The significance of serum tumor markers combine with the ultrasound in mature cystic teratoma of ovary

Objective To evaluate the clinical significance of serum tumor markers combine with the ultrasound checking in ovarian teratoma.Methods 422 patients with cystic teratoma of ovary diagnosed by postoperative were selected whose tumor markers including CA199,CA125,CA724,CEA,AFP and the ultrasound checking were studied.Results 230 patients were tested for serum CA199 and 118 patients had the levels above 27 U/ml with the positive rate of 51.30%.364 patients were tested for serum CA125 and 79 patients had elevated CA125 levels(35 U/ml).Excluded the 56 patients who suffered from other diseases which could cause increased CA125 levels(for example early pregnancy,endometriosis,torsion of the pedicle of ovarian cyst,acute pelvic inflammatory disease and so on),the positive rate was 6.32%.63 patients were tested for CA724 only two was abnormal and the positive rate was 3.17%.159 patients were detected CEA and 142 patients were detected AFP and no abnormal were found.All patients underwent the ultrasound check and 323 teratoma patients were diagnosed before operation and were proved after operation pathological diagnosis with the positive rate of 76.54%.The mean diameter of the CA199 positive group was(7.92±2.19)cm,which was bigger than that of the negative group(4.86±1.65)cm(P=0.023).The positive rate of the CA199 both sides was much higher than that of single side(P=0.003).Conclusions The bigger of the diameter of the mature cystic teratoma,the higher of the positive rate of the CA199.The positive rate of the CA199 was higher when teratomas was both sides.Combined with the ultrasound checking,CA199 may have clinical significance in the diagnosis of mature ovarian teratoma and improve the accuracy of preoperative diagnosis.