Changes of mast cells and eosinophilic granulocytes in ectopic endometrium of rats

Objective:To observe the changes of the number and localization of mast cells and eosinocytes in ectopic endometrium from EMT model rats and to study the relationship between mast cells, eosinocytes and endometriosis. Methods: Rat endometriosis model was established; eutopic and ectopic endometrium were acquired for light and electron microscopic examination every day after operation. Results: Some mast cells were seen in the ectopic endometrium after operation. From the 8th day after operation, numerous mast cells were noted around blood vessels and the fibrotic interstitium; from the 9th day after operation the number of eosinophilic granulocyte increased in ectopic endometrium. Conclusion: The number and the distribution of mast cells and eosinocytes in ectopic endometrium may be related to the development and progression of endometriosis.