The Long-Lasting Persistence of SARS-CoV-2 Nucleic Acid in COVID-19 Patients

Abstract Background: Although recurring cases of COVID-19 have been sporadically reported, the long-persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still arguable. We aimed to provide the evidences of recovered COVID-19 patients with long-lasting positive SARS-CoV-2 RNA tests in a Chinese hospital. Case presentations: We reported 4 discharged patients with COVID-19 patients relapsed during the period of self-quarantine, leading to an extended disease course. All of four patients were historically healthy without known underlying diseases (diabetes, hypertension, cancer, i.e.) which may influence the disease course. Conclusion: The persistent course of SARS-COV-2 nucleic acid test positive in these 4 cases was prolonged, which provided some ideas for the long-term existence of SARS-COV-2 RNA in convalescent patients.