Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2
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Pre-vaccination frequencies of naive and transitional B cells and post-vaccination fold changes in activated CD8+ T cells correlated with antibody titers to the BNT162b2 mRNA vaccine.
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Abstract
ABSTRACT We analyzed peripheral blood mononuclear cells (PBMCs) of each 20 individuals with a high anti-SARS-CoV-2 antibody titer and a low antibody titer out of 1,774 healthcare workers who received BNT162b2 mRNA vaccine. A higher antibody titer was associated with the frequencies of naïve and transitional B cells before vaccination. In addition, fold changes in the frequency of activated CD8 + T cells upon vaccination were correlated with the antibody titers.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00