Enhancing the Efficacy of Cancer Immunotherapy by Supportive High-Dose Vitamin C Therapy

In vitro results and murine experiments consistently demonstrate the cytotoxic effect of vitamin C (AA) on cancer cells, but current clinical evidence for high-dose i.v. AA’s (HDVC) therapeutic effect is ambivalent. The discrepancy may be due to the lack of knowledge regarding the AA's mode of action. Recently, we introduced a novel hypothesis suggesting an alternative synthesis mechanism of adenosine triphosphate (ATP) involving specific cellular structures: Structure for Energy Transformation. Fe-S clusters, AA, ATP, D-glucose, uric acid, NO, and H2PO4- molecules are involved in the glucose – ATP energy transformation process. We suppose that AA is responsible for the continuous electron transfer in cells. AA initiates the energy transformation in the multiplex electron transfer chains, where O2- radicals are formed for carbon oxidation. These radicals destroy cancer cells when glucose is unavailable in the reaction. Using supportive high-dose vitamin C therapy might increase the effectiveness of immunotherapy for cancer.