Impact of Hypertension on Outcomes of Patients with High-Grade Gliomas:  A Propensity-Matched Study from the Global Federated Health Research Network

Impact of Hypertension on Outcomes of Patients with High-Grade Gliomas: A Propensity-Matched Study from the Global Federated Health Research Network | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Impact of Hypertension on Outcomes of Patients with High-Grade Gliomas: A Propensity-Matched Study from the Global Federated Health Research Network Sarah Eidbo, John Malin, Alejandro Blaubach, Akshay Ratnani, Riley Marotta, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6406384/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose : Hypertension (HTN) is known to cause endothelial dysfunction; disrupting the blood-brain barrier and cerebral blood flow. Gliomas also disrupt cerebral vasculature, via tumor-associated vascular abnormalities and healthy tissue displacement. This retrospective analysis aimed to study differences between patients diagnosed with one of three high-grade gliomas and HTN. Methods : We used TriNetX's US Collaborative Network to study the impact of HTN on adult patients with one of three high-grade gliomas: glioblastoma multiforme (GBM), astrocytoma, or oligodendroglioma (ODG) using ICD-10 codes. We tracked these patients for five years to assess outcomes including all-cause mortality, cerebral infarct, seizures, cerebral edema, and emergency endotracheal intubation. Results : The GBM+HTN cohort showed significantly higher risk of all-cause mortality (HR 1.18, 95% CI 1.094 - 1.271, p<0.000), cerebral edema (HR 1.359, 95% CI 1.236 - 1.494, p<0.001), seizures (HR 1.624, 95% CI 1.459 - 1.808, p=0.007), and hemorrhagic stroke (HR 1.255, 95% CI 1.038 – 1.516, p=0.015). The ODG+HTN cohort demonstrated significantly increased risk of all-cause mortality (HR 1.398, 95% CI 1.040 - 1.879, p=0.001), emergency endotracheal intubation (HR 1.381, 95% CI 0.590 - 3.230, p=0.012), and cerebral edema (HR 0.904, 95% CI 0.680 - 1.203, p=0.023). There were no significant differences between HTN and control cohorts in the astrocytoma group. Conclusions : Patients with high-grade gliomas and HTN differ significantly. Patients with HTN appear to be at a higher risk of all-cause mortality, cerebral edema, seizures, and emergency endotracheal intubation; depending on tumor type. Further research is warranted. Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6406384","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":448353840,"identity":"d0c61d11-4c73-43ae-ac3b-a521f9d29b8a","order_by":0,"name":"Sarah 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Propensity-Matched Study from the Global Federated Health Research Network","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-6406384/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6406384/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003ePurpose\u003c/strong\u003e: Hypertension (HTN) is known to cause endothelial dysfunction; disrupting the blood-brain barrier and cerebral blood flow. Gliomas also disrupt cerebral vasculature, via tumor-associated vascular abnormalities and healthy tissue displacement. This retrospective analysis aimed to study differences between patients diagnosed with one of three high-grade gliomas and HTN.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: We used TriNetX's US Collaborative Network to study the impact of HTN on adult patients with one of three high-grade gliomas: glioblastoma multiforme (GBM), astrocytoma, or oligodendroglioma (ODG) using ICD-10 codes. We tracked these patients for five years to assess outcomes including all-cause mortality, cerebral infarct, seizures, cerebral edema, and emergency endotracheal intubation.\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: The GBM+HTN cohort showed significantly higher risk of all-cause mortality (HR 1.18, 95% CI 1.094 - 1.271, p\u0026lt;0.000), cerebral edema (HR 1.359, 95% CI 1.236 - 1.494, p\u0026lt;0.001), seizures (HR 1.624, 95% CI 1.459 - 1.808, p=0.007), and hemorrhagic stroke (HR 1.255, 95% CI 1.038 – 1.516, p=0.015). The ODG+HTN cohort demonstrated significantly increased risk of all-cause mortality (HR 1.398, 95% CI 1.040 - 1.879, p=0.001), emergency endotracheal intubation (HR 1.381, 95% CI 0.590 - 3.230, p=0.012), and cerebral edema (HR 0.904, 95% CI 0.680 - 1.203, p=0.023). There were no significant differences between HTN and control cohorts in the astrocytoma group.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e: Patients with high-grade gliomas and HTN differ significantly. Patients with HTN appear to be at a higher risk of all-cause mortality, cerebral edema, seizures, and emergency endotracheal intubation; depending on tumor type. Further research is warranted. \u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Impact of Hypertension on Outcomes of Patients with High-Grade Gliomas: A Propensity-Matched Study from the Global Federated Health Research Network","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-04-29 03:18:08","doi":"10.21203/rs.3.rs-6406384/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"0d005807-686a-4513-b470-7e87e0e80573","owner":[],"postedDate":"April 29th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-05-25T03:28:16+00:00","versionOfRecord":[],"versionCreatedAt":"2025-04-29 03:18:08","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6406384","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6406384","identity":"rs-6406384","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}