Strain differences in the response to the 5-HT1A receptor agonist, 8-OH-DPAT

Lynda Uphouse, Sharmin Maswood, Astra Jackson, Karen Brown, Julia Prullage, Tonya Brown Myers, Farzana Shaheen
In: Pharmacology Biochemistry and Behavior · 2002 · vol. 72(3) , pp. 533–542 · doi:10.1016/s0091-3057(02)00714-1 · PMID:12175449 · W2027526307
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Abstract

Fischer and Sprague-Dawley ovariectomized rats were hormonally primed with estradiol benzoate (EB) and progesterone, and the ability of the 5-HT(1A) receptor agonist, (+/-) 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), to inhibit lordosis behavior was examined. Both strains showed rapid inhibition of lordosis behavior following either intraperitoneal or subcutaneous treatment with 8-OH-DPAT. Similarly, in both strains, pretreatment with EB (1 week prior to estrogen and progesterone priming) attenuated the lordosis-inhibiting effects of 8-OH-DPAT. However, Sprague-Dawley females showed a greater decline in lordosis behavior with a lower dose of 8-OH-DPAT than did Fischer females. The strain difference was present in females that had been preprimed with EB as well as in females receiving a single estrogen and progesterone priming. Moreover, strain differences were present across different priming doses of EB. Sprague-Dawley females were also more likely to show flat body posture after injection with 8-OH-DPAT so that the greater sensitivity of this strain to the 5-HT(1A) receptor agonist was not restricted to the drug's effect on lordosis behavior. These findings lead to the suggestion that, relative to Fischer rats, Sprague-Dawley females are more responsive to the 5-HT(1A) receptor agonist. Possible explanations for this strain difference are discussed.

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SciLite annotations

organisms 3
cloning vector pb-5-xor-degron-tvmvs-mcp-cnot7-tevs-degron-e2a-mcp-tevs-tvmvs-cnot7-f2a-ntevp-frb-t2a-fkbp-ctevp-p2a-l7ae-smash rattus sp. rattus sp.
chemicals 7
estriol acetate benzoate progesterone hydroxyl estrogen progesterone estrogen progesterone

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