Systemic Inflammatory Response After Open, Laparoscopic and Robotic Surgery in Endometrial Cancer Patients

R Pilka, Radovan Pilka, Radim Marek, Tomáš Adam, Tomas Adam, Milan Kudela, M Kudela, D Ondrová, Dana Ondrová, David Neubert, Jozef Hambálek, Martin Maděrka, M Maděrka, Dagmar Solichová, Lenka Kujovská Krčmová, Bohuslav Melichar
Anticancer research · 2016 · vol. 36(6) , pp. 2909–22 · PMID:27272805 · W2412095892
Other OA: closed CC0
View on OpenAlex View on PubMed
⚙ AI-generated summary by qwen3.7-flash, 2026-09-11 ⓘ

This study analyzed inflammatory and nutritional biomarkers in 109 endometrial cancer patients undergoing open, laparoscopic, or robotic surgery, finding differential postoperative responses to surgical trauma across these approaches.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

AIM: To study inflammatory response and nutritional biomarkers in operated endometrial cancer (EC) patients. MATERIALS AND METHODS: A total 109 consecutive EC patients undergoing open laparotomy (LT), laparoscopic (LS) or robot-assisted surgery (RS) were studied. Twenty four patients served as controls. Pre- and postoperative levels of inflammatory and nutritional biomarkers were analyzed prospectively. RESULTS: The estimated blood loss was significantly lower in RS compared to all other groups. C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Hemoglobin, retinol, alpha-tocopherol, vitamin D and citrulline concentrations decreased and inflammatory biomarkers increased after surgery to a different extent in LT, LS, RS and control groups. CONCLUSION: The present data demonstrate a differential response to surgical trauma in patients with endometrial carcinoma.

My notes (saved in your browser only)

MeSH descriptors

Endometrial Neoplasms Inflammation Laparoscopy Robotic Surgical Procedures Adult Aged Aged, 80 and over Biomarkers C-Reactive Protein C-Reactive Protein Endometrial Neoplasms Endometrial Neoplasms Female Humans Inflammation Interleukin-6 Interleukin-6 Laparoscopy Middle Aged Neopterin

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (22)

Source provenance

openalex
last seen: 2026-05-10T10:19:41.460405+00:00
pubmed
last seen: 2026-10-08T21:17:59.733123+00:00
License: CC0 · commercial use OK