Metabolic Level and Hypothalamic-Pituitary-Gonadal Axis (HPGA) Function in Prepubertal Male Children with Simple Obesity and Sexual Retardation

Abstract With the increasing morbidity of obesity in children and adolescents in worldwide,more and more diseases are recognized by people. Our aim was to study the effects of obesity on metabolic level and hypothalamic-pituitary-gonadal axis function in prepubertal males.Ninety-two patients participated in our study and then were divided into two groups according to whether the peak value of LH was less than 4.8 mIU/ml in Gonadotropin-releasing hormone(GnRH) stimulation test. All of them were underwent a comprehensive physical examination,laboratory tests and imaging examinations.The obesity with sexual retardation group in bone age, BMISDS, blood pressure, testicular volume and penile length, IGF-1SDS, HOMA-IR, AST, ALT, HDL-C, LDL-C and triglyceride were significantly different from control group (P < 0.01).There were significant differences in age, BMISDS, diastolic blood pressure, penile length and HDL-C between normal HPGA group and hypogonadotropic hypogonadism(HH) group (P < 0.01).FSH and INB had statistical differences before and after human chorionic gonadotropin (HCG) stimulation test between the two groups(P < 0.05), while T and DHT had statistical differences after the test (P < 0.01). Conclusion Prepubertal obesity can cause metabolic disorders and increase the risk of metabolic syndrome, and lead to sexual retardation.