IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 39099 participants

Abstract Background Over the past two decades, many studies concentrated the association between a common polymorphism ( rs1800795 ) from interleukin-6 (IL-6) gene and Diabetes Mellitus (DM) risk have been published, however, the results remain ambiguous and indefinite.Methods In current, we performed a comprehensive analysis to explore above relationship. A search was conducted in the PubMed, Embase, Chinese (CNKI and Wanfang) databases, covering all papers published until Sep 20, 2019. Odds ratios (OR) with 95% confidence intervals (CI) was applied to evaluate the strength of this association. Publication bias was assessed with both Begg and Egger’s tests.Results Overall, 26 case-control studies with 5973 T2DM patients and 13968 controls, and 11 case-control studies (10193 T1DM patients and 8965 health controls) were included for analysis in our study. Finally, significant decreased association was observed between the rs1800795 polymorphism and T2DM risk in overall sample, Asians and hospital-based subgroup (for example: C-allele vs. G-allele: OR = 0.65, 95%CI = 0.53-0.81, P < 0.05), however, increased associations were found from Mixed population and hospital-based subgroup between rs1800795 polymorphism and T1DM susceptibility (for example: CC vs. GG: OR = 2.45, 95%CI = 1.18-5.07, P = 0.016 for Mixed individuals).Conclusions In summary, there had a definite evidence to confirm that IL-6 rs1800795 polymorphism was associated with susceptibility of decreased T2DM and increased T1DM.