Effects of PKF 115–584 on cell proliferation.

Sachiko Matsuzaki (405488), Claude Darcha (405489)
2015 · doi:10.1371/journal.pone.0061690.g006 · W6923293839
other OA: green CC0
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This in vitro study investigated the effects of PKF 115–584, a small-molecule antagonist of the Tcf/ß-Catenin complex, on cell proliferation in endometrial and endometriotic tissues. The researchers compared basal proliferation rates and the percent inhibition induced by the drug between epithelial and stromal cells from patients with deep infiltrating, ovarian, and superficial peritoneal endometriosis and their matched eutopic endometrium. Results indicated that the compound significantly inhibited cell proliferation in both tissue types across different menstrual phases, with statistically significant differences observed when comparing diseased tissue to healthy controls. This paper is centrally about endometriosis — specifically examining the inhibitory effect of a Wnt pathway antagonist on proliferative activity in various forms of the disease.

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Abstract

A, B: Basal cell proliferation in non-treated epithelial (A) and stromal (B) cells of endometriotic tissue and matched eutopic endometrium of the same patients. C, D: Percent inhibition of cell proliferation in epithelial (C) and stromal (D) cells of endometriotic tissue and matched eutopic endometrium of the same patients treated with PKF 115–584. Results are presented as the mean+SEM. Basal cell proliferation is presented as OD. Percent inhibition of cell proliferation is calculated as percent of vehicle control. P: proliferative phase, S: secretory phase. DE: deep infiltrating endometriosis (epithelial cells: P: n = 7, S: n = 8; stromal cells: P: n = 7, S:n = 9 ). OE: ovarian endometriosis (epithelial cells: P: n = 7 S: n = 6; stromal cells: P: n = 7, S: n = 8 ). SE: superficial peritoneal endometriosis (epithelial cells: P: n = 6, S: n = 6; stromal cells: P: n = 6, S: n = 7 ). A: p<.05 versus matched eutopic endometrium of the same patients.
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In Vitro Effects of a Small-Molecule Antagonist of the Tcf/ß-Catenin Complex on Endometrial and Endometriotic Cells of Patients with Endometriosis Figure 6 Effects of PKF 115–584 on cell proliferation. A, B: Basal cell proliferation in non-treated epithelial (A) and stromal (B) cells of endometriotic tissue and matched eutopic endometrium of the same patients. C, D: Percent inhibition of cell proliferation in epithelial (C) and stromal (D) cells of endometriotic tissue and matched eutopic endometrium of the same patients treated with PKF 115–584. Results are presented as the mean+SEM. Basal cell proliferation is presented as OD. Percent inhibition of cell proliferation is calculated as percent of vehicle control. P: proliferative phase, S: secretory phase. DE: deep infiltrating endometriosis (epithelial cells: P: n = 7, S: n = 8; stromal cells: P: n = 7, S:n = 9 ). OE: ovarian endometriosis (epithelial cells: P: n = 7 S: n = 6; stromal cells: P: n = 7, S: n = 8 ). SE: superficial peritoneal endometriosis (epithelial cells: P: n = 6, S: n = 6; stromal cells: P: n = 6, S: n = 7 ). A: p<.05 versus matched eutopic endometrium of the same patients.

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