Multi-centre retrospective study compared the outcomes of laparoscopic and open gastric resection for gastric cancer

Abstract The use of minimally invasive techniques has not attained the same widespread acceptance for the treatment of more advanced tumors, principally because of existing concerns about its feasibility and oncological adequacy. Laparoscopy is rarely used to treat stomach malignancy. We compared the outcomes of laparoscopic gastrectomy with those of open surgery, and results evaluated . There is still a debate regarding whether one of these options is superior. We need to compare the primary and secondary outcomesof laparoscopic versus open gastrectomy in patients with locallyadvanced gastric cancer, therefore, complete acceptance as a legitimate therapy is hampered by the lack of thorough investigation of long-term oncological consequences, including recurrence and fatality. Methods We retrospectively evaluated patients who underwent laparoscopic or open gastrectomy between February 2015 and November 2022. After collecting the database from the board sheet of our Zagzig University Hospital and six other specialist surgical hospitals, patients were divided into two groups: open surgery and laparoscopic surgery. Logistic regression was used to compare the 30-day complications and fatalities in both groups. Results The Risk ratio (RR) and 95% confidence interval (CI) were calculated. For consistent results, the mean difference (MD) or standardized mean difference (SMD) and 95% confidence interval (CI) were calculated. The meta-analysis was conducted using Review Manager 5.3 and STATA software. A total of 8,232 gastric cancer patients were divided into two groups based on the type of surgery they underwent: open gastrectomy (n= 7,450; 90.5%) and laparoscopic surgery (n = 782; 9.5%). Preoperative measurement of risk variables was important (CI = 0.45-0.82, p = 0.001, odds ratio [OR] 0.61, 95% confidence interval). We found no significant differences in mortality between groups when the preoperative risk variable was measured (OR = 0.74; 95% CI = 0.32-1.72; p = 0.481).