroids was found in LF or NJ populations, which is similar with the result reported by Huang et al [13]. While Tong et al.found high level resistance to both organophosphates and pyrethroids in five field S. litura populations during 2010 to 2012 [14]. This opposite phenomenon could be explained by metabolic-based activation and passivation of insecticides. Multiple studies had revealed a direct link between elevated P450 activities and organophosphate and pyrethroids resistances in insects [17]. However, some P450s can also be involved in the activation of insecticides, chemically modifying insecticides to biologically active forms, as is the case for some organophosphorus insecticides [7]. For example, chlorpyrifos can be converted to chlorpyrifos-oxon by P450 and chlorpyrifos-oxon is 100-fold toxicity than chlorpyrifos [18-19]. Thus different sets of up-regulated P450s in insects could cause cross resistance or negative cross resistance between organophosphates and pyrethroids. Cytochrome P450 monooxygenases can mediate resistance to most insecticides for their genetic diversity, broad substrate specificity and catalytic versatility. Go enrichment of up-regulated DEGs in LFvsGX and NJvsGX groups showed that oxidation-reduction process and metabolic process were significantly enriched (Figure 4). Furthermore, P450s involved metabolism of xenobiotics and drug metabolism pathways were also enriched in KEGG enrichment analysis (Figure 6). Besides, P450s inhibitor (PBO) significantly increased the toxicity to pyrethroids in LF and NJ populations (Figure 1). Therefore, up-regulated P450s should be the major reason for pyrethroids resistance in LF and NJ populations. The qRT-PCR results indicated that most selected P450 genes were significantly over expressed in the four resistant populations, especially for CYP2, CYP3, CYP10, CYP12 and CYP14 (Table 10). Furthermore, the expression level of CYP3, CYP12 and CYP14, which were annotated as CYP321A8, CYP6AE43 and CYP6AB31, respectively, showed good correlation with pyrethroids resistance level among GX, CZ, NJ, LF and JD populations. CYP321A8 and CYP6AB31 could be induced by deltamethrin, lambda-cyhalothrin and lambda-cyhalothrin, respectively, and had high expression level in midgut and fat body [20-22]. CYP6AE43 of S. frugiperda could only be detected in the midgut and malpighian tubules [23].However, there is building evidence that the key tissues for the metabolism of most compounds are midgut, malpighian tubules and fat body [23-24]. Therefore, P450 genes that had higher expression levels in these tissues may be involved in xenobiotic detoxification. Hence, most up-regulated P450s might be the set of pyrethroids detoxified genes in S. litura , especially for CYP3, CYP12 and CYP14 in consideration of the higher expression level and detoxify function. COE were classified as Phase I detoxification enzymes and perform hydrolysis reaction at the first step of detoxification. It has been demonstrated that COE were involved in insecticide resistance, especially for organophosphates, pyrethroids and carbamates [25]. For instance, the over-expression of carboxylesterase E4 in Myaus persicae enhanced degradation and sequestration of pyrethroids, organophosphates and carbamates [26]. According to Go enrichment analysis of up-regulated DEGs, hydrolase activity was enriched in LF and NJ populations (Figure 4). Validation in qRT-PCR revealed that the 4 selected COEs were higher expressed in resistance populations, especially for COE4 (Table 10). Although only slight synergism to fenvalerate and cyhalothrim by DEF was observed (Figure 1), COE may also play an important role in pyrethroids resistance in consideration of the enrichment analysis and high expression level in the four resistance populations. The products of Phase I reactions often become substrates for Phase II enzymes, such as GST and UGT, that add glutathione and glycosyl groups, respectively. Insect GSTs are a superfamily of detoxification enzymes and had been reported to be associated with resistance to pyrethroids, organophosphorus and organochlorine insecticides [27].In contrast to organochlorine and organophosphorus resistance, GSTs are not involved in the direct metabolism of pyrethroids but rather are involved in the sequestration of pyrethroids and/or the detoxification of lipid peroxidation products induced by pyrethroids [28-29]. Functional study of GSTs in Nilaparvata lugens showed that NlGSTD1 had peroxidase activity and confers pyrethroids resistance via gene amplification [29]. Two S. litura GST ( Slgste2 and Slgste3 ) were reported to be induced by carbaryl, Bt and DDT, which suggested that Slgste2 and Slgste3 may play roles in detoxifying various insecticides in S. litura [30].Here, total 32 GSTs were annotated and mapped in S. litura , and 23 GST genes had high expression level in both LF and NJ populations. GST3, which was annotated as GST1 and showed good correlation with the resistance level among the four resistant populations, was reported to possess high binding activities to deltamethrin [31], indicating the role of higher expression levels of GSTs in pyrethroids resistance in S. litura . UGT mediated glycoside conjugation is an important metabolic pathway for the biotransformation of multiple lipophilic endogenous and exogenous compounds, including insecticides. Kaplanoglu et al. demonstrated that silencing of CYP4Q3 and UGT2 significantly increased susceptibility of resistant beetles to imidacloprid, indicating that over-expression of these two genes contributes to imidacloprid resistance [32]. UGT5, annotated as UGT33T2, was significantly over expressed and had the highest expression level among the tested UGT genes in the four pyrethroids resistant populations. The involvement of UGT5 in pyrethroids resistance needs to be further studied. Majority ABC proteins function as primary-active transporters that bind and hydrolyze ATP while transporting a large diversity of substrates across lipid membranes. Bariami et al. showed that ABCB4 was up-regulated in a pyrethroids resistant strain of A. aegypti [33]. RNA-seq analysis and qRT-PCR revealed that four ABC transporters were up-regulated in a deltamethrin resistant strain of Cimex lectularius and RNAi mediated knockdown of these ABC genes resulted in an increased susceptibility to betacyfluthrin in deltamethrin resistant female bed bugs [34]. Among the 6 selected ABC unigenes, only ABC5 (annotated as ABCB3) was significantly up-regulated in the four pyrethroids resistant populations, which indicated a possible role of ABC5 in pyrethroids resistance. Decreased penetration rate was well documented to be involved in insecticides resistance [35]. Here, it was also cued by our GO enrichment results, where the down-regulated DEGs was enriched in chitin metabolism process, chitin binding, and structure constitutent of cuticle term (Figure 5, Additional file 5). Conclusions A comprehensive comparison of metabolism related genes expression profiles between pyrethroid-resistant and pyrethroid-susceptible populations had been conducted by RNA-Seq and qRT-PCR. Metabolism-based resistance to pyrethroids was in a serious situation in S. litura and over-expressed P450s was the major reason for pyrethroids resistance based on the synergism experiments and enrichment analysis of DEGs. Other metabolism related genes like GSTs, COEs, UGTs and ABC transporters were also involved in pyrethroids resistance for their higher expression level in several resistant populations. Besides, different insecticide penetration may also account for pyrethroids resistance in S. litura for the down-regulated DEGs enriched in chitin metabolism process. And CYP3, CYP12, CYP14, GST3, UGT5, COE4 and ABC5 were the most valuable genes for further functional identification as their expression level showed good correlation with pyrethroids resistant level among the tested populations and the high expression level. Constitutive over-expression of multiple CYPs, COEs, GSTs, UGTs, and ABC transporters is associated with neonicotinoid resistance in the whitefly, Bemisia tabaci [36], Lygus lineolaris [37], and Aphis gossypii [38]as well as pyrethroids resistance in the house fly, Musca domestica [39]. Our study provides a comprehensive understanding that CYPs, COEs, GSTs, UGTs, and ABC transporters may associated with pyrethroids resistance in S. litura , which will greatly extend our understanding of metabolism-based insecticide resistance mechanism, and facilitate the further identification of pyrethroids resistance involved genes. Methods Insect culture and bioassay GX population of S. litura was kindly provided by Guangxi Tianyuan Biochemistry Corp., Ltd and served as susceptible population. It had been reared on artificial diet in the laboratory without exposure to any insecticide for more than 70 generations. LF, NJ, CZ and JD populations were collected from Langfang, Hebei province, Nanjing, Changzhou, Jiangsu province, and Shanghai respectively. The rear condition was 26±1℃and 60-70% relative humidity with a 14:10 h of light:dark photoperiod. Insecticides were diluted to 7 concentrations and 36 larvae were included in each concentration. One microlitre insecticide in acetone was applied on the thoracic dorsum of the third instars larvae by Hamilton syringe. For synergism experiments, PBO, DEF, and DEM were applied 1 h before insecticide treatment at 10 μg larva -1 (dissolved in acetone), respectively, and pyrethroid insecticides were applied at the tenth of LD 50 . Control groups were applied with PBO, DEF, DEM alone. Larvae were held individually in a 12-well tissue culture plates with artificial diet and the mortality was checked 48 or 72 h after treatment. RNA extraction and quality determination Total RNA was extracted from the third instars larvae (18 larvae per group) using TaKaRa MiniBEST Universal RNA Extraction Kit (Takara) according to the manufacturer’s instructions. The integrity and quality of the total RNA were examined by RNA Nano 6000 Assay Kit, Agilent 2100 and 1% agarose gels. Three biological replicates were prepared in each population. Library preparation for transcriptome sequencing Total 3 µg RNA per sample was used as input material for RNA sample preparations. Sequencing libraries were generated using NEBNext ® Ultra™ RNA Library Prep Kit for Illumina ® (NEB, USA) following manufacturer’s recommendations. Briefly, mRNA was purified from total RNA using poly-T oligo-attached magnetic beads. First strand cDNA was synthesized using random hexamer primer and M-MuLV Reverse Transcriptase (RNase H - ). Second strand cDNA synthesis was subsequently performed using DNA Polymerase I and RNase H. To select cDNA fragments of preferentially 150-200 bp in length, the library fragments were purified with AMPure XP system (Beckman Coulter, Beverly, USA) and library quality was assessed on the Agilent Bioanalyzer 2100 system. The clustering of the index-coded samples was performed on a cBot Cluster Generation System using TruSeq PE Cluster Kit v3-cBot-HS (Illumina) according to the manufacturer’s instructions. After cluster generation, nine libraries (GX1, GX2, GX3, LF1, LF2, LF3, NJ1, NJ2, NJ3) preparations were sequenced on an Illumina Hiseq platform and paired-end reads were generated (Novogene, China). Quality control, Transcriptome assembly and Gene functional annotation Clean data were obtained by removing reads containing adapter, reads containing ploy-N and low quality reads from raw data. Q20, Q30, GC-content and sequence duplication level of the clean data were calculated and all the downstream analyses were conducted based on clean data with high quality. Transcriptome assembly was accomplished using Trinity [40] with min_kmer_cov set to 2 by default and all other parameters set default. Gene function was annotated based on Nr, Nt, Pfam, Swiss-Prot database and KOG/COG, with a significant threshold of E-value ≤ 10 -5 . The GO terms for functional categorization were analyzed using Blast2go software with the E-value threshold ≤ 10 -6 . The pathway assignments were carried out by sequence searches against the KEGG database, with the E-value threshold ≤ 10 -10 . Differential expression analysis of unigenes Differential expression analysis between the three populations was performed using the DESeq R package (1.10.1). DESeq provide statistical routines for determining differential expression in digital gene expression data using a model based on the negative binomial distribution. The resulting P values were adjusted using the Benjamini and Hochberg’s approach for controlling the false discovery rate. Genes with an adjusted p -value<0.05 found by DESeq were assigned as differentially expressed. GO enrichment analysis of the DEGs was implemented by the GOseq R packages based on Wallenius non-central hyper-geometric distribution [41]. KOBAS software was used to test the statistical enrichment of DEGs in KEGG pathways [42]. Validation of the RNA-Seq DEGs To validate the transcriptional results from RNA-Seq and computational analysis, 35 unigenes were selected for quantitative RT-PCR (qRT-PCR). EF1α and RPL10 were used as housekeeping genes to normalize the expression of each gene [43].First strand cDNA was synthesized from 1 μg total RNA using FastQuant RT Kit (With gDNase) (TIANGEN, Beijing, China) according to the manufacturer’s protocol. Primers were designed based on the measured mRNA sequences using Primer Premier 5.0 software and are summarized in Additional file 6. SuperReal PreMix Plus (SYBR Green, TIANGEN, Beijing, China) was used in a 20 μl system with 2×Super real SYBR Mix (10 μl), cDNA (1 μl), 50×ROX (0.4 μl) and each primer (0.6 μL, 10 μM) by ABI Prism 7500 Real-Time PCR System (Applied Biosystems by Life Technologies, Foster, CA, USA). Thermal cycling was run at 95℃ for 15 min, followed by 40 cycles of 95℃ for 10 s and 60℃ for 32 s. A melting curve was added as a final step to make sure the PCR product was unique and specific. Each test was repeated with 3 independent mRNA samples and each reaction was carried out in triplicate. Statistical analysis The data of bioassay was analyzed with SPSS 16.0 (SPSS, Chicago, IL, USA). The results of qRT-PCR were calculated with the Ct value on 7500 software v2.3 (Applied Biosystems by Life Technologies, Foster, CA, USA) according to the 2 - △△ Ct method. Student t-test was performed to analyze the statistical difference between means. A p -value<0.05 was considered statistically significant. Abbreviations ABC, ATP-binding cassette transporters; BP, biologic process; CC, cellular component; DEF, S,S,S-tributylphosphorothioate; DEGs, differentially expressed genes; DEM, diethyl maleate; COE, carboxylesterases; GO, gene ontology; GST, glutathione S-transferase; KEGG, Kyoto encyclopedia of genes and genomes; KOG/COG, clusters of orthologous groups of proteins; MF, molecular function; NCBI, National Center for Biotecnology Information; Nr, NCBI non-redundant protein sequences database; Nt, NCBI non-redundant nucleotide sequences database; NTSR, non-target-site based resistance; P450, cytochrome P450 monooxygenase; PBO, piperonyl butoxide; Pfam, protein family; RR, resistance ratio; RNA-Seq, RNA-sequence; SRA, sequence read archive; TSR: target-based resistance; UGT, UDP-glycosyltransferase. Declarations Acknowledgements This work was supported by The National Natural Science Foundation of China (No. 31801765). Availability of data and materials The datasets supporting the conclusions of this article are included within the article and its additional files. The raw Illumina sequence reads have been deposited in the NCBI Sequence Read Archive (SRA) database with accession number PRJNA541123. Authors’ contributions This study was designed and performed by DZL and LX. DZL analyzed the sequencing data, performed qRT-PCR validations and wrote the manuscript. The collection of insect materials was conducted by YM and JHW. XLC and CJW provided helpful suggestion in data analysis and manuscript revision. All authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Ethics approval and consent to participate This research did not involve any human subjects, human material, or human data. S. litura in current research did not belong to the endangered or protected species. References 1. Rao GR, Dhingra S. Shift in the susceptibility level of Spodoptera litura (Delhiand Guntur populations) to cypermethrin and fenvalerate. J Entomol Res. 1996;20:225-227. 2. Armes NJ, Wightman JA, Jadhav DR, Ranga Rao GV. Status of insecticide resistance in Spodoptera litura in Andhra Pradesh India. Pestic Sci. 1997;50:240-248. 3. Ahmad M, Arif I, Ahmad M. Occurrence of insecticide resistance in field populations of Spodoptera litura (Lepidoptera: Noctuidae) in Pakistan. Crop Prot. 2007; 26:807-809. 4. Ahmad M, Sayyed AH, Saleem MA. Evidence for field evolved resistance to newer insecticides in Spodoptera litura (Lepidoptera: Noctuidae) from Pakistan. Crop Prot. 2008; 27:1367-1372. 5. Saleem M, Hussain D, Ghouse G, Abbas M, Fisher SW. Monitoring of insecticide resistance in Spodoptera litura (Lepidoptera: Noctuidae) from four districts of Punjab, Pakistan to conventional and new chemistry insecticides. Crop Prot. 2016;79:177-184. 6. Wan P, Wu KM, Huang MS, Yu DZ, Wu JP. Population dynamics of Spodoptera litura (Lepidoptera: Noctuidae) on Bt cotton in the Yangtze River Valley of China. Environ. Entomol. 2008; 37:1043-1048. 7. Perry T, Batterham P, Daborn PJ. The biology of insecticidal activity and resistance. Insect Biochem Mol Biol. 2011;41:411-422. 8. Soderlund DM, Knipple DC. The molecular biology of knockdown resistance to pyrethroid insecticides. Insect Biochem Mol Biol. 2003;33:563-577. 9. Vais H, Williamson MS, Devonshire AL, Usherwood PN. The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Pest Manage Sci. 2001; 57:877-888. 10. Bajda S, Dermauw W, Greenhalgh R, Nauen R, Tirry L, Clark RM, Leeuwen TV. Transcriptome profiling of a spirodiclofen susceptible and resistant strain of the European red mite Panonychus ulmi using strand-specific RNA-seq. BMC Genomics, 2015;16:974-999. 11. Van Emon J. The Omics Revolution in Agricultural Research. J Agric Food Chem. 2016;64:36-44. 12. Varshney RK, Nayak SN, May GD, Jackson SA. Next-generation sequencing technologies and their implications for crop genetics and breeding. Trends Biotechnol. 2009;7:522-530. 13. Huang S, Xu J, Han Z. Baseline toxicity data of insecticides against the common cutworm Spodoptera litura (Fabricius) and a comparison of resistance monitoring methods. Int J Pest Manage. 2006;52:209-213. 14. Tong H, Su Q, Zhou X, Bai L. Field resistance of Spodoptera litura (Lepidoptera: Noctuidae) to organophosphates, pyrethroids, carbamates and four newer chemistry insecticides in Hunan, China. J Pest Sci. 2013; 86:599-609. 15. Shad SA, Sayyed AH, Fazal S, Saleem MA, Zaka AM, Ali M. Field evolved resistance to carbamates, organophosphates, pyrethroids, and new chemistry insecticides in Spodoptera litura Fab. (Lepidoptera: Noctuidae). J Pestic Sci. 2012; 85:153-162. 16. Cheng TC, Wu JQ, Wu YQ, Chilukuri RV, Huang LH, Yamamoto K. et al. Genomic adaptation to polyphagy and insecticides in a major East Asian noctuid pest. Nat. Ecol. & Evol. 2017; DOI: 10.1038/s41559-017-0314-4. 17. Oakeshott JG, Farnsworth CA, East PD, Scott C, Han YC, Wu YD, Russell RJ. How many genetic options for evolving insecticide resistance in heliothine and spodopteran pests? Pest Manage Sci. 2013; 69:889-896. 18. Fujioka K, Casida JE. Glutathione S -transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives. Chem Res Toxicol. 2007;20:1211-1217. 19. Monnet-Tschudi F, Zurich MG, Schilter B. Maturation-dependent effects of chlor-pyrifos and parathion and their oxygen analogs on acetyl-cholinesterase and neuronal and glial markers in aggregating brain cell cultures. Toxicol Appl Pharmacol. 2000;165:175-183. 20. Wang RL, Staehelin C, Xia QQ, Su YJ, Zeng RS. Identification and Characterization of CYP9A40 from the Tobacco Cutworm Moth ( Spodoptera litura ), a Cytochrome P450 Gene Induced by Plant Allelochemicals and Insecticides. Int J Mol Sci. 2015;16:22606-22620. 21. Wang RL, He YN, Staehelin C, Liu SW, Su YJ, Zhang JE. Identification of two cytochrome monooxygenase P450 genes, CYP321A7 and CYP321A9 , from the tobacco cutworm moth ( Spodoptera litura ) and their expression in response to plant allelochemicals. Int J Mol Sci. 2017;18:2278-2289. 22. Hu B, Zhang SH, Ren MM, Tian XR, Wei Q, Mburu DK, Su JY. The expression of Spodoptera exigua P450 and UGT genes: tissue specificity and response to insecticides. Insect Sci. 2017;doi:10.1111/1744-7917.12538. 23. Giraudo M, Hilliou F, Fricaux T, Audant P, Feyereisen R, Goff GL. Cytochrome P450s from the fall armyworm ( Spodoptera frugiperda ): responses to plant allelochemicals and pesticides. Insect Mol Biol. 2015;24:115-128. 24. Scott JG. Insect cytochrome P450s: Thinking beyond detoxification. Recent Advances in Insect Physiology. Toxicol Mol Biol. 2008; 117-124. 25. Oakeshott JG, Claudianos C, Campbell PM, Newcomb RD, Russell RJ. In Biochemical genetics and genomics of insect esterases; Publisher: Elsevier BV, 2005;5:309-381. 26. Field LM, Devonshire AL. Evidence that the E4 and FE4 esterase genes responsible for insecticide resistance in the aphid Myzus persicae (Sulzer) are part of a gene family.Biochem J. 1998;330:169-173. 27. Li XC, Schuler MA, Berenbaum MR. Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics. Annu Rev Entomol. 2007;52:231-253. 28. Vontas JG, Small GJ, Hemingway J. Glutathione S -transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens . Biochem J. 2001; 357:65-72. 29. Vontas JG, Small GJ, Nikou DC. Purification, molecular cloning and heterologous expression of a glutathione S -transferase involved in insecticide resistance from the rice brown plan thopper, Nilaparvata lugens . Biochem J. 2002;362:329-337. 30. Deng HM, Huang YF, Feng QL, Zheng SC. Two epsilon glutathione S -transferase cDNAs from the common cutworm, Spodoptera litura : characterization and developmental and induced expression by insecticides. J Insect Physiol. 2009;55: 1174-1183. 31. Xu ZB, Zou XP, Zhang N, Feng QL, Zheng SC. Detoxification of insecticides, allechemicals and heavy metals by glutathione S-transferase SlGSTE1 in the gut of Spodoptera litura . Insect Science. 2015; 22:503-511. 32. Kaplanoglu E, Chapman P, Scott IM, Donly C. Overexpression of a cytochrome P450 and a UDP-glycosyltransferase is associated with imidacloprid resistance in the Colorado potato beetle, Leptinotarsa decemlineata . Sci Rep. 2017;DOI:10.1038/s41598-017-01961-4. 33. Bariami V, Jones CM, Poupardin R, Vontas J, Ranson H. Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethroid resistance in the dengue vector, Aedes aegypti . PLoS Neglected Trop Dis. 2012;6:e1692. 34. Zhu F, Gujar H, Gordon JR, Haynes KF, Potter MF, Palli SR. Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides. Sci Rep. 2013;3:1456-1463. 35. Strycharz JP, Lao A, Li HM, Qiu XH, Lee SH, Sun WL. Resistance in the highly DDT-resistant 91-R strain of Drosophila melanogaster involves decreased penetration, increased metabolism, and direct excretion. Pestic Biochem Physiol. 2013;107:207-217. 36. Yang N, Xie W, Yang X, Wang SL, Wu QJ, Li R. et al. Transcriptomic and proteomic responses of sweet potato whitefly, Bemisia tabaci , to thiamethoxam. PLoS One. 2013;8:e61820. 37. Zhu YC, Luttrell R. Altered gene regulation and potential association with metabolic resistance development to imidacloprid in the tarnished plant bug, Lygus lineolaris . Pest Manage Sci. 2015;71: 40-57. 38. Pan Y, Peng TF, Gao XW, Zhang L, Yang C, Xi JH. et al. Transcriptomic comparison of thiamethoxam-resistance adaptation in resistant and susceptible strains of Aphis gossypii Glover. Comp Biochem Physiol., Part D: Genomics Proteomics. 2015; 13:10-15. 39. Gao Q, Li M, Sheng C, Scott JG, Qiu XH. Multiple cytochrome P450s overexpressed in pyrethroid resistant house flies ( Musca domestica ). Pestic Biochem Physiol. 2012;104:252-260. 40. Grabherr MG, Haas BJ, Yassour M, Levin JZ, Thompson DA, Amit I. et al. Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol. 2011;20:644-652. 41. Young MD, Wakefield MJ, Smyth GK, Oshlack A. Gene ontology analysis for RNA-seq: accounting for selection bias. Genome Biol. 2010;11:1-12. 42. Mao X, Cai T, Olyarchuk JG, Wei L. Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary. Bioinf. 2005;21:3787-3793. 43. Lu Y, Yuan M, Gao X, Kang T, Zhan S, Wan H, Li J. Identification and Validation of Reference Genes for Gene Expression Analysis Using Quantitative PCR in Spodoptera litura (Lepidoptera: Noctuidae). PLoS One. 2013;8:e68059. Tables Table 1. Toxicity of different insecticides to GX population Insecticides GX Slope (SE) LD 50 (95% FI) (µg/larva) R 2 RR Fenvalerate 2.592 (0.289) 0.004 (0.003-0.005) 0.951 1.0 Beta cypermethrin 3.238 (0.364) 0.004 (0.002-0.011) 0.833 1.0 Cyhalothrin 2.346 (0.274) 0.002 (0.001-0.002) 0.957 1.0 Phoxim 2.238 (0.334) 0.219 (0.122-0.540) 0.879 1.0 Profenofos 3.226 (0.508) 0.065 (0.052-0.080) 0.979 1.0 Chlorpyrifos 1.617 (0.286) 0.243 (0.175-0.349) 0.948 1.0 Chlorantraniliprole 3.848 (0.586) 0.001 (0.001-0.002) 0.970 1.0 Bromine cyantraniliprole 1.064 (0.157) 0.002 (0.001-0.003) 0.938 1.0 Imidacloprid 1.882 (0.273) 0.573 (0.425-0.784) 0.965 1.0 Methomyl 1.743 (0.367) 0.010 (0.004-0.015) 0.853 1.0 Emamectin benzoate 1.524 (0.440) 0.011 (0.004-0.016) 0.798 1.0 Resistance ratio (RR) = LD 50 value of field population/ LD 50 value of GX population Table 2. Toxicity of different insecticides to LF population Insecticides LF Slope (SE) LD 50 (95% FI) (µg/larva) R 2 RR Fenvalerate 1.312 (0.302) 3.238 (1.933-4.804) 0.925 809.5 Beta cypermethrin 1.962 (0.290) 0.565 (0.410-0.753) 0.929 141.3 Cyhalothrin 1.063 (0.223) 3.528 (2.129-5.941) 0.971 1764.0 Phoxim 1.752 (0.298) 0.092 (0.058-0.128) 0.978 0.4 Profenofos 4.018 (0.659) 0.118 (0.096-0.143) 0.999 1.8 Chlorpyrifos 1.879 (0.375) 0.086 (0.039-0.129) 0.933 0.4 Chlorantraniliprole 1.777 (0.267) 0.004 (0.003-0.005) 0.960 4.0 Bromine cyantraniliprole 1.583 (0.261) 0.011 (0.008-0.017) 0.997 5.5 Imidacloprid 3.120 (0.487) 3.298 (2.604-4.126) 0.991 5.8 Methomyl 1.250 (0.178) 0.048 (0.008-0.168) 0.830 4.8 Emamectin benzoate 1.090 (0.253) 0.028 (0.008-0.052) 0.981 2.6 Table 3. Toxicity of different insecticides to NJ population Insecticides NJ Slope (SE) LD 50 (95% FI) (µg/larva) R 2 RR Fenvalerate 1.330 (0.339) 1.288 (0.379-2.172) 0.981 322.0 Beta cypermethrin 1.679 (0.351) 0.163 (0.073-0.249) 0.901 40.8 Cyhalothrin 1.347 (0.264) 1.902 (1.176-2.927) 0.990 951.0 Phoxim 2.911 (0.410) 0.121 (0.095-0.151) 0.986 0.6 Profenofos 2.120 (0.451) 0.253 (0.172-0.343) 0.969 3.9 Chlorpyrifos 2.125 (0.297) 0.095 (0.072-0.126) 0.957 0.4 Chlorantraniliprole 1.662 (0.254) 0.005 (0.003-0.007) 0.978 5.0 Bromine cyantraniliprole 1.329 (0.236) 0.017 (0.011-0.027) 0.898 8.5 Imidacloprid 1.210 (0.462) 11.33 (5.887-66.473) 0.920 19.8 Methomyl 1.985 (0.326) 0.077 (0.057-0.115) 0.962 7.7 Emamectin benzoate 1.952 (0.293) 0.030 (0.021-0.041) 0.976 2.7 Table 4. The sequencing data quality of nine S. litura samples Sample Raw Reads Clean Reads Clean Bases (G) Error (%) Q20 a (%) Q30 b (%) GC Content (%) GX1 62007376 59467694 8.92 0.02 96.74 91.94 47.37 GX2 63447084 60901328 9.14 0.02 96.83 92.10 47.14 GX3 54466924 52267042 7.84 0.02 96.84 92.11 47.23 LF1 61103822 58580638 8.79 0.02 96.68 91.78 46.39 LF2 59399040 57018846 8.55 0.02 96.88 92.21 46.44 LF3 55142308 52908196 7.94 0.02 96.78 91.98 46.23 NJ1 53662738 51429712 7.71 0.02 96.58 91.56 46.54 NJ2 53682236 51474730 7.72 0.02 96.73 91.88 46.51 NJ3 61665510 59119284 8.87 0.02 96.90 92.22 46.34 a Q20: the percentage of bases with a Phred value > 20 b Q30: the percentage of bases with a Phred value > 30 Table 5. Summary of assembly quality of S. litura RNA-seq Assembly quality parameters Transcript Unigene Length 200-500bp 79168 22583 Length 500-1kbp 23312 21928 Length 1-2kbp 16865 16846 Length ＞ 2kbp 20658 20657 Min length 201 201 Median length 419 876 Mean length 1039 1571 Max length 29587 29587 N50 value a 2377 2790 N90 value b 340 637 Total number 140003 82014 Total nucleotides 145522193 128847016 a N50, 50 % of the assembled bases were incorporated into sequences with length of N50 or longer b N90, 90 % of the assembled bases were incorporated into sequences with length of N90 or longer Table 6. Gene annotation by BLAST-searching against public databases Public database Number of unigenes Percentage (%) Annotated in NR 41212 50.24 Annotated in NT 22566 27.51 Annotated in KO 17722 21.60 Annotated in SwissPort 30369 37.02 Annotated in PFAM 31887 38.87 Annotated in GO 32111 39.15 Annotated in KOG 22893 27.91 Annotated in all databases 8974 10.94 Annotated in at least one database 47185 57.53 Total unigenes 82014 100.00 Table 7. qRT-PCR validation of pyrethroids resistance related candidate DEGs in LF/GX and NJ/GX groups Gene name Access Number (NR) Function annotation Species Expression fold of LF/GX Expression fold of NJ/GX RNA-seq Validation RNA-seq Validation CYP1 AKH15488.1 CYP9A40 Spodoptera litura 663.43 1.82* 76.13 1.72* CYP2 ADA68173.1 CYP6B29V1 S. litura 11.59 20.65* 18.86 30.16* CYP3 AGO62006.1 CYP321A8 Spodoptera frugiperda 53.41 41.51* 24.31 32.71* CYP4 AFP20588.1 CYP6AE47 Spodoptera littoralis 8.68 5.80* 3.01 1.99* CYP5 AID54863.1 CYP340G1 Helicoverpa armigera 14.20 15.15* 5.10 5.85* CYP6 ADA68175.1 CYP321B1 S. litura 5.39 6.43* 4.94 9.59* CYP7 AID54877.1 CYP4G9 H. armigera 217.34 2.03* 550.81 2.27* CYP8 AID54870.1 CYP354A4 H. armigera 408.08 2.67* 395.66 1.86* CYP9 BAM73813.1 CYP6AB4 Bombyx mori 3.06 1.73* 3.67 1.62* CYP10 AGO62000.1 CYP4G74 S. frugiperda 226.10 11.28* 590.83 44.46* CYP11 AFP20600.1 CYP4S8V1 S. littoralis 2.73 1.92 * 3.96 2.37 * CYP12 AID55427.1 CYP6AE43 S. frugiperda 11.26 358.27 * 7.10 237.95 * CYP13 AAL48300.1 CYP4L4 Mamestra brassicae 3.16 2.73 * 3.99 3.50 * CYP14 AFP20591.1 CYP6AB31 S. littoralis 5.42 2.66 * 6.25 2.77 * GST1 AIH07591.1 Sigma 4 S. litura 8.64 7.24 * 9.36 10.70 * GST2 AIH07594.1 Delta 1 S. litura 4.82 4.86 * 3.93 5.72 * GST3 AAS79891.1 GST1 S. litura 44.61 67.31 * 22.61 48.24 * GST4 AIH07601.1 Omega 2 S. litura 2.52 2.49 * 3.01 2.48 * GST5 AIH07597.1 Delta 4 S. litura 2.30 1.94 * 1.83 1.68 * UGT1 AEW43126.1 UGT40F2 H. armigera 17.93 20.49 * 5.62 9.16 * UGT2 AHY99686.1 UGT40R3 S. littoralis 6.50 4.39 * 3.79 2.37 * UGT3 AHY99688.1 UGT41D2 S. littoralis 4.80 4.52 * 6.49 6.81 * UGT4 AHY99682.1 UGT33J2 S. littoralis 7.32 4.31 * 13.63 11.10 * UGT5 AHY99683.1 UGT33T2 S. littoralis 15.85 309.49 * 53.45 3236.54 * COE1 ADR64697.1 CXE13 S. litura 5.95 4.21 * 2.77 2.33 * COE2 AFI64313.1 Acidic lipase H. armigera 7.60 7.56 * 4.89 5.75 * COE3 ADF43475.1 CCE014a H. armigera 107.96 0.32 111.99 0.47 COE4 AFI64313.1 Acidic lipase H. armigera 53.93 87.57 * 13.56 27.89 * COE5 XP_004924046.1 Arylsulfatase B-like B. mori 12.30 6.51 * 2.45 2.13 * ABC1 AKC34899.1 ABCC1-like S. litura 2.67 1.03 3.13 1.30 ABC2 AKC34055.1 ABCC3 S. litura 1.77 1.07 2.47 0.94 ABC3 AIB06821.1 ABCC2 Spodoptera exigua 1.51 1.09 2.63 2.00 * ABC4 XP_012549772.1 MDR B. mori 1.79 1.21 1.94 1.38 ABC5 ADV76538.1 ABCB3 T. ni 4.73 6.30 * 10.53 16.84 * ABC6 XP_012544694.1 ABCCX2 B. mori 1.98 1.01 1.68 1.11 Table 8. Toxicity of pyrethroids insecticide to CZ population Insecticides CZ Slope (SE) LD 50 (95% FI) (µg/larva) R 2 RR Fenvalerate 1.119 (0.266) 0.338 (0.101-0.609) 0.952 84.5 Beta cypermethrin 1.462 (0.333) 0.046 (0.014-0.083) 0.991 11.5 Cyhalothrin 1.006 (0.254) 1.357 (0.619-2.581) 0.966 678.5 Table 9. Toxicity of pyrethroids insecticide to JD population Insecticides JD Slope (SE) LD 50 (95% FI) (µg/larva) R 2 RR Fenvalerate 1.603(0.253) 36.496 (25.858-51.746) 0.956 9123.5 Beta cypermethrin 1.745(0.265) 2.598 (1.898-3.702) 0.982 642.0 Cyhalothrin 1.213(0.239) 13.972 (7.025-21.737) 0.951 6986.0 Table 10. Relative expression level of candidate DEGs among GX, CZ, LF, NJ and JD populations. Gene name Relative expression level GX CZ NJ LF JD CYP1 1.00 1.32 1.72 1.82 1.28 CYP2 1.00 0.80 30.16 20.65 12.41 CYP3 1.00 2.31 32.71 41.51 66.14 CYP4 1.00 1.20 1.99 5.80 5.51 CYP5 1.00 2.15 5.85 15.15 1.90 CYP6 1.00 1.43 9.59 6.43 3.60 CYP7 1.00 0.19 2.27 2.03 0.57 CYP8 1.00 2.14 1.86 2.67 1.28 CYP9 1.00 1.79 1.62 1.73 1.41 CYP10 1.00 1.34 44.46 11.28 5.01 CYP11 1.00 1.95 2.37 1.92 1.08 CYP12 1.00 118.32 237.95 358.27 270.86 CYP13 1.00 1.56 3.50 2.73 1.10 CYP14 1.00 2.60 2.77 2.66 3.02 GST1 1.00 2.84 10.70 7.24 5.26 GST2 1.00 3.55 5.72 4.86 3.40 GST3 1.00 5.57 48.24 67.31 86.90 GST4 1.00 2.01 2.48 2.49 2.32 GST5 1.00 1.85 1.68 1.94 1.86 UGT1 1.00 1.12 9.16 20.49 11.95 UGT2 1.00 1.21 2.37 4.39 3.62 UGT3 1.00 0.75 6.81 4.52 2.55 UGT4 1.00 0.37 11.102 4.313 4.464 UGT5 1.00 255.66 3236.54 309.49 4.32 COE1 1.00 2.63 2.32 4.21 2.12 COE2 1.00 5.96 5.75 7.56 5.84 COE3 1.00 1.68 2.80 1.82 0.74 COE4 1.00 20.96 27.89 87.57 13.92 COE5 1.00 3.67 2.13 6.51 3.48 ABC1 1.00 1.84 1.30 1.03 1.38 ABC2 1.00 1.74 0.94 1.07 1.88 ABC3 1.00 0.84 2.00 1.09 0.61 ABC4 1.00 3.98 1.38 1.21 1.68 ABC5 1.00 2.54 16.84 6.30 6.75 ABC6 1.00 0.98 1.11 1.01 1.00 Table 11. The number and expression level of metabolism related genes among GX, LF and NJ populations Classes of Enzyme Total Number Expression level of LF/GX ＞ 1 Expression level of NJ/GX ＞ 1 Expressed higher both in LF and NJ P450 139 101 97 65 GST 32 27 29 23 COE 77 50 46 35 UGT 38 32 33 25 ABC 60 47 45 35 Additional File Legend Additional file 1: Pearson correlation between susceptible (GX) and resistant populations (LF and NJ). (PDF 132 kb) Additional file 2: Similarity distribution of sequence comparison by BLAST search. (PDF 67 kb) Additional file 3: Species that Spodoptera litura unigenes were annotated by BLAST search in Nr database. (PDF 72 kb) Additional file 4: The Venn diagram of differential expression genes between LFvsGX and NJvsGX groups. (A) The Venn diagram of up-regulated genes between LFvsGX and NJvsGX groups; (B) The Venn diagram of down-regulated genes between LFvsGX and NJvsGX groups. (PDF 71 kb) Additional file 5: Directed acyclic graph of down-regulated differential expression genes enriched GO terms. (A) Directed acyclic graph of down-regulated differential expression genes enriched GO terms in LFvsGX group; (B) Directed acyclic graph of down-regulated differential expression genes enriched GO terms in NJvsGX group. (PDF 200 kb) Additional file 6: Primers used for qRT-PCR validation. (XLSX 16 kb) Supplementary Files Additionalfile1.pdf Additionalfile2.pdf Additionalfile3.pdf Additionalfile4.pdf Additionalfile6.docx Additionalfile5.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-996","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":89167,"identity":"28aba6f0-3dbe-4cc2-946e-edb659678969","order_by":1,"name":"Dongzhi Li","email":"","orcid":"","institution":"Henan Institute of Science and Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Dongzhi","middleName":"","lastName":"Li","suffix":""},{"id":89168,"identity":"fab5330c-749d-44a8-8194-6cff460f6422","order_by":2,"name":"Yu Mei","email":"","orcid":"","institution":"Institute of Biomass Energy, Xinjiang Academy of Agricultural Science","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yu","middleName":"","lastName":"Mei","suffix":""},{"id":89169,"identity":"4db9718a-a555-43ea-9d68-cc9caf712551","order_by":3,"name":"Jianhua Wang","email":"","orcid":"","institution":"Henan Institute of Science and Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jianhua","middleName":"","lastName":"Wang","suffix":""},{"id":89170,"identity":"ac8832c0-be02-4113-9c2a-160ac80c971f","order_by":4,"name":"Xiling Chen","email":"","orcid":"","institution":"Henan Institute of Science and Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xiling","middleName":"","lastName":"Chen","suffix":""},{"id":89171,"identity":"ad86cd01-cf74-4198-8778-a5e34eec3e0f","order_by":5,"name":"Chengju Wang","email":"","orcid":"","institution":"College of Science, China Agricultural University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Chengju","middleName":"","lastName":"Wang","suffix":""},{"id":89172,"identity":"286ed488-897b-494b-a15d-e3352f694a85","order_by":6,"name":"Li Xu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA/ElEQVRIiWNgGAWjYFAC5oYDIIqPgYERxJBjY28/QEALI0QLGxCDGMZ8PGcSCGphQNaSOE/CwQCvBoMbiY0HGGru5LGxNzAc+Nhmk94mwZDA8KNiG04tkjMSgQ479qyYjecAw8GZbWm5bdKNBxh7ztzGqYVfIrHh8B+2w4ltEvkfDvOcOZzbJnMggZmxDbcWNgmQLf+AWuQfMAC1/E9nk0gwwKsFZMsBxjaQLQxALRUHEghqkex5CNTSB/JLAsPBGRXJhm3AQD6Izy8Gx5MPf2D4diePn/0A44MPBnby8u3tBx/8qMCtBQoOJKByCanH1DIKRsEoGAWjABkAAMlXXJB4H2A/AAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0001-8875-4445","institution":"Henan Institute of Science and Technology","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Li","middleName":"","lastName":"Xu","suffix":""}],"badges":[],"createdAt":"2019-05-22 13:53:26","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.9783/v1","doiUrl":"https://doi.org/10.21203/rs.2.9783/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":88426,"identity":"46a2d80b-ca11-4d75-9bc0-3bea5f39cefa","added_by":"auto","created_at":"2019-09-17 13:59:20","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":109737,"visible":true,"origin":"","legend":"Synergists effect of PBO, DEF and DEM to pyrethroid insecticides in LF(A) and NJ(B) populations.","description":"","filename":"Fig1.png","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Fig 1.png"},{"id":88429,"identity":"8e2e8984-ae7f-4964-bd78-b7286d86dda0","added_by":"auto","created_at":"2019-09-17 13:59:21","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":136529,"visible":true,"origin":"","legend":"Gene ontology (GO) classification of unigenes function. The unigenes were summarized in subgroups of biological process, cellular component and molecular function.","description":"","filename":"Fig2.png","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Fig 2.png"},{"id":88431,"identity":"57840730-d930-42b5-88fb-a4ef006dc0f9","added_by":"auto","created_at":"2019-09-17 13:59:21","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":200221,"visible":true,"origin":"","legend":"Pathway classified by KEGG annotation. The y-axis represented KEGG pathways. The x-axis indicated the percentage of a specific category of genes in each main classification. According to participation in KEGG pathways, genes were divided into five groups: A, cellular processes; B, environmental information processing; C, genetic information processing; D, metabolism; E, organism systems.","description":"","filename":"Fig3.png","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Fig 3.png"},{"id":88433,"identity":"1bc60f5c-29ed-4e00-81cb-b627e293c1c9","added_by":"auto","created_at":"2019-09-17 13:59:21","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":205137,"visible":true,"origin":"","legend":"GO enrichment of up-regulated unigenes in LFvsGX (A) and NJvsGX (B) groups.","description":"","filename":"Fig4.png","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Fig 4.png"},{"id":88435,"identity":"8fdc673b-cd0c-46fa-9ede-ede78a7f4d1e","added_by":"auto","created_at":"2019-09-17 13:59:22","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":314679,"visible":true,"origin":"","legend":"GO enrichment of down-regulated unigenes in LFvsGX (A) and NJvsGX (B) groups.","description":"","filename":"Fig5.png","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Fig 5.png"},{"id":88437,"identity":"3a868a7c-91ae-431e-82cd-476a100e7c60","added_by":"auto","created_at":"2019-09-17 13:59:22","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":199578,"visible":true,"origin":"","legend":"KEGG enrichment of up-regulated unigenes in LFvsGX (A) and NJvsGX (B) groups. The arrows indicate xenobiotic compounds metabolism related pathways.","description":"","filename":"Fig6.png","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Fig 6.png"},{"id":13467703,"identity":"e70330d2-a1a5-405e-a296-0633a301c195","added_by":"auto","created_at":"2021-09-16 20:56:02","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1728650,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-996/v1/c64407a0-5d30-4429-9d5c-df2d91886151.pdf"},{"id":88436,"identity":"85c8af2d-e6ce-4018-8e03-de4d32d8f2d5","added_by":"auto","created_at":"2019-09-17 13:59:22","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":135836,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile1.pdf","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Additional file 1.pdf"},{"id":88434,"identity":"071c27e8-9068-46de-a4d6-75329c12c175","added_by":"auto","created_at":"2019-09-17 13:59:22","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":68882,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile2.pdf","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Additional file 2.pdf"},{"id":88432,"identity":"cf70e8ad-8f88-4007-8aba-7f24c38e6b40","added_by":"auto","created_at":"2019-09-17 13:59:21","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":73910,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile3.pdf","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Additional file 3.pdf"},{"id":88430,"identity":"a3f23f9b-5e4b-4570-a4d2-124061852388","added_by":"auto","created_at":"2019-09-17 13:59:21","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":72747,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile4.pdf","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Additional file 4.pdf"},{"id":88428,"identity":"a459789a-39fc-4300-8eb8-9ce764db4499","added_by":"auto","created_at":"2019-09-17 13:59:20","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":15736,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile6.docx","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Additional file 6.docx"},{"id":88425,"identity":"3d0cc117-3727-4243-8953-72ccfe042aa2","added_by":"auto","created_at":"2019-09-17 13:59:20","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":205698,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile5.pdf","url":"https://assets-eu.researchsquare.com/files/4091b98c-133c-4423-a3ee-748ce404555d/v1/Additional file 5.pdf"}],"financialInterests":"","formattedTitle":"Transcriptome analysis of molecular mechanism to pyrethroids resistance in Spodoptera litura","fulltext":[{"header":"Background","content":"\u003cp\u003eThe common cutworm, \u003cem\u003eSpodoptera litura\u003c/em\u003e (Fabricius), is a polyphagous agricultural pest worldwide and caused enormous losses\n to many economical crops like cotton, soybean, tobacco and vegetables. Insecticides\n resistance developed rapidly in the last decades due to its extensively application.\n To date, \u003cem\u003eS. litura\u003c/em\u003e has evolved high resistance to multiple conventional and new insecticides, which\n led to both failure control of pest and the destruction of natural enemies [1-6].\n \u003c/p\u003e\n \n\u003cp\u003eInsecticides resistance is the consequence of pest evolutionary adaptation to insecticides\n selection, a genetic phenomenon, which is conferred by target-site-based resistance\n (TSR) and non-target-based resistance (NTSR) mechanisms [7]. TSR is endowed by gene\n mutations in target enzymes, which can be easily detected by sequencing. Multiple\n mutations in sodium channel conferring resistance to pyrethroid insecticides had been\n identified in insect species, such as L1014F, L1014S, M918V, L925I, E435K, C785R,\n P1999L, F1538I, A1410V, M1524I, D1549V, T929I and M918T [8-9]. NTSR is achieved by mechanisms reducing insecticide concentration reaching the target-site,\n including metabolism-based resistance, which enhanced detoxification rate of insecticide by cytochrome P450 monooxygenase (P450), glutathione \u003cem\u003eS\u003c/em\u003e-transferase (GST), carboxylesterases (COE), UDP-glycosyltransferase (UGT) and ATP-binding\n cassette transporters (ABC) [10]. Synergism is the primary step to identify the involvement\n of metabolism-related enzyme by piperonyl butoxide (PBO), diethyl maleate (DEM) and\n S,S,S-tributylphosphorothioate (DEF), which are inhibitors of P450, GST and COE, respectively\n [7]. The determination of putative gene expression and detoxification enzyme activity\n is also employed to explore the mechanism of metabolism-based resistance. However,\n these methods only establishing the resistance phenotype is metabolic involved, fails\n to comprehensively identify the individual genes responsible for insecticide resistance.\u003c/p\u003e\n \n\u003cp\u003eThe transcriptome is the complete set of all transcripts within a cell or tissue,\n that reflect the mRNA expression levels of different genes in a given sample [11].\n RNA-Sequence (RNA-Seq) provided opportunity for the comprehensive analysis of pest\n transcriptome without reference genome in greater depth than ever before [12]. Although\n multiple researches have investigated the resistance of\u003cem\u003e S. litura\u003c/em\u003eto various insecticides, molecular mechanism of metabolic resistance in \u003cem\u003eS. litura\u003c/em\u003e is still not well defined due to lack of detailed genetic and sequence information\n [13-14]. In addition, pyrethroid insecticides were widely applied to control \u003cem\u003eS. litura\u003c/em\u003e and other agricultural pests, for its high efficiency and low toxicity to mammalian\n animals. Yet excessive usage has imposed pyrethroids resistance the most severe situation [15]. To minimize the evolution\n of resistance and prolong the life time of insecticide, the molecular mechanisms for\n pyrethroids resistance in this pest should be declared. In this study, RNA-seq was\n performed by Illumina HiSeq™ 2000 sequencing platform and the transcriptome of pyrethroid-resistant\n and pyrethroid-susceptible populations were compared to provide new insights into\n mechanism of metabolism-based resistance to pyrethroids in \u003cem\u003eS. litura\u003c/em\u003e.\u003c/p\u003e\n "},{"header":"Results","content":"\u003ch2\u003eToxicity of insecticides to \u003cem\u003eS. litura\u003c/em\u003e\u003c/h2\u003e\n \n\u003cp\u003eEleven insecticides were chosen to test the toxicity to the larvae of GX, LF and NJ\n populations. High level resistance to fenvalerate, beta-cypermethrin and cyhalothrin were found, which were 809.5-, 141.3-, 1764.0-fold in LF population and 322.0-, 40.8-,\n 951.0-fold in NJ population, respectively, compared with that in GX population (Table\n 1-3). LF and NJ populations showed no resistance to phoxim, profenofos, chlorpyrifos\n and emamectin benzoate, with resistance ratio (RR) lower than 5.0-fold. However, low\n resistance had been developed to chlorantraniliprole, bromine cyantraniliprole, imidacloprid\n and methomyl, with RR ranged from 4.0 to 19.8-fold. The results above indicated that\n field-collect populations of \u003cem\u003eS. litura\u003c/em\u003e had high level resistance to pyrethroid, which was urgent to be managed.\u003c/p\u003e\n \n\u003cp\u003e(Table 1-3 Insert here)\u003c/p\u003e\n \n\u003cp\u003eTo determine the involvement of detoxification enzyme for pyrethroids resistance in\n \u003cem\u003eS. litura\u003c/em\u003e, the synergists of P450, COE and GST, namely PBO, DEF and DEM, were used before pyrethroids\n treatment. Results showed that PBO increased pyrethroids toxicity distinctly in both LF and NJ populations, while DEF and DEM increased fenvalerate and cyhalothrin toxicity\n slightly and had no influence on beta-cypermethrin toxicity (Figure 1).\u003c/p\u003e\n \n\u003cp\u003e(Figure 1 Insert here)\u003c/p\u003e\n \n\u003ch2\u003eIllumina sequencing and reads assembly\u003c/h2\u003e\n \n\u003cp\u003eRNA-Seq was conducted with three cDNA libraries of GX, LF and NJ populations, respectively.\n Clean reads ranging from 51429712 to 60901328 per cDNA library were obtained by removing\n reads containing adapter, ploy-N and low quality reads from raw data (Table 4). According\n to the sequence analysis, almost 97% raw reads had Phred-like quality score at the\n Q20 level (an error probability of 1%), with GC content around 47%. Clean reads were\n used to assemble 140003 transcripts and 82014 unigenes ranging from 201 to 29587 bp\n (Table 5). Pearson correlation coefficients of different RNA samples in the same population\n ranged from 0.868 to 0.916, which was higher than 0.525 to 0.648 between different\n populations (Additional file 1). \u003c/p\u003e\n \n\u003cp\u003e\n (Table 4-5 Insert here)\n \u003c/h2\u003e\n \n\u003ch2\u003eFunctional annotation of unigenes\u003c/h2\u003e\n \n\u003cp\u003eSeven databases, (NCBI non-redundant protein sequences database (Nr), NCBI non-redundant\n nucleotide sequences data-base (Nt), Pfam (Protein family), KOG/COG (Clusters of Orthologous\n Groups of proteins), Swiss-port, KyotoEncyclopedia of Genes and Genomes (KEGG) and\n Geneontology (GO) database) were used for unigenes functional annotation. There are\n 47185 (57.53%) unigenes annotated in at least one databases, and 8974 (10.94%) unigenes\n annotated in all databases. Among the annotated unigenes, 50.24% hit in Nr database,\n 39.15% in GO database and 38.87% in Pfam database (Table 6). More than 90% annotated unigenes had nucleotides similarity above\n 60% (Additional file 2). The results of Nr database annotation indicated that \u003cem\u003eS. litura\u003c/em\u003e has 41.3% sequence similarity to \u003cem\u003eBombyx mori\u003c/em\u003e, 16.2% to \u003cem\u003eDanaus plexippus\u003c/em\u003e, 14.1% to \u003cem\u003ePlutella xylostella\u003c/em\u003e, 1.9 % to \u003cem\u003eHelicoverpa armigera\u003c/em\u003e and 1.6% to \u003cem\u003ePapilio xuthus\u003c/em\u003e (Additional file 3).\u003c/p\u003e\n \n\u003cp\u003e(Table 6 Insert here)\u003c/h2\u003e\n \n\u003cp\u003eGO assignments were used to predict gene function. Total 82014 unigenes were classified\n into 54 subgroups, including molecular function (MF), biological process (BP) and\n cellular component (CC). In BP, cellular process was the largest subgroup, followed\n by metabolic process and single-organism process. In CC, the largest two subgroups\n were cell and cell part, respectively. For MF, binding and catalytic activity formed\n the largest two subgroups (Figure 2). \u003c/p\u003e\n \n\u003cp\u003e(Figure 2 Insert here)\u003c/p\u003e\n \n\u003cp\u003eKEGG database was used for understanding high-level functions and utilities of the\n biological system from molecular-level information. 20164 unigenes were divided into\n five groups, among which 5622 unigenes (27.88%) were involved in organism systems;\n 5563 unigenes (27.59%) were involved in metabolism; 3023 unigenes (14.99%) were involved\n in environmental information processing; 3002 unigenes (14.89%) were involved in cellular\n processes; 2954 unigenes (14.65%) were involved in genetic information processing\n (Figure 3). \u003c/p\u003e\n \n\u003cp\u003e(Figure 3 Insert here)\u003c/h2\u003e\n \n\u003ch2\u003eDifferential gene expression among LFvsGX and NJvsGX groups\u003c/p\u003e\n \n\u003cp\u003eIn order to explore the molecular mechanism of pyrethroid resistance, differentially\n expressed genes (DEGs) were selected according to \u003cem\u003eq\u003c/em\u003e-value\u0026lt;0.05 and |log\u003csub\u003e2\u003c/sub\u003e (Fold change)|\u0026gt;1. Compared with the transcriptome of GX population, there are 18043\n DEGs (10063 up-regulated and 7980 down-regulated) in LF population and 20370 DEGs\n (11147 up-regulated and 9223 down-regulated) in NJ population, respectively. And 11739\n DEGs were found involved in both LFvsGX and NJvsGX groups, including 5720 up-regulated\n and 5442 down-regulated genes (Additional file 4). \u003c/p\u003e\n \n\n \n\u003ch2\u003eGO and KEGG enrichment of the DEGs\u003c/h2\u003e\n \n\u003cp\u003eTo further analysis the function of DEGs, GO and KEGG enrichment analysis were conducted.\n According to GO enrichment, the up-regulated unigenes in LFvsGX group were enriched into multiple GO terms belonging to 20 BP, 5 CC and 20 MF; while 20 BP and 20 MF in NJvsGX group. In BP, the top three largest GO terms were metabolic process, single-organism process\n and oxidation-reduction process in both LFvsGX and NJvsGX groups. In MF, the top three largest GO terms were catalytic activity, hydrolase activity and oxidoreductase activity in LFvsGX group, while catalytic activity, oxidoreductase\n activity and peptidase activity in NJvsGX group (Figure 4). \u003c/p\u003e\n \n\u003cp\u003e(Figure 4 Insert here)\u003c/h2\u003e\n \n\u003cp\u003eMuch less unigenes were significantly enriched in the down-regulated GO terms in both LFvsGX and NJvsGX groups, including chitin metabolic process and chitin binding, which indicated that different\n epidermal penetration rate may be involved in pyrethroid resistant \u003cem\u003eS. litura\u003c/em\u003e populations (Figure 5).\u003c/p\u003e\n \n\u003cp\u003e(Figure 5 Insert here)\u003c/h2\u003e\n \n\u003cp\u003eAmong the top-twenty enriched KEGG pathway terms in LFvsGX and NJvsGX groups, fourteen terms were shared in both groups, including metabolism of xenobiotics by\n cytochrome P450 and drug metabolism-cytochrome P450 pathways (figure 6). The results\n of GO and KEGG enrichment suggested that metabolism was the main enriched terms of\n DEGs and should be a main reason of pyrethroids resistance in \u003cem\u003eS. litura.\u003c/em\u003e\u003c/p\u003e\n \n\u003cp\u003e(Figure 6 Insert here)\u003c/h2\u003e\n \n\u003ch2\u003eValidation of the candidate DEGs\u003c/h2\u003e\n \n\u003cp\u003eBased on the high reading count and significant high expression level in RNA-Seq,\n 14 P450, 5 COE, 5 GST, 5 UGT and 6 ABC up-regulated unigenes were screened out and\n validated by qRT-PCR. Among the 35 selected DEGs, 30 unigenes (including 14 P450, 5 GST, 5 UGT, 4 COE, and 1 ABC)\n were both significantly up-regulated by qRT-PCR validation in LFvsGX and NJvsGX groups\n (Table 7). CYP12 (annotated as CYP6AE43) had the highest expression level among all\n the P450 unigenes, with 358.27-fold in LF and 237.95-fold in NJ population. UGT5 (annotated\n as UGT33T2) had the highest expression level among all the UGT unigenes, with 309.49-fold\n in LF and 3236.54-fold in NJ population.\u003c/p\u003e\n \n\u003cp\u003e(Table 7 Insert here)\u003c/h2\u003e\n \n\u003ch2\u003eThe expression of candidate DEGs in additional two field populations\u003c/h2\u003e\n \n\u003cp\u003eCZ and JD are another two field populations with high resistance level to pyrethroid\n insecticides. Compared with GX population, CZ showed 84.5-fold resistance to fenvalerate,\n 11.5-fold resistance to beta cypermethrin and 678.5-fold resistance to cyhalothrin\n (Table 8), while JD showed 9123.5-fold resistance to fenvalerate, 642.0-fold resistance\n to beta cypermethrin and 6986.0-fold resistance to cyhalothrin (Table 9). \u003c/p\u003e\n \n\u003cp\u003e(Table 8-9 Insert here)\u003c/p\u003e\n \n\u003cp\u003eBased on the RR values, resistance level of JD\u0026gt;LF\u0026gt;NJ\u0026gt;CZ\u0026gt;GX could be concluded. To\n further validate candidate DEGs, the expression level of the up-regulated DEGs in\n LF and NJ populations were also determined by qRT-PCR in CZ and JD populations. Results\n indicated that 13 unigenes (CYP3, CYP12, CYP14, GST1, GST2, GST3, GST4, UGT5, COE1,\n COE2, COE4, COE5 and ABC5) were also significantly higher expressed in the two additional\n populations. UGT5 had the highest expression level among all the tested UGT genes\n in the four pyrethroids resistant populations. The expression level of CYP3 and GST3\n among the four field-collected populations conformed well with their pyrethroid resistance\n level. While the expression level of CYP12, CYP14, COE4 and ABC5, showed good correlation\n with their pyrethroids resistant level in at least three field-collected populations\n (Table 10).\u003c/p\u003e\n \n\u003cp\u003e(Table 10 Insert here)\u003c/h2\u003e"},{"header":"Disscusion","content":"\u003cp\u003e Insecticides continue to be key weapon for insect control in agriculture. However,\n the evolution of insecticides resistance due to strong selection imposed by widespread\n insecticides usage threatens the weapons’ availability. Studying the molecular mechanism\n of insecticides resistance, especially for metabolism-based resistance, provides valuable insights into how genetic, physiological and biochemical changes\n in insects and opens windows for improving future pest control. In the present study, the transcriptome of GX, NJ and LF populations were sequenced by Illumina platform\n with high criteria of data quality (Table 4), enabling assembling of 140003 transcripts\n and 82014 unigenes (Table 5-6). GO and KEGG enrichment analysis of DEGs indicated\n that LF and NJ populations have relative high ability in oxidation-reduction activity,\n hydrolase activity and P450 involved metabolic process than GX population (Figure\n 4, 6). Recently, Cheng et al. [16] conducted the genome sequencing of \u003cem\u003eS. litura\u003c/em\u003e, and 138 P450, 47 GST, 110 COE and 54 ABC genes were annotated, which was consistent with our transcriptome results (Table 11). In addition, the validation of genes expression level showed that RNA-Seq\n results were well coincident with that of qRT-PCR (Table 10). Therefore, the RNA-Seq\n results were reliable and this information will facilitate further researches on pyrethroids\n resistance and other physiological processed in\u003cem\u003e S. litura\u003c/em\u003e. \u003c/p\u003e\n \n\u003cp\u003e(Table 11 Insert here)\u003c/h2\u003e\n \n\u003cp\u003eBioassay result in LF and NJ populations of \u003cem\u003eS. litura \u003c/em\u003eshowed high level resistance to fenvalerate, beta cypermethrin and cyhalothrin (Table\n 1-3). However, resistance to beta cypermethrin was much lower than that to fenvalerate and cyhalothrin in both LF and NJ populations,\n which might result from different sets of detoxification enzymes to each insecticide.\n No cross-resistance between organophosphates and pyrethroids was found in LF or NJ populations, which is similar with the result reported by Huang\n et al [13]. While Tong et al.found high level resistance to both organophosphates and pyrethroids in five field \u003cem\u003eS. litura \u003c/em\u003epopulations during 2010 to 2012 [14]. This opposite phenomenon could be explained\n by metabolic-based activation and passivation of insecticides. Multiple studies had\n revealed a direct link between elevated P450 activities and organophosphate and pyrethroids resistances in insects [17]. However, some P450s can also be involved in the activation\n of insecticides, chemically modifying insecticides to biologically active forms, as\n is the case for some organophosphorus insecticides [7]. For example, chlorpyrifos\n can be converted to chlorpyrifos-oxon by P450 and chlorpyrifos-oxon is 100-fold toxicity\n than chlorpyrifos [18-19]. Thus different sets of up-regulated P450s in insects could\n cause cross resistance or negative cross resistance between organophosphates and pyrethroids.\n \u003c/p\u003e\n \n\u003cp\u003eCytochrome P450 monooxygenases can mediate resistance to most insecticides for their\n genetic diversity, broad substrate specificity and catalytic versatility. Go enrichment of up-regulated DEGs in LFvsGX and NJvsGX groups showed that oxidation-reduction\n process and metabolic process were significantly enriched (Figure 4). Furthermore,\n P450s involved metabolism of xenobiotics and drug metabolism pathways were also enriched\n in KEGG enrichment analysis (Figure 6). Besides, P450s inhibitor (PBO) significantly\n increased the toxicity to pyrethroids in LF and NJ populations (Figure 1). Therefore,\n up-regulated P450s should be the major reason for pyrethroids resistance in LF and\n NJ populations. The qRT-PCR results indicated that most selected P450 genes were\n significantly over expressed in the four resistant populations, especially for CYP2,\n CYP3, CYP10, CYP12 and CYP14 (Table 10). Furthermore, the expression level of CYP3,\n CYP12 and CYP14, which were annotated as CYP321A8, CYP6AE43 and CYP6AB31, respectively,\n showed good correlation with pyrethroids resistance level among GX, CZ, NJ, LF and\n JD populations. \u003cem\u003eCYP321A8\u003c/em\u003e and \u003cem\u003eCYP6AB31\u003c/em\u003e could be induced by deltamethrin, lambda-cyhalothrin and lambda-cyhalothrin, respectively, and had high expression level in midgut and\n fat body [20-22]. \u003cem\u003eCYP6AE43\u003c/em\u003e of \u003cem\u003eS. \u003c/em\u003e\u003cem\u003efrugiperda\u003c/em\u003ecould only be detected in the midgut and malpighian tubules [23].However, there is building evidence that the key tissues for the metabolism of most\n compounds are midgut, malpighian tubules and fat body [23-24]. Therefore, P450 genes\n that had higher expression levels in these tissues may be involved in xenobiotic detoxification.\n Hence, most up-regulated P450s might be the set of pyrethroids detoxified genes in\n \u003cem\u003eS. litura\u003c/em\u003e, especially for CYP3, CYP12 and CYP14 in consideration of the higher expression level\n and detoxify function.\u003c/p\u003e\n \n\u003cp\u003eCOE were classified as Phase I detoxification enzymes and perform hydrolysis reaction\n at the first step of detoxification. It has been demonstrated that COE were involved\n in insecticide resistance, especially for organophosphates, pyrethroids and carbamates\n [25]. For instance, the over-expression of carboxylesterase E4 in \u003cem\u003eMyaus persicae\u003c/em\u003e enhanced degradation and sequestration of pyrethroids, organophosphates and carbamates\n [26]. According to Go enrichment analysis of up-regulated DEGs, hydrolase activity\n was enriched in LF and NJ populations (Figure 4). Validation in qRT-PCR revealed that the 4 selected COEs were higher expressed\n in resistance populations, especially for COE4 (Table 10). Although only slight synergism\n to fenvalerate and cyhalothrim by DEF was observed (Figure 1), COE may also play an\n important role in pyrethroids resistance in consideration of the enrichment analysis\n and high expression level in the four resistance populations.\u003c/p\u003e\n \n\u003cp\u003eThe products of Phase I reactions often become substrates for Phase II enzymes, such\n as GST and UGT, that add glutathione and glycosyl groups, respectively. Insect GSTs\n are a superfamily of detoxification enzymes and had been reported to be associated\n with resistance to pyrethroids, organophosphorus and organochlorine insecticides [27].In contrast to organochlorine and organophosphorus resistance, GSTs are not involved\n in the direct metabolism of pyrethroids but rather are involved in the sequestration\n of pyrethroids and/or the detoxification of lipid peroxidation products induced by\n pyrethroids [28-29]. Functional study of GSTs in \u003cem\u003eNilaparvata lugens\u003c/em\u003e showed that \u003cem\u003eNlGSTD1\u003c/em\u003e had peroxidase activity and confers pyrethroids resistance via gene amplification\n [29]. Two \u003cem\u003eS. litura\u003c/em\u003e GST (\u003cem\u003eSlgste2\u003c/em\u003e and \u003cem\u003eSlgste3\u003c/em\u003e) were reported to be induced by carbaryl, Bt and DDT, which suggested that Slgste2\n and Slgste3 may play roles in detoxifying various insecticides in \u003cem\u003eS. litura\u003c/em\u003e [30].Here, total 32 GSTs were annotated and mapped in \u003cem\u003eS. litura\u003c/em\u003e, and 23 GST genes had high expression level in both LF and NJ populations. GST3,\n which was annotated as \u003cem\u003eGST1\u003c/em\u003e and showed good correlation with the resistance level among the four resistant populations,\n was reported to possess high binding activities to deltamethrin [31], indicating the\n role of higher expression levels of GSTs in pyrethroids resistance in \u003cem\u003eS. litura\u003c/em\u003e.\u003c/p\u003e\n \n\u003cp\u003eUGT mediated glycoside conjugation is an important metabolic pathway for the biotransformation\n of multiple lipophilic endogenous and exogenous compounds, including insecticides.\n Kaplanoglu et al. demonstrated that silencing of \u003cem\u003eCYP4Q3\u003c/em\u003e and \u003cem\u003eUGT2\u003c/em\u003e significantly increased susceptibility of resistant beetles to imidacloprid, indicating\n that over-expression of these two genes contributes to imidacloprid resistance [32].\n UGT5, annotated as UGT33T2, was significantly over expressed and had the highest expression\n level among the tested UGT genes in the four pyrethroids resistant populations. The\n involvement of UGT5 in pyrethroids resistance needs to be further studied. \u003c/p\u003e\n \n\u003cp\u003eMajority ABC proteins function as primary-active transporters that bind and hydrolyze\n ATP while transporting a large diversity of substrates across lipid membranes. Bariami\n et al. showed that ABCB4 was up-regulated in a pyrethroids resistant strain of \u003cem\u003eA. aegypti \u003c/em\u003e[33]. RNA-seq analysis and qRT-PCR revealed that four ABC transporters were up-regulated\n in a deltamethrin resistant strain of \u003cem\u003eCimex lectularius\u003c/em\u003e and RNAi mediated knockdown of these ABC genes resulted in an increased susceptibility\n to betacyfluthrin in deltamethrin resistant female bed bugs [34]. Among the 6 selected\n ABC unigenes, only ABC5 (annotated as ABCB3) was significantly up-regulated in the\n four pyrethroids resistant populations, which indicated a possible role of ABC5 in\n pyrethroids resistance. \u003c/p\u003e\n \n\u003cp\u003eDecreased penetration rate was well documented to be involved in insecticides resistance\n [35]. Here, it was also cued by our GO enrichment results, where the down-regulated\n DEGs was enriched in chitin metabolism process, chitin binding, and structure constitutent\n of cuticle term (Figure 5, Additional file 5). \u003c/p\u003e\n \n\n \n\u003ch4\u003eConclusions\u003c/h4\u003e\n \n\u003cp\u003eA comprehensive comparison of metabolism related genes expression profiles between\n pyrethroid-resistant and pyrethroid-susceptible populations had been conducted by\n RNA-Seq and qRT-PCR. Metabolism-based resistance to pyrethroids was in a serious situation\n in \u003cem\u003eS. litura\u003c/em\u003e and over-expressed P450s was the major reason for pyrethroids resistance based on\n the synergism experiments and enrichment analysis of DEGs. Other metabolism related\n genes like GSTs, COEs, UGTs and ABC transporters were also involved in pyrethroids\n resistance for their higher expression level in several resistant populations. Besides,\n different insecticide penetration may also account for pyrethroids resistance in \u003cem\u003eS. litura\u003c/em\u003e for the down-regulated DEGs enriched in chitin metabolism process. And CYP3, CYP12,\n CYP14, GST3, UGT5, COE4 and ABC5 were the most valuable genes for further functional\n identification as their expression level showed good correlation with pyrethroids\n resistant level among the tested populations and the high expression level. Constitutive\n over-expression of multiple CYPs, COEs, GSTs, UGTs, and ABC transporters is associated\n with neonicotinoid resistance in the whitefly, \u003cem\u003eBemisia tabaci\u003c/em\u003e [36], \u003cem\u003eLygus lineolaris\u003c/em\u003e [37], and \u003cem\u003eAphis gossypii\u003c/em\u003e [38]as well as pyrethroids resistance in the house fly, \u003cem\u003eMusca domestica\u003c/em\u003e [39]. Our study provides a comprehensive understanding that CYPs, COEs, GSTs, UGTs,\n and ABC transporters may associated with pyrethroids resistance in \u003cem\u003eS. litura\u003c/em\u003e, which will greatly extend our understanding of metabolism-based insecticide resistance\n mechanism, and facilitate the further identification of pyrethroids resistance involved\n genes.\u003c/p\u003e\n "},{"header":"Methods","content":"\u003ch2\u003eInsect culture and bioassay\u003c/h2\u003e\n \n\u003cp\u003eGX population of \u003cem\u003eS. litura\u003c/em\u003e was kindly provided by Guangxi Tianyuan Biochemistry Corp., Ltd and served as susceptible\n population. It had been reared on artificial diet in the laboratory without exposure\n to any insecticide for more than 70 generations. LF, NJ, CZ and JD populations were\n collected from Langfang, Hebei province, Nanjing, Changzhou, Jiangsu province, and\n Shanghai respectively. The rear condition was 26±1℃and 60-70% relative humidity with a 14:10 h of light:dark photoperiod. Insecticides\n were diluted to 7 concentrations and 36 larvae were included in each concentration.\n One microlitre insecticide in acetone was applied on the thoracic dorsum of the third\n instars larvae by Hamilton syringe. For synergism experiments, PBO, DEF, and DEM were applied 1 h before insecticide treatment at 10 μg larva\u003csup\u003e-1 \u003c/sup\u003e(dissolved in acetone), respectively, and pyrethroid insecticides were applied at the tenth of LD\u003csub\u003e50\u003c/sub\u003e. Control groups were applied with PBO, DEF, DEM alone. Larvae were held individually\n in a 12-well tissue culture plates with artificial diet and the mortality was checked\n 48 or 72 h after treatment. \u003c/p\u003e\n \n\n \n\u003ch2\u003eRNA extraction and quality determination\u003c/h2\u003e\n \n\u003cp\u003eTotal RNA was extracted from the third instars larvae (18 larvae per group) using\n TaKaRa MiniBEST Universal RNA Extraction Kit (Takara) according to the manufacturer’s instructions. The integrity and quality of the total RNA were examined by RNA Nano 6000 Assay Kit,\n Agilent 2100 and 1% agarose gels. Three biological replicates were prepared in each\n population. \u003c/p\u003e\n \n\n \n\u003ch2\u003eLibrary preparation for transcriptome sequencing\u003c/h2\u003e\n \n\u003cp\u003eTotal 3 µg RNA per sample was used as input material for RNA sample preparations.\n Sequencing libraries were generated using NEBNext\u003csup\u003e®\u003c/sup\u003e Ultra™ RNA Library Prep Kit for Illumina\u003csup\u003e®\u003c/sup\u003e (NEB, USA) following manufacturer’s recommendations. Briefly, mRNA was purified from\n total RNA using poly-T oligo-attached magnetic beads. First strand cDNA was synthesized\n using random hexamer primer and M-MuLV Reverse Transcriptase (RNase H\u003csup\u003e-\u003c/sup\u003e). Second strand cDNA synthesis was subsequently performed using DNA Polymerase I\n and RNase H. To select cDNA fragments of preferentially 150-200 bp in length, the\n library fragments were purified with AMPure XP system (Beckman Coulter, Beverly, USA)\n and library quality was assessed on the Agilent Bioanalyzer 2100 system. The clustering\n of the index-coded samples was performed on a cBot Cluster Generation System using\n TruSeq PE Cluster Kit v3-cBot-HS (Illumina) according to the manufacturer’s instructions.\n After cluster generation, nine libraries (GX1, GX2, GX3, LF1, LF2, LF3, NJ1, NJ2,\n NJ3) preparations were sequenced on an Illumina Hiseq platform and paired-end reads\n were generated (Novogene, China).\u003c/p\u003e\n \n\n \n\u003ch2\u003eQuality control, Transcriptome assembly and Gene functional annotation\u003c/h2\u003e\n \n\u003cp\u003eClean data were obtained by removing reads containing adapter, reads containing ploy-N\n and low quality reads from raw data. Q20, Q30, GC-content and sequence duplication\n level of the clean data were calculated and all the downstream analyses were conducted\n based on clean data with high quality. Transcriptome assembly was accomplished using\n Trinity [40] with min_kmer_cov set to 2 by default and all other parameters set default.\n Gene function was annotated based on Nr, Nt, Pfam, Swiss-Prot database and KOG/COG, with a significant threshold of \u003cem\u003eE-value \u003c/em\u003e≤ 10\u003csup\u003e-5\u003c/sup\u003e. The GO terms for functional categorization were analyzed using Blast2go software with\n the \u003cem\u003eE-value \u003c/em\u003ethreshold ≤ 10\u003csup\u003e-6\u003c/sup\u003e. The pathway assignments were carried out by sequence searches against the KEGG database,\n with the \u003cem\u003eE-value \u003c/em\u003ethreshold ≤ 10\u003csup\u003e-10\u003c/sup\u003e.\u003c/p\u003e\n \n\n \n\u003ch2\u003eDifferential expression analysis of unigenes\u003c/h2\u003e\n \n\u003cp\u003eDifferential expression analysis between the three populations was performed using\n the DESeq R package (1.10.1). DESeq provide statistical routines for determining differential\n expression in digital gene expression data using a model based on the negative binomial\n distribution. The resulting \u003cem\u003eP\u003c/em\u003e values were adjusted using the Benjamini and Hochberg’s approach for controlling\n the false discovery rate. Genes with an adjusted \u003cem\u003ep\u003c/em\u003e-value\u0026lt;0.05 found by DESeq were assigned as differentially expressed.\u003c/p\u003e\n \n\u003cp\u003eGO enrichment analysis of the DEGs was implemented by the GOseq R packages based on Wallenius non-central hyper-geometric\n distribution [41]. KOBAS software was used to test the statistical enrichment of DEGs\n in KEGG pathways [42].\u003c/p\u003e\n \n\n \n\u003ch2\u003eValidation of the RNA-Seq DEGs\u003c/h2\u003e\n \n\u003cp\u003eTo validate the transcriptional results from RNA-Seq and computational analysis, 35\n unigenes were selected for quantitative RT-PCR (qRT-PCR). \u003cem\u003eEF1α \u003c/em\u003eand \u003cem\u003eRPL10 \u003c/em\u003ewere used as housekeeping genes to normalize the expression of each gene [43].First strand cDNA was synthesized from 1 μg total RNA using FastQuant RT Kit (With gDNase) (TIANGEN, Beijing, China) according\n to the manufacturer’s protocol. Primers were designed based on the measured mRNA sequences using Primer Premier\n 5.0 software and are summarized in Additional file 6. SuperReal PreMix Plus (SYBR\n Green, TIANGEN, Beijing, China) was used in a 20 μl system with 2×Super real SYBR Mix (10 μl), cDNA (1 μl), 50×ROX (0.4 μl) and each primer\n (0.6 μL, 10 μM) by ABI Prism 7500 Real-Time PCR System (Applied Biosystems by Life\n Technologies, Foster, CA, USA). Thermal cycling was run at 95℃ for 15 min, followed by 40 cycles of 95℃ for 10 s and 60℃ for 32 s. A melting curve was added as a final step to make sure the PCR product\n was unique and specific. Each test was repeated with 3 independent mRNA samples and\n each reaction was carried out in triplicate.\u003c/p\u003e\n \n\n \n\u003ch2\u003eStatistical analysis\u003c/h2\u003e\n \n\u003cp\u003eThe data of bioassay was analyzed with SPSS 16.0 (SPSS, Chicago, IL, USA). The results\n of qRT-PCR were calculated with the Ct value on 7500 software v2.3 (Applied Biosystems\n by Life Technologies, Foster, CA, USA) according to the 2\u003csup\u003e-\u003c/sup\u003e\u003csup\u003e△△\u003c/sup\u003e\u003csup\u003eCt\u003c/sup\u003emethod. Student t-test was performed to analyze the statistical difference between\n means. A \u003cem\u003ep\u003c/em\u003e-value\u0026lt;0.05 was considered statistically significant.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eABC, ATP-binding cassette transporters; BP, biologic process; CC, cellular component;\n DEF, S,S,S-tributylphosphorothioate; DEGs, differentially expressed genes; DEM, diethyl\n maleate; COE, carboxylesterases; GO, gene ontology; GST, glutathione S-transferase;\n KEGG, Kyoto encyclopedia of genes and genomes; KOG/COG, clusters of orthologous groups\n of proteins; MF, molecular function; NCBI, National Center for Biotecnology Information;\n Nr, NCBI non-redundant protein sequences database; Nt, NCBI non-redundant nucleotide\n sequences database; NTSR, non-target-site based resistance; P450, cytochrome P450\n monooxygenase; PBO, piperonyl butoxide; Pfam, protein family; RR, resistance ratio;\n RNA-Seq, RNA-sequence; SRA, sequence read archive; TSR: target-based resistance; UGT,\n UDP-glycosyltransferase.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eAcknowledgements\u003c/h2\u003e\n \n\u003cp\u003eThis work was supported by The National Natural Science Foundation of China (No. 31801765).\u003c/p\u003e\n \n\n \n\u003cp\u003eAvailability of data and materials\u003c/p\u003e\u003cp\u003eThe datasets supporting the conclusions of this article are included within the article\n and its additional files. The raw Illumina sequence reads have been deposited in the\n NCBI Sequence Read Archive (SRA) database with accession number PRJNA541123.\u003c/p\u003e\n \n\u003cp\u003eAuthors’ contributions\u003c/p\u003e\n \n\u003cp\u003eThis study was designed and performed by DZL and LX. DZL analyzed the sequencing data,\n performed qRT-PCR validations and wrote the manuscript. The collection of insect materials\n was conducted by YM and JHW. XLC and CJW provided helpful suggestion in data analysis\n and manuscript revision. All authors read and approved the final manuscript.\u003c/p\u003e\n \n\u003cp\u003eCompeting interests\u003c/p\u003e\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n \n\u003cp\u003eEthics approval and consent to participate\u003c/p\u003e\u003cp\u003e This research did not involve any human subjects, human material, or human data.\n \u003cem\u003eS. litura\u003c/em\u003e in current research did not belong to the endangered or protected species.\u003c/p\u003e"},{"header":"References","content":"\u003cp\u003e1. Rao GR, Dhingra S. Shift in the susceptibility level of \u003cem\u003eSpodoptera litura \u003c/em\u003e(Delhiand Guntur populations) to cypermethrin and fenvalerate. J Entomol Res. 1996;20:225-227.\u003c/p\u003e\n \n\u003cp\u003e2. Armes NJ, Wightman JA, Jadhav DR, Ranga Rao GV. Status of insecticide resistance\n in \u003cem\u003eSpodoptera litura\u003c/em\u003e in Andhra Pradesh India. Pestic Sci. 1997;50:240-248.\u003c/p\u003e\n \n\u003cp\u003e3. Ahmad M, Arif I, Ahmad M. Occurrence of insecticide resistance in field populations\n of \u003cem\u003eSpodoptera litura\u003c/em\u003e (Lepidoptera: Noctuidae) in Pakistan. Crop Prot. 2007; 26:807-809.\u003c/p\u003e\n \n\u003cp\u003e4. Ahmad M, Sayyed AH, Saleem MA. Evidence for field evolved resistance to newer insecticides\n in \u003cem\u003eSpodoptera litura\u003c/em\u003e (Lepidoptera: Noctuidae) from Pakistan. Crop Prot. 2008; 27:1367-1372.\u003c/p\u003e\n \n\u003cp\u003e5. Saleem M, Hussain D, Ghouse G, Abbas M, Fisher SW. Monitoring of insecticide resistance\n in\u0026nbsp;\u003cem\u003eSpodoptera litura\u003c/em\u003e\u0026nbsp;(Lepidoptera: Noctuidae) from four districts of Punjab, Pakistan to conventional\n and new chemistry insecticides. Crop Prot. 2016;79:177-184.\u003c/p\u003e\n \n\u003cp\u003e6. Wan P, Wu KM, Huang MS, Yu DZ, Wu JP. Population dynamics of \u003cem\u003eSpodoptera litura\u003c/em\u003e (Lepidoptera: Noctuidae) on Bt cotton in the Yangtze River Valley of China. Environ.\n Entomol. 2008; 37:1043-1048. \u003c/p\u003e\n \n\u003cp\u003e7. Perry T, Batterham P, Daborn PJ. The biology of insecticidal activity and resistance.\n Insect Biochem Mol Biol. 2011;41:411-422.\u003c/p\u003e\n \n\u003cp\u003e8. Soderlund DM, Knipple DC. The molecular biology of knockdown resistance to pyrethroid\n insecticides. Insect Biochem Mol Biol. 2003;33:563-577.\u003c/p\u003e\n \n\u003cp\u003e9. Vais H, Williamson MS, Devonshire AL, Usherwood PN. The molecular interactions\n of pyrethroid insecticides with insect and mammalian sodium channels. Pest Manage\n Sci. 2001; 57:877-888.\u003c/p\u003e\n \n\u003cp\u003e10. Bajda S, Dermauw W, Greenhalgh R, Nauen R, Tirry L, Clark RM, Leeuwen TV. Transcriptome\n profiling of a spirodiclofen susceptible and resistant strain of the European red\n mite\u003cem\u003e Panonychus ulmi\u003c/em\u003e using strand-specific RNA-seq. BMC Genomics, 2015;16:974-999.\u003c/p\u003e\n \n\u003cp\u003e11. Van Emon J. The Omics Revolution in Agricultural Research. J Agric Food Chem.\n 2016;64:36-44.\u003c/p\u003e\n \n\u003cp\u003e12. Varshney RK, Nayak SN, May GD, Jackson SA. Next-generation sequencing technologies\n and their implications for crop genetics and breeding. Trends Biotechnol. 2009;7:522-530.\u003c/p\u003e\n \n\u003cp\u003e13. Huang S, Xu J, Han Z. Baseline toxicity data of insecticides against the common\n cutworm \u003cem\u003eSpodoptera litura\u003c/em\u003e (Fabricius) and a comparison of resistance monitoring methods. Int J Pest Manage.\n 2006;52:209-213.\u003c/p\u003e\n \n\u003cp\u003e14. Tong H, Su Q, Zhou X, Bai L. Field resistance of \u003cem\u003eSpodoptera litura\u003c/em\u003e (Lepidoptera: Noctuidae) to organophosphates, pyrethroids, carbamates and four newer\n chemistry insecticides in Hunan, China. J Pest Sci. 2013; 86:599-609.\u003c/p\u003e\n \n\u003cp\u003e15. Shad SA, Sayyed AH, Fazal S, Saleem MA, Zaka AM, Ali M. Field evolved resistance\n to carbamates, organophosphates, pyrethroids, and new chemistry insecticides in \u003cem\u003eSpodoptera litura\u003c/em\u003e Fab. (Lepidoptera: Noctuidae). J Pestic Sci. 2012; 85:153-162.\u003c/p\u003e\n \n\u003cp\u003e16. Cheng TC, Wu JQ, Wu YQ, Chilukuri RV, Huang LH, Yamamoto K. et al. Genomic adaptation\n to polyphagy and insecticides in a major East Asian noctuid pest. Nat. Ecol. \u0026amp; Evol.\n 2017; DOI: 10.1038/s41559-017-0314-4.\u003c/p\u003e\n \n\u003cp\u003e17. Oakeshott JG, Farnsworth CA, East PD, Scott C, Han YC, Wu YD, Russell RJ. How\n many genetic options for evolving insecticide resistance in heliothine and spodopteran\n pests? Pest Manage Sci. 2013; 69:889-896.\u003c/p\u003e\n \n\u003cp\u003e18. Fujioka K, Casida JE. Glutathione \u003cem\u003eS\u003c/em\u003e-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-,\n and S-alkylglutathione derivatives. Chem Res Toxicol. 2007;20:1211-1217.\u003c/p\u003e\n \n\u003cp\u003e19. Monnet-Tschudi F, Zurich MG, Schilter B. Maturation-dependent effects of chlor-pyrifos\n and parathion and their oxygen analogs on acetyl-cholinesterase and neuronal and glial\n markers in aggregating brain cell cultures. Toxicol Appl Pharmacol. 2000;165:175-183.\u003c/p\u003e\n \n\u003cp\u003e20. Wang RL, Staehelin C, Xia QQ, Su YJ, Zeng RS. Identification and Characterization\n of\u003cem\u003e CYP9A40\u003c/em\u003e from the Tobacco Cutworm Moth (\u003cem\u003eSpodoptera litura\u003c/em\u003e), a Cytochrome \u003cem\u003eP450\u003c/em\u003e Gene Induced by Plant Allelochemicals and Insecticides. Int J Mol Sci. 2015;16:22606-22620.\u003c/p\u003e\n \n\u003cp\u003e21. Wang RL, He YN, Staehelin C, Liu SW, Su YJ, Zhang JE. Identification of two cytochrome\n monooxygenase P450 genes, \u003cem\u003eCYP321A7\u003c/em\u003e and \u003cem\u003eCYP321A9\u003c/em\u003e, from the tobacco cutworm moth (\u003cem\u003eSpodoptera litura\u003c/em\u003e) and their expression in response to plant allelochemicals. Int J Mol Sci. 2017;18:2278-2289.\u003c/p\u003e\n \n\u003cp\u003e22. Hu B, Zhang SH, Ren MM, Tian XR, Wei Q, Mburu DK, Su JY. The expression of \u003cem\u003eSpodoptera exigua\u003c/em\u003e P450 and UGT genes: tissue specificity and response to insecticides. Insect Sci.\n 2017;doi:10.1111/1744-7917.12538.\u003c/p\u003e\n \n\u003cp\u003e23. Giraudo M, Hilliou F, Fricaux T, Audant P, Feyereisen R, Goff GL. Cytochrome P450s\n from the fall armyworm (\u003cem\u003eSpodoptera frugiperda\u003c/em\u003e): responses to plant allelochemicals and pesticides. Insect Mol Biol. 2015;24:115-128.\u003c/p\u003e\n \n\u003cp\u003e24. Scott JG. Insect cytochrome P450s: Thinking beyond detoxification. Recent Advances\n in Insect Physiology. Toxicol Mol Biol. 2008; 117-124. \u003c/p\u003e\n \n\u003cp\u003e25. Oakeshott JG, Claudianos C, Campbell PM, Newcomb RD, Russell RJ. In Biochemical\n genetics and genomics of insect esterases; Publisher: Elsevier BV, 2005;5:309-381.\u003c/p\u003e\n \n\u003cp\u003e26. Field LM, Devonshire AL. Evidence that the \u003cem\u003eE4\u003c/em\u003e and \u003cem\u003eFE4\u003c/em\u003e esterase genes responsible for insecticide resistance in the aphid \u003cem\u003eMyzus persicae\u003c/em\u003e (Sulzer) are part of a gene family.Biochem J. 1998;330:169-173.\u003c/p\u003e\n \n\u003cp\u003e27. Li XC, Schuler MA, Berenbaum MR. Molecular mechanisms of metabolic resistance\n to synthetic and natural xenobiotics. Annu Rev Entomol. 2007;52:231-253.\u003c/p\u003e\n \n\u003cp\u003e28. Vontas JG, Small GJ, Hemingway J. Glutathione \u003cem\u003eS\u003c/em\u003e-transferases as antioxidant defence agents confer pyrethroid resistance in \u003cem\u003eNilaparvata lugens\u003c/em\u003e. Biochem J. 2001; 357:65-72.\u003c/p\u003e\n \n\u003cp\u003e29. Vontas JG, Small GJ, Nikou DC. Purification, molecular cloning and heterologous\n expression of a glutathione \u003cem\u003eS\u003c/em\u003e-transferase involved in insecticide resistance from the rice brown plan thopper,\n \u003cem\u003eNilaparvata lugens\u003c/em\u003e. Biochem J. 2002;362:329-337.\u003c/p\u003e\n \n\u003cp\u003e30. Deng HM, Huang YF, Feng QL, Zheng SC. Two epsilon glutathione \u003cem\u003eS\u003c/em\u003e-transferase cDNAs from the common cutworm, \u003cem\u003eSpodoptera litura\u003c/em\u003e: characterization and developmental and induced expression by insecticides. J Insect\n Physiol. 2009;55: 1174-1183.\u003c/p\u003e\n \n\u003cp\u003e31. Xu ZB, Zou XP, Zhang N, Feng QL, Zheng SC. Detoxification of insecticides, allechemicals\n and heavy metals by glutathione S-transferase SlGSTE1 in the gut of \u003cem\u003eSpodoptera litura\u003c/em\u003e. Insect Science. 2015; 22:503-511.\u003c/p\u003e\n \n\u003cp\u003e32. Kaplanoglu E, Chapman P, Scott IM, Donly C. Overexpression of a cytochrome P450\n and a UDP-glycosyltransferase is associated with imidacloprid resistance in the Colorado\n potato beetle, \u003cem\u003eLeptinotarsa decemlineata\u003c/em\u003e. Sci Rep. 2017;DOI:10.1038/s41598-017-01961-4.\u003c/p\u003e\n \n\u003cp\u003e33. Bariami V, Jones CM, Poupardin R, Vontas J, Ranson H. Gene amplification, ABC\n transporters and cytochrome P450s: unraveling the molecular basis of pyrethroid resistance\n in the dengue vector, \u003cem\u003eAedes aegypti\u003c/em\u003e. PLoS Neglected Trop Dis. 2012;6:e1692.\u003c/p\u003e\n \n\u003cp\u003e34. Zhu F, Gujar H, Gordon JR, Haynes KF, Potter MF, Palli SR. Bed bugs evolved unique\n adaptive strategy to resist pyrethroid insecticides. Sci Rep. 2013;3:1456-1463.\u003c/p\u003e\n \n\u003cp\u003e35. Strycharz JP, Lao A, Li HM, Qiu XH, Lee SH, Sun WL. Resistance in the highly DDT-resistant \u003cem\u003e91-R\u003c/em\u003e strain of \u003cem\u003eDrosophila melanogaster\u003c/em\u003e involves decreased penetration, increased metabolism, and direct excretion. Pestic\n Biochem Physiol. 2013;107:207-217.\u003c/p\u003e\n \n\u003cp\u003e36. Yang N, Xie W, Yang X, Wang SL, Wu QJ, Li R. et al. Transcriptomic and proteomic\n responses of sweet potato whitefly, \u003cem\u003eBemisia tabaci\u003c/em\u003e, to thiamethoxam. PLoS One. 2013;8:e61820.\u003c/p\u003e\n \n\u003cp\u003e37. Zhu YC, Luttrell R. Altered gene regulation and potential association with metabolic\n resistance development to imidacloprid in the tarnished plant bug, \u003cem\u003eLygus lineolaris\u003c/em\u003e. Pest Manage Sci. 2015;71: 40-57.\u003c/p\u003e\n \n\u003cp\u003e38. Pan Y, Peng TF, Gao XW, Zhang L, Yang C, Xi JH. et al. Transcriptomic comparison\n of thiamethoxam-resistance adaptation in resistant and susceptible strains of \u003cem\u003eAphis gossypii \u003c/em\u003eGlover. Comp Biochem Physiol., Part D: Genomics Proteomics. 2015; 13:10-15.\u003c/p\u003e\n \n\u003cp\u003e39. Gao Q, Li M, Sheng C, Scott JG, Qiu XH. Multiple cytochrome P450s overexpressed\n in pyrethroid resistant house flies (\u003cem\u003eMusca domestica\u003c/em\u003e). Pestic Biochem Physiol. 2012;104:252-260.\u003c/p\u003e\n \n\u003cp\u003e40. Grabherr MG, Haas BJ, Yassour M, Levin JZ, Thompson DA, Amit I. et al. Full-length\n transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol.\n 2011;20:644-652.\u003c/p\u003e\n \n\u003cp\u003e41. Young MD, Wakefield MJ, Smyth GK, Oshlack A. Gene ontology analysis for RNA-seq:\n accounting for selection bias. Genome Biol. 2010;11:1-12.\u003c/p\u003e\n \n\u003cp\u003e42. Mao X, Cai T, Olyarchuk JG, Wei L. Automated genome annotation and pathway identification\n using the KEGG Orthology (KO) as a controlled vocabulary. Bioinf. 2005;21:3787-3793.\u003c/p\u003e\n \n\u003cp\u003e43. Lu Y, Yuan M, Gao X, Kang T, Zhan S, Wan H, Li J. Identification and Validation\n of Reference Genes for Gene Expression Analysis Using Quantitative PCR in \u003cem\u003eSpodoptera litura\u003c/em\u003e (Lepidoptera: Noctuidae). PLoS One. 2013;8:e68059. \u003c/p\u003e"},{"header":"Tables","content":"\u003cp style=\"text-align: center; line-height: 12.0pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eTable 1. \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eToxicity of different insecticides to GX population\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"568\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eInsecticides\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 293.1pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"6\" width=\"391\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eGX\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e\u0026nbsp; Slope (SE)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"3\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLD\u003csub\u003e50 \u003c/sub\u003e(95% FI) (\u0026micro;g/larva)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-indent: 6.0pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eR\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eRR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eFenvalerate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2.592 (0.289)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.004 (0.003-0.005)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.951\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eBeta cypermethrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e3.238 (0.364)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.004 (0.002-0.011)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.833\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eCyhalothrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2.346 (0.274)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.002 (0.001-0.002)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.957\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003ePhoxim\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2.238 (0.334)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.219 (0.122-0.540)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.879\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eProfenofos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e3.226 (0.508)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.065 (0.052-0.080)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.979\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eChlorpyrifos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.617 (0.286)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.243 (0.175-0.349)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.948\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eChlorantraniliprole\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e3.848 (0.586)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.001 (0.001-0.002)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.970\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eBromine cyantraniliprole\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.064 (0.157)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.002 (0.001-0.003)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.938\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eImidacloprid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.882 (0.273)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.573 (0.425-0.784)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.965\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eMethomyl\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.743 (0.367)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.010 (0.004-0.015)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.853\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 133.0pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"177\"\u003e\n\u003cp style=\"text-align: center; line-height: 12.0pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eEmamectin benzoate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center; line-height: 12.0pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.524 (0.440)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center; line-height: 12.0pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.011 (0.004-0.016)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; line-height: 12.0pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.798\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 30.85pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"41\"\u003e\n\u003cp style=\"text-align: center; line-height: 12.0pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"177\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"113\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"19\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"161\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"9\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"47\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"41\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left; line-height: 150%; text-autospace: none;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif;\"\u003eResistance ratio (RR) = LD\u003csub\u003e50\u003c/sub\u003e value of field population/ LD\u003csub\u003e50\u003c/sub\u003e value of GX population\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 200%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eTable 2. \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eToxicity of different insecticides to LF population\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"568\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eInsecticides\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 280.9pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"6\" width=\"375\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLF\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 76.4pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eSlope (SE)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 132.35pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"3\" width=\"176\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLD\u003csub\u003e50 \u003c/sub\u003e(95% FI) (\u0026micro;g/larva)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eR\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eRR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eFenvalerate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.312 (0.302)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e3.238 (1.933-4.804)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.925\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e809.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eBeta cypermethrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.962 (0.290)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.565 (0.410-0.753)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.929\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e141.3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eCyhalothrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.063 (0.223)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e3.528 (2.129-5.941)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.971\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1764.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003ePhoxim\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.752 (0.298)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.092 (0.058-0.128)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.978\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eProfenofos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e4.018 (0.659)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.118 (0.096-0.143)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.999\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eChlorpyrifos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.879 (0.375)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.086 (0.039-0.129)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.933\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eChlorantraniliprole\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.777 (0.267)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.004 (0.003-0.005)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.960\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e4.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eBromine cyantraniliprole\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.583 (0.261)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.011 (0.008-0.017)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.997\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e5.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eImidacloprid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e3.120 (0.487)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e3.298 (2.604-4.126)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.991\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e5.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eMethomyl\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.250 (0.178)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.048 (0.008-0.168)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.830\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e4.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 145.2pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"194\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eEmamectin benzoate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 83.15pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.090 (0.253)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.15pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"155\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.028 (0.008-0.052)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.981\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.8pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2.6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"194\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"102\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"9\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"155\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"13\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"38\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"58\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: center; line-height: 200%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eTable 3. \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eToxicity of different insecticides to NJ population\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"568\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eInsecticides\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 286.0pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"6\" width=\"381\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eNJ\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 77.95pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eSlope (SE)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"3\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLD\u003csub\u003e50 \u003c/sub\u003e(95% FI) (\u0026micro;g/larva)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eR\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eRR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eFenvalerate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.330 (0.339)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.288 (0.379-2.172)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.981\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e322.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eBeta cypermethrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.679 (0.351)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.163 (0.073-0.249)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.901\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e40.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eCyhalothrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.347 (0.264)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.902 (1.176-2.927)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.990\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e951.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003ePhoxim\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2.911 (0.410)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.121 (0.095-0.151)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.986\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eProfenofos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2.120 (0.451)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.253 (0.172-0.343)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.969\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e3.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eChlorpyrifos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2.125 (0.297)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.095 (0.072-0.126)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.957\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eChlorantraniliprole\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.662 (0.254)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.005 (0.003-0.007)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.978\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e5.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eBromine cyantraniliprole\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.329 (0.236)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.017 (0.011-0.027)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.898\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e8.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eImidacloprid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.210 (0.462)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e11.33 (5.887-66.473)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.920\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e19.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eMethomyl\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.985 (0.326)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.077 (0.057-0.115)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.962\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e7.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 140.1pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"187\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eEmamectin benzoate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.952 (0.293)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"161\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.030 (0.021-0.041)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.55pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.976\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.95pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"187\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"104\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"9\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"161\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"19\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"38\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"51\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin-left: 24.0pt; text-align: left; text-indent: -24.0pt; line-height: 200%; text-autospace: none;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 150%; tab-stops: 17.65pt center 207.65pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif;\"\u003eTable 4. \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif;\"\u003eThe sequencing data quality of nine\u003cem\u003e S. litura\u003c/em\u003e samples\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"568\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.05pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eSample\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 58.8pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"78\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eRaw Reads\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.5pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"63\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eClean\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Reads\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 74.9pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"3\" width=\"100\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eClean Bases (G)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 36.15pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eError\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eQ20\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eQ30\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 73.4pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"98\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGC Content (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGX1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 58.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"78\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e62007376\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"82\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e59467694\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e8.92\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"54\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e96.74\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e91.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 73.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"98\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e47.37\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGX2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 58.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"78\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e63447084\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"82\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e60901328\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e9.14\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"54\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e96.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e92.10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 73.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"98\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e47.14\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGX3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 58.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"78\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e54466924\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"82\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e52267042\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e7.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"54\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e96.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e92.11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 73.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"98\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e47.23\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eLF1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 58.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"78\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e61103822\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"82\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e58580638\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e8.79\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"54\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e96.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e91.78\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 73.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"98\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e46.39\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eLF2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 58.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"78\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e59399040\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"82\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e57018846\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e8.55\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"54\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e96.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e92.21\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 73.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"98\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e46.44\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eLF3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 58.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"78\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e55142308\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"82\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e52908196\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e7.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"54\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e96.78\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e91.98\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 73.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"98\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e46.23\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eNJ1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 58.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"78\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e53662738\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"82\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e51429712\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e7.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"54\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e96.58\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e91.56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 73.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"98\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e46.54\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eNJ2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 58.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"78\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e53682236\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"82\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e51474730\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e7.72\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"54\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e96.73\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e91.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 73.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"98\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e46.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.05pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eNJ3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 58.8pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"78\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e61665510\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.65pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"82\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e59119284\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e8.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.2pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"54\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e96.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e92.22\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 73.4pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"98\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e46.34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"73\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"78\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"63\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"19\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"76\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"5\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"48\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"57\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"50\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"98\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eQ20: the percentage of bases with a Phred value \u0026gt; 20 \u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eQ30: the percentage of bases with a Phred value \u0026gt; 30 \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 200%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eTable 5. \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eSummary of assembly quality of \u003cem\u003eS. litura\u003c/em\u003e RNA-seq\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"568\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eAssembly quality parameters\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eTranscript\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eUnigene\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLength 200-500bp\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e79168\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e22583\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLength \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e500-1kbp\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e23312\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e21928\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLength \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1-2kbp\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e16865\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e16846\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLength \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: SimSun; color: windowtext;\"\u003e＞\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2kbp\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e20658\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e20657\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eMin length\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e201\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e201\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eMedian length\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e419\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e876\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eMean length\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1039\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1571\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eMax length\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e29587\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e29587\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eN50 value\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2377\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2790\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eN90 value\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e340\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e637\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eTotal number\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e140003\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e82014\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 161.35pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"215\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eTotal nucleotides\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 122.7pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"164\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e145522193\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e128847016\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eN50, 50 % of the assembled bases were incorporated into sequences with length of N50 or longer\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eN90, 90 % of the assembled bases were incorporated into sequences with length of N90 or longer\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-indent: 12.05pt; line-height: 200%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-indent: 12.05pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eTable 6. \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGene annotation by BLAST-searching against public databases\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"568\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003ePublic database\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eNumber of unigenes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003ePercentage (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eAnnotated in NR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e41212\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e50.24\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eAnnotated in NT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e22566\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e27.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eAnnotated in KO\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e17722\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e21.60\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eAnnotated in SwissPort\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e30369\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e37.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eAnnotated in PFAM\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e31887\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e38.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eAnnotated in GO\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e32111\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e39.15\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eAnnotated in KOG\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e22893\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e27.91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eAnnotated in all databases\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e8974\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e10.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eAnnotated in at least one database\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e47185\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e57.53\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 210.95pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"281\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eTotal unigenes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"151\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e82014\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.75pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e100.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: center; text-indent: 12.05pt; text-autospace: none;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; text-indent: 12.05pt; text-autospace: none;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; text-indent: 12.05pt; text-autospace: none;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eTable 7.\u003c/span\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eqRT-PCR validation of pyrethroids resistance related candidate DEGs in \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eLF/GX and NJ/GX groups\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"margin-left: -44.25pt; border-collapse: collapse; border: none;\" width=\"680\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" rowspan=\"2\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eGene name\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" rowspan=\"2\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAccess\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eNumber (NR)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" rowspan=\"2\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eFunction annotation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" rowspan=\"2\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u0026nbsp; Species\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.3pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"4\" width=\"142\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eExpression fold of LF/GX\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.3pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"4\" width=\"142\"\u003e\n\u003cp style=\"tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eExpression fold of NJ/GX\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 56.7pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp; RNA-seq\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"3\" width=\"76\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eValidation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;RNA-seq\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"66\"\u003e\n\u003cp style=\"tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eValidation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.8pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.8pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.8pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAKH15488.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.8pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP9A40\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.8pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eSpodoptera litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.8pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e663.43\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.8pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.82*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.8pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e76.13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.8pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.72*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eADA68173.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP6B29V1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e11.59\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e20.65*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e18.86\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e30.16*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAGO62006.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP321A8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eSpodoptera frugiperda\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e53.41\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e41.51*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e24.31\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e32.71*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAFP20588.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP6AE47\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eSpodoptera littoralis\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e8.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e5.80*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.99*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAID54863.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP340G1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eHelicoverpa armigera\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e14.20\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e15.15*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e5.10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e5.85*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eADA68175.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP321B1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e5.39\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e6.43*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e4.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e9.59*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAID54877.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP4G9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eH. armigera\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e217.34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.03*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e550.81\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.27*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAID54870.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP354A4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eH. armigera\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e408.08\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.67*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e395.66\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.86*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eBAM73813.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP6AB4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eBombyx mori\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.06\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.73*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.67\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.62*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAGO62000.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP4G74\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. frugiperda\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e226.10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e11.28*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e590.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e44.46*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAFP20600.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP4S8V1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. littoralis\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.73\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.92\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.37\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAID55427.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP6AE43\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. frugiperda\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e11.26\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e358.27\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e7.10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e237.95\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAAL48300.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP4L4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eMamestra brassicae\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.16\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.73\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.50\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP14\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAFP20591.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP6AB31\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. littoralis\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e5.42\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.66\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e6.25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.77\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eGST1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAIH07591.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eSigma 4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e8.64\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e7.24\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e9.36\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e10.70\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eGST2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAIH07594.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eDelta 1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e4.82\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e4.86\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e5.72\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eGST3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAAS79891.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eGST1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e44.61\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e67.31\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e22.61\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e48.24\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eGST4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAIH07601.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eOmega 2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.49\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.48\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eGST5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAIH07597.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eDelta 4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.94\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.68\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAEW43126.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT40F2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eH. armigera\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e17.93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e20.49\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e5.62\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e9.16\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAHY99686.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT40R3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. littoralis\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e6.50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e4.39\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.79\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.37\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAHY99688.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT41D2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. littoralis\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e4.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e4.52\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e6.49\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e6.81\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAHY99682.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT33J2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. littoralis\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e7.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e4.31\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e13.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e11.10\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 11.35pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.35pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.35pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAHY99683.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.35pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT33T2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.35pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. littoralis\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.35pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e15.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.35pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e309.49\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.35pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e53.45\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.35pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3236.54\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.05pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.05pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCOE1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.05pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eADR64697.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.05pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCXE13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.05pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.05pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e5.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.05pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e4.21\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.05pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.05pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.33\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 14.65pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.65pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCOE2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.65pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAFI64313.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.65pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAcidic lipase\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.65pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eH. armigera\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.65pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e7.60\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.65pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e7.56\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.65pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e4.89\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.65pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e5.75\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 12.05pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCOE3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eADF43475.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCCE014a\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eH. armigera\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e107.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e0.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e111.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e0.47\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 12.05pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCOE4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAFI64313.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAcidic lipase\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eH. armigera\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e53.93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e87.57\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e13.56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e27.89\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.95pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.95pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eCOE5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.95pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eXP_004924046.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.95pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eArylsulfatase B-like\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.95pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eB. mori\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.95pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e12.30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.95pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e6.51\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.95pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.45\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.95pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.13\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 12.05pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABC1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAKC34899.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABCC1-like \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.67\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e3.13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 12.05pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.25pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABC2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAKC34055.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABCC3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eS. litura\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.07\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.47\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e0.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.25pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABC3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.25pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eAIB06821.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.25pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABCC2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.25pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eSpodoptera exigua\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.25pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.25pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.09\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.25pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e2.00\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 18.45pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 18.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABC4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 18.45pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eXP_012549772.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 18.45pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eMDR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 18.45pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eB. mori\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 18.45pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.79\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 18.45pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.21\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 18.45pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 18.45pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.38\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 11.85pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.85pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABC5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.85pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eADV76538.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.85pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABCB3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.85pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eT. ni\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.85pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e4.73\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.85pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e6.30\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.85pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e10.53\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 11.85pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e16.84\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.7pt;\"\u003e\n\u003ctd style=\"width: 42.55pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABC6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eXP_012544694.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" width=\"123\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eABCCX2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003eB. mori\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.6pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" colspan=\"2\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.98\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" colspan=\"2\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" colspan=\"2\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; font-family: 'Times New Roman',serif;\"\u003e1.11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"57\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"104\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"123\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"113\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"12\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"63\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"9\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"57\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"9\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"57\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"9\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"66\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: center; text-autospace: none;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; text-autospace: none;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eTable 8.\u003c/span\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eToxicity of pyrethroids insecticide to \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCZ population\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"568\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 1.65in; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\" width=\"158\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eInsecticides\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 307.3pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"4\" width=\"410\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eCZ\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 78.0pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eSlope (SE)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLD\u003csub\u003e50\u0026nbsp; \u003c/sub\u003e(95% FI)\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e (\u0026micro;g/larva)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eR\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.15pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eRR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 1.65in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"158\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eFenvalerate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.119 (0.266)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.338 (0.101-0.609)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.952\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e84.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 1.65in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"158\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eBeta cypermethrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.462 (0.333)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.046 (0.014-0.083)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.991\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e11.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 1.65in; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"158\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eCyhalothrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.006 (0.254)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.357 (0.619-2.581)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.966\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.15pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e678.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left; line-height: 200%; text-autospace: none;\"\u003e\u003cspan style=\"line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; text-autospace: none;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eTable 9.\u003c/span\u003e\u003c/strong\u003e \u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eToxicity of pyrethroids insecticide to \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eJD population\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"568\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 111.75pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\" width=\"149\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eInsecticides\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 314.35pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"4\" width=\"419\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eJD\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 77.95pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eSlope (SE)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.45pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLD\u003csub\u003e50\u0026nbsp; \u003c/sub\u003e(95% FI)\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e (\u0026micro;g/larva)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eR\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.15pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eRR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 111.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"149\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eFenvalerate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.603(0.253)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e36.496 (25.858-51.746)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.956\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e9123.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 111.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"149\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eBeta cypermethrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.745(0.265)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e2.598 (1.898-3.702)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.982\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e642.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 111.75pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"149\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eCyhalothrin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.213(0.239)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.45pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e13.972 (7.025-21.737)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 37.8pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"50\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e0.951\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.15pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e6986.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eTable 10.\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e Relative expression level of candidate DEGs among GX, CZ, LF, NJ and JD populations.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"568\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGene name\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 355.1pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"5\" width=\"473\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eRelative expression level\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 63.35pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eGX\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eCZ\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eNJ\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eLF\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eJD\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.72\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.82\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.28\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e30.16\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e20.65\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e12.41\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.31\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e32.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e41.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e66.14\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.20\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e5.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e5.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.15\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e5.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e15.15\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.43\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e9.59\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e6.43\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e3.60\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.19\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.27\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.57\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.14\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.86\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.67\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.28\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.79\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.62\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.73\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.41\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e44.46\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e11.28\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e5.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.37\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.92\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.08\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e118.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e237.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e358.27\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e270.86\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e3.50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.73\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCYP14\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.60\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.66\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e3.02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGST1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e10.70\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e7.24\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e5.26\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGST2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e3.55\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e5.72\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e4.86\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e3.40\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGST3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e5.57\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e48.24\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e67.31\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e86.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGST4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.48\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.49\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eGST5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.86\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e9.16\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e20.49\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e11.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.21\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.37\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e4.39\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e3.62\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e6.81\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e4.52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.55\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.37\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e11.102\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e4.313\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e4.464\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eUGT5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e255.66\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e3236.54\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e309.49\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e4.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCOE1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e4.21\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCOE2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e5.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e5.75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e7.56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e5.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCOE3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.82\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.74\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCOE4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e20.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e27.89\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e87.57\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e13.92\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eCOE5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e3.67\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e6.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e3.48\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eABC1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.38\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eABC2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.74\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.07\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eABC3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.09\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.61\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eABC4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e3.98\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.38\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.21\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eABC5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e2.54\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e16.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e6.30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e6.75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 71.0pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center; tab-stops: 36.7pt;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eABC6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.35pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"84\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.65pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"105\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e0.98\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.0pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 71.05pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003eTable 11.\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif;\"\u003e The number and expression level of metabolism related genes among GX, LF and NJ populations\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" width=\"572\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 70.75pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eClasses of Enzyme\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eTotal Number \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eExpression level of LF/GX \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: SimSun; color: windowtext;\"\u003e＞\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"123\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eExpression level of NJ/GX \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: SimSun; color: windowtext;\"\u003e＞\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 103.3pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"138\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eExpressed higher both in LF and NJ\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 77.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e\u0026nbsp;P450\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e139\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 115.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"154\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e101\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 87.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"116\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e97\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e65\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 77.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eGST\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 115.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"154\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e27\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 87.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"116\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e29\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e23\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 77.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eCOE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 115.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"154\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 87.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"116\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e46\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e35\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 77.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eUGT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e38\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 115.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"154\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 87.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"116\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e33\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 77.85pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eABC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e60\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 115.5pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"154\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e47\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 87.3pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"116\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e45\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.85pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 12.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003e35\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"94\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"9\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"76\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"132\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"22\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"101\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"15\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"122\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin-left: 24.0pt; text-align: left; text-indent: -24.0pt; line-height: 200%; text-autospace: none;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"},{"header":"Additional File Legend","content":"\u003cp\u003eAdditional file 1: Pearson correlation between susceptible (GX) and resistant populations (LF and NJ).\n (PDF 132 kb)\u003c/p\u003e\n \n\u003cp\u003eAdditional file 2: Similarity distribution of sequence comparison by BLAST search. (PDF 67 kb)\u003c/p\u003e\n \n\u003cp\u003eAdditional file 3: Species that\u003cem\u003eSpodoptera litura\u003c/em\u003e unigenes were annotated by BLAST search in Nr database. (PDF 72 kb)\u003c/p\u003e\n \n\u003cp\u003eAdditional file 4: The Venn diagram of differential expression genes between LFvsGX and NJvsGX groups.\n (A) The Venn diagram of up-regulated genes between LFvsGX and NJvsGX groups; (B) The\n Venn diagram of down-regulated genes between LFvsGX and NJvsGX groups. (PDF 71 kb)\u003c/p\u003e\n \n\u003cp\u003eAdditional file 5: Directed acyclic graph of down-regulated differential expression genes enriched GO\n terms. (A) Directed acyclic graph of down-regulated differential expression genes\n enriched GO terms in LFvsGX group; (B) Directed acyclic graph of down-regulated differential\n expression genes enriched GO terms in NJvsGX group. (PDF 200 kb)\u003c/p\u003e\n \n\u003cp\u003eAdditional file 6: Primers used for qRT-PCR validation. (XLSX 16 kb)\u003c/p\u003e\n "}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Spodoptera litura, pyrethroids, resistance mechanism, transcriptome, metabolism-related","lastPublishedDoi":"10.21203/rs.2.9783/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.9783/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Background\n\nSpodoptera litura is a destructive agricultural pest and had evolved resistance to multiple insecticides, especially pyrethroids. At present, the resistance mechanism to pyrethroids remains unclear.\n\nResults\n\nFour field-collected populations, namely CZ, LF, NJ and JD, were identified to have high resistance to pyrethroids, and the resistant ratio ranged from 40.8 to 1764.0-fold. To explore pyrethroids resistance mechanism, the transcriptome between pyrethroid-resistant (LF and NJ) and pyrethroid-susceptible (GX) populations were compared by RNA-sequence. Results showed that multiple differential expressed genes were enriched in metabolism-related GO terms and KEGG pathways. 35 up-regulated metabolism-related genes were screened to verify by qRT-PCR. Consistent up-regulation of 13 unigenes, including 3 P450s, 4 GSTs, 1 UGTs, 4 COEs and 1ABC, were verified in the additional pyrethroids resistant populations CZ and JD. The expression level of CYP3 and GST3, which were homologous to CYP321A8 and GST1, respectively, showed good correlation with their pyrethroids resistance level among CZ, LF, NJ and JD populations. While the expression level of CYP12, CYP14, COE4 and ABC5 showed good correlation with their pyrethroids resistance level in at least three populations. UGT5 had the highest expression level among the tested UGT genes in the four pyrethroids resistant populations.\n\nConclusion\n\nCYP3, CYP12, CYP14, GST3, COE4, UGT5 and ABC5 play important roles in pyrethroids resistance among the four field-collected populations. Our study provided a valuable resource for further study of pyrethroid resistance mechanisms in S. litura.","manuscriptTitle":"Transcriptome analysis of molecular mechanism to pyrethroids resistance in Spodoptera litura","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2019-05-24 19:06:16","doi":"10.21203/rs.2.9783/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"e34064f4-3cce-4c54-87ae-ae0f263406b7","owner":[],"postedDate":"May 24th, 2019","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":12548,"name":"Epigenetics \u0026 Genomics"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2019-05-24 19:06:16","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-996","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-996","version":["v1"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}