ATP-Binding Cassette Cholesterol Transporter–1 (ABC1) G1051A, and G2706A Gene Polymorphism in patients with primary hyperlipidemi

Abstract Objective: we aimed to investigate the effects of ABCA1 G2706A and G1051A gene polymorphisms on glycemic levels, and inflammatory markers as hs-CRP, and fibrinogen in patients with primary hyperlipidemia.Material, and Method:Sixty male and 78 female patients participated in the study. DNAs of white blood cells were isolated, and ABCA1 G2706A, and G1051A gene polymorphisms were analyzed using PCR. Results: Among patients included in the study, systolic blood pressures of the patients carrying AA genotype in ABCA-1 2706 gene polymorphism were lower relative to those having AG, and GG genotypes. (p=0.027). Statistical analysis performed between ABCA1 G1051A (R219K) gene polymorphism, and HDL-cholesterol levels revealed that HDL-cholesterol level was statistically significantly higher in patients with GG genotype when compared with those having AA, and AG genotypes (p=0.047). The presence of metabolic syndrome did not differ statistically significantly among patients carrying ABCA1 G2706A polymorphism. [GA genotype vs GG genotype (p=0.321, OR: 0.364), AA genotype vs GG genotype (p=0.438, OR: 0.534)]. Incidence of metabolic syndrome in ABCA1 gene G1051A polymorphism in patients carrying GG genotype was significantly more frequently detected in those having GA (p=0.001, OR: 5.816) or AA (p=0.039, OR: 3.619) genotype. On the other hand, the individuals with AA genotype had lower systolic blood pressures.Conclusion: ABCA1 gene polymorphism has been seen to be correlated with hypertension, and metabolic syndrome apart from HDL-cholesterol metabolism