Case Report: Formulation of Balanced Medicinal Cannabis in the Tapering of Opioids in Non-Cancer Chronic Pain

Case Report: Formulation of Balanced Medicinal Cannabis in the Tapering of Opioids in Non-Cancer Chronic Pain | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Case Report: Formulation of Balanced Medicinal Cannabis in the Tapering of Opioids in Non-Cancer Chronic Pain Andres David Turizo Smith, Juan Rafael López Sánchez This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6386043/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract This case report discusses the management of chronic non-oncologic pain in a 28-year-old female patient with spinal cord injury using a balanced medicinal cannabis formulation. The patient, initially on opioids and gabapentin, underwent multiple pharmacological interventions, including Tapentadol and Pregabalin, with variable success. Eventually, a balanced cannabis formulation (THC 12 mg/ml - CBD 14 mg/ml) allowed for successful opioid tapering, resulting in improved pain control and reduced anxiety symptoms. Psychiatric and toxicology evaluations were recommended but not attended. This case highlights the potential of medicinal cannabis as an alternative therapeutic option in opioid management for chronic pain. Anesthesiology & Pain Medicine Chronic pain management Medicinal cannabis Opioid use disorder Clinical case report Clinical management Quality of life Spinal cord injury Cannabinoids Palliative care Integrative medicine Full Text Additional Declarations The authors declare potential competing interests as follows: Dr. Juan Rafael López Sánchez MD acknowledges a conflict of interest as he serves as the Scientific Director of the clinic and receives honoraria from it. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6386043","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":439006809,"identity":"6c09781b-2004-4ccb-b8bf-e7dd80356375","order_by":0,"name":"Andres David Turizo Smith","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA70lEQVRIiWNgGAWjYHACAyCWADEYHwAJGagIXmDYANXCDFLKQ6wWMGCTIEoL/+zm7Y9591jY8/OfTqvm3WHHw8DevE2CocYGpxaJO8cKm3meSTBLzsjddpv3TDIPA8+xMgmGY2m4rbmRY9jMc0CCzeAGL1BLGzMPg0SOmQRjw2GcOuShWngMzp/dVszbVs/DIP8GvxYDqBYJgwO525h52w4DbeHBr8XwRlrhzDkHJAyAftksObftOA8bT1qxRQIev8jdSN7w4c2BOmCInd344W1btRw/++GNNz7gCTFMwAYiEkjQMApGwSgYBaMAEwAAEkJKRsBaKuEAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0003-0358-4008","institution":"Universidad Nacional de Colombia","correspondingAuthor":true,"prefix":"","firstName":"Andres","middleName":"David Turizo","lastName":"Smith","suffix":""},{"id":439006810,"identity":"8a4b454c-f316-483e-b10e-c8e46943dffb","order_by":1,"name":"Juan Rafael López Sánchez","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAuElEQVRIiWNgGAWjYBACxgbmBgYGNhsQs/EAkVoYQVrSwEzitIBUArUcBjOJ08I8+2Dzpxtl5+3Wth8G2lJjE03Yjr7ENumcc7eTt51JBGo5lpbbQFBLD2Mbc27b7WSzA0AtjA2HidLS/Dm37Vyy2fmHxGtpkM5tO2BndoMEW0B+SU4wuwG0JYEYvxj2MB/+nFNmZ292Pv3hgw81NkRogapIBNMJhJSDgDyUtidG8SgYBaNgFIxQAADCA0hE0lJmWQAAAABJRU5ErkJggg==","orcid":"","institution":"Clinica Zerenia,","correspondingAuthor":true,"prefix":"","firstName":"Juan","middleName":"Rafael López","lastName":"Sánchez","suffix":""}],"badges":[],"createdAt":"2025-04-06 10:09:18","currentVersionCode":1,"declarations":{"humanSubjects":true,"vertebrateSubjects":false,"conflictsOfInterestStatement":true,"humanSubjectEthicalGuidelines":true,"humanSubjectConsent":true,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":true,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-6386043/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6386043/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":80266020,"identity":"944b2b32-7ff3-41f5-a1d0-e75abb1722b9","added_by":"auto","created_at":"2025-04-10 02:03:16","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":413584,"visible":true,"origin":"","legend":"","description":"","filename":"CaseReportFormulationofBalancedMedicinalCannabisintheTaperingofopioidsfinalversion.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6386043/v1_covered_dd4a70a1-fafc-4c18-828d-1eedbb5d0e7c.pdf"}],"financialInterests":"The authors declare potential competing interests as follows: Dr. Juan Rafael López Sánchez MD acknowledges a conflict of interest as he serves as the Scientific\nDirector of the clinic and receives honoraria from it.","formattedTitle":"\u003cp\u003eCase Report: Formulation of Balanced Medicinal Cannabis in the Tapering of Opioids in Non-Cancer Chronic Pain\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Chronic pain management, Medicinal cannabis, Opioid use disorder, Clinical case report, Clinical management, Quality of life, Spinal cord injury, Cannabinoids, Palliative care, Integrative medicine","lastPublishedDoi":"10.21203/rs.3.rs-6386043/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6386043/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThis case report discusses the management of chronic non-oncologic pain in a 28-year-old female patient with spinal cord injury using a balanced medicinal cannabis formulation. The patient, initially on opioids and gabapentin, underwent multiple pharmacological interventions, including Tapentadol and Pregabalin, with variable success. Eventually, a balanced cannabis formulation (THC 12 mg/ml - CBD 14 mg/ml) allowed for successful opioid tapering, resulting in improved pain control and reduced anxiety symptoms. Psychiatric and toxicology evaluations were recommended but not attended. This case highlights the potential of medicinal cannabis as an alternative therapeutic option in opioid management for chronic pain.\u003c/p\u003e","manuscriptTitle":"Case Report: Formulation of Balanced Medicinal Cannabis in the Tapering of Opioids in Non-Cancer Chronic Pain","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-04-10 01:55:07","doi":"10.21203/rs.3.rs-6386043/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"0ab306bf-53f6-4598-be9e-d4051f160307","owner":[],"postedDate":"April 10th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":46940708,"name":"Anesthesiology \u0026 Pain Medicine"}],"tags":[],"updatedAt":"2025-04-10T01:55:07+00:00","versionOfRecord":[],"versionCreatedAt":"2025-04-10 01:55:07","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6386043","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6386043","identity":"rs-6386043","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}