Interpolymer Interactions and Physicochemical Properties of Dual-Jet Electrospun PCL/PVA Nanofibers for Tunable Biodegradable Mats

Interpolymer Interactions and Physicochemical Properties of Dual-Jet Electrospun PCL/PVA Nanofibers for Tunable Biodegradable Mats | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Interpolymer Interactions and Physicochemical Properties of Dual-Jet Electrospun PCL/PVA Nanofibers for Tunable Biodegradable Mats Javad Esmaeilzadeh, Ali Khorsand Zak This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7662981/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract This study explores the development and characterization of dual-jet electrospun nanofibrous mats composed of polycaprolactone (PCL) and polyvinyl alcohol (PVA), designed to integrate the advantageous properties of both polymers into a structurally cohesive and functionally responsive scaffold. The dual-nozzle electrospinning process produced uniform, bead-free, and interpenetrating fibrous architectures. FTIR analysis indicated intermolecular hydrogen bonding between the hydroxyl groups of PVA and the carbonyl groups of PCL, suggesting enhanced interfacial compatibility between the polymer phases. The composite mats exhibited improved tensile strength (~ 0.8 MPa) and elongation (~ 130%) compared to single-polymer controls, along with pH-responsive degradation behavior and high water absorption capacity (~ 800%). Water vapor transmission rate measurements confirmed adequate breathability (3100 g/m²/day), while in vitro assays demonstrated excellent cytocompatibility and fibroblast adhesion. Although no active antimicrobial agents were included, the mats showed mild antibacterial activity, likely influenced by their surface morphology and physicochemical composition. Overall, the findings highlight the potential of dual-jet electrospun PCL/PVA mats as tunable, biocompatible platforms for biomedical applications requiring balanced mechanical performance, moisture management, and controlled degradation. Biological sciences/Biotechnology Physical sciences/Chemistry Physical sciences/Materials science Dual-jet electrospinning Polycaprolactone Polyvinyl alcohol Interpolymer interaction Nanofibrous scaffold Biodegradable composite Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7662981","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":535037777,"identity":"77595e86-e4b4-4fa5-aba2-f9972d5a4cea","order_by":0,"name":"Javad 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Mats","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Dual-jet electrospinning, Polycaprolactone, Polyvinyl alcohol, Interpolymer interaction, Nanofibrous scaffold, 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The dual-nozzle electrospinning process produced uniform, bead-free, and interpenetrating fibrous architectures. FTIR analysis indicated intermolecular hydrogen bonding between the hydroxyl groups of PVA and the carbonyl groups of PCL, suggesting enhanced interfacial compatibility between the polymer phases.\u003c/p\u003e\u003cp\u003eThe composite mats exhibited improved tensile strength (~\u0026thinsp;0.8 MPa) and elongation (~\u0026thinsp;130%) compared to single-polymer controls, along with pH-responsive degradation behavior and high water absorption capacity (~\u0026thinsp;800%). Water vapor transmission rate measurements confirmed adequate breathability (3100 g/m\u0026sup2;/day), while in vitro assays demonstrated excellent cytocompatibility and fibroblast adhesion. Although no active antimicrobial agents were included, the mats showed mild antibacterial activity, likely influenced by their surface morphology and physicochemical composition.\u003c/p\u003e\u003cp\u003eOverall, the findings highlight the potential of dual-jet electrospun PCL/PVA mats as tunable, biocompatible platforms for biomedical applications requiring balanced mechanical performance, moisture management, and controlled degradation.\u003c/p\u003e","manuscriptTitle":"Interpolymer Interactions and Physicochemical Properties of Dual-Jet Electrospun PCL/PVA Nanofibers for Tunable Biodegradable Mats","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-10-28 16:49:31","doi":"10.21203/rs.3.rs-7662981/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"67479599-1afc-4d86-9c0b-ea0d789b13f0","owner":[],"postedDate":"October 28th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":56883893,"name":"Biological sciences/Biotechnology"},{"id":56883894,"name":"Physical sciences/Chemistry"},{"id":56883895,"name":"Physical sciences/Materials science"}],"tags":[],"updatedAt":"2026-04-27T08:06:22+00:00","versionOfRecord":[],"versionCreatedAt":"2025-10-28 16:49:31","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7662981","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7662981","identity":"rs-7662981","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}