Cellular membranes as Quantum-to-Classical Transducers via 1836:1 mass-anisotropy

Cellular membranes as Quantum-to-Classical Transducers via 1836:1 mass-anisotropy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Cellular membranes as Quantum-to-Classical Transducers via 1836:1 mass-anisotropy Prasanth Ariyannur This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-9269552/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Biological energy transduction is classically described by Mitchellian chemiosmosis via stochastic proton diffusion. However, anomalous kinetic isotope effects (KIE) and localized surface conduction indicate sub-atomic mechanisms extending beyond classical thermodynamics. Here, we identify the 1836:1 mass-anisotropy between the proton and electron as the fundamental physical driver of a Quantum-to-Classical Transducer (QCT). Utilizing the Caldeira-Leggett framework, we show that the electronic wavefunction undergoes a non-adiabatic Quantum Search for optimal redox trajectories, which is subsequently rectified into Classical Storage via environmental decoherence. We quantify the polyanionic glycocalyx as a dielectric rectifier that induces wavefunction collapse at a 2.4 THz resonance frequency. The evolutionary transition from Hadean sulfur-based acceptors to modern oxygen respiration reduced decoherence time by 75%, increasing bioenergetic power density. Furthermore, we demonstrate that aromatic residues mediate this sub-atomic rectification, providing a unified physical chemistry framework for membrane charge translocation. Biological sciences/Biophysics/Membrane biophysics Biological sciences/Biophysics/Bioenergetics Full Text Additional Declarations There is NO Competing Interest. Supplementary Files ExtendedData.docx Extended Data Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9269552","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":616484088,"identity":"6d61b0e3-8bc9-42a1-ae22-19d9079b24f0","order_by":0,"name":"Prasanth Ariyannur","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4UlEQVRIiWNgGAWjYLCCBAjF+ABI8PCRooXZAKSFjRTL2CTAJCFl5gzMzz48bLPLM5fIfVb5NcdOho2B+eGjG3i0WDawGc9IbEsutpyRbnZbdlsy0GFsxsY5eLQYHGAwZkhsY07ccCON7bbkNmagFh42afxa2D8DtdSDtRRLbqsnRgsPyJbDYC2MH7cdJqzFspmnmCHh3PHEDWeeMUszbjvOw8ZMwC/m7O2bGX+UVSduOJ7G+PHntmp7fvbmh4/xOowZSDBC44KZB0ziUQ7WAib/QDiMPwioHgWjYBSMgpEJAFRiQjLIgUQ3AAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0003-0888-8094","institution":"Karuna Medical College","correspondingAuthor":true,"prefix":"","firstName":"Prasanth","middleName":"","lastName":"Ariyannur","suffix":""}],"badges":[],"createdAt":"2026-03-30 16:12:13","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-9269552/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-9269552/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":106403962,"identity":"932f08e4-be9d-418e-bb6c-767b5be9a4b9","added_by":"auto","created_at":"2026-04-08 09:15:16","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":989432,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-9269552/v1_covered_0e5fd3c6-9319-4fc9-9994-1f780da2e5aa.pdf"},{"id":106293980,"identity":"3591a08d-0cbb-4c99-8a7f-fc9115c92573","added_by":"auto","created_at":"2026-04-07 08:15:09","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":26250,"visible":true,"origin":"","legend":"Extended Data","description":"","filename":"ExtendedData.docx","url":"https://assets-eu.researchsquare.com/files/rs-9269552/v1/cffad5fd9287736dfe631bd7.docx"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e Competing Interest.","formattedTitle":"Cellular membranes as Quantum-to-Classical Transducers via 1836:1 mass-anisotropy","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-9269552/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-9269552/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Biological energy transduction is classically described by Mitchellian chemiosmosis via stochastic proton diffusion. 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