Symptomatic vitamin E deficiency diagnosed after histological recognition of myometrial lipofuscinosis

David J. Evans, Daniel M. Berney, D J Pollock
In: The Lancet · 1995 · vol. 346(8974) , pp. 545–546 · doi:10.1016/s0140-6736(95)91384-x · PMID:7658782 · W2056282365
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In a patient with chronic malabsorption, histological identification of myometrial lipofuscinosis during hysterectomy for endometrial hyperplasia revealed vitamin E deficiency, the correction of which improved neurological symptoms.

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Abstract

We report a 44-year-old woman in whom intestinal bypass for obesity at age 23 resulted in chronic malabsorption. After hysterectomy for menorrhagia due to atypical endometrial hyperplasia, the finding of myometrial lipofuscinosis led to a demonstration of vitamin E deficiency. Vitamin E supplementation led to an unexpected improvement in the unsteadiness of gait and slurring of speech of which she had also complained. We suggest that supplementation with vitamin E should be routine in all patients with persistent severe steatorrhoea.

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