The expression of Bcl-2 and Fas in the ectopic focus of adenomyosis under the action of mifepristone

Objective The intention of this experiment is to discuss the expression-change of cellular apoptosis factors,Bal-2 and Fas,under the action of mifepristone in myometrium ectopic foucs of the patients of adenomyosis.We also discuss that the cellular apoptosis factors,Bcl-2 and Fas,show the periodical change in the proliferative stage and the progestational stage,whether or not.Methods The research object are 180 patients,who had been clinical definited as adenomyosis,inquiried operation treatment in the department of gynaecology and obstetrics in Changchun Center hospital from January 2003 to January 2009.All the patients are randomly divided into two groups,one is experimental group,the other one is control group.In the experimental group,all the patients are given mifepristone by mouth before the operations,then the expression of Bcl-2 and Fas genes in ectopic foucs is measured by immunohistochemical method.Results In the experiment group and the contral group,the proliferative stage contrast with the progestational stage,Bcl-2 and Fas are expressed persistently and have no periodical change.To compare the experiment group with the control group,Bcl-2 lowers obviously and Fas has increased obviously in the experimental group comparing with that in the control group.Conclusion(1)In the ectopic foucs of adenomyosis,mifepristone can decline the rate of the positive expression of Bcl-2,which is the cellular apoptosis inhibitive factor,and at the same time raise the rate of the positive expression of Fas,which is the cellular apoptosis enhancing factor.It can reduce the cellular apoptosis enhancement in the ectopic focus.(2)In the ectopic foucs of adenomyosis,it shows that the expression of Bcl-2 and Fas are persistently and have no obvious periodical change in the proliferative stage and progestational stage.It may be induce many cells which in the ectopic foucs to avert apoptosis and make the rate of cellular apoptosis to lower obviously.The weakening of cellular apoptosis of ectopic endometrium may be one of the etiopathogenesis of adenomyosis.