Evolving paradigms in the diagnosis and management of premenopausal women with abnormal uterine bleeding

Mine Senem Yılmaz Aksoy, Teymur Bornaun
In: The European Research Journal · 2024 · vol. 10(4) , pp. 414–425 · doi:10.18621/eurj.1478034 · W4400095264
article OA: diamond CC0
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review explores advanced diagnostic techniques and personalized medical/surgical treatments for abnormal uterine bleeding in premenopausal women, highlighting multidisciplinary approaches for improved patient outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This review addresses evolving paradigms for diagnosing and managing abnormal uterine bleeding (AUB) in premenopausal women, drawing on evidence about endometrial cancer risk, hyperplasia, and benign endometrial conditions such as polyps, and on classification systems like FIGO PALM-COEIN. It synthesizes findings on how imaging and endometrial sampling contribute to evaluating uterine pathology, and it discusses limitations such as variability in diagnostic accuracy across sampling and imaging modalities and reliance on evidence largely derived from broader or heterogeneous populations. A major emphasis is on structured symptom classification and the endometrial pathology framework needed to guide follow-up and treatment decisions in reproductive-age patients. Relevance to endometriosis: adenomyosis is explicitly mentioned in the referenced literature (e.g., Liu et al. on platelet-induced epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in adenomyosis), though the paper’s main focus is abnormal uterine bleeding evaluation in premenopausal women.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Abnormal uterine bleeding (AUB) is a common gynecological complaint among premenopausal women, encompassing a wide range of underlying disorders that complicate diagnosis and management. The evolving paradigms in medical science now incorporate advanced imaging techniques, personalized medicine, and molecular diagnostics to improve the accuracy of diagnoses and the effectiveness of treatment plans. This review examines recent advancements in the diagnostic approach, including the use of transvaginal ultrasonography, hysteroscopy, and biomarker analysis, which have significantly refined the identification of endometrial pathologies. Furthermore, we discuss the shift towards individualized treatment strategies that consider patient-specific factors such as age, reproductive plans, and comorbidities, facilitating tailored therapies. Special attention is given to the role of medical therapies ranging from hormonal treatments to novel non-hormonal drugs, as well as the consideration of minimally invasive surgical options as part of a comprehensive management strategy. By integrating current research findings with clinical practice guidelines, this article aims to provide a synthesized view of the dynamic field of AUB management, proposing a multidisciplinary approach to enhance patient outcomes in premenopausal women.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (41)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK