Açaí signaling pathways in endometriosis.

Daniel Escorsim Machado (3350489), Karina Cristina Rodrigues-Baptista (3350498), Jessica Alessandra-Perini (3350507), Roberto Soares de Moura (3350510), Thiago Alves dos Santos (3350504), Kariny Gomes Pereira (3350492), Yasmin Marinho da Silva (3350513), Pergentino José Cunha Souza (3350495), Luiz Eurico Nasciutti (410515), Jamila Alessandra Perini (3350501)
2016 · doi:10.1371/journal.pone.0166059.g006 · W6923190887
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This study investigates the therapeutic potential of Euterpe oleracea extract, commonly known as Açaí, in an experimental model of endometriosis. The researchers focused on the endometriotic microenvironment where macrophages drive angiogenesis and inflammation through the upregulation of VEGF, iNOS, and COX-2 genes. They found that Açaí treatment reduces the number of activated macrophages, thereby suppressing the expression of these target genes and inhibiting the maintenance and growth of endometriotic lesions. This paper is centrally about endometriosis — specifically examining how Açaí signaling pathways modulate macrophage activity to reduce lesion progression.

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Abstract

In the endometriotic microenvironment, the macrophages are essential to promote the angiogenesis process and inflammation because it leads to increase the VEGF, iNOS and COX-2 genes expression. Açaí acts in this pathway and decreases the number of activated macrophages resulting in the reduction of the target genes expression, suppressing the maintenance and growth of endometriotic lesion.
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Euterpe oleracea Extract (Açaí) Is a Promising Novel Pharmacological Therapeutic Treatment for Experimental Endometriosis Fig 6 Açaí signaling pathways in endometriosis. In the endometriotic microenvironment, the macrophages are essential to promote the angiogenesis process and inflammation because it leads to increase the VEGF, iNOS and COX-2 genes expression. Açaí acts in this pathway and decreases the number of activated macrophages resulting in the reduction of the target genes expression, suppressing the maintenance and growth of endometriotic lesion.

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endometriosis

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