Açaí signaling pathways in endometriosis.

Daniel Escorsim Machado (3350489), Karina Cristina Rodrigues-Baptista (3350498), Jessica Alessandra-Perini (3350507), Roberto Soares de Moura (3350510), Thiago Alves dos Santos (3350504), Kariny Gomes Pereira (3350492), Yasmin Marinho da Silva (3350513), Pergentino José Cunha Souza (3350495), Luiz Eurico Nasciutti (410515), Jamila Alessandra Perini (3350501)
2016 · doi:10.1371/journal.pone.0166059.g006 · W6923190887
other OA: green CC0
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Abstract

In the endometriotic microenvironment, the macrophages are essential to promote the angiogenesis process and inflammation because it leads to increase the VEGF, iNOS and COX-2 genes expression. Açaí acts in this pathway and decreases the number of activated macrophages resulting in the reduction of the target genes expression, suppressing the maintenance and growth of endometriotic lesion.

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endometriosis

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